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1. 发明授权

US06780595B2 Human Tbx20 gene and uses 失效
标题翻译：人类Tbx20基因及用途
公开(公告)号：US06780595B2
公开(公告)日：2004-08-24
申请号：US10082272
申请日：2002-02-26
申请人： Youmin Shu , Wufang Fan , Karl F. Kovacs , Xuan Li , Gilbert Jay
发明人： Youmin Shu , Wufang Fan , Karl F. Kovacs , Xuan Li , Gilbert Jay
IPC分类号： C12Q168
CPC分类号： C12Q1/6883 , A61K38/00 , C07K14/47 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G06Q30/0601
摘要： The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are expressed in heart and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions of the heart and eye.
摘要翻译：本发明涉及新型多核苷酸，它们编码的多肽，抗体及其特异性结合伴侣的所有方面及其在研究，诊断，药物发现，治疗，临床医学，法医学和医学等方面的应用。多核苷酸被表达因此在各种方式中有用，包括但不限于作为分子标志物，作为药物靶标，以及用于检测，诊断，分期，监测，预后，预防或治疗，确定疾病的易感性等和心脏和眼睛的条件。

2. 发明授权

US06455292B1 Full-length serine protein kinase in brain and pancreas 有权
标题翻译：脑和胰腺全长丝氨酸蛋白激酶
公开(公告)号：US06455292B1
公开(公告)日：2002-09-24
申请号：US09930181
申请日：2001-08-16
申请人： Youmin Shu , Wufang Fan , Karl F. Kovacs , Michael Zidanic , Gilbert Jay
发明人： Youmin Shu , Wufang Fan , Karl F. Kovacs , Michael Zidanic , Gilbert Jay
IPC分类号： C12N912
CPC分类号： C12N9/1205 , G01N33/573 , G01N2333/9121
摘要： The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science, pathology, and medicine. The polynucleotides are expressed in brain and pancreas and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to diseases and conditions, especially relating to brain and pancreas.
摘要翻译：本发明涉及新型多核苷酸的所有方面，其编码的多肽，抗体及其特异性结合伴侣，以及它们在研究，诊断，药物发现，治疗，临床医学，法医学，病理学和医学中的应用。多核苷酸在脑和胰腺中表达，因此可以多种方式使用，包括但不限于作为分子标志物，作为药物靶标，以及用于检测，诊断，分期，监测，预后，预防或治疗，确定易感性对疾病和病症，特别是与脑和胰腺有关。

3. 发明申请

US20050019818A1 Human TBX20 gene and uses 审中-公开
标题翻译：人类TBX20基因及用途
公开(公告)号：US20050019818A1
公开(公告)日：2005-01-27
申请号：US10921807
申请日：2004-08-20
申请人： Youmin Shu , Wufang Fan , Karl Kovacs , Xuan Li , Gilbert Jay
发明人： Youmin Shu , Wufang Fan , Karl Kovacs , Xuan Li , Gilbert Jay
IPC分类号： A61K38/00 , C07K14/47 , C12Q1/68 , C07H21/04 , C12N9/10 , C12P21/04
CPC分类号： C12Q1/6883 , A61K38/00 , C07K14/47 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G06Q30/0601
摘要： The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are expressed in heart and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions of the heart and eye.
摘要翻译：本发明涉及新型多核苷酸，它们编码的多肽，抗体及其特异性结合伴侣的所有方面及其在研究，诊断，药物发现，治疗，临床医学，法医学和医学等方面的应用。多核苷酸被表达因此在各种方式中有用，包括但不限于作为分子标志物，作为药物靶标，以及用于检测，诊断，分期，监测，预后，预防或治疗，确定疾病的易感性等和心脏和眼睛的条件。

4. 发明授权

US07053193B2 Breast cancer transcription factor gene and uses 有权
公开(公告)号：US07053193B2
公开(公告)日：2006-05-30
申请号：US10054935
申请日：2002-01-25
申请人： Zairen Sun , Wufang Fan , Karl F. Kovacs , Xuan Li , Gilbert Jay
发明人： Zairen Sun , Wufang Fan , Karl F. Kovacs , Xuan Li , Gilbert Jay
IPC分类号： C07H21/04
CPC分类号： G01N33/57415 , A01K2217/05 , A61K38/00 , C07K14/4702 , C12Q1/6886
摘要： The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides, Urb-ctf, are expressed in breast cancer and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions especially related to breast cancer.

