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1. 发明申请

US20150132345A1 NITRIC OXIDE-SEQUESTERING TOPICAL FORMULATIONS 审中-公开
标题翻译：氮氧化物 - 氨基酸序列制剂
公开(公告)号：US20150132345A1
公开(公告)日：2015-05-14
申请号：US14117045
申请日：2012-05-09
申请人： Yossef Av-Gay , Horacio Bach
发明人： Yossef Av-Gay , Horacio Bach
IPC分类号： A61K33/00 , A61K9/70 , A61Q17/00 , A61K9/06 , A61K8/02 , A61Q19/00 , A61K8/19 , A61K9/08
CPC分类号： A61K33/00 , A61K8/0208 , A61K8/19 , A61K9/06 , A61K9/08 , A61K9/7007 , A61K31/7036 , A61K2800/22 , A61K2800/45 , A61K2800/87 , A61Q17/005 , A61Q19/00
摘要： Topical formulations, comprising a carrier having gaseous nitric oxide sequestered therein, and optionally further comprising a pharmaceutically, cosmetic or cosmeceutically active agent, which are useful is medical, cosmetic or cosmeceutic applications, are provided herein. Systems, devices and processes for obtaining such formulations are also disclosed.
摘要翻译：在本文中提供了包含其中存在气态一氧化氮的载体和任选地进一步包含药学，化妆品或药妆活性剂的载体，其有用的是医药，化妆品或药妆品应用。还公开了用于获得这种制剂的系统，装置和方法。

2. 发明授权

US5753435A Oxido reductase enzyme system obtainable from P. chrysogenum, the set of genes encoding the same and the use of oxido reductase enzyme systems or genes encoding the same for increasing antibiotic production 失效
标题翻译：从产黄青霉获得的氧化还原酶系统，编码它们的一组基因和使用氧化还原酶系统或编码它们的基因用于增加抗生素生产
公开(公告)号：US5753435A
公开(公告)日：1998-05-19
申请号：US386729
申请日：1995-02-10
申请人： Yair Aharonowitz , Lucia Helena Maria Van Der Voort , Gerald Cohen , Reolof Ary Lans Bovenberg , Rachel Schreiber , Anat Argaman , Yossef Av-Gay , Helena Maria Nan , Alfred Kattevilder , Harriet Palissa , Henk Van Liempt
发明人： Yair Aharonowitz , Lucia Helena Maria Van Der Voort , Gerald Cohen , Reolof Ary Lans Bovenberg , Rachel Schreiber , Anat Argaman , Yossef Av-Gay , Helena Maria Nan , Alfred Kattevilder , Harriet Palissa , Henk Van Liempt
IPC分类号： C12N9/02 , C12P37/00 , C12Q1/68 , C12N9/06 , C12N15/53
CPC分类号： C12N9/0036 , C12P37/00
摘要： A new oxido reductase enzyme activity obtainable from P. chrysogenum, involved in the production of .beta.-lactams, the set of genes encoding said enzyme activity, and a method to enhance said production by using the above-mentioned oxido reductase system and other oxido reductase systems or genes encoding for the same are disclosed.
摘要翻译：参与β-内酰胺的生产的产黄青素的新的氧化还原酶活性，编码所述酶活性的基因组以及通过使用上述氧化还原酶系统和其它氧化还原酶来增强所述产生的方法公开了编码其的系统或基因。

3. 发明授权

US10350112B2 Antimicrobial gas impregnated devices and methods 有权
公开(公告)号：US10350112B2
公开(公告)日：2019-07-16
申请号：US12825370
申请日：2010-06-29
申请人： Yossef Av-Gay , David Greenberg
发明人： Yossef Av-Gay , David Greenberg
IPC分类号： A61F11/00 , A61K33/00 , A61L31/04 , A61L31/10 , A61L31/16 , A61M27/00
摘要： A nitric oxide gas-releasing conduit configured for surgical implantation through a patient's tympanic membrane. The nitric oxide gas-releasing conduit comprises a gas-permeable cured resin material configured for releasably sequestering therein gas. The gas-permeable cured resin material is charged with nitric oxide gas. The nitric oxide gas-releasing conduit may be optionally coated with an antimicrobial gas-releasing composition. The gas-releasing coating composition may be configured to release nitric oxide.

