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1. 发明申请

US20080009703A1 Magnetic resonance imaging system 有权
标题翻译：磁共振成像系统
公开(公告)号：US20080009703A1
公开(公告)日：2008-01-10
申请号：US11797878
申请日：2007-05-08
申请人： Yoshitaka Bito , Hisaaki Ochi , Yo Taniguchi , Satoshi Hirata , Toru Shirai
发明人： Yoshitaka Bito , Hisaaki Ochi , Yo Taniguchi , Satoshi Hirata , Toru Shirai
IPC分类号： A61B5/05
CPC分类号： G01R33/485 , G01R33/5608
摘要： A magnetic resonance imaging system capable of conducting spectroscopic imaging with an improved SNR without degrading the spatial resolution includes edge-preserving filter processing means for spectroscopic imaging. The edge-preserving filter processing means executes processing including the steps of calculating spectral similarity in spatial neighborhoods (spatially neighboring voxels) at each voxel in spectroscopic imaging data, calculating a spectral weight according to the spectral similarity, and conducting weighted smoothing for compounding spectra of spatial neighborhoods (spatially neighboring voxels) according to the spectral weight.
摘要翻译：能够在不降低空间分辨率的情况下以改善的SNR进行光谱成像的磁共振成像系统包括用于分光成像的边缘保留滤波处理装置。边缘保留滤波处理装置执行处理，其包括以下步骤：计算分光成像数据中的每个体素的空间邻域（空间相邻体素）中的频谱相似度，根据频谱相似度计算频谱权重，以及进行加权平滑化，根据光谱权重的空间邻域（空间相邻体素）。

2. 发明授权

US08030924B2 Magnetic resonance imaging system 有权
标题翻译：磁共振成像系统
公开(公告)号：US08030924B2
公开(公告)日：2011-10-04
申请号：US11797878
申请日：2007-05-08
申请人： Yoshitaka Bito , Hisaaki Ochi , Yo Taniguchi , Satoshi Hirata , Toru Shirai
发明人： Yoshitaka Bito , Hisaaki Ochi , Yo Taniguchi , Satoshi Hirata , Toru Shirai
IPC分类号： G01V3/00
CPC分类号： G01R33/485 , G01R33/5608
摘要： A magnetic resonance imaging system capable of conducting spectroscopic imaging with an improved SNR without degrading the spatial resolution includes edge-preserving filter processing means for spectroscopic imaging. The edge-preserving filter processing means executes processing including the steps of calculating spectral similarity in spatial neighborhoods (spatially neighboring voxels) at each voxel in spectroscopic imaging data, calculating a spectral weight according to the spectral similarity, and conducting weighted smoothing for compounding spectra of spatial neighborhoods (spatially neighboring voxels) according to the spectral weight.
摘要翻译：能够在不降低空间分辨率的情况下以改善的SNR进行光谱成像的磁共振成像系统包括用于分光成像的边缘保留滤波处理装置。边缘保留滤波处理装置执行处理，其包括以下步骤：计算分光成像数据中的每个体素的空间邻域（空间相邻体素）中的频谱相似度，根据频谱相似度计算频谱权重，以及进行加权平滑化，根据光谱权重的空间邻域（空间相邻体素）。