5. 发明申请

US20060241015A1 Cancer genes 审中-公开
标题翻译：癌症基因
公开(公告)号：US20060241015A1
公开(公告)日：2006-10-26
申请号：US10502394
申请日：2003-01-24
申请人： Zairen Sun , Xuan Li , Gilbert Jay , Karl Kovacs , Wufang Fan , Youmin Shu
发明人： Zairen Sun , Xuan Li , Gilbert Jay , Karl Kovacs , Wufang Fan , Youmin Shu
IPC分类号： A61K38/17 , G06Q10/00 , C12Q1/68 , G01N33/574 , C07H21/04 , C12P21/06 , C07K14/82
CPC分类号： G01N33/574 , A61K38/00 , C07K14/4748 , C12Q1/6886 , C12Q2600/136 , G06Q50/22 , Y02A90/22 , Y02A90/26
摘要： The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are differentially expressed in prostate and breast cancers and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., cancers.
摘要翻译：本发明涉及新型多核苷酸的所有方面，它们编码的多肽，抗体及其特异性结合伴侣，以及它们在研究，诊断，药物发现，治疗，临床医学，法医学和医学等中的应用。多核苷酸是差异化的在前列腺癌和乳腺癌中表达，因此可用于多种方式，包括但不限于作为分子标志物，作为药物靶标，以及用于检测，诊断，分期，监测，预后，预防或治疗，确定易感性，等等，癌症。

6. 发明申请

US20050120393A1 Full-length prostate selective polynucleotides and polypeptides 审中-公开
标题翻译：全长前列腺选择性多核苷酸和多肽
公开(公告)号：US20050120393A1
公开(公告)日：2005-06-02
申请号：US10485555
申请日：2002-08-02
申请人： Zairen Sun , Xuan Li , Gilbert Jay , Karl Kovacs , Youmin Shu , Wufang Fan
发明人： Zairen Sun , Xuan Li , Gilbert Jay , Karl Kovacs , Youmin Shu , Wufang Fan
IPC分类号： A01K67/00 , C07H21/04 , C07K14/47 , C07K14/705 , C12Q1/68 , G01N33/50 , G01N33/574 , G06F17/60
CPC分类号： C07K14/47 , A01K2267/0331 , C07K14/4702 , C07K14/705 , C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , G01N33/5091 , G01N33/57434 , G01N2500/10 , G01N2800/342
摘要： The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science, pathology, and medicine, etc. The polynucleotides are expressed in prostate and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions relating to prostate, such as prostate cancers, as well as other disease and conditions.
摘要翻译：本发明涉及新型多核苷酸，它们编码的多肽，抗体及其特异性结合伴侣的所有方面及其在研究，诊断，药物发现，治疗，临床医学，法医学，病理学和医学等方面的应用。多核苷酸在前列腺中表达，因此可用于多种方式，包括但不限于作为分子标志物，作为药物靶标，以及用于检测，诊断，分期，监测，预后，预防或治疗，确定等等的倾向，与前列腺相关的疾病和病症，如前列腺癌，以及其他疾病和病症。

7. 发明申请

US20050055733A1 Small intestine and colon genes 审中-公开
标题翻译：小肠和结肠基因
公开(公告)号：US20050055733A1
公开(公告)日：2005-03-10
申请号：US10482838
申请日：2002-07-08
申请人： Zairen Sun , Xuan Li , Gilbert Jay , Karl Kovacs , Youmin Shu , Wufang Fan
发明人： Zairen Sun , Xuan Li , Gilbert Jay , Karl Kovacs , Youmin Shu , Wufang Fan
IPC分类号： C07K14/47 , C12Q1/68 , A01K67/00 , C07K14/705
CPC分类号： C07K14/47
摘要： The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science, pathology, and medicine, etc. The polynucleotides are expressed in small intestine or colon and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions relating to small intestine or colon.
摘要翻译：本发明涉及新型多核苷酸，它们编码的多肽，抗体及其特异性结合伴侣的所有方面及其在研究，诊断，药物发现，治疗，临床医学，法医学，病理学和医学等方面的应用。多核苷酸在小肠或结肠中表达，因此可以多种方式使用，包括但不限于作为分子标志物，作为药物靶标，以及用于检测，诊断，分期，监测，预后，预防或治疗，确定易感性等等，与小肠或结肠相关的疾病和病症。