4. 发明授权

US09814623B2 Antimicrobial gas impregnating devices and methods 有权
公开(公告)号：US09814623B2
公开(公告)日：2017-11-14
申请号：US12825373
申请日：2010-06-29
申请人： Yossef Av-Gay , David Greenberg
发明人： Yossef Av-Gay , David Greenberg
IPC分类号： A61F11/00 , A61M27/00 , A61K33/00 , A61L31/04 , A61L31/10 , A61L31/16
CPC分类号： A61F11/002 , A61K33/00 , A61L31/04 , A61L31/10 , A61L31/16 , A61L2300/114 , A61L2300/404 , A61L2300/45 , A61L2430/14 , A61M27/002
摘要： A nitric oxide gas-releasing conduit configured for surgical implantation through a patient's tympanic membrane. The nitric oxide gas-releasing conduit comprises a gas-permeable cured resin material configured for releasably sequestering therein gas. The gas-permeable cured resin material is charged with nitric oxide gas. The nitric oxide gas-releasing conduit may be optionally coated with an antimicrobial gas-releasing composition. The gas-releasing coating composition may be configured to release nitric oxide.

5. 发明授权

US08043246B2 Antimicrobial gas-releasing ear drainage tubes 有权
标题翻译：抗菌气体释放耳道引流管
公开(公告)号：US08043246B2
公开(公告)日：2011-10-25
申请号：US12234599
申请日：2008-09-19
申请人： Yossef Av-Gay , David Greenberg
发明人： Yossef Av-Gay , David Greenberg
IPC分类号： B65D85/00
CPC分类号： A61F11/002 , A61K33/00 , A61L31/04 , A61L31/10 , A61L31/16 , A61L2300/114 , A61L2300/404 , A61L2300/45 , A61L2430/14 , A61M27/002
摘要： A nitric oxide gas-releasing conduit configured for surgical implantation through a patient's tympanic membrane. The nitric oxide gas-releasing conduit comprises a gas-permeable cured resin material configured for releasably sequestering therein gas. The gas-permeable cured resin material is charged with nitric oxide gas. The nitric oxide gas-releasing conduit may be optionally coated with an antimicrobial gas-releasing composition. The gas-releasing coating composition may be configured to release nitric oxide.
摘要翻译：一氧化氮气体释放导管，其构造成用于通过患者的鼓膜进行手术植入。一氧化氮气体释放导管包括构造成可释放地将其中的气体隔离的气体可渗透的固化树脂材料。透气性固化树脂材料装有一氧化氮气体。一氧化氮气体释放管道可任选地涂覆有抗微生物气体释放组合物。气体释放涂料组合物可以被配置为释放一氧化氮。

6. 发明申请

US20130078298A1 GASEOUS NITRIC OXIDE-SEQUESTERING PRODUCTS AND PROCESSES OF PREPARING SAME 审中-公开
标题翻译：气体氮氧化物测序产品及其制备方法
公开(公告)号：US20130078298A1
公开(公告)日：2013-03-28
申请号：US13697374
申请日：2011-05-09
申请人： Yossef Av-Gay , Christopher C. Miller , Deborah Bohbot , Gilly Regev-Shoshani
发明人： Yossef Av-Gay , Christopher C. Miller , Deborah Bohbot , Gilly Regev-Shoshani
IPC分类号： B65D25/00 , B65B5/00
CPC分类号： B65D25/00 , A61L15/22 , A61L15/46 , A61L27/14 , A61L27/54 , A61L28/0007 , A61L28/0038 , A61L29/04 , A61L29/16 , A61L31/04 , A61L31/16 , A61L2300/114 , B65B5/00
摘要： A process of preparing articles having gaseous NO sequestered therein is disclosed, as well as articles prepared thereby. Also disclosed are articles having gaseous NO sequestered therewithin and having reduced amount of oxygen-containing and/or nitrogen-containing reactive species. Also disclosed are processes of preparing packaged articles having a non-gas permeable package that comprises gaseous NO therein and packaged articles made therefrom. Also disclosed are charging devices which can be utilized in the above-described processes. The articles prepared by the above-described processes are preferably medical devices such as indwelling catheters, intubation devices and tampons. Tampons having sequestered therein gaseous NO, uses thereof and processes of preparing same are also disclosed.
摘要翻译：公开了一种制备具有气态NO螯合的制品的方法，以及由此制备的制品。还公开了具有在其中螯合的气态NO并具有减少量的含氧和/或含氮反应性物质的制品。还公开了制备具有包含气态NO的非气体可渗透包装的包装制品的包装制品和由其制成的包装制品的方法。还公开了可以在上述处理中使用的充电装置。通过上述方法制备的制品优选为诸如留置导管，插管装置和棉塞的医疗装置。卫生棉条在其中存储有气态NO，其用途及其制备方法也被公开。

