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1. 发明申请

US20050171440A1 Optical system for measuring metabolism in a body and imaging method 有权
公开(公告)号：US20050171440A1
公开(公告)日：2005-08-04
申请号：US11037338
申请日：2005-01-19
申请人： Atsushi Maki , Hideaki Koizumi , Fumio Kawaguchi , Yuichi Yamashita , Yoshitoshi Ito
发明人： Atsushi Maki , Hideaki Koizumi , Fumio Kawaguchi , Yuichi Yamashita , Yoshitoshi Ito
IPC分类号： A61B5/00 , A61B5/05 , A61B5/055 , A61B5/18 , A61B6/00 , A61B6/03
CPC分类号： A61B5/0059 , A61B5/0042 , A61B5/055 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B5/6814 , A61B5/7207 , A61B5/7228 , A61B6/03 , A61B6/507 , A61B2562/0219 , A61B2562/0233 , A61B2562/046
摘要： In an optical measurement system and imaging method adapted to measure in vivo information in a living body without harming the living body, light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface of the living body. Light is utilized to image the results of the measurements, in which the measuring time is shortened by estimating fluctuation attributable to the living body, and the presence or absence of a change in measured signal can be decided easily by displaying an estimation signal and a measured signal at a time.

2. 发明授权

US06282438B1 Optical system for measuring metabolism in a body and imaging method 失效
标题翻译：用于测量身体代谢的光学系统和成像方法
公开(公告)号：US06282438B1
公开(公告)日：2001-08-28
申请号：US09203610
申请日：1998-12-02
申请人： Atsushi Maki , Hideaki Koizumi , Fumio Kawaguchi , Yuichi Yamashita , Yoshitoshi Ito
发明人： Atsushi Maki , Hideaki Koizumi , Fumio Kawaguchi , Yuichi Yamashita , Yoshitoshi Ito
IPC分类号： A61B600
CPC分类号： A61B5/0059 , A61B5/0042 , A61B5/055 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B5/6814 , A61B5/7207 , A61B5/7228 , A61B6/03 , A61B6/507 , A61B2562/0219 , A61B2562/0233 , A61B2562/046
摘要： Light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface of the living body. After completion of the measurement or during the measurement, changes in concentration values of absorbers in the living body are determined from the living body transmitting light intensity levels of the plurality of wavelengths detected at the respective detection points and a measuring point is set on a perpendicular extending through an intermediate point between the incident point and each detection point so as to image a function of the living body. In living body optical measurement system and method, the measuring time is shortened by estimating fluctuation attributable to the living body, the presence or absence of a change in measured signal can be decided easily by displaying an estimation signal and a measured signal at a time, and a local change in. hemodynamic movement can be measured by detecting light rays transmitting through the interior of the living body by the two light detectors disposed at different two sites (equidistant from the light incident point) on a subject and by separating only the local change in hemodynamic movement from an overall change in hemodynamic movement in the living body in accordance with a logarithmic difference between the two detection signals.
摘要翻译：以多个不同频率强度调制的多个波长的光线照射在生物体的表面上的多个照射位置上，并且生物体的时间变化透射与各个相对应的光强度水平波长和各个照射位置在生物体的表面上的不同位置处被测量。在测量完成之后或在测量期间，生物体中的吸收体的浓度值的变化是根据在各个检测点处检测到的多个波长的光强度水平来发射的，并且将测量点设定在垂直方向延伸穿过入射点和每个检测点之间的中间点，以便对活体的功能进行成像。在生物体光学测量系统和方法中，通过估计归因于生物体的波动来缩短测量时间，通过一次显示估计信号和测量信号可以容易地确定测量信号的变化是否存在，并且可以通过检测设置在被摄体上不同的两个位置（等于光入射点的位置）的两个光检测器检测通过生物体的内部的光线，并且仅分离本地根据两个检测信号之间的对数差异，从生物体的血液动力学运动的总体变化中改变血流动力学运动。