3. 发明授权

US09097778B2 Magnetic resonance device with diffusion gradient phase variation positionally corrected 有权
标题翻译：具有扩散梯度相位变化的磁共振装置位置校正
公开(公告)号：US09097778B2
公开(公告)日：2015-08-04
申请号：US13140484
申请日：2010-02-03
申请人： Yoshitaka Bito , Satoshi Hirata , Hisaaki Ochi , Koji Hirata , Toru Shirai , Yosuke Otake
发明人： Yoshitaka Bito , Satoshi Hirata , Hisaaki Ochi , Koji Hirata , Toru Shirai , Yosuke Otake
IPC分类号： G01R33/485 , G01R33/563
CPC分类号： G01R33/485 , G01R33/56341
摘要： In the diffusion spectroscopic imaging, in which intensity of molecular diffusion is imaged with separating chemical substances, with suppressing artifacts resulting from object motion of an object, spatial resolution, spectral band and SNR are maintained, and measurement accuracy is enhanced. A measurement for acquiring diffusion SI data is repeated a plurality of times with changing acquisition timing, phase variation of each measurement result is corrected, and a diffusion SI image is reconstructed from the corrected measurement results. In addition, the phase variation is calculated for every point in the space from the diffusion SI data acquired by each measurement or navigation data obtained by each measurement. The phase correction is independently performed for every point in the space.
摘要翻译：在通过分离化学物质成像分子扩散强度的扩散光谱成像中，通过抑制由物体的物体运动产生的伪影，保持了空间分辨率，光谱带和SNR，并且提高了测量精度。通过改变获取定时多次重复获取扩散SI数据的测量，校正每个测量结果的相位变化，并从校正的测量结果重建扩散SI图像。此外，根据通过各测量获得的扩散SI数据或通过每次测量获得的导航数据，计算空间中每个点的相位变化。对于空间中的每一个点都独立执行相位校正。

4. 发明申请

US20120049845A1 MAGNETIC RESONANCE DEVICE 有权
标题翻译：磁共振装置
公开(公告)号：US20120049845A1
公开(公告)日：2012-03-01
申请号：US13140484
申请日：2010-02-03
申请人： Yoshitaka Bito , Satoshi Hirata , Hisaaki Ochi , Koji Hirata , Toru Shirai , Yosuke Otake
发明人： Yoshitaka Bito , Satoshi Hirata , Hisaaki Ochi , Koji Hirata , Toru Shirai , Yosuke Otake
IPC分类号： G01R33/32
CPC分类号： G01R33/485 , G01R33/56341
摘要： In the diffusion spectroscopic imaging, in which intensity of molecular diffusion is imaged with separating chemical substances, with suppressing artifacts resulting from object motion of an object, spatial resolution, spectral band and SNR are maintained, and measurement accuracy is enhanced. A measurement for acquiring diffusion SI data is repeated a plurality of times with changing acquisition timing, phase variation of each measurement result is corrected, and a diffusion SI image is reconstructed from the corrected measurement results. In addition, the phase variation is calculated for every point in the space from the diffusion SI data acquired by each measurement or navigation data obtained by each measurement. The phase correction is independently performed for every point in the space.
摘要翻译：在通过分离化学物质成像分子扩散强度的扩散光谱成像中，通过抑制由物体的物体运动产生的伪影，保持了空间分辨率，光谱带和SNR，并且提高了测量精度。通过改变获取定时多次重复获取扩散SI数据的测量，校正每个测量结果的相位变化，并从校正的测量结果重建扩散SI图像。此外，根据通过各测量获得的扩散SI数据或通过每次测量获得的导航数据，计算空间中的每个点的相位变化。对于空间中的每一个点都独立执行相位校正。

5. 发明授权

US08188739B2 Nuclear magnetic resonance imaging apparatus 有权
标题翻译：核磁共振成像装置
公开(公告)号：US08188739B2
公开(公告)日：2012-05-29
申请号：US12519197
申请日：2007-06-29
申请人： Toru Shirai , Yoshitaka Bito , Yo Taniguchi , Satoshi Hirata
发明人： Toru Shirai , Yoshitaka Bito , Yo Taniguchi , Satoshi Hirata
IPC分类号： G01V3/00
CPC分类号： G01R33/485 , G01R33/483 , G01R33/5602 , G01R33/5607
摘要： A method for obtaining the most appropriate amplitude of signal suppression pulse, which suppresses unnecessary signals from the substance not subjected to measurement, highly accurately, swiftly and stably, and an MRI apparatus that enables the optimization are provided.A pulse amplitude adjusting means equipped in the MRI apparatus acquires signals while changing the amplitude of signal suppression pulse and calculates signal absolute values and phase values, and computes reference signals, which are polarized signal absolute values, based on the changes in signal phase values. This reference signals are subjected to polynomial fitting. A value which makes this fitting curve is 0 or closes to 0 is set as the optimal pulse amplitude.
摘要翻译：提供了一种用于获得信号抑制脉冲的最适当振幅的方法，其能够高度准确，快速且稳定地抑制不被测量的物质的不必要的信号，并且提供能够进行优化的MRI装置。装备在MRI装置中的脉冲幅度调整装置在改变信号抑制脉冲的振幅的同时获取信号，并且计算信号绝对值和相位值，并且基于信号相位值的变化来计算作为极化信号绝对值的参考信号。该参考信号经过多项式拟合。使该拟合曲线为0或接近0的值被设定为最佳脉冲幅度。

