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1. 发明申请

US20090246186A1 AGENT FOR IMPROVING NERVOUS SYSTEM CELL FUNCTIONS 审中-公开
标题翻译：改善神经系统细胞功能的代理
公开(公告)号：US20090246186A1
公开(公告)日：2009-10-01
申请号：US12295258
申请日：2007-03-29
申请人： Yoshiyuki Shinagawa , Hideyuki Kishida , Taizo Kawabe , Hirokazu Sakamoto , Hiroshi Kubo , Kazunori Hosoe
发明人： Yoshiyuki Shinagawa , Hideyuki Kishida , Taizo Kawabe , Hirokazu Sakamoto , Hiroshi Kubo , Kazunori Hosoe
IPC分类号： A61K31/122 , A61P25/00
CPC分类号： A61K31/09 , A61K31/122
摘要： The present invention aims to activate neural cells in brain, and further provide a useful composition having an action to protect intracerebral neural cells from external and internal stresses.An agent for improving a neural cell function containing reduced coenzyme Q as an active ingredient, more specifically, an agent for activating neural cells and an agent for protecting neural cells, is useful, and can be used for the improvement or prophylaxis of central neurological diseases or neuropathy symptoms derived from or associated with a neurodegenerative disease, promotion of cognitive function or improvement of learning and memory disorders.
摘要翻译：本发明旨在激活脑中的神经细胞，并进一步提供一种有用的组合物，其具有保护脑内神经细胞免受外部和内部应激的作用。用于改善包含还原型辅酶Q作为活性成分的神经细胞功能的药剂，更具体地，用于激活神经细胞的药剂和用于保护神经细胞的药剂是有用的，并且可用于改善或预防中枢神经系统疾病或由神经退行性疾病引起或与之相关的神经病症状，促进认知功能或改善学习和记忆障碍。

2. 发明申请

US20100028319A1 COMPOSITION FOR PREVENTION OR TREATMENT OF DIABETES 审中-公开
标题翻译：用于预防或治疗糖尿病的组合物
公开(公告)号：US20100028319A1
公开(公告)日：2010-02-04
申请号：US12525446
申请日：2008-01-31
申请人： Hirokazu Sakamoto , Hideyuki Kishida , Kazunori Hosoe
发明人： Hirokazu Sakamoto , Hideyuki Kishida , Kazunori Hosoe
IPC分类号： A61K38/43 , C07H19/20 , A61P7/12
CPC分类号： A61K31/7076 , A23K20/10 , A23K20/105 , A23K20/116 , A23K20/121 , A23K20/137 , A23K20/174 , A23K50/40 , A23L33/10 , A23V2002/00 , A23V2200/328 , A23V2250/30
摘要： The present invention aims to provide a composition which has an extremely broad range of applications, has an excellent safety, and can be used for preventing, ameliorating, or therapeutically-treating diabetes.The present invention provides an agent for preventing, ameliorating, or therapeutically-treating diabetes or a diabetic complication, a glycemic control agent, and an insulin secretion-promoting agent, each of which contains reduced coenzyme A as an active ingredient. The present invention also provides a method for preventing, ameliorating, or therapeutically-treating diabetes or a diabetic complication, which includes administration of the aforementioned agent.
摘要翻译：本发明旨在提供一种应用范围非常广泛，安全性优异的组合物，可用于预防，改善或治疗糖尿病。本发明提供了用于预防，改善或治疗糖尿病或糖尿病并发症的药剂，血糖控制剂和胰岛素分泌促进剂，其各自含有还原型辅酶A作为活性成分。本发明还提供了预防，改善或治疗性治疗糖尿病或糖尿病并发症的方法，其包括给药前述药剂。

