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1. 发明申请

US20080020012A1 Collagen scaffolds, medical implants with same and methods of use 审中-公开
标题翻译：胶原支架，医用植入物及其使用方法
公开(公告)号：US20080020012A1
公开(公告)日：2008-01-24
申请号：US11821320
申请日：2007-06-22
申请人： Young Ju , Francis Moussy , Thomas Koob
发明人： Young Ju , Francis Moussy , Thomas Koob
IPC分类号： A61K9/00 , A61B5/145
CPC分类号： A61L27/48 , A61B5/14542 , A61B5/1486 , A61B5/14865 , A61L27/18 , A61L27/24 , A61L27/34 , A61L27/54 , A61L27/56 , A61L31/044 , A61L31/10 , A61L31/129 , A61L2400/02 , A61L2400/18 , A61L2420/02 , C08L89/06
摘要： The subject invention concerns non-degradable three dimensional porous collagen scaffolds and coatings. These scaffolds can be prepared around sensors for implantation into a body. A specific embodiment of the invention concerns implantable glucose sensors. Sensors comprising a collagen scaffold of the invention have improved biocompatibility by minimizing tissue reactions while stimulating angiogenesis. The subject invention also concerns methods for preparing collagen scaffolds of the invention. The subject invention also concerns sensors that have a collagen scaffold of the invention around the exterior of the sensor.
摘要翻译：本发明涉及不可降解的三维多孔胶原支架和涂层。这些支架可以围绕用于植入体内的传感器来制备。本发明的具体实施方案涉及可植入的葡萄糖传感器。包含本发明的胶原支架的传感器通过在刺激血管发生的同时最小化组织反应来改善生物相容性。本发明还涉及制备本发明的胶原支架的方法。本发明还涉及在传感器的外部具有本发明的胶原支架的传感器。

2. 发明授权

US07534330B2 Epoxy enhanced polymer membrane to increase durability of biosensors 有权
标题翻译：环氧增强聚合物膜增加生物传感器的耐久性
公开(公告)号：US07534330B2
公开(公告)日：2009-05-19
申请号：US11161979
申请日：2005-08-24
申请人： Bazhang Yu , Francis Moussy
发明人： Bazhang Yu , Francis Moussy
IPC分类号： C25B9/02 , B32B27/38 , C12Q1/00 , G01N33/50
CPC分类号： A61B5/14532 , A61B5/14865 , C12Q1/006 , Y10T428/31511 , Y10T428/31529
摘要： The present invention provides a polymer membrane enhanced with cured epoxy resin for use as the outer membrane of biosensors. The membrane includes approximately 30-80% epoxy resin adhesives, 10-60% polymer such as poly(vinyl chloride), polycarbonate and polyurethane and 0-30% plasticizers and 5-15% surface modifier reagent such as polyethylene oxide-containing block copolymers. Utilizing the polymer membrane of the present invention, a three-layered sensing element has been developed. This sensing element will be particularly useful for miniaturized biosensors used for in vitro blood measurements or for continuous in vivo monitoring such as implantable biosensors. This element includes an enzyme layer, an interference-eliminating layer and the novel polymer member of the present invention as the outer polymer layer. This novel sensing element shows excellent response characteristics in solutions and has an extremely long lifetime. This technology is particularly useful for improving the lifetime of implantable biosensors.
摘要翻译：本发明提供了一种用固化环氧树脂增强的聚合物膜，用作生物传感器的外膜。膜包括约30-80％的环氧树脂粘合剂，10-60％的聚合物，例如聚（氯乙烯），聚碳酸酯和聚氨酯，以及0-30％的增塑剂和5-15％的表面改性剂如含聚环氧乙烷的嵌段共聚物。利用本发明的聚合物膜，开发了三层感测元件。该感测元件对于用于体外血液测量或连续体内监测的小型化生物传感器（例如可植入生物传感器）将特别有用。该元件包括酶层，干涉消除层和作为外聚合物层的本发明的新型聚合物构件。这种新颖的感应元件在溶液中显示出优异的响应特性，寿命极长。该技术对于改善可植入生物传感器的寿命特别有用。