7. 发明申请

US20090255536A1 Biofilm-Inhibiting Catheters and Tubings 审中-公开
标题翻译：生物膜抑制导管和管
公开(公告)号：US20090255536A1
公开(公告)日：2009-10-15
申请号：US12420671
申请日：2009-04-08
申请人： Yossef Av-Gay , Livia Mahler , Christopher C. Miller
发明人： Yossef Av-Gay , Livia Mahler , Christopher C. Miller
IPC分类号： A61L29/16 , A61M16/04 , A61M27/00 , B05D7/24
CPC分类号： A61L29/16 , A61L2300/114 , A61L2300/404 , A61M16/04 , A61M16/0465 , A61M2025/0056
摘要： Antimicrobial and biofilm-inhibiting nitric oxide-releasing medical appliances for installation into a patient, and processes for producing the medical appliances. The medical appliances are configured for conveying materials into and out of the patient's body and may comprise tubings or pouching systems. The medical appliances comprise a gas-permeable cured resin material selected from the group consisting of curable silicones, polyvinyl acetates, thermoplastic elastomers, acrylonitrile-butadiene-styrene copolymer rubber, polyurethanes and selected combinations thereof, wherein the gas-permeable cured resin material comprises a matrix suitable for releasably sequestering therein permeating gases. A plurality of nitric-oxide gas-releasing moieties is sequestered within and through the gas-permeable resin material. Nitric oxide is released from at least a portion of said plurality of nitric oxide gas-releasing moieties upon contact of the medical appliance with a moisture source. Exemplary medical appliances include endotracheal tubes, crichotracheotomy tubes, urinary catheters, wound drainage tubes, central intravenous catheters, peripheral intravenous catheters, and poucing systems.
摘要翻译：用于安装到患者体内的抗菌和生物膜抑制一氧化氮释放医疗器具，以及用于生产医疗器具的方法。医疗器具被配置为将材料输送进入和离开患者身体，并且可以包括管道或包囊系统。所述医疗器具包括选自可固化的硅酮，聚乙酸乙烯酯，热塑性弹性体，丙烯腈 - 丁二烯 - 苯乙烯共聚物橡胶，聚氨酯及其选择的组合的透气性固化树脂材料，其中透气性固化树脂材料包括基质适于在其中可释放地封闭渗透气体。多个一氧化氮气体释放部分被隔离在透气性树脂材料内并通过透气性树脂材料。当医疗器具与湿气源接触时，一氧化氮从所述多个一氧化氮气体释放部分的至少一部分释放。示例性医疗器具包括气管内导管，气管切开术管，导尿管，伤口引流管，中央静脉导管，外周静脉导管和灌注系统。

8. 发明申请

US20090131883A1 ANTIMICROBIAL GAS-RELEASING EAR DRAINAGE TUBES 有权
标题翻译：抗菌气体释放排水管
公开(公告)号：US20090131883A1
公开(公告)日：2009-05-21
申请号：US12234599
申请日：2008-09-19
申请人： Yossef Av-Gay , David Greenberg
发明人： Yossef Av-Gay , David Greenberg
IPC分类号： A61F11/00 , B05D5/00
CPC分类号： A61F11/002 , A61K33/00 , A61L31/04 , A61L31/10 , A61L31/16 , A61L2300/114 , A61L2300/404 , A61L2300/45 , A61L2430/14 , A61M27/002
摘要： A nitric oxide gas-releasing conduit configured for surgical implantation through a patient's tympanic membrane. The nitric oxide gas-releasing conduit comprises a gas-permeable cured resin material configured for releasably sequestering therein gas. The gas-permeable cured resin material is charged with nitric oxide gas. The nitric oxide gas-releasing conduit may be optionally coated with an antimicrobial gas-releasing composition. The gas-releasing coating composition may be configured to release nitric oxid.
摘要翻译：一氧化氮气体释放导管，其构造成用于通过患者的鼓膜进行手术植入。一氧化氮气体释放导管包括构造成可释放地将其中的气体隔离的气体可渗透的固化树脂材料。透气性固化树脂材料装有一氧化氮气体。一氧化氮气体释放管道可任选地涂覆有抗微生物气体释放组合物。气体释放涂料组合物可以被配置为释放一氧化氮。

