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1. 发明授权

US08729028B2 Noggin-derived peptide and use thereof 有权
标题翻译：来源于肽的肽及其用途
公开(公告)号：US08729028B2
公开(公告)日：2014-05-20
申请号：US13145390
申请日：2009-11-24
申请人： Young Ji Chung , Young Deug Kim , Eun Mi Kim , Sang Su Song , Il Hong , Kyoung Mi Cho , Su Mi Kim , Sang Min Han
发明人： Young Ji Chung , Young Deug Kim , Eun Mi Kim , Sang Su Song , Il Hong , Kyoung Mi Cho , Su Mi Kim , Sang Min Han
IPC分类号： A61K38/03 , C07K4/00
CPC分类号： C07K14/475 , A61K38/00 , C07K5/1019 , C07K2319/00
摘要： Disclosed are a noggin-derived peptide and a composition containing the same for promoting hair growth, improving skin conditions, providing anti-inflammatory function, or preventing or treating bone diseases. The disclosed noggin-derived peptide performs a function identical or similar to that of natural human noggin and is superior in stability and skin permeability as compared thereto. The composition containing the peptide of the present disclosure as an active ingredient exhibits remarkably superior effects in treating, preventing or improving growth factor-related symptoms, e.g. hair loss, skin conditions or cut, or treating, preventing or improving growth factor overexpression-related symptoms. Therefore, the superior activity and stability of the peptide of the present disclosure are greatly advantageous in application to medicine, quasi-drugs and cosmetics.
摘要翻译：公开了一种头蛋白衍生肽和含有其的组合物，其用于促进毛发生长，改善皮肤状况，提供抗炎功能，或预防或治疗骨骼疾病。所公开的头蛋白衍生肽具有与天然人头蛋白相同或相似的功能，并且与其相比具有优异的稳定性和皮肤渗透性。含有本公开的肽作为活性成分的组合物在治疗，预防或改善生长因子相关症状方面表现出显着的优异效果，例如，脱发，皮肤状况或切割，或治疗，预防或改善生长因子过表达相关症状。因此，本公开的肽的优异的活性和稳定性在应用于医药，准药物和化妆品方面是非常有利的。

2. 发明授权

US08497241B2 WNT10-derived peptide and use thereof 有权
标题翻译： WNT10衍生肽及其用途
公开(公告)号：US08497241B2
公开(公告)日：2013-07-30
申请号：US13393370
申请日：2009-11-24
申请人： Young Ji Chung , Eun Mi Kim , Sang Su Song , Kyoung Mi Cho
发明人： Young Ji Chung , Eun Mi Kim , Sang Su Song , Kyoung Mi Cho
IPC分类号： A61K38/08 , A61P17/00 , A61P17/14 , A61P35/00 , A61P19/10 , A61P19/02 , A61P3/10 , A61Q19/08 , C07K7/06
CPC分类号： A61K8/64 , A61K38/18 , A61Q7/00 , A61Q19/00 , C07K14/475
摘要： The present invention relates to a WNT10-derived peptide, a composition for improving hair loss and skin conditions using the same, and a composition for treating a WNT10 signal transduction pathway-related disorder and DKK-1 protein-induced disorder the same. WNT10-derived peptide of the present invention possesses identical or similar activities to natural-occurring WNT10, and has much higher stability and skin penetration potency than natural-occurring WNT10. Therefore, the composition containing the present peptide not only shows excellent effects on improvement in hair loss (for example, promotion of hair growth or production of hair), but also has superior efficacies on treatment of a WNT10 signal transduction pathway-related disorder and a DKK-1 protein-induced disorder. In addition, the outstanding activity and stability of the present peptide described above may be greatly advantageous in application to pharmaceutical compositions, quasi-drugs and cosmetics.
摘要翻译：本发明涉及WNT10衍生肽，用于改善脱发的组合物和使用该组合物的皮肤状态，以及用于治疗WNT10信号转导途径相关病症和DKK-1蛋白诱导障碍的组合物。本发明的WNT10衍生肽具有与天然存在的WNT10相同或相似的活性，并且具有比天然存在的WNT10高得多的稳定性和皮肤穿透效力。因此，含有本发明肽的组合物对于改善脱发（例如，促进头发生长或毛发生产）显示出优异的效果，而且对治疗WNT10信号转导通路相关病症和 DKK-1蛋白诱导的病症。此外，上述本发明肽的突出活性和稳定性在用于药物组合物，准药物和化妆品中可能是非常有利的。

