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1. 发明授权

US4883879A Cephalosporin compounds, processes for their preparation and antibacterial agents 失效
标题翻译：头孢菌素化合物，其制备方法和抗菌剂
公开(公告)号：US4883879A
公开(公告)日：1989-11-28
申请号：US296765
申请日：1989-01-13
申请人： Yoshiyuki Zama , Nobuo Ishiyama , Tsuneo Saita , Takanobu Naito , Masao Hirose , Masaaki Yokoyama , Taiji Asano , Hisato Senda , Keiji Sekine , Shigeru Sanai
发明人： Yoshiyuki Zama , Nobuo Ishiyama , Tsuneo Saita , Takanobu Naito , Masao Hirose , Masaaki Yokoyama , Taiji Asano , Hisato Senda , Keiji Sekine , Shigeru Sanai
IPC分类号： C07D417/12 , C07D501/00 , C07D501/20 , C07D501/34 , C07D501/36 , C07D501/59
CPC分类号： C07D417/12 , C07D501/00
摘要： A cephalosporin compound having the formula: ##STR1## wherein R.sub.1 is a hydrogen atom, a halogen atom, a methoxy group, a substituted or unsubstituted vinyl group, or --CH.sub.2 --A wherein A is a hydrogen atom, an azido group, an acyloxy group, a carbamoyloxy group, a substituted or unsubstituted heterocyclic group (wherein the hetrocyclic ring is a 5- or 6-membered heterocyclic ring having from 1 to 4 oxygen, nitrogen or sulfur atoms), or a substituted or unsubstituted heterocyclic thio group (wherein the heterocyclic ring is a monocyclic or bicyclic heterocyclic ring having from 1 to 5 oxygen, nitrogen or sulfur atoms), or a pharmaceutically acceptable salt thereof.

2. 发明授权

US4822786A Cephalosporin compounds, and antibacterial agents 失效
标题翻译：头孢菌素化合物和抗菌剂
公开(公告)号：US4822786A
公开(公告)日：1989-04-18
申请号：US63077
申请日：1987-06-17
申请人： Yoshiyuki Zama , Nobuo Ishiyama , Tsuneo Saita , Takanobu Naito , Masao Hirose , Masaaki Yokoyama , Taiji Asano , Hisato Senda , Keiji Sekine , Shigeru Sanai
发明人： Yoshiyuki Zama , Nobuo Ishiyama , Tsuneo Saita , Takanobu Naito , Masao Hirose , Masaaki Yokoyama , Taiji Asano , Hisato Senda , Keiji Sekine , Shigeru Sanai
IPC分类号： C07D417/12 , C07D501/00 , C07D501/20 , C07D501/34 , C07D501/36 , C07D501/59 , C07D501/38 , A61K31/545
CPC分类号： C07D417/12 , C07D501/00
摘要： A cephalosporin compound having the formula: ##STR1## wherein R.sub.1 is a hydrogen atom, a halogen atom, a methoxy group, a substituted or unsubstituted vinyl group, or --CH.sub.2 --A wherein A is a hydrogen atom, an azido group, an acyloxy group, a carbamoyloxy group, a subsituted or unsubstituted heterocyclic group (wherein the hetrocyclic ring is a 5- or 6-membered heterocyclic ring having from 1 to 4 oxygen, nitrogen or sulfur atoms), or a substituted or unsubstituted heterocyclic thio group (wherein the heterocyclic ring is a monocyclic or bicyclic heterocyclic ring having from 1 to 5 oxygen, nitrogen or sulfur atoms), or a pharmaceutically acceptable salt thereof.
摘要翻译：具有下式的头孢菌素化合物：其中R1是氢原子，卤原子，甲氧基，取代或未取代的乙烯基或-CH2-A，其中A是氢原子，叠氮基酰氧基，氨基甲酰氧基，取代或未取代的杂环基（其中，杂环是具有1至4个氧，氮或硫原子的5或6元杂环）或取代或未取代的杂环硫代基团（其中杂环是具有1至5个氧，氮或硫原子的单环或双环杂环）或其药学上可接受的盐。