3. 发明授权

US09579422B2 Collagen scaffolds, medical implants with same and methods of use 有权
标题翻译：胶原支架，医用植入物及其使用方法
公开(公告)号：US09579422B2
公开(公告)日：2017-02-28
申请号：US14642137
申请日：2015-03-09
申请人： Young Min Ju , Francis Moussy , Thomas J. Koob
发明人： Young Min Ju , Francis Moussy , Thomas J. Koob
IPC分类号： A61L27/48 , A61L27/24 , A61L27/34 , A61L31/04 , A61L31/10 , A61L27/54 , A61L31/12 , A61B5/1486
CPC分类号： A61L27/48 , A61B5/14542 , A61B5/1486 , A61B5/14865 , A61L27/18 , A61L27/24 , A61L27/34 , A61L27/54 , A61L27/56 , A61L31/044 , A61L31/10 , A61L31/129 , A61L2400/02 , A61L2400/18 , A61L2420/02 , C08L89/06
摘要： The subject invention concerns non-degradable three dimensional porous collagen scaffolds and coatings. These scaffolds can be prepared around sensors for implantation into a body. A specific embodiment of the invention concerns implantable glucose sensors. Sensors comprising a collagen scaffold of the invention have improved biocompatibility by minimizing tissue reactions while stimulating angiogenesis. The subject invention also concerns methods for preparing collagen scaffolds of the invention. The subject invention also concerns sensors that have a collagen scaffold of the invention around the exterior of the sensor.
摘要翻译：本发明涉及不可降解的三维多孔胶原支架和涂层。这些支架可以围绕用于植入体内的传感器来制备。本发明的具体实施方案涉及可植入的葡萄糖传感器。包含本发明的胶原支架的传感器通过在刺激血管发生的同时最小化组织反应来改善生物相容性。本发明还涉及制备本发明的胶原支架的方法。本发明还涉及在传感器的外部具有本发明的胶原支架的传感器。

4. 发明授权

US06366794B1 Generic integrated implantable potentiostat telemetry unit for electrochemical sensors 失效
标题翻译：用于电化学传感器的通用集成植入式恒电位遥测单元
公开(公告)号：US06366794B1
公开(公告)日：2002-04-02
申请号：US09443764
申请日：1999-11-19
申请人： Francis Moussy , Robert W. Conlan , Markham C. Godwin , Richard D. Beach
发明人： Francis Moussy , Robert W. Conlan , Markham C. Godwin , Richard D. Beach
IPC分类号： A61G505
CPC分类号： A61L27/54 , A61B5/0031 , A61B5/14532 , A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/00 , C08L89/00 , C08L27/12 , C08L33/14 , C08L39/06
摘要： A generic implantable puck that can be used with a number of biosensor configurations. This generic implantable potentiostat telemetry unit (the puck) can also be part of a system to detect glucose concentrations. An electrochemical system partially implantable into a body for detecting glucose concentrations therein is presented. The system comprises an electrochemical sensor, a transmitting puck including an electric circuit connected to the electrochemical sensor for transmitting a signal indicative of the glucose concentrations in the body. There is at least one receiver for receiving the signal from the transmitting puck and a computer system coupled tlo the at least one receiver for processing the signal for patient diagnosis and treatment.
摘要翻译：可与多个生物传感器配置一起使用的通用植入式冰球。该通用植入式恒电位遥测单元（冰球）也可以是检测葡萄糖浓度的系统的一部分。提出了部分可植入体内用于检测葡萄糖浓度的电化学系统。该系统包括电化学传感器，包括连接到电化学传感器的电路的发射盘，用于传送指示体内葡萄糖浓度的信号。存在至少一个接收器，用于从发送盘接收信号，以及计算机系统，耦合至少一个接收器，用于处理用于患者诊断和治疗的信号。

5. 发明申请

US20060289307A1 Epoxy Enhanced Polymer Membrane to Increase Durability of Biosensors 有权
标题翻译：环氧增强聚合物膜提高生物传感器的耐久性
公开(公告)号：US20060289307A1
公开(公告)日：2006-12-28
申请号：US11161979
申请日：2005-08-24
申请人： Bazhang Yu , Francis Moussy
发明人： Bazhang Yu , Francis Moussy
IPC分类号： G01N33/487 , C12Q1/00
CPC分类号： A61B5/14532 , A61B5/14865 , C12Q1/006 , Y10T428/31511 , Y10T428/31529
摘要： The present invention provides a polymer membrane enhanced with cured epoxy resin for use as the outer membrane of biosensors. The membrane includes approximately 30-80% epoxy resin adhesives, 10-60% polymer such as poly(vinyl chloride), polycarbonate and polyurethane and 0-30% plasticizers and 5-15% surface modifier reagent such as polyethylene oxide-containing block copolymers. Utilizing the polymer membrane of the present invention, a three-layered sensing element has been developed. This sensing element will be particularly useful for miniaturized biosensors used for in vitro blood measurements or for continuous in vivo monitoring such as implantable biosensors. This element includes an enzyme layer, an interference-eliminating layer and the novel polymer member of the present invention as the outer polymer layer. This novel sensing element shows excellent response characteristics in solutions and has an extremely long lifetime. This technology is particularly useful for improving the lifetime of implantable biosensors.
摘要翻译：本发明提供了一种用固化环氧树脂增强的聚合物膜，用作生物传感器的外膜。膜包括约30-80％的环氧树脂粘合剂，10-60％的聚合物，例如聚（氯乙烯），聚碳酸酯和聚氨酯，以及0-30％的增塑剂和5-15％的表面改性剂如含聚环氧乙烷的嵌段共聚物。利用本发明的聚合物膜，开发了三层感测元件。该感测元件对于用于体外血液测量或连续体内监测的小型化生物传感器（例如可植入生物传感器）将特别有用。该元件包括酶层，干涉消除层和作为外聚合物层的本发明的新型聚合物构件。这种新颖的感应元件在溶液中显示出优异的响应特性，寿命极长。该技术对于改善可植入生物传感器的寿命特别有用。