3. 发明申请

US20080138326A1 Method for cancer treatment, carcinogenesis suppression or mitigation of adverse reactions of anticancer agents 审中-公开
标题翻译：癌症治疗方法，致癌作用抑制或缓解抗癌药物的不良反应
公开(公告)号：US20080138326A1
公开(公告)日：2008-06-12
申请号：US11987946
申请日：2007-12-06
申请人： Toshihide Fujii , Masanori Kato , Hirokazu Sakamoto , Yoshiyuki Shinagawa , Mitsuaki Kitano , Kazunori Hosoe
发明人： Toshihide Fujii , Masanori Kato , Hirokazu Sakamoto , Yoshiyuki Shinagawa , Mitsuaki Kitano , Kazunori Hosoe
IPC分类号： A61K38/43 , A61P35/00
CPC分类号： A61K31/05 , A23L33/15 , A23V2002/00 , A23V2200/308 , A23V2250/314
摘要： Provided is a method for suppressing carcinogenesis, treating cancer, or mitigating adverse reactions of anticancer agents, with low prevalence of adverse reactions by administering an effective amount of a reduced coenzyme Q as an active ingredient. In the method, the reduced coenzyme Q can be administered in the form of pharmaceuticals, cosmeceutical, cosmetics, foods such as functional foods (supplements, health aid foods, nutritional supplementary foods, nutrient-fortified foods, nutrient-adjusted foods, health beverages, foods for specified health uses, foods with nutrient function claims), animal drugs, animal feeds, or animal foods.
摘要翻译：本发明提供一种通过施用有效量的还原型辅酶Q作为有效成分来抑制癌发生，治疗癌症或减轻抗癌药物的不良反应，低不良反应发生率的方法。在该方法中，还原型辅酶Q可以以药物，药妆，化妆品，功能性食品（补充剂，保健食品，营养补充食品，营养强化食品，营养调整食品，保健饮料，用于特定健康用途的食物，具有营养功能要求的食品），动物药物，动物饲料或动物食品。

4. 发明授权

US5508765A Matrix-addressed type display device 失效
标题翻译：矩阵寻址型显示设备
公开(公告)号：US5508765A
公开(公告)日：1996-04-16
申请号：US258380
申请日：1994-06-10
申请人： Naoki Nakagawa , Satoru Kawamoto , Hirokazu Sakamoto , Masahiro Hayama
发明人： Naoki Nakagawa , Satoru Kawamoto , Hirokazu Sakamoto , Masahiro Hayama
IPC分类号： G02F1/1343 , G02F1/136 , G02F1/1362 , G02F1/1368 , G09F9/30 , H01L21/336 , H01L27/12 , H01L29/78 , H01L29/786 , G02F1/133
CPC分类号： G02F1/136213
摘要： A matrix-addressed type display device has display material sandwiched between two substrates facing each other, and a transparent pixel electrode disposed in matrix arrangement. The display device display characters by the application of a voltage selectively to the transparent pixel electrode by the use of a thin-film transistor. To improve display characteristics, an electric charge capacitor is provided in each pixel. This electric charge capacitor is connected to an adjacent gate electrode path and includes a transparent inner bottom electrode sandwiched between a dielectric substrate and a transparent pixel electrode. A transparent dielectric film is Interposed between the transparent pixel electrode and the transparent inner bottom electrode.
摘要翻译：矩阵寻址型显示装置具有夹在彼此面对的两个基板之间的显示材料和以矩阵排列设置的透明像素电极。显示装置通过使用薄膜晶体管通过选择性地向透明像素电极施加电压来显示字符。为了改善显示特性，在每个像素中提供电荷电容器。该电荷电容器连接到相邻的栅电极路径，并且包括夹在电介质基板和透明像素电极之间的透明内底电极。在透明像素电极和透明内底电极之间插入透明电介质膜。

5. 发明授权

US08617603B2 Coated tablet 有权
标题翻译：涂层片
公开(公告)号：US08617603B2
公开(公告)日：2013-12-31
申请号：US13607395
申请日：2012-09-07
申请人： Hironobu Kato , Hirokazu Sakamoto
发明人： Hironobu Kato , Hirokazu Sakamoto
IPC分类号： A61K9/28 , A61K9/20
CPC分类号： A61K9/284 , A61K9/2846 , A61K31/155 , A61K31/164 , A61K31/24 , A61K31/245 , A61K31/4178 , A61K31/431 , A61K31/5383
摘要： A main object of the present invention is to provide a novel coated tablet which contains a drug having a guanidino group and does not suffer an obvious color change even when packed in a one-dose pack together with a drug having a (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl (DMDO) group. The present invention provides a coated tablet characterized in that an uncoated tablet containing a drug having a guanidino group has been coated with a polyvinyl alcohol for film coating which comprises polyvinyl alcohol, acrylic acid, and methyl methacrylate.
摘要翻译：本发明的主要目的是提供一种包含胍基的药物的新颖的包衣片剂，即使当与含有（5-甲基-2-吡咯烷酮）的药物一起包装在一次包装中时也不会发生明显的变色， 2-氧代-1,3-二氧杂环戊烯-4-基）甲基（DMDO）。本发明提供了一种包衣片，其特征在于，包含含有胍基的药物的未包衣片剂已经用包含聚乙烯醇，丙烯酸和甲基丙烯酸甲酯的薄膜包衣用聚乙烯醇涂覆。