6. 发明申请

US20130214785A1 MAGNETIC RESONANCE IMAGING DEVICE 有权
标题翻译：磁共振成像装置
公开(公告)号：US20130214785A1
公开(公告)日：2013-08-22
申请号：US13881739
申请日：2011-10-26
申请人： Toru Shirai , Yoshitaka Bito , Satoshi Hirata , Yoshihisa Soutome , Yo Taniguchi
发明人： Toru Shirai , Yoshitaka Bito , Satoshi Hirata , Yoshihisa Soutome , Yo Taniguchi
IPC分类号： G01R33/36
CPC分类号： G01R33/3621 , A61B5/055 , G01R33/465 , G01R33/4828 , G01R33/485 , G01R33/5611
摘要： Images of two or more kinds of substances showing different chemical shifts, such as water image and metabolite image, are obtained without extending measurement time. For example, images of two or more kinds of desired substances showing different chemical shifts, such as water image and metabolite image, are obtained by one time of execution of an imaging sequence. In this execution, a pre-pulse is applied so that signals of the substances to be separated shift on the image, and magnetic resonance signals are received with receiver RF coils in a number not smaller than the number of types of the substances to be separated. An image reconstructed from the magnetic resonance signals is separated into images of the individual substances using sensitivity maps of the receiver RF coils. Then, correction is performed for returning the shifted image to the original position. Further, residual signals induced by errors generated in the measurement and the separation processing are eliminated by using spectroscopic images obtained after the separation.
摘要翻译：在不延长测量时间的情况下，获得显示不同化学位移的两种或更多种物质的图像，例如水图像和代谢物图像。例如，通过一次执行成像序列，可以获得显示不同化学位移的两种或更多种所需物质的图像，例如水图像和代谢物图像。在该执行中，施加预脉冲，使得要分离的物质的信号在图像上移动，并且用接收器RF线圈接收不少于待分离物质的数量的数量的磁共振信号。使用接收机RF线圈的灵敏度图将从磁共振信号重构的图像分离成各个物质的图像。然后，执行用于将移动的图像返回到原始位置的校正。此外，通过使用分离后获得的分光图像来消除由测量和分离处理中产生的误差引起的残留信号。