3. 发明申请

US20120245086A1 WNT10-Derived Peptide and Use Thereof 有权
标题翻译： WNT10衍生肽及其用途
公开(公告)号：US20120245086A1
公开(公告)日：2012-09-27
申请号：US13393370
申请日：2009-11-24
申请人： Young Ji Chung , Eun Mi Kim , Sang Su Song , Kyoung Mi Cho
发明人： Young Ji Chung , Eun Mi Kim , Sang Su Song , Kyoung Mi Cho
IPC分类号： A61K38/08 , A61P17/00 , A61Q19/08 , A61P17/14 , A61P35/00 , A61P19/10 , A61P19/02 , A61P3/10 , C07K7/06 , A61P19/00
CPC分类号： A61K8/64 , A61K38/18 , A61Q7/00 , A61Q19/00 , C07K14/475
摘要： The present invention relates to a WNT10-derived peptide, a composition for improving hair loss and skin conditions using the same, and a composition for treating a WNT10 signal transduction pathway-related disorder and DKK-1 protein-induced disorder using the same. WNT10-derived peptide of the present invention possesses identical or similar activities to natural-occurring WNT10, and has much higher stability and skin penetration potency than natural-occurring WNT10. Therefore, the composition containing the present peptide not only shows excellent effects on improvement in hair loss (for example, promotion of hair growth or production of hair), but also has superior efficacies on treatment of a WNT10 signal transduction pathway-related disorder and a DKK-1 protein-induced disorder. In addition, the outstanding activity and stability of the present peptide described above may be greatly advantageous in application to pharmaceutical compositions, quasi-drugs and cosmetics.
摘要翻译：本发明涉及WNT10衍生肽，用于改善脱发的组合物和使用该组合物的皮肤状态，以及使用该组合物治疗WNT10信号转导通路相关病症和DKK-1蛋白质诱导障碍的组合物。本发明的WNT10衍生肽具有与天然存在的WNT10相同或相似的活性，并且具有比天然存在的WNT10高得多的稳定性和皮肤穿透效力。因此，含有本发明肽的组合物对于改善脱发（例如，促进头发生长或毛发生产）显示出优异的效果，而且对治疗WNT10信号转导通路相关病症和 DKK-1蛋白诱导的病症。此外，上述本发明肽的突出活性和稳定性在用于药物组合物，准药物和化妆品中可能是非常有利的。

4. 发明申请

US20110312884A1 Noggin-Derived Peptide and Use Thereof 有权
标题翻译： Noggin衍生肽及其用途
公开(公告)号：US20110312884A1
公开(公告)日：2011-12-22
申请号：US13145390
申请日：2009-11-24
申请人： Young Ji Chung , Young Deug Kim , Eun Mi Kim , Sang Su Song , Il Hong , Kyoung Mi Cho , Su Mi Kim , Sang Min Han
发明人： Young Ji Chung , Young Deug Kim , Eun Mi Kim , Sang Su Song , Il Hong , Kyoung Mi Cho , Su Mi Kim , Sang Min Han
IPC分类号： A61K38/10 , C07K7/08 , A61K38/08 , A61P29/00 , A61K8/64 , A61P19/08 , A61Q19/00 , A61Q19/08 , A61Q7/00 , C07K7/06 , A61P17/00
CPC分类号： C07K14/475 , A61K38/00 , C07K5/1019 , C07K2319/00
摘要： Disclosed are a noggin-derived peptide and a composition containing the same for promoting hair growth, improving skin conditions, providing anti-inflammatory function, or preventing or treating bone diseases. The disclosed noggin-derived peptide performs a function identical or similar to that of natural human noggin and is superior in stability and skin permeability as compared thereto. The composition containing the peptide of the present disclosure as an active ingredient exhibits remarkably superior effects in treating, preventing or improving growth factor-related symptoms, e.g. hair loss, skin conditions or cut, or treating, preventing or improving growth factor overexpression-related symptoms. Therefore, the superior activity and stability of the peptide of the present disclosure are greatly advantageous in application to medicine, quasi-drugs and cosmetics.
摘要翻译：公开了一种头蛋白衍生肽和含有其的组合物，其用于促进毛发生长，改善皮肤状况，提供抗炎功能，或预防或治疗骨骼疾病。所公开的头蛋白衍生肽具有与天然人头蛋白相同或相似的功能，并且与其相比具有优异的稳定性和皮肤渗透性。含有本公开的肽作为活性成分的组合物在治疗，预防或改善生长因子相关症状方面表现出显着的优异效果，例如，脱发，皮肤状况或切割，或治疗，预防或改善生长因子过表达相关症状。因此，本公开的肽的优异的活性和稳定性在应用于医药，准药物和化妆品方面是非常有利的。

