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1. 发明申请

US20080268065A1 FUNCTIONAL FOOD FOR AMELIORATING ENGOGENOUS MELATONIN SECRETION RHYTHM AND FUNCTIONAL FOOD FOR AMELIORATING CIRCADIAN RHYTHM 失效
标题翻译：功能性食品，用于调理植物油分泌蛋白质和功能性食品
公开(公告)号：US20080268065A1
公开(公告)日：2008-10-30
申请号：US11952839
申请日：2007-12-07
申请人： Yoshinori MORIYAMA , Seiji Tsuboi , Akihiro Masuyama , Toshiaki Takano , Keita Ueno , Toshiyuki Kai
发明人： Yoshinori MORIYAMA , Seiji Tsuboi , Akihiro Masuyama , Toshiaki Takano , Keita Ueno , Toshiyuki Kai
IPC分类号： A61K35/20 , A61P43/00
CPC分类号： A61K35/747 , A23L33/10 , A61K35/20
摘要： The invention provides agents for phase-adjusting or enhancing the amplitude of an endogenous melatonin secretion rhythm and for improving a circadian rhythm, which may be taken daily and continuously, have excellent safety, and may effectively prevent or ameliorate disorders of an endogenous melatonin secretion rhythm or of a circadian rhythm without administration of exogenous melatonin, as well as functional food containing such an agent, which may prevent or ameliorate various symptoms, such as sleep disorder or prolonged sleep latency. The agent for phase-adjusting or enhancing the amplitude of an endogenous melatonin secretion rhythm according to the invention contains whey as the active component. The functional food for improving an endogenous melatonin secretion rhythm according to the invention contains the agent for phase-adjusting or enhancing the amplitude of an endogenous melatonin secretion rhythm. The functional food for improving a circadian rhythm contains the agent for improving a circadian rhythm.
摘要翻译：本发明提供用于相位调节或增强内源性褪黑激素分泌节律的振幅并改善可以每天和连续摄取的昼夜节律的药剂，具有优异的安全性，并且可以有效地预防或改善内源性褪黑激素分泌节律的病症或不伴有外源性褪黑激素的昼夜节律，以及含有这种药剂的功能食品，其可以预防或改善诸如睡眠障碍或延长睡眠潜伏期的各种症状。根据本发明的用于相位调节或增强内源性褪黑激素分泌节律的幅度的试剂含有乳清作为活性成分。根据本发明的用于改善内源性褪黑激素分泌节律的功能性食物含有用于相位调节或增强内源性褪黑素分泌节律的幅度的试剂。用于改善昼夜节律的功能性食物包含用于改善昼夜节律的药剂。

2. 发明授权

US08067034B2 Functional food for ameliorating endogenous melatonin secretion rhythm and functional food for ameliorating circadian rhythm 失效
标题翻译：用于改善内源性褪黑素分泌节律的功能性食物和用于改善昼夜节律的功能性食物
公开(公告)号：US08067034B2
公开(公告)日：2011-11-29
申请号：US11952839
申请日：2007-12-07
申请人： Yoshinori Moriyama , Seiji Tsuboi , Akihiro Masuyama , Toshiaki Takano , Keita Ueno , Toshiyuki Kai
发明人： Yoshinori Moriyama , Seiji Tsuboi , Akihiro Masuyama , Toshiaki Takano , Keita Ueno , Toshiyuki Kai
IPC分类号： A61K35/20
CPC分类号： A61K35/747 , A23L33/10 , A61K35/20
摘要： Disclosed are agents for phase-adjusting or enhancing the amplitude of an endogenous melatonin secretion rhythm and for improving a circadian rhythm, as well as functional food containing such an agent, which may prevent or ameliorate various symptoms, such as sleep disorder or prolonged sleep latency. The agent contains whey as the active component.
摘要翻译：公开了用于相位调节或增强内源性褪黑激素分泌节律的振幅和用于改善昼夜节律的药剂，以及含有这种药剂的功能性食物，其可以预防或改善各种症状，例如睡眠障碍或延长的睡眠潜伏期。药剂含有乳清作为活性成分。