7. 发明授权

US09389289B2 Magnetic resonance imaging device 有权
标题翻译：磁共振成像装置
公开(公告)号：US09389289B2
公开(公告)日：2016-07-12
申请号：US13881739
申请日：2011-10-26
申请人： Toru Shirai , Yoshitaka Bito , Satoshi Hirata , Yoshihisa Soutome , Yo Taniguchi
发明人： Toru Shirai , Yoshitaka Bito , Satoshi Hirata , Yoshihisa Soutome , Yo Taniguchi
IPC分类号： G01R33/36 , A61B5/055 , G01R33/465 , G01R33/48 , G01R33/485 , G01R33/561
CPC分类号： G01R33/3621 , A61B5/055 , G01R33/465 , G01R33/4828 , G01R33/485 , G01R33/5611
摘要： Images of two or more kinds of substances showing different chemical shifts, such as water image and metabolite image, are obtained without extending measurement time. For example, images of two or more kinds of desired substances showing different chemical shifts, such as water image and metabolite image, are obtained by one time of execution of an imaging sequence. In this execution, a pre-pulse is applied so that signals of the substances to be separated shift on the image, and magnetic resonance signals are received with receiver RF coils in a number not smaller than the number of types of the substances to be separated. An image reconstructed from the magnetic resonance signals is separated into images of the individual substances using sensitivity maps of the receiver RF coils. Then, correction is performed for returning the shifted image to the original position. Further, residual signals induced by errors generated in the measurement and the separation processing are eliminated by using spectroscopic images obtained after the separation.
摘要翻译：在不延长测量时间的情况下，获得显示不同化学位移的两种或更多种物质的图像，例如水图像和代谢物图像。例如，通过一次执行成像序列，可以获得显示不同化学位移的两种或更多种所需物质的图像，例如水图像和代谢物图像。在该执行中，施加预脉冲，使得要分离的物质的信号在图像上移动，并且用接收器RF线圈接收不少于待分离物质的数量的数量的磁共振信号。使用接收机RF线圈的灵敏度图将从磁共振信号重构的图像分离成各个物质的图像。然后，执行用于将移动的图像返回到原始位置的校正。此外，通过使用分离后获得的分光图像来消除由测量和分离处理中产生的误差引起的残留信号。

8. 发明申请

US20100097062A1 Nuclear Magnetic Resonance Imaging Apparatus 有权
标题翻译：核磁共振成像仪器
公开(公告)号：US20100097062A1
公开(公告)日：2010-04-22
申请号：US12519197
申请日：2007-06-29
申请人： Toru Shirai , Yoshitaka Bito , Yo Taniguchi , Satoshi Hirata
发明人： Toru Shirai , Yoshitaka Bito , Yo Taniguchi , Satoshi Hirata
IPC分类号： G01V3/14
CPC分类号： G01R33/485 , G01R33/483 , G01R33/5602 , G01R33/5607
摘要： A method for obtaining the most appropriate amplitude of signal suppression pulse, which suppresses unnecessary signals from the substance not subjected to measurement, highly accurately, swiftly and stably, and an MRI apparatus that enables the optimization are provided.A pulse amplitude adjusting means equipped in the MRI apparatus acquires signals while changing the amplitude of signal suppression pulse and calculates signal absolute values and phase values, and computes reference signals, which are polarized signal absolute values, based on the changes in signal phase values. This reference signals are subjected to polynomial fitting. A value which makes this fitting curve is 0 or closes to 0 is set as the optimal pulse amplitude.
摘要翻译：提供了一种用于获得信号抑制脉冲的最适当振幅的方法，其能够高度准确，快速且稳定地抑制不被测量的物质的不必要的信号，并且提供能够进行优化的MRI装置。装备在MRI装置中的脉冲幅度调整装置在改变信号抑制脉冲的振幅的同时获取信号，并且计算信号绝对值和相位值，并且基于信号相位值的变化来计算作为极化信号绝对值的参考信号。该参考信号经过多项式拟合。使该拟合曲线为0或接近0的值被设定为最佳脉冲幅度。

