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1. 发明授权

US5354264A Gas pressure driven infusion system by hydrogel electrolysis 失效
标题翻译：通过水凝胶电解气压驱动输液系统
公开(公告)号：US5354264A
公开(公告)日：1994-10-11
申请号：US18937
申请日：1993-02-17
申请人： You H. Bae , Ick C. Kwon
发明人： You H. Bae , Ick C. Kwon
IPC分类号： A61M5/142 , A61M5/155 , A61M1/30
CPC分类号： A61M5/155 , A61M2005/14204
摘要： A drug delivery device is described which utilizes gas pressure from free oxygen and hydrogen derived from the electrolysis of water at the electrodes in negatively charged polymeric hydrogels by electro-osmosis. The gas pressure forces the infusion of the drugs through appropriate means into the body. The rate of electrolysis which produces the oxygen and hydrogen is controlled by an electric current. Therefore the rate of drug delivery can be predetermined and precisely controlled. The current is activated and controlled by an electronic timer or a biomedical control system. The negatively charged hydrogel polymers have mechanical strength and rigidity and allow water to flow through the polymer network toward the cathode ensuring a continuous water supply to the electrodes inside the hydrogel system by electro-osmosis. The hydrogels may be recharged (reswollen) with water or simply replaced. Because the containment of water within the hydrogel structure is not position dependent, gravity plays no part in the gel location within the gas generation unit as in prior art units. Therefore, the contact between the electrodes and water for purposes of electrolysis is position independent.
摘要翻译：描述了一种药物输送装置，其利用来自游离氧气的压力和源于电极中的水的电压，通过电渗透在带负电荷的聚合物水凝胶中。气体压力迫使药物通过适当的方式输入身体。产生氧和氢的电解速率由电流控制。因此，可以预先确定和精确地控制药物递送的速度。电流被电子定时器或生物医学控制系统激活和控制。带负电荷的水凝胶聚合物具有机械强度和刚性，并且允许水通过聚合物网络流向阴极，从而确保通过电渗水连续供水到水凝胶体系内的电极。水凝胶可以用水再次充电（再溶胀）或简单地更换。因为水凝胶结构内的水的容纳不依赖于位置，所以在现有技术单元中，重力在气体发生单元内的凝胶位置中不起作用。因此，为了电解目的，电极和水之间的接触是位置无关的。

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