6. 发明授权

US5534025A Vascular bioartificial organ 失效
标题翻译：血管生物人工器官
公开(公告)号：US5534025A
公开(公告)日：1996-07-09
申请号：US257120
申请日：1994-06-08
申请人： Francis Moussy
发明人： Francis Moussy
IPC分类号： A61F2/02 , A61F2/04
CPC分类号： A61F2/022
摘要： A bioartificial organ is provided which is inserted as an anastomosis between an artery and a vein. Blood flowing through the fluid conduits of the device is separated by a semi-permeable membrane from a chamber containing living cells or tissue.
摘要翻译：提供生物人造器官，其作为动脉和静脉之间的吻合插入。流过装置的流体导管的血液由半透膜与包含活细胞或组织的腔室隔开。

7. 发明申请

US20080206829A1 EPOXY ENHANCED POLYMER MEMBRANE TO INCREASE DURABILITY OF BIOSENSORS 有权
标题翻译：环氧增强聚合物膜增加生物传感器的耐久性
公开(公告)号：US20080206829A1
公开(公告)日：2008-08-28
申请号：US12015614
申请日：2008-01-17
申请人： Bazhang Yu , Francis Moussy
发明人： Bazhang Yu , Francis Moussy
IPC分类号： C12N11/00 , C08K5/092 , C08K5/521 , C08L71/02
CPC分类号： A61B5/14532 , A61B5/14865 , C12Q1/006 , Y10T428/31511 , Y10T428/31529
摘要： The present invention provides a polymer membrane enhanced with cured epoxy resin for use as the outer membrane of biosensors. The membrane includes approximately 30-80% epoxy resin adhesives, 10-60% polymer such as poly(vinyl chloride), polycarbonate and polyurethane and 0-30% plasticizers and 5-15% surface modifier reagent such as polyethylene oxide-containing block copolymers. Utilizing the polymer membrane of the present invention, a three-layered sensing element has been developed. This sensing element will be particularly useful for miniaturized biosensors used for in vitro blood measurements or for continuous in vivo monitoring such as implantable biosensors. This element includes an enzyme layer, an interference-eliminating layer and the novel polymer member of the present invention as the outer polymer layer. This novel sensing element shows excellent response characteristics in solutions and has an extremely long lifetime. This technology is particularly useful for improving the lifetime of implantable biosensors.
摘要翻译：本发明提供了一种用固化环氧树脂增强的聚合物膜，用作生物传感器的外膜。膜包括约30-80％的环氧树脂粘合剂，10-60％的聚合物，例如聚（氯乙烯），聚碳酸酯和聚氨酯，以及0-30％的增塑剂和5-15％的表面改性剂如含聚环氧乙烷的嵌段共聚物。利用本发明的聚合物膜，开发了三层感测元件。该感测元件对于用于体外血液测量或连续体内监测的小型化生物传感器（例如可植入生物传感器）将特别有用。该元件包括酶层，干涉消除层和作为外聚合物层的本发明的新型聚合物构件。这种新颖的感应元件在溶液中显示出优异的响应特性，寿命极长。该技术对于改善可植入生物传感器的寿命特别有用。

8. 发明授权

US10449270B2 Collagen scaffolds, medical implants with same and methods of use 有权
公开(公告)号：US10449270B2
公开(公告)日：2019-10-22
申请号：US15443003
申请日：2017-02-27
申请人： Young Min Ju , Francis Moussy , Thomas J. Koob
发明人： Young Min Ju , Francis Moussy , Thomas J. Koob
IPC分类号： A61L27/24 , C07K14/78 , A61L27/48 , A61L27/34 , A61L31/04 , A61L31/10 , A61L27/54 , A61L31/12 , A61B5/145 , A61B5/1486 , A61L27/18 , A61L27/56
摘要： The subject invention concerns non-degradable three dimensional porous collagen scaffolds and coatings. These scaffolds can be prepared around sensors for implantation into a body. A specific embodiment of the invention concerns implantable glucose sensors. Sensors comprising a collagen scaffold of the invention have improved biocompatibility by minimizing tissue reactions while stimulating angiogenesis. The subject invention also concerns methods for preparing collagen scaffolds of the invention. The subject invention also concerns sensors that have a collagen scaffold of the invention around the exterior of the sensor.