3. 发明授权

US07286870B2 Optical system for measuring metabolism in a body and imaging method 有权
标题翻译：用于测量身体代谢的光学系统和成像方法
公开(公告)号：US07286870B2
公开(公告)日：2007-10-23
申请号：US09900144
申请日：2001-07-09
申请人： Atsushi Maki , Hideaki Koizumi , Fumio Kawaguchi , Yuichi Yamashita , Yoshitoshi Ito
发明人： Atsushi Maki , Hideaki Koizumi , Fumio Kawaguchi , Yuichi Yamashita , Yoshitoshi Ito
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A61B5/0042 , A61B5/055 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B5/6814 , A61B5/7207 , A61B5/7228 , A61B6/03 , A61B6/507 , A61B2562/0219 , A61B2562/0233 , A61B2562/046
摘要： In an optical measurement system and imaging method adapted to measure in vivo information in a living body without harming the living body, light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface of the living body. Light is utilized to image the results of the measurements, in which the measuring time is shortened by estimating fluctuation attributable to the living body, and the presence or absence of a change in measured signal can be decided easily by displaying an estimation signal and a measured signal at a time.
摘要翻译：在适于测量活体内的体内信息而不损害生物体的光学测量系统和成像方法中，以多个不同频率强度调制的多个波长的光线照射在多个照射位置在生物体的表面上，在生物体的表面的不同位置测量发射对应于各个波长和各个照射位置的光强度水平的生物体的随时间变化。光被用于对测量结果进行成像，其中通过估计归因于生物体的波动来缩短测量时间，并且可以通过显示估计信号和测量的信号来容易地确定测量信号的变化的存在或不存在信号一次。

4. 发明授权

US5586554A Optical system for measuring metabolism in a body 失效
标题翻译：用于测量身体新陈代谢的光学系统
公开(公告)号：US5586554A
公开(公告)日：1996-12-24
申请号：US197749
申请日：1994-02-16
申请人： Atsushi Maki , Fumio Kawaguchi , Yuichi Yamashita , Yoshitoshi Ito
发明人： Atsushi Maki , Fumio Kawaguchi , Yuichi Yamashita , Yoshitoshi Ito
IPC分类号： A61B10/00 , A61B5/00 , A61B5/145 , G01N21/17 , A61B5/05
CPC分类号： A61B5/0073 , A61B5/0059
摘要： An optical system is arranged to irradiate light to the inside of a test subject and detect the light passed through the test subject for obtaining information about the inside of the test subject. The optical system includes a light source for generating rays of light having different wavelengths, an apparatus for irradiating the rays of light to corresponding spots on the test subject, an apparatus for detecting the light passed through the test subject at plural detecting spots on the test subject, and an apparatus for dispersing the detected light. The rays of light to be irradiated to the test subject have a visible wavelength to a near infrared one. The apparatus for irradiating light operates to irradiate the rays of light of each of the wavelengths to the test subject substantially at one time or by shifting the irradiating times according to each of the wavelengths. The apparatus for irradiating light contains the apparatus for dispersing the irradiated light into respective wavelengths. The rays of light dispersed by the dispersing apparatus are irradiated to the test subject.
摘要翻译：光学系统被布置成将光照射到测试对象的内部，并检测通过测试对象的光以获得关于测试对象内部的信息。光学系统包括用于产生具有不同波长的光线的光源，用于将光线照射到测试对象上的相应点的设备，用于检测在测试中的多个检测点处通过测试对象的光的设备主体和用于分散检测到的光的装置。要照射到受试对象的光线具有近红外线的可见波长。用于照射光的装置基本上一次照射每个波长的光线到测试对象，或者根据每个波长移动照射时间。用于照射光的装置包含用于将照射的光分散到各个波长的装置。将由分散装置分散的光线照射到测试对象。

5. 发明授权

US08050744B2 Optical system for measuring metabolism in a body and imaging method 有权
标题翻译：用于测量身体代谢的光学系统和成像方法
公开(公告)号：US08050744B2
公开(公告)日：2011-11-01
申请号：US11037338
申请日：2005-01-19
申请人： Atsushi Maki , Hideaki Koizumi , Fumio Kawaguchi , Yuichi Yamashita , Yoshitoshi Ito
发明人： Atsushi Maki , Hideaki Koizumi , Fumio Kawaguchi , Yuichi Yamashita , Yoshitoshi Ito
IPC分类号： A61B6/00 , A61B5/00
CPC分类号： A61B5/0059 , A61B5/0042 , A61B5/055 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B5/6814 , A61B5/7207 , A61B5/7228 , A61B6/03 , A61B6/507 , A61B2562/0219 , A61B2562/0233 , A61B2562/046
摘要： In an optical measurement system and imaging method adapted to measure in vivo information in a living body without harming the living body, light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface of the living body. Light is utilized to image the results of the measurements, in which the measuring time is shortened by estimating fluctuation attributable to the living body, and the presence or absence of a change in measured signal can be decided easily by displaying an estimation signal and a measured signal at a time.
摘要翻译：在适于测量活体内的体内信息而不损害生物体的光学测量系统和成像方法中，以多个不同频率强度调制的多个波长的光线照射在多个照射位置在生物体的表面上，在生物体的表面的不同位置测量发射对应于各个波长和各个照射位置的光强度水平的生物体的随时间变化。光被用于对测量结果进行成像，其中通过估计归因于生物体的波动来缩短测量时间，并且可以通过显示估计信号和测量的信号来容易地确定测量信号的变化的存在或不存在信号一次。

