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1. 发明授权

US08344173B2 Dendritic oligopeptide-grafteded cyclotriphosphazene, a process for the preparation thereof and a drug delivery system containing the same 有权
标题翻译：树突状寡肽接枝的环三磷腈，其制备方法和含有它们的药物递送系统
公开(公告)号：US08344173B2
公开(公告)日：2013-01-01
申请号：US12990089
申请日：2009-04-28
申请人： Youn Soo Sohn , Yong Joo Jun , Sung Mo Choi
发明人： Youn Soo Sohn , Yong Joo Jun , Sung Mo Choi
IPC分类号： C07C271/12 , C07K5/00
CPC分类号： A61K47/24 , A61K9/0024 , C07F9/65815
摘要： A cyclotriphosphazene represented by Formula 1 prepared by introducing a dendritic tetrapeptide and a hydrophilic polyethylene glycol into a cyclotriphosphazene ring, a method of preparing the same, and a drug carrier including the cyclotriphosphazene of Formula 1.The compound according to the present invention may form a strong molecular hydrogel in a very low concentration of 2 w/w % or less. Furthermore, the hydrogel prepared using the compound of Formula 1 exhibits biodegradability, thermosensitivity at around body temperature, biocompatibility with protein drugs, and an easy way to prepare along with a sustained release property without any burst effect in the early stage of release. Therefore, the present cyclotriphosphazene molecular hydrogel may be efficiently used as a drug carrier for a sustained release of a drug, particularly, a protein drug.
摘要翻译：通过将环状三磷腈环中引入树枝状四肽和亲水性聚乙二醇制备的式1所示的环三磷腈，其制备方法和包含式1的环三磷腈的药物载体。根据本发明的化合物可以形成强分子水凝胶的浓度为2w / w％以下。此外，使用式1化合物制备的水凝胶显示生物降解性，体温周围的热敏感性，与蛋白质药物的生物相容性，以及在释放的早期阶段，缓释性能良好而不发生突发作用的简便方法。因此，本发明的环三磷腈分子水凝胶可以有效地用作药物载体，用于药物，特别是蛋白质药物的持续释放。

2. 发明申请

US20110046347A1 DENDRITIC OLIGOPEPTIDE-GRAFTEDED CYCLOTRIPHOSPHAZENE, A PROCESS FOR THE PREPARATION THEREOF AND A DRUG DELIVERY SYSTEM CONTAINING THE SAME 有权
标题翻译：致密性低聚赖氨酸环孢菌素，其制备方法和含有其的药物递送系统
公开(公告)号：US20110046347A1
公开(公告)日：2011-02-24
申请号：US12990089
申请日：2009-04-28
申请人： Youn Soo Sohn , Yong Joo Jun , Sung Mo Choi
发明人： Youn Soo Sohn , Yong Joo Jun , Sung Mo Choi
IPC分类号： C07K5/113 , C07K1/00
CPC分类号： A61K47/24 , A61K9/0024 , C07F9/65815
摘要： A cyclotriphosphazene represented by Formula 1 prepared by introducing a dendritic tetrapeptide and a hydrophilic polyethylene glycol into a cyclotriphosphazene ring, a method of preparing the same, and a drug carrier including the cyclotriphosphazene of Formula 1.The compound according to the present invention may form a strong molecular hydrogel in a very low concentration of 2 w/w % or less. Furthermore, the hydrogel prepared using the compound of Formula 1 exhibits biodegradability, thermosensitivity at around body temperature, biocompatibility with protein drugs, and an easy way to prepare along with a sustained release property without any burst effect in the early stage of release. Therefore, the present cyclotriphosphazene molecular hydrogel may be efficiently used as a drug carrier for a sustained release of a drug, particularly, a protein drug.
摘要翻译：通过将环状三磷腈环中引入树枝状四肽和亲水性聚乙二醇制备的式1所示的环三磷腈，其制备方法和包含式1的环三磷腈的药物载体。根据本发明的化合物可以形成强分子水凝胶的浓度为2w / w％以下。此外，使用式1化合物制备的水凝胶显示生物降解性，体温周围的热敏感性，与蛋白质药物的生物相容性，以及在释放的早期阶段，缓释性能良好而不发生突发作用的简便方法。因此，本发明的环三磷腈分子水凝胶可以有效地用作药物载体，用于药物，特别是蛋白质药物的持续释放。

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