9. 发明授权

US07183094B2 Bacterial mycothiol S-conjugate amidase family 失效
标题翻译：细菌霉菌S共轭酰胺酶家族
公开(公告)号：US07183094B2
公开(公告)日：2007-02-27
申请号：US10427218
申请日：2003-04-30
申请人： Gerald L. Newton , Yossef Av-Gay , Robert C. Fahey
发明人： Gerald L. Newton , Yossef Av-Gay , Robert C. Fahey
IPC分类号： C12N9/80
CPC分类号： C12P19/26 , C12N9/80
摘要： The present invention provides a family of bacterial acyl glucosaminylinositol amidases with amidase activity against S-conjugate amides, particularly mycothiol-derived S-conjugate amides. The invention amidases are characterized by a highly conserved 20 amino acid N-terminal region and four highly conserved histidine-containing regions and by having amidase activity, particularly amide hydrolase activity. The invention further provides methods for using the invention amidases in drug screening assays to determine compounds with antibiotic activity or compounds that inhibit activity or production of endogenous acyl glucosaminyl inositol amidase in bacteria. The invention further provides methods for detoxifying a toxic substance by contacting the toxic substance with an invention amidase, for example, by expression of the amidase under environmental conditions in a bacterium.
摘要翻译：本发明提供了一种具有针对S-缀合物酰胺的酰胺酶活性的细菌性酰基葡糖胺基肌氨酰胺酶家族，特别是由咪唑硫醇衍生的S-共轭酰胺。本发明酰胺酶的特征在于高度保守的20个氨基酸的N-末端区域和4个高度保守的组氨酸区域，并具有酰胺酶活性，特别是酰胺水解酶活性。本发明还提供了在药物筛选测定中使用本发明的方法来测定具有抗生素活性的化合物或抑制细菌内源性酰基葡糖胺基肌醇酰胺酶活性或产生的化合物。本发明还提供了通过使有毒物质与发酵酰胺酶接触来使毒性物质解毒的方法，例如通过在环境条件下在细菌中表达酰胺酶。

10. 发明授权

US5652132A Oxido reductase enzyme system obtainable from P. chrysogenum, the set of genes encoding the same and the use of oxido reductase enzyme systems or genes encoding the same for increasing antibiotic production 失效
标题翻译：从产黄青霉获得的氧化还原酶系统，编码它们的一组基因和使用氧化还原酶系统或编码它们的基因用于增加抗生素生产
公开(公告)号：US5652132A
公开(公告)日：1997-07-29
申请号：US274043
申请日：1994-07-12
申请人： Yair Aharonowitz , Lucia Helena Maria Van Der Voort , Gerald Cohen , Roelof Ary Lans Bovenberg , Rachel Schreiber , Anat Argaman , Yossef Av-Gay , Helena Maria Nan , Alfred Kattevilder , Harriet Pa Lissa , Henk Van Liempt
发明人： Yair Aharonowitz , Lucia Helena Maria Van Der Voort , Gerald Cohen , Roelof Ary Lans Bovenberg , Rachel Schreiber , Anat Argaman , Yossef Av-Gay , Helena Maria Nan , Alfred Kattevilder , Harriet Pa Lissa , Henk Van Liempt
IPC分类号： C12N1/15 , C07K14/00 , C12N9/02 , C12N15/09 , C12N15/53 , C12P35/00 , C12P37/00 , C12R1/82 , C12N9/06
CPC分类号： C12N9/0004 , C07K14/00 , C12N9/0036 , C12P37/00 , Y10S435/935
摘要： A new oxido reductase enzyme activity obtainable from P. chrysogenum, involved in the production of .beta.-lactams, the set of genes encoding said enzyme activity, and a method to enhance said production by using the above-mentioned oxido reductase system and other oxido reductase systems or genes encoding for the same have been disclosed.
摘要翻译：参与β-内酰胺的生产的产黄青素的新的氧化还原酶活性，编码所述酶活性的基因组以及通过使用上述氧化还原酶系统和其它氧化还原酶来增强所述产生的方法已经公开了编码其的系统或基因。

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