8. 发明申请

US20050069886A1 Prostate cancer genes 审中-公开
标题翻译：前列腺癌基因
公开(公告)号：US20050069886A1
公开(公告)日：2005-03-31
申请号：US10494940
申请日：2002-11-07
申请人： Zairen Sun , Xuan Li , Gilbert Jay , Karl Kovacs , Wufang Fan
发明人： Zairen Sun , Xuan Li , Gilbert Jay , Karl Kovacs , Wufang Fan
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are differentially-regulated in prostate cancer and are therefore useful in variety of ways. including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions, to prostate cancer.
摘要翻译：本发明涉及新型多核苷酸的所有方面，它们编码的多肽，抗体及其特异性结合伴侣，以及它们在研究，诊断，药物发现，治疗，临床医学，法医学和医学等中的应用。多核苷酸是差异化的在前列腺癌中有调节作用，因此在各种方面都是有用的。包括但不限于作为药物靶标的分子标记，以及用于检测，诊断，分期，监测，预后，预防或治疗，确定前列腺癌的疾病和病症等等。

9. 发明授权

US07115393B2 Melanocortin-1 receptor and methods of use 有权
标题翻译：黑皮素-1受体及其使用方法
公开(公告)号：US07115393B2
公开(公告)日：2006-10-03
申请号：US10164717
申请日：2002-06-10
申请人： Youmin Shu , Xuan Li , Anthony C. Yee , Gilbert Jay
发明人： Youmin Shu , Xuan Li , Anthony C. Yee , Gilbert Jay
IPC分类号： C07K14/72 , C12N15/12
CPC分类号： C07K14/47
摘要： The present invention relates to all facets of novel polynucleotides for melanocortin-1 receptors, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions especially relating to melanocortin-1, such as melanoma, pigmentation disorders and conditions, inflammation, etc.
摘要翻译：本发明涉及用于黑皮质素-1受体的新型多核苷酸的所有方面，它们编码的多肽，抗体及其特异性结合伴侣，以及它们在研究，诊断，药物发现，治疗，临床医学，法医学和医学等方面的应用多核苷酸可以多种方式使用，包括但不限于作为分子标志物，作为药物靶标，以及用于检测，诊断，分期，监测，预后，预防或治疗，确定疾病等的易感性，以及特别是与黑皮质素-1有关的病症，如黑素瘤，色素沉着病和病症，炎症等。

10. 发明申请

US20060026700A1 Tissue specific genes and gene clusters 审中-公开
标题翻译：组织特异性基因和基因簇
公开(公告)号：US20060026700A1
公开(公告)日：2006-02-02
申请号：US10511538
申请日：2003-04-15
申请人： Gilbert Jay , Richard Lebovitz , Youmin Shu , Zairen Sun , Meng Wu
发明人： Gilbert Jay , Richard Lebovitz , Youmin Shu , Zairen Sun , Meng Wu
IPC分类号： A01K67/027 , A61K48/00 , C12Q1/68
CPC分类号： C12Q1/6881 , A61K38/00 , C07K14/723 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to genes and genes clusters which are expressed in a tissue specific maner. For example, the invention relates to a group of genes encoding GPCR-like receptors that are involved in the function and activity of the immune system. These genes are organized into a discrete cluster at chromosomal location 1q22 (the “immune gene complex”) and span about 700 kb of DNA. The region closest to the centromere comprises genes that are expressed predominantly in the thymus, while the distal region comprises genes which are expressed predominantly in the bone marrow and other hematopoietic cells. Another cluster of GPCR genes is located at chromosomal band 11q24. These genes are expressed predominantly in pancreatic tissue, establishing this region of chromosome 11 as a unique gene complex involved in pancreatic function. A cluster of transmembrane and GPCR-type receptor genes is also located at chromosomal band 11q12.2. These genes are expressed predominantly in the spleen (hence, “spleen gene” cluster), as well as other tissues of the immune and reticuloendothelial system (RES), indicating that establishing this region of the chromosome is involved in spleen, lymphoid, and/or reticuloendothelial function. Finally, genes coding for membrane proteins have been identified which are expressed selectively in bone marrow, kidney, pancreas, and retina.
摘要翻译：本发明涉及在组织特异性施肥器中表达的基因和基因簇。例如，本发明涉及编码参与免疫系统的功能和活性的GPCR样受体的一组基因。这些基因被组织成染色体位置1q22（“免疫基因复合体”）并跨越约700kb DNA的离散簇。最靠近着丝粒的区域包括主要在胸腺中表达的基因，而远端区域包含主要在骨髓和其他造血细胞中表达的基因。另一组GPCR基因位于染色体条带11q24。这些基因主要在胰腺组织中表达，将该染色体11区域作为涉及胰腺功能的独特基因复合体。跨膜和GPCR型受体基因簇也位于染色体条带11q12.2。这些基因主要在脾脏（因此，“脾基因”簇）以及免疫和网状内皮系统（RES）的其他组织中表达，表明建立该染色体区域涉及脾，淋巴和/ 或网状内皮功能。最后，已经鉴定了编码膜蛋白的基因，其在骨髓，肾，胰腺和视网膜中选择性表达。

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