6. 发明授权

US5803909A Optical system for measuring metabolism in a body and imaging method 失效
标题翻译：用于测量身体代谢的光学系统和成像方法
公开(公告)号：US5803909A
公开(公告)日：1998-09-08
申请号：US539871
申请日：1995-10-06
申请人： Atsushi Maki , Hideaki Koizumi , Fumio Kawaguchi , Yuichi Yamashita , Yoshitoshi Ito
发明人： Atsushi Maki , Hideaki Koizumi , Fumio Kawaguchi , Yuichi Yamashita , Yoshitoshi Ito
IPC分类号： A61B5/00 , A61B5/05 , A61B5/055 , A61B5/18 , A61B6/00 , A61B6/03
CPC分类号： A61B5/0059 , A61B5/0042 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B5/6814 , A61B2562/0219 , A61B2562/0233 , A61B2562/046 , A61B5/055 , A61B5/7207 , A61B5/7228 , A61B6/03 , A61B6/507
摘要： Light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface Changes in concentration values of absorbers are determined from the living body transmitting light intensity levels and a measuring point is set on a perpendicular extending through an intermediate point between the incident point and each detection point to image a function of the living body. The measuring time is shortened by estimating fluctuation attributable to the living body, and a local change in hemodynamic movement can be measured by detecting light rays transmitting through the interior of the living body by light detection at two different sites (equidistant from the light incident point) on a subject and by separating only the local change in hemodynamic movement from an overall change in hemodynamic movement in the living body in accordance with a logarithmic difference between the two detection signals.
摘要翻译：以多个不同频率强度调制的多个波长的光线照射在生物体的表面上的多个照射位置上，并且生物体的时间变化透射与各个相对应的光强度水平波长和各个照射位置在表面上的不同位置被测量吸收体的浓度值的变化由生物体透射光强度水平确定，并且测量点设置在延伸穿过入射点和每个之间的中间点的垂直检测点成像生物体的功能。通过估计生物体的波动来缩短测量时间，并且可以通过在两个不同位置（等于光入射点的光检测）检测透射通过生物体内部的光线来测量血液动力学运动的局部变化），并且根据两个检测信号之间的对数差异仅分离血液动力学运动的局部变化与生物体中的血液动力学运动的总体变化。

7. 发明授权

US07440794B2 Optical system for measuring metabolism in a body and imaging method 有权
标题翻译：用于测量身体代谢的光学系统和成像方法
公开(公告)号：US07440794B2
公开(公告)日：2008-10-21
申请号：US11037282
申请日：2005-01-19
申请人： Atsushi Maki , Hideaki Koizumi , Fumio Kawaguchi , Yuichi Yamashita , Yoshitoshi Ito
发明人： Atsushi Maki , Hideaki Koizumi , Fumio Kawaguchi , Yuichi Yamashita , Yoshitoshi Ito
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/0042 , A61B5/055 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B5/6814 , A61B5/7207 , A61B5/7228 , A61B6/03 , A61B6/507 , A61B2562/0219 , A61B2562/0233 , A61B2562/046
摘要： In an optical measurement system and imaging method adapted to measure in vivo information in a living body without harming the living body, light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface of the living body. Light is utilized to image the results of the measurements, in which the measuring time is shortened by estimating fluctuation attributable to the living body, and the presence or absence of a change in measured signal can be decided easily by displaying an estimation signal and a measured signal at a time.
摘要翻译：在适于测量活体内的体内信息而不损害生物体的光学测量系统和成像方法中，以多个不同频率强度调制的多个波长的光线照射在多个照射位置在生物体的表面上，在生物体的表面的不同位置测量发射对应于各个波长和各个照射位置的光强度水平的生物体的随时间变化。光被用于对测量结果进行成像，其中通过估计归因于生物体的波动来缩短测量时间，并且可以通过显示估计信号和测量的信号来容易地确定测量信号的变化的存在或不存在信号一次。