3. 发明申请

US20070207134A1 FUNCTIONAL FOOD FOR AMELIORATING ENGOGENOUS MELATONIN SECRETION RHYTHM AND FUNCTIONAL FOOD FOR AMELIORATING CIRCADIAN RHYTHM 审中-公开
标题翻译：功能性食品，用于调理植物油分泌蛋白质和功能性食品
公开(公告)号：US20070207134A1
公开(公告)日：2007-09-06
申请号：US10599446
申请日：2005-03-31
申请人： Yoshinori Moriyama , Seiji Tsuboi , Akihiro Masuyama , Toshiaki Takano , Keita Ueno , Toshiyuki Kai
发明人： Yoshinori Moriyama , Seiji Tsuboi , Akihiro Masuyama , Toshiaki Takano , Keita Ueno , Toshiyuki Kai
IPC分类号： A61K35/74 , A61K38/17
CPC分类号： A61K35/747 , A23L33/10 , A61K35/20
摘要： The invention provides agents for phase-adjusting or enhancing the amplitude of an endogenous melatonin secretion rhythm and for improving a circadian rhythm, which may be taken daily and continuously, have excellent safety, and may effectively prevent or ameliorate disorders of an endogenous melatonin secretion rhythm or of a circadian rhythm without administration of exogenous melatonin, as well as functional food containing such an agent, which may prevent or ameliorate various symptoms, such as sleep disorder or prolonged sleep latency. The agent for phase-adjusting or enhancing the amplitude of an endogenous melatonin secretion rhythm according to the invention contains whey as the active component. The functional food for improving an endogenous melatonin secretion rhythm according to the invention contains the agent for phase-adjusting or enhancing the amplitude of an endogenous melatonin secretion rhythm. The functional food for improving a circadian rhythm contains the agent for improving a circadian rhythm.
摘要翻译：本发明提供用于相位调节或增强内源性褪黑激素分泌节律的振幅并改善可以每天和连续摄取的昼夜节律的药剂，具有优异的安全性，并且可以有效地预防或改善内源性褪黑激素分泌节律的病症或不伴有外源性褪黑激素的昼夜节律，以及含有这种药剂的功能食品，其可以预防或改善诸如睡眠障碍或延长睡眠潜伏期的各种症状。根据本发明的用于相位调节或增强内源性褪黑激素分泌节律的幅度的试剂含有乳清作为活性成分。根据本发明的用于改善内源性褪黑激素分泌节律的功能性食物含有用于相位调节或增强内源性褪黑素分泌节律的幅度的试剂。用于改善昼夜节律的功能性食物包含用于改善昼夜节律的药剂。

4. 发明授权

US06994987B1 Process for producing tripeptides 失效
标题翻译：生产三肽的方法
公开(公告)号：US06994987B1
公开(公告)日：2006-02-07
申请号：US10129471
申请日：2000-11-10
申请人： Naoyuki Yamamoto , Keita Ueno , Masahiro Ejiri
发明人： Naoyuki Yamamoto , Keita Ueno , Masahiro Ejiri
IPC分类号： C12P21/06 , C12N1/20
CPC分类号： C12P21/06
摘要： A process for efficiently, easily and stably producing tripeptides Val-Pro-Pro and Ile-Pro-Pro, which are useful as hypotensive drugs, anti-stress drugs, etc., by an enzymatic method. This process involves the step of cleaving a milk casein-containing material with a proteinase to form an intermediate peptide selected from the group consisting of a peptide containing the sequence Val-Pro-Pro but having no Pro other than this sequence, a peptide containing the sequence Ile-Pro-Pro but having no Pro other than this sequence, and a mixture of these peptides, and then cleaving the intermediate peptide with a peptidase to thereby give at least one of the tripeptides Val-Pro-Pro and Ile-Pro-Pro.
摘要翻译：用于通过酶法有效，容易和稳定地产生三肽Val-Pro-Pro和Ile-Pro-Pro的方法，其可用作降压药物，抗压药物等。该方法包括用蛋白酶切割含有乳酪蛋白的原料的步骤，以形成选自含有Val-Pro-Pro序列但不含该序列的Pro的肽的中间体肽，含有序列Ile-Pro-Pro但不具有该序列的Pro，以及这些肽的混合物，然后用肽酶切割中间肽，从而得到至少一种三肽Val-Pro-Pro和Ile-Pro- 专业

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