9. 发明申请

US20080221430A1 APPARATUS FOR MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：磁共振成像装置
公开(公告)号：US20080221430A1
公开(公告)日：2008-09-11
申请号：US12030893
申请日：2008-02-14
申请人： Hisaaki OCHI , Yo Taniguchi , Yoshihisa Soutome , Yoshitaka Bito
发明人： Hisaaki OCHI , Yo Taniguchi , Yoshihisa Soutome , Yoshitaka Bito
IPC分类号： A61B5/055
CPC分类号： G01R33/5601 , G01R33/54 , G01R33/5616 , G01R33/5617
摘要： A magnetic resonance imaging (MRI) apparatus for high-speed and high-accuracy detection of cell positions labeled with magnetic nanoparticles. A transmitter coil is controlled to generate amplitude-modulated burst RF pulses as excitation RF pulses whose amplitude is modulated by a function that repeatedly inverts the polarity of multiple high-frequency magnetic field sub-pulses separated time-wise and changes the amplitude at each polarity inversion, moreover the time interval of the amplitude-modulated burst RF pulse is set to effectively 1/(2×a first frequency), and the transmitter coil controlled so the carrier frequency of the amplitude-modulated burst RF pulse is set to a second frequency shifted substantially from the first frequency of the magnetic resonance frequency of the proton at the magnetic field strength in the MRI apparatus. The first frequency is here determined based on magnetic nanoparticle information loaded from the magnetic nanoparticle information storage unit and the magnetic resonance frequency of the proton in the static magnetic field. The MRI apparatus can in this way detect the position of cells labeled with magnetic nanoparticles, with high-speed and high accuracy.
摘要翻译：一种磁共振成像（MRI）装置，用于高速和高精度检测用磁性纳米颗粒标记的细胞位置。发射器线圈被控制以产生幅度调制的突发RF脉冲作为激励RF脉冲，其幅度通过重复地反转时间间隔分离的多个高频磁场子脉冲的极性并改变每个极性的振幅的函数来调制此外，调幅脉冲串RF脉冲的时间间隔被有效地设置为1 /（2×a第一频率），并且被控制的发射机线圈被调制的调幅脉冲串RF脉冲的载波频率设置为第二频移基本上从MRI装置中的磁场强度的质子的磁共振频率的第一频率开始。这里基于从磁性纳米颗粒信息存储单元加载的磁性纳米颗粒信息和静态磁场中质子的磁共振频率来确定第一频率。 MRI装置可以以这种方式以高速和高精度检测用磁性纳米颗粒标记的细胞的位置。

10. 发明授权

US5808467A RF probe and inspection system using NMR using the same 失效
标题翻译：射频探头和使用核磁共振的检查系统
公开(公告)号：US5808467A
公开(公告)日：1998-09-15
申请号：US653315
申请日：1996-05-24
申请人： Hisaaki Ochi , Yo Taniguchi , Kenichi Okajima , Yoshitaka Bito , Etsuji Yamamoto
发明人： Hisaaki Ochi , Yo Taniguchi , Kenichi Okajima , Yoshitaka Bito , Etsuji Yamamoto
IPC分类号： G01R33/3415 , G01V3/00
CPC分类号： G01R33/3415
摘要： In the inspection system using nuclear magnetic resonance comprising magnetic field generators such as a static magnetic field, a gradient magnetic field, and an RF magnetic field, an RF probe for detecting an NMR signal from a subject, and a calculator for operating a detected signal by the RF probe, a RF probe for detection comprises a plurality of coils arranged in the predetermined direction and includes a plurality of switching elements and the inspection system selects two or more coils from the plurality of coils for each measurement of NMR signals, turns the switching elements connected to the selected coils ON, turns the switching elements connected to coils other than the selected coils OFF, changes a combination of two or more coils for each measurement of NMR signals, and changes the sensitivity distribution of the RF probe in the predetermined direction according to the Wavelet basis function for each measurement of NMR signals.
摘要翻译：在使用包括诸如静磁场，梯度磁场和RF磁场的磁场发生器的核磁共振的检查系统中，用于检测来自被检体的NMR信号的RF探针和用于操作检测信号的计算器通过RF探头，用于检测的RF探针包括沿预定方向布置的多个线圈，并且包括多个开关元件，并且检查系统从每个测量NMR信号中选择来自多个线圈的两个或更多个线圈，连接到所选择的线圈的开关元件接通，将与所选线圈以外的线圈相连的开关元件断开，对每个NMR信号的测量改变两个或更多个线圈的组合，并将RF探针的灵敏度分布改变为预定的根据每个NMR信号测量的小波基函数的方向。

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