5. 发明授权

US08969296B2 TGFP-CAP peptide and its uses 有权
标题翻译： TGFP-CAP肽及其用途
公开(公告)号：US08969296B2
公开(公告)日：2015-03-03
申请号：US12596479
申请日：2007-09-12
申请人： Yong-Ji Chung , Young Deug Kim , Eun Mi Kim , Jun Young Choi , Jin Seuk Kim , Sang Su Song , Kyoung Mi Cho
发明人： Yong-Ji Chung , Young Deug Kim , Eun Mi Kim , Jun Young Choi , Jin Seuk Kim , Sang Su Song , Kyoung Mi Cho
IPC分类号： A61K8/64 , C07K7/08 , A61K38/00 , C07K14/495 , A61K38/18 , A61Q19/02
CPC分类号： C07K14/495 , A61K8/64 , A61K38/00 , A61K38/1841 , A61Q19/02 , C07K7/08
摘要： The present invention relates to a GFP-CAP peptide having an amino acid sequence derived from TGF-β1 (transforming growth factor-β1) and a cell adhesion sequence, wherein the amino acid sequence derived from TGF-β1 consists of the amino acid sequence of SEQ ID NO:1 and the TGFP-CAP peptide is represented by the following formula I: Ile-Trp-Ser-Leu-Asp-Thr-Gln-Tyr-Cell adhesion sequence (I). The TGFP-CAP peptide of the present invention exhibits excellent anti-angiogenic activity. In addition, the TGFP-CAP peptide of the present invention prevents effectively melanin generation in skin to have skin whitening effects. The present peptide shows much higher stability and permeability to skin than natural-occurring TGF-β1. Such plausible activities and safety of the present peptide enable advantageously to application to drugs, quasi-drugs and cosmetics.
摘要翻译：本发明涉及具有衍生自TGF-β1（转化生长因子-β1）的氨基酸序列的GFP-CAP肽和细胞粘附序列，其中衍生自TGF-β1的氨基酸序列由的SEQ ID NO：1的氨基酸序列和TGFP-CAP肽由下式I表示：Ile-Trp-Ser-Leu-Asp-Thr-Gln-Tyr-细胞粘附序列（I）。本发明的TGFP-CAP肽表现出优异的抗血管生成活性。此外，本发明的TGFP-CAP肽有效地防止皮肤中的黑色素产生，从而具有皮肤美白效果。本发明的肽比天然存在的TGF-β1显示出更高的对皮肤的稳定性和渗透性。本发明肽的这种合理的活性和安全性有利地适用于药物，准药物和化妆品。

6. 发明申请

US20100160238A1 TGFP-CAP Peptide and its Uses 有权
标题翻译： TGFP-CAP肽及其用途
公开(公告)号：US20100160238A1
公开(公告)日：2010-06-24
申请号：US12596479
申请日：2007-09-12
申请人： Yong Ji Chung , Young Deug Kim , Eun Mi Kim , Jun Young Choi , Jin Seuk Kim , Sang Su Song , Kyoung Mi Cho
发明人： Yong Ji Chung , Young Deug Kim , Eun Mi Kim , Jun Young Choi , Jin Seuk Kim , Sang Su Song , Kyoung Mi Cho
IPC分类号： C07K14/495 , C07K7/06 , C07K7/08 , A61K38/08 , A61K38/10 , A61K38/16 , A61P37/06 , A61P35/00 , A61P27/06 , A61P19/02 , A61P29/00 , A61P25/28 , A61P17/02 , A61P17/06 , A61P9/10 , A61P1/00
CPC分类号： C07K14/495 , A61K8/64 , A61K38/00 , A61K38/1841 , A61Q19/02 , C07K7/08
摘要： The present invention relates to a GFP-CAP peptide having an amino acid sequence derived from TGF-β1 (transforming growth factor-β1) and a cell adhesion sequence, wherein the amino acid sequence derived from TGF-β1 consists of the amino acid sequence of SEQ ID NO:1 and the TGFP-CAP peptide is represented by the following formula I: Ile-Trp-Ser-Leu-Asp-Thr-Gln-Tyr-Cell adhesion sequence (I). The TGFP-CAP peptide of the present invention exhibits excellent anti-angiogenic activity. In addition, the TGFP-CAP peptide of the present invention prevents effectively melanin generation in skin to have skin whitening effects. The present peptide shows much higher stability and permeability to skin than natural-occurring TGF-β1. Such plausible activities and safety of the present peptide enable advantageously to application to drugs, quasi-drugs and cosmetics.
摘要翻译：本发明涉及具有衍生自TGF-β1（转化生长因子-β1）的氨基酸序列的GFP-CAP肽和细胞粘附序列，其中衍生自TGF-β1的氨基酸序列由的SEQ ID NO：1的氨基酸序列和TGFP-CAP肽由下式I表示：Ile-Trp-Ser-Leu-Asp-Thr-Gln-Tyr-细胞粘附序列（I）。本发明的TGFP-CAP肽表现出优异的抗血管生成活性。此外，本发明的TGFP-CAP肽有效地防止皮肤中的黑色素产生，从而具有皮肤美白效果。本发明的肽比天然存在的TGF-β1显示出更高的对皮肤的稳定性和渗透性。本发明肽的这种合理的活性和安全性有利地适用于药物，准药物和化妆品。

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