6. 发明申请

US20130189360A1 COMPRESSED COMPOSITION 审中-公开
标题翻译：压缩成分
公开(公告)号：US20130189360A1
公开(公告)日：2013-07-25
申请号：US13813756
申请日：2011-08-03
申请人： Hirokazu Sakamoto , Kentaro Nagane , Masami Nohara
发明人： Hirokazu Sakamoto , Kentaro Nagane , Masami Nohara
IPC分类号： A61K9/20
CPC分类号： A61K9/20 , A61K9/2081 , A61K9/5078 , A61K31/4439
摘要： An object of the present invention is to provide a compressed composition that is superior in terms of maintaining the function of a film or in terms of content uniformity even during tableting process.The present invention provides a compressed composition, comprising: coated granules containing a physiologically active compound or pharmacologically acceptable salt thereof, and an excipient, wherein the excipient contains at least one selected from the group consisting of low-substituted hydroxypropylcellulose, lactose and crystalline cellulose, and the total amount thereof is 0.5 parts by weight or more in 1 part by weight of the excipient, and the excipient is physically mixed with or coated onto the coated granules followed by compressing at low pressure.
摘要翻译：本发明的目的是提供一种压缩组合物，即使在压片过程中，在保持膜的功能或者含量均匀性方面也是优异的。本发明提供一种压缩组合物，其包含：含有生理活性化合物或其药理学上可接受的盐的赋形剂和赋形剂，其中所述赋形剂含有选自低取代羟丙基纤维素，乳糖和结晶纤维素中的至少一种，并且其总量在1重量份的赋形剂中为0.5重量份以上，赋形剂与涂覆的颗粒物理混合或涂覆在其上，然后在低压下压制。

7. 发明授权

US5066106A Liquid crystal display device having redundant buses 失效
标题翻译：具有冗余总线的液晶显示装置
公开(公告)号：US5066106A
公开(公告)日：1991-11-19
申请号：US296763
申请日：1989-01-13
申请人： Hirokazu Sakamoto , Makoto Ohtani , Naoki Nakagawa , Taro Maejima , Masahiro Hayama
发明人： Hirokazu Sakamoto , Makoto Ohtani , Naoki Nakagawa , Taro Maejima , Masahiro Hayama
IPC分类号： H01L27/12 , G02F1/136 , G02F1/1362 , G02F1/1368 , H01L29/78 , H01L29/786
CPC分类号： G02F1/1362 , G02F2001/13629 , G02F2202/103 , G02F2202/104
摘要： A liquid crystal display device includes a transparent conductive film display electrode on a transparent insulating substrate, a plurality of lower layer source conductors disposed simultaneously with a plurality of gate electrode conductors on the substrate, the source conductors intersecting the gate electrode conductors, a gate insulation film on the gate electrode conductors, the lower layer source conductors, and the display electrode, a semiconductor film disposed on the gate insulation film at a position overlying the gate electrode conductors, a drain electrode connected to the display electrode and disposed on the semiconductor film and the gate insulation film, and an upper layer source electrode conductor connected to the lower layer source conductors, the upper layer source electrode conductor disposed on the gate insulation film and the semiconductor film and forming a double-layer structure with the lower layer source conductors.
摘要翻译：液晶显示装置包括在透明绝缘基板上的透明导电膜显示电极，与基板上的多个栅电极导体同时设置的多个下层源极导体，与栅极导体相交的源极导体，栅极绝缘在栅极电极导体，下层源极导体和显示电极上形成膜，在覆盖栅极导体的位置配置在栅极绝缘膜上的半导体膜，连接到显示电极并设置在半导体膜上的漏电极和栅极绝缘膜，以及连接到下层源极导体的上层源极电极导体，设置在栅极绝缘膜和半导体膜上的上层源极电极导体，并与下层源极导体形成双层结构。

8. 发明授权

US08282956B2 Coated tablet 有权
标题翻译：涂层片
公开(公告)号：US08282956B2
公开(公告)日：2012-10-09
申请号：US12304015
申请日：2007-06-12
申请人： Hironobu Kato , Hirokazu Sakamoto
发明人： Hironobu Kato , Hirokazu Sakamoto
IPC分类号： A61K9/20 , A61K9/28 , A61K9/30 , A61K9/42
CPC分类号： A61K9/284 , A61K9/2846 , A61K31/155 , A61K31/164 , A61K31/24 , A61K31/245 , A61K31/4178 , A61K31/431 , A61K31/5383
摘要： A main object of the present invention is to provide a novel coated tablet which contains a drug having a guanidino group and does not suffer an obvious color change even when packed in a one-dose pack together with a drug having a (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl (DMDO) group. The present invention provides a coated tablet characterized in that an uncoated tablet containing a drug having a guanidino group has been coated with a polyvinyl alcohol for film coating which comprises polyvinyl alcohol, acrylic acid, and methyl methacrylate.
摘要翻译：本发明的主要目的是提供一种包含胍基的药物的新颖的包衣片剂，即使当与含有（5-甲基-2-吡咯烷酮）的药物一起包装在一次包装中时也不会发生明显的变色， 2-氧代-1,3-二氧杂环戊烯-4-基）甲基（DMDO）。本发明提供了一种包衣片，其特征在于，包含含有胍基的药物的未包衣片剂已经用包含聚乙烯醇，丙烯酸和甲基丙烯酸甲酯的薄膜包衣用聚乙烯醇涂覆。

