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    • 2. 发明授权
    • Biodegradable aliphatic polyester grafted with polyether and a process for preparing the same
    • 用聚醚接枝的可生物降解的脂肪族聚酯及其制备方法
    • US06221977B1
    • 2001-04-24
    • US09405753
    • 1999-09-27
    • Jung-Ki ParkKuk Young ChoChang-Hyeon Kim
    • Jung-Ki ParkKuk Young ChoChang-Hyeon Kim
    • C08G6308
    • C08G63/664C08L71/02C08L2666/18
    • The present invention provides a process for preparing biodegradable aliphatic polyester grafted with polyether which comprises a step of ring opening polymerization of a hydrophilic monomer of epoxide-substituted ethyleneglycolmethylether oligomer or ethyleneglycol oligomer, and a biocompatible cyclic monomer forming polymer backbone with the said monomer, and a non-toxic biodegradable polymer prepared therefrom. In accordance with the invention, the graft ratio and molecular weight of polyether in the biodegradable aliphatic polyester can be easily controlled, and the hydrophlicity and crystallinity are also regulated thereby. The biodegradable polymer of the invention has features of minimized protein adhesion and superior softness, due to its hydrophilic side-chain. Accordingly, it can be applied as biomedical polymers such as the matrices for drug delivery system, suture thread, or bioabsorbable and water-soluble polymers.
    • 本发明提供一种制备用聚醚接枝的可生物降解的脂肪族聚酯的方法,其包括环氧化物取代的乙二醇甲基醚低聚物或乙二醇低聚物的亲水性单体和与所述单体形成生物相容的环状单体的聚合物主链的开环聚合步骤,以及 由其制备的无毒可生物降解聚合物。 根据本发明,可以容易地控制可生物降解的脂族聚酯中的聚醚的接枝率和分子量,并且还调节亲水性和结晶度。 本发明的生物可降解聚合物具有由于其亲水性侧链而使蛋白质粘附和蛋白质粘度最小的特征。 因此,其可以用作生物医学聚合物,例如用于药物递送系统,缝合线或生物可吸收和水溶性聚合物的基质。