8. 发明授权

US5408093A Optical computed tomography equipment having image inverting optical device 失效
标题翻译：具有图像反转光学装置的光学计算机断层摄影设备
公开(公告)号：US5408093A
公开(公告)日：1995-04-18
申请号：US204370
申请日：1994-03-11
申请人： Yoshitoshi Ito , Fumio Kawaguchi , Yuichi Yamashita , Atsushi Maki
发明人： Yoshitoshi Ito , Fumio Kawaguchi , Yuichi Yamashita , Atsushi Maki
IPC分类号： A61B5/00 , G02B5/04 , A61B6/03 , G02B6/00
CPC分类号： A61B5/0073
摘要： Optical computed tomography equipment adapted to speed up the scanning of a subject under test using irradiated light so as to shorten the measuring time involved. The light from a light source (15-1, 15-2) is guided over an optical fiber thread (12-5c) to an image inverting optical system comprising a dovetail prism (13-1) and two lenses (14-2, 14-1). Past the optical system, the light enters one of the threads making up an optical fiber (12-1). As the dovetail prism (13-1) is rotated around its optical axis, the light from the optical fiber thread (12-5c) consecutively enters different threads of the optical fiber (12-1), causing the irradiation position to scan a subject (11) of the test. The incident light, having passed through the subject (11) in various directions, goes through the respective threads of the optical fiber (12-1) to reach the image inverting optical device. From there, the light enters the corresponding threads of an optical fiber (12-4) and is detected by photo detectors (16-2a, 16-2b, etc.).
摘要翻译： PCT No.PCT / JP93 / 01220 Sec。 371日期：1994年3月11日 102（e）1994年3月11日PCT 1993年8月30日PCT公布。公开号WO94 / 05209 日期：1994年3月17日。光学计算机断层摄影设备适用于使用照射光加速对受试者的扫描，以缩短测量时间。来自光源（15-1,15-2）的光被引导到光纤线（12-5c）上，到包括燕尾棱镜（13-1）和两个透镜（14-2）的图像反转光学系统， 14-1）。通过光学系统，光进入组成光纤的线之一（12-1）。当燕尾棱镜（13-1）围绕其光轴旋转时，来自光纤线（12-5c）的光连续地进入光纤（12-1）的不同螺纹，使得照射位置扫描对象（11）的测试。已经穿过被摄体（11）的各个方向的入射光穿过光纤（12-1）的各个螺纹，到达图像反转光学装置。从那里，光进入光纤（12-4）的相应螺纹，并由光电检测器（16-2a，16-2b等）检测。

9. 发明授权

US07715904B2 Optical system for measuring metabolism in a body and imaging method 有权
标题翻译：用于测量身体代谢的光学系统和成像方法
公开(公告)号：US07715904B2
公开(公告)日：2010-05-11
申请号：US11037339
申请日：2005-01-19
申请人： Atsushi Maki , Hideaki Koizumi , Fumio Kawaguchi , Yuichi Yamashita , Yoshitoshi Ito
发明人： Atsushi Maki , Hideaki Koizumi , Fumio Kawaguchi , Yuichi Yamashita , Yoshitoshi Ito
IPC分类号： A61B6/00 , A61B5/00
CPC分类号： A61B5/0059 , A61B5/0042 , A61B5/055 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B5/6814 , A61B5/7207 , A61B5/7228 , A61B6/03 , A61B6/507 , A61B2562/0219 , A61B2562/0233 , A61B2562/046
摘要： In an optical measurement system and imaging method adapted to measure in vivo information in a living body without harming the living body, light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface of the living body. Light is utilized to image the results of the measurements, in which the measuring time is shortened by estimating fluctuation attributable to the living body, and the presence or absence of a change in measured signal can be decided easily by displaying an estimation signal and a measured signal at a time.
摘要翻译：在适于测量活体内的体内信息而不损害生物体的光学测量系统和成像方法中，以多个不同频率强度调制的多个波长的光线照射在多个照射位置在生物体的表面上，在生物体的表面的不同位置测量发射对应于各个波长和各个照射位置的光强度水平的生物体的随时间变化。光被用于对测量结果进行成像，其中通过估计归因于生物体的波动来缩短测量时间，并且可以通过显示估计信号和测量的信号来容易地确定测量信号的变化的存在或不存在信号一次。

10. 发明申请

US20050148857A1 Optical system for measuring metabolism in a body and imaging method 有权
公开(公告)号：US20050148857A1
公开(公告)日：2005-07-07
申请号：US11037282
申请日：2005-01-19
申请人： Atsushi Maki , Hideaki Koizumi , Fumio Kawaguchi , Yuichi Yamashita , Yoshitoshi Ito
发明人： Atsushi Maki , Hideaki Koizumi , Fumio Kawaguchi , Yuichi Yamashita , Yoshitoshi Ito
IPC分类号： A61B5/00 , A61B5/05 , A61B5/055 , A61B5/18 , A61B6/00 , A61B6/03
CPC分类号： A61B5/0059 , A61B5/0042 , A61B5/055 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B5/6814 , A61B5/7207 , A61B5/7228 , A61B6/03 , A61B6/507 , A61B2562/0219 , A61B2562/0233 , A61B2562/046
摘要： In an optical measurement system and imaging method adapted to measure in vivo information in a living body without harming the living body, light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface of the living body. Light is utilized to image the results of the measurements, in which the measuring time is shortened by estimating fluctuation attributable to the living body, and the presence or absence of a change in measured signal can be decided easily by displaying an estimation signal and a measured signal at a time.

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