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1. 发明授权

US08008292B2 Condensed benzamide compounds and inhibitors of vanilloid receptor subtype 1 (VR1) activity 有权
标题翻译：浓缩的苯甲酰胺化合物和香草素受体亚型1（VR1）活性的抑制剂
公开(公告)号：US08008292B2
公开(公告)日：2011-08-30
申请号：US11183265
申请日：2005-07-15
申请人： Yoshihisa Koga , Shinji Yata , Takashi Watanabe , Takuya Matsuo , Takayuki Yamasaki , Masahiro Sakata , Wataru Kondo , Hidekazu Ozeki , Yoshikazu Hori
发明人： Yoshihisa Koga , Shinji Yata , Takashi Watanabe , Takuya Matsuo , Takayuki Yamasaki , Masahiro Sakata , Wataru Kondo , Hidekazu Ozeki , Yoshikazu Hori
IPC分类号： A61K31/535 , C07D265/36 , C07D498/02
CPC分类号： A61K45/06 , C07D401/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： To provide a compound having an excellent inhibitory effect on vanilloid receptor subtype 1 (VR1) activity which is effective in treating diseases to which the vanilloid receptor subtype 1 (VR1) activity is involved, such as pain, acute pain, chronic pain, neuropathic pain, rheumatoid arthritis pain, neuralgia, etc. and a pharmaceutical composition containing the compound. The object has been attained by a condensed benzamide compound represented by the following formula (the symbols in the formula have the same meanings defined in the specification) or its salt:
摘要翻译：为了提供对于涉及涉及香草素受体亚型1（VR1）活性的疾病（例如疼痛，急性疼痛，慢性疼痛，神经性疼痛）有效治疗对香草素受体亚型1（VR1）活性具有优异抑制作用的化合物，类风湿性关节炎疼痛，神经痛等，以及含有该化合物的药物组合物。本发明的目的是通过下述式（式中的符号与说明书中所定义的相同含义）或其盐进行缩合的苯甲酰胺化合物来实现：

2. 发明申请

US20060035882A1 CONDENSED BENZAMIDE COMPOUNDS AND INHIBITORS OF VANILLOID RECEPTOR SUBTYPE 1 (VR1) ACTIVITY 有权
标题翻译：甘氨酸受体亚型1（VR1）活性的简并的苄基化合物和抑制剂
公开(公告)号：US20060035882A1
公开(公告)日：2006-02-16
申请号：US11183265
申请日：2005-07-15
申请人： Yoshihisa Koga , Shinji Yata , Takashi Watanabe , Takuya Matsuo , Takayuki Yamasaki , Masahiro Sakata , Wataru Kondo , Hidekazu Ozeki , Yoshikazu Hori
发明人： Yoshihisa Koga , Shinji Yata , Takashi Watanabe , Takuya Matsuo , Takayuki Yamasaki , Masahiro Sakata , Wataru Kondo , Hidekazu Ozeki , Yoshikazu Hori
IPC分类号： A61K31/5513 , A61K31/553 , A61K31/554
CPC分类号： A61K45/06 , C07D401/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： To provide a compound having an excellent inhibitory effect on vanilloid receptor subtype 1 (VR1) activity which is effective in treating diseases to which the vanilloid receptor subtype 1 (VR1) activity is involved, such as pain, acute pain, chronic pain, neuropathic pain, rheumatoid arthritis pain, neuralgia, etc. and a pharmaceutical composition containing the compound. The object has been attained by a condensed benzamide compound represented by the following formula (the symbols in the formula have the same meanings defined in the specification) or its salt:
摘要翻译：为了提供对于涉及涉及香草素受体亚型1（VR1）活性的疾病（例如疼痛，急性疼痛，慢性疼痛，神经性疼痛）有效治疗对香草素受体亚型1（VR1）活性具有优异抑制作用的化合物，类风湿性关节炎疼痛，神经痛等，以及含有该化合物的药物组合物。本发明的目的是通过下述式（式中的符号与说明书中所定义的相同含义）或其盐进行缩合的苯甲酰胺化合物来实现：

3. 发明申请

US20110212952A1 3,4-DIHYDROBENZOXAZINE COMPOUNDS AND INHIBITORS OF VANILLOID RECEPTOR SUBTYPE 1 (VRI) ACTIVITY 审中-公开
标题翻译：丹酚酸受体亚型1（VRI）活性的3,4-二氢苯并恶唑化合物和抑制剂
公开(公告)号：US20110212952A1
公开(公告)日：2011-09-01
申请号：US13019030
申请日：2011-02-01
申请人： Yoshihisa Koga , Shinji Yata , Takayuki Yamasaki , Tatsuya Matsumoto , Masahiro Sakata , Wataru Kondo , Yoshikazu Hori
发明人： Yoshihisa Koga , Shinji Yata , Takayuki Yamasaki , Tatsuya Matsumoto , Masahiro Sakata , Wataru Kondo , Yoshikazu Hori
IPC分类号： A61K31/538 , C07D413/04 , C07D413/14 , A61P25/24 , A61P25/04 , A61P31/12 , A61P29/00 , A61P17/00 , A61P11/06 , A61P1/04 , A61P13/00
CPC分类号： C07D413/04 , C07D413/14
摘要： A 3,4-dihydrobenzoxazine compound of the present invention is represented by the following formula [1] (wherein X is a nitrogen atom or CR3; R1 is a hydrogen atom or a halogen atom; R2 is a C1-6 alkoxy group which may be substituted with the same or different 1 to 5 substituents selected from a halogen atom and a hydroxyl group; and R3 is a halogen atom. However, R1 is a halogen atom when X is CR3). This compound is effective in treating diseases to which the vanilloid receptor subtype 1 (VR1) activity is involved, such as pain, etc.
摘要翻译：本发明的3,4-二氢苯并恶嗪化合物由下式[1]表示（其中X为氮原子或CR 3; R 1为氢原子或卤素原子; R 2为C 1-6烷氧基，被相同或不同的1至5个选自卤素原子和羟基的取代基取代; R3为卤素原子，但当X为CR 3时，R 1为卤素原子。该化合物可有效治疗涉及到香草素受体亚型1（VR1）活性的疾病，如疼痛等。