9. 发明申请

US20100233262A1 COATED TABLET 有权
标题翻译：涂层片
公开(公告)号：US20100233262A1
公开(公告)日：2010-09-16
申请号：US12304015
申请日：2007-06-12
申请人： Hironobu Kato , Hirokazu Sakamoto
发明人： Hironobu Kato , Hirokazu Sakamoto
IPC分类号： A61K9/32 , A61K38/12 , A61K38/10 , A61K38/09 , A61K38/08 , A61K31/496 , A61K31/4178 , A61K31/351 , A61K31/245 , A61K31/155
CPC分类号： A61K9/284 , A61K9/2846 , A61K31/155 , A61K31/164 , A61K31/24 , A61K31/245 , A61K31/4178 , A61K31/431 , A61K31/5383
摘要： A main object of the present invention is to provide a novel coated tablet which contains a drug having a guanidino group and does not suffer an obvious color change even when packed in a one-dose pack together with a drug having a (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl (DMDO) group. The present invention provides a coated tablet characterized in that an uncoated tablet containing a drug having a guanidino group has been coated with a polyvinyl alcohol for film coating which comprises polyvinyl alcohol, acrylic acid, and methyl methacrylate.
摘要翻译：本发明的主要目的是提供一种包含胍基的药物的新颖的包衣片剂，即使当与含有（5-甲基-2-吡咯烷酮）的药物一起包装在一次包装中时也不会发生明显的变色， 2-氧代-1,3-二氧杂环戊烯-4-基）甲基（DMDO）。本发明提供了一种包衣片，其特征在于，包含含有胍基的药物的未包衣片剂已经用包含聚乙烯醇，丙烯酸和甲基丙烯酸甲酯的薄膜包衣用聚乙烯醇涂覆。

10. 发明申请

US20080286254A1 Composition comprising licorice polyphenol 审中-公开
标题翻译：包含甘草多酚的组合物
公开(公告)号：US20080286254A1
公开(公告)日：2008-11-20
申请号：US12153371
申请日：2008-05-16
申请人： Hirokazu Sakamoto , Yuji Tominaga , Shiro Kitamura , Shinichi Yokota
发明人： Hirokazu Sakamoto , Yuji Tominaga , Shiro Kitamura , Shinichi Yokota
IPC分类号： A61K45/00 , A61K36/484 , A61K33/30 , A61K33/24 , A61K36/752 , A61K36/82 , A61K36/67 , A61K36/45 , A61K36/906 , A61P3/04 , A61P9/12 , A61P3/10
CPC分类号： A61K36/06 , A23D9/007 , A23K20/111 , A23K50/40 , A23L33/105 , A23V2002/00 , A61K36/45 , A61K36/484 , A61K36/67 , A61K36/73 , A61K36/74 , A61K36/752 , A61K36/82 , A61K36/87 , A61K36/9068 , A61K45/06 , A61K2300/00 , A23V2250/2132 , A23V2200/328
摘要： A composition containing a licorice polyphenol and other active ingredient (antioxidant ingredient, polyphenol other than licorice polyphenol or a component relating to lipid absorption or metabolism) is highly safe, can be produced easily, and can be utilized for foods and drinks such as health food, food with health claims (specified health food, food with nutrient function claims) and the like, pharmaceutical products, quasi-drugs, cosmetics and the like. In addition, since the composition has a body fat accumulation suppressing effect, a body fat decomposition promoting effect or energy production promoting effect, it is useful for the treatment of obesity, metabolic syndrome and the like.
摘要翻译：含有甘草多酚等活性成分（抗氧化成分，除了甘草多酚以外的多酚或与脂质吸收或代谢有关的成分）的组合物是高度安全的，可以容易地制造，并且可以用于食品和饮料如保健食品，具有健康要求的食品（特定保健食品，具有营养功能要求的食品）等，药品，准药物，化妆品等。此外，由于该组合物具有体脂肪蓄积抑制效果，身体脂肪分解促进效果或能量产生促进作用，因此可用于治疗肥胖症，代谢综合征等。

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