3. 发明授权

US5668147A Quinolinecarboxylic acid derivatives and salts thereof 失效
标题翻译：喹啉羧酸衍生物及其盐
公开(公告)号：US5668147A
公开(公告)日：1997-09-16
申请号：US632474
申请日：1996-04-25
申请人： Jun Nakano , Hideto Fukui , Tetsuo Shibata , Hisato Senda , Tetsuro Maejima , Yayoi Watanuki , Tadashi Arika
发明人： Jun Nakano , Hideto Fukui , Tetsuo Shibata , Hisato Senda , Tetsuro Maejima , Yayoi Watanuki , Tadashi Arika
IPC分类号： C07D207/08 , C07D207/09 , C07D207/14 , C07D207/16 , C07D401/04 , C07D403/06 , C07D471/04 , C07D215/233 , A61K31/47
CPC分类号： C07D207/08 , C07D207/09 , C07D207/14 , C07D207/16 , C07D401/04 , C07D403/06 , C07D471/04
摘要： Quinolinecarboxylic acid derivatives which are represented by the general formula (I) ##STR1## wherein R.sub.1 is a C.sub.1 to C.sub.6 alkyl group which may be substituted, a C.sub.2 to C.sub.6 alkenyl group which may be substituted, a C.sub.3 to C.sub.7 cycloalkyl group which my be substituted or an aryl group which may be substituted,R.sub.2 is hydrogen atom; a halogen atom; hydroxyl group which may be protected, amino group or a C.sub.1 to C.sub.6 alkylamino group each of which may be protected; a C.sub.1 to C.sub.6 dialkylamino group or a C.sub.1 to C.sub.6 alkyl group,R.sub.3 is hydrogen atom or a C.sub.1 to C.sub.6 alkyl group,A is nitrogen atom or ##STR2## wherein A' is hydrogen atom. a halogen atom, a C.sub.1 to C.sub.6 alkyl group, a C.sub.1 to C.sub.6 alkoxyl group which may be substituted, cyano group, or nitro group, and A' may form a ring with R.sub.1 ; the ring may include oxygen atom, nitrogen atom, or sulfur atom as a constituent atom; the ring may be substituted with a C.sub.1 to C.sub.6 alkyl group,X is hydroxymethyl group; aminomethyl group or amino group each of which may be protected,and salts thereof, and antibacterial agents which comprise the quinolinecarboxylic acid derivatives and salts thereof as active ingredients, and therapeutical methods thereby.
摘要翻译： PCT No.PCT / JP94 / 01815 Sec。 371日期：1996年4月25日 102（e）日期1996年4月25日PCT 1994年10月27日PCT PCT。第WO95 / 11902号公报日期：1995年5月4日由通式（I）表示的喹啉羧酸衍生物被取代，可被取代的C2〜C6链烯基，被取代的C3〜C7环烷基或可被取代的芳基被取代，R2是氢原子; 卤素原子; 可被保护的羟基，氨基或可被保护的C1-C6烷基氨基; C1至C6二烷基氨基或C1至C6烷基，R3为氢原子或C1至C6烷基，A为氮原子或其中A'为氢原子。卤素原子，C1〜C6烷基，可被取代的C1〜C6烷氧基，氰基或硝基，A'可以与R1形成环; 环可以包括氧原子，氮原子或硫原子作为构成原子; 该环可以被C1-C6烷基取代，X是羟甲基; 各自可被保护的氨基甲基或氨基，及其盐，以及包含喹啉羧酸衍生物及其盐作为活性成分的抗菌剂及其治疗方法。

4. 发明授权

US5276041A Oxime derivatives 失效
标题翻译：肟衍生物
公开(公告)号：US5276041A
公开(公告)日：1994-01-04
申请号：US972306
申请日：1992-11-05
申请人： Jun Nakano , Hideto Fukui , Hisamitsu Haigoh , Hisato Senda , Wakao Iwatani , Tadashi Arika
发明人： Jun Nakano , Hideto Fukui , Hisamitsu Haigoh , Hisato Senda , Wakao Iwatani , Tadashi Arika
IPC分类号： C07D401/04 , A61K31/47
CPC分类号： C07D401/04 , Y02P20/55
摘要： An oxime derivative of the formula: ##STR1## wherein R is a hydrogen atom or a C.sub.1-5 alkyl group, R.sub.1 is a hydrogen atom, a C.sub.1-5 alkyl group or a carboxyl-protecting group, R.sub.2 is a hydrogen atom, a halogen atom, a hydroxyl group or an amino group, R.sub.3 is a C.sub.3-7 cycloalkyl group, R.sub.4 is a hydrogen atom, a halogen atom or a C.sub.1-4 alkoxy group, each of R.sub.5 and R.sub.6 which may be the same or different, is a hydrogen atom or a C.sub.1-5 alkyl group, or R.sub.5 and R.sub.6 together represent a C.sub.2-4 alkylene group which forms together with the adjacent carbon atom a C.sub.3-5 ring, provided that when R.sub.2 is a hydrogen atom, R.sub.4 is a C.sub.1-4 alkoxy group, m is an integer of 0 or 1, and n is an integer of from 1 to 3; or its pharmaceutically acceptable salt.
摘要翻译：下式的肟衍生物：（*化学结构*）（I）其中R是氢原子或C1-5烷基，R1是氢原子，C1-5烷基或羧基保护基，R2 是氢原子，卤素原子，羟基或氨基，R3是C3-7环烷基，R4是氢原子，卤素原子或C1-4烷氧基，R5和R6各自可以是相同或不同，为氢原子或C1-5烷基，或R5和R6一起表示与相邻碳原子一起形成C3-5环的C2-4亚烷基，条件是当R2为氢原子，R4为C1-4烷氧基，m为0或1的整数，n为1〜3的整数，或其药学上可接受的盐。

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