9. 发明授权

US07799191B2 Epoxy enhanced polymer membrane to increase durability of biosensors 有权
标题翻译：环氧增强聚合物膜增加生物传感器的耐久性
公开(公告)号：US07799191B2
公开(公告)日：2010-09-21
申请号：US12015614
申请日：2008-01-17
申请人： Bazhang Yu , Francis Moussy
发明人： Bazhang Yu , Francis Moussy
IPC分类号： C25B9/02 , B32B27/38 , C08L63/00 , C12Q1/00 , G01N33/50
CPC分类号： A61B5/14532 , A61B5/14865 , C12Q1/006 , Y10T428/31511 , Y10T428/31529
摘要： The present invention provides a polymer membrane enhanced with cured epoxy resin for use as the outer membrane of biosensors. The membrane includes approximately 30-80% epoxy resin adhesives, 10-60% polymer such as poly(vinyl chloride), polycarbonate and polyurethane and 0-30% plasticizers and 5-15% surface modifier reagent such as polyethylene oxide-containing block copolymers. Utilizing the polymer membrane of the present invention, a three-layered sensing element has been developed. This sensing element will be particularly useful for miniaturized biosensors used for in vitro blood measurements or for continuous in vivo monitoring such as implantable biosensors. This element includes an enzyme layer, an interference-eliminating layer and the novel polymer member of the present invention as the outer polymer layer. This novel sensing element shows excellent response characteristics in solutions and has an extremely long lifetime. This technology is particularly useful for improving the lifetime of implantable biosensors.
摘要翻译：本发明提供了一种用固化环氧树脂增强的聚合物膜，用作生物传感器的外膜。膜包括约30-80％的环氧树脂粘合剂，10-60％的聚合物，例如聚（氯乙烯），聚碳酸酯和聚氨酯，以及0-30％的增塑剂和5-15％的表面改性剂如含聚环氧乙烷的嵌段共聚物。利用本发明的聚合物膜，开发了三层感测元件。该感测元件对于用于体外血液测量或连续体内监测的小型化生物传感器（例如可植入生物传感器）将特别有用。该元件包括酶层，干涉消除层和作为外聚合物层的本发明的新型聚合物构件。这种新颖的感应元件在溶液中显示出优异的响应特性，寿命极长。该技术对于改善可植入生物传感器的寿命特别有用。

10. 发明授权

US06497729B1 Implant coating for control of tissue/implant interactions 有权
标题翻译：用于控制组织/植入物相互作用的植入物涂层
公开(公告)号：US06497729B1
公开(公告)日：2002-12-24
申请号：US09443857
申请日：1999-11-19
申请人： Francis Moussy , Donald Kreutzer , Diane Burgess , Jeffrey Koberstein , Fotios Papadimitrakopoulos , Samuel Huang
发明人： Francis Moussy , Donald Kreutzer , Diane Burgess , Jeffrey Koberstein , Fotios Papadimitrakopoulos , Samuel Huang
IPC分类号： A61F202
CPC分类号： A61L27/54 , A61B5/0031 , A61B5/14532 , A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/00 , C08L89/00 , C08L27/12 , C08L33/14 , C08L39/06
摘要： A tissue/implant interface, comprising an implant and a bioactive polymer layer adjacent at least a portion of the outer surface of the implant, wherein the polymer layer contains at least one tissue response modifier covalently attached to the polymer layer or entrapped within the polymer layer in a quantity effective to control the tissue response at the site of implantation. Preferably, the at least one tissue response modifier controls inflammation, fibrosis, and/or neovascularization. Exemplary tissue response modifiers include, but are not limited to, steroidal and non-steroidal anti-inflammatory agents, anti-fibrotic agents, anti-proliferative agents, cytokines, cytokine inhibitors, neutralizing antibodies, adhesive ligands, and combinations thereof. Use of the various combinations of tissue response modifiers with bioactive polymers provides a simple, flexible and effective means to control the implant/tissue interphase, improving implant lifetime and function.
摘要翻译：一种组织/植入界面，包括植入物和生物活性聚合物层，所述生物活性聚合物层邻近所述植入物的外表面的至少一部分，其中所述聚合物层含有共价连接到所述聚合物层或被截留在所述聚合物层内的至少一个组织响应调节剂其数量有效地控制植入部位的组织反应。优选地，所述至少一种组织反应调节剂控制炎症，纤维化和/或新生血管形成。示例性组织应答调节剂包括但不限于甾体和非甾体抗炎剂，抗纤维化剂，抗增殖剂，细胞因子，细胞因子抑制剂，中和抗体，粘合剂配体及其组合。使用组织反应调节剂与生物活性聚合物的各种组合提供了简单，灵活和有效的手段来控制植入物/组织间期，提高植入物寿命和功能。

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