4. 发明授权

US07906508B2 3,4-dihydrobenzoxazine compounds and inhibitors of vanilloid receptor subtype 1 (VRI) activity 有权
标题翻译： 3,4-二氢苯并恶嗪化合物和香草素受体亚型1（VRI）活性的抑制剂
公开(公告)号：US07906508B2
公开(公告)日：2011-03-15
申请号：US11616962
申请日：2006-12-28
申请人： Yoshihisa Koga , Shinji Yata , Takayuki Yamasaki , Tatsuya Matsumoto , Masahiro Sakata , Wataru Kondo , Yoshikazu Hori
发明人： Yoshihisa Koga , Shinji Yata , Takayuki Yamasaki , Tatsuya Matsumoto , Masahiro Sakata , Wataru Kondo , Yoshikazu Hori
IPC分类号： C07D413/04 , C07D413/14 , A61K31/538
CPC分类号： C07D413/04 , C07D413/14
摘要： A 3,4-dihydrobenzoxazine compound of the present invention is represented by the following formula [1] (wherein X is a nitrogen atom or CR3; R1 is a hydrogen atom or a halogen atom; R2 is a C1-6 alkoxy group which may be substituted with the same or different 1 to 5 substituents selected from a halogen atom and a hydroxyl group; and R3 is a halogen atom. However, R1 is a halogen atom when X is CR3). This compound is effective in treating diseases to which the vanilloid receptor subtype 1 (VR1) activity is involved, such as pain, etc.
摘要翻译：本发明的3,4-二氢苯并恶嗪化合物由下式[1]表示（其中X为氮原子或CR 3; R 1为氢原子或卤素原子; R 2为C 1-6烷氧基，被相同或不同的1至5个选自卤素原子和羟基的取代基取代; R3为卤素原子，但当X为CR 3时，R 1为卤素原子。该化合物可有效治疗涉及到香草素受体亚型1（VR1）活性的疾病，如疼痛等。

5. 发明申请

US20070149517A1 3,4-DIHYDROBENZOXAZINE COMPOUNDS AND INHIBITORS OF VANILLOID RECEPTOR SUBTYPE 1 (VRI) ACTIVITY 有权
标题翻译：丹酚酸受体亚型1（VRI）活性的3,4-二氢苯并恶唑化合物和抑制剂
公开(公告)号：US20070149517A1
公开(公告)日：2007-06-28
申请号：US11616962
申请日：2006-12-28
申请人： Yoshihisa Koga , Shinji Yata , Takayuki Yamasaki , Tatsuya Matsumoto , Masahiro Sakata , Wataru Kondo , Yoshikazu Hori
发明人： Yoshihisa Koga , Shinji Yata , Takayuki Yamasaki , Tatsuya Matsumoto , Masahiro Sakata , Wataru Kondo , Yoshikazu Hori
IPC分类号： A61K31/538 , C07D265/36
CPC分类号： C07D413/04 , C07D413/14
摘要： A 3,4-dihydrobenzoxazine compound of the present invention is represented by the following formula [1] (wherein X is a nitrogen atom or CR3; R1 is a hydrogen atom or a halogen atom; R2 is a C1-6 alkoxy group which may be substituted with the same or different 1 to 5 substituents selected from a halogen atom and a hydroxyl group; and R3 is a halogen atom. However, R1 is a halogen atom when X is CR3). This compound is effective in treating diseases to which the vanilloid receptor subtype 1 (VR1) activity is involved, such as pain, etc.
摘要翻译：本发明的3,4-二氢苯并恶嗪化合物由下式[1]表示（其中X为氮原子或CR 3，R 1为氢原子或卤素原子; R 2是可被相同或不同的1至5个选自卤素原子和羟基的取代基取代的C 1-6烷氧基; 3是卤素原子，但当X是CR 3时，R 1是卤素原子。该化合物可有效治疗涉及到香草素受体亚型1（VR1）活性的疾病，如疼痛等。

6. 发明申请

US20060035939A1 3-Aminobenzamide compounds and inhibitors of vanilloid receptor subtype 1 (VR1) activity 审中-公开
标题翻译： 3-氨基苯甲酰胺化合物和香草素受体亚型1（VR1）活性抑制剂
公开(公告)号：US20060035939A1
公开(公告)日：2006-02-16
申请号：US11181235
申请日：2005-07-14
申请人： Yoshihisa Koga , Shinji Yata , Takashi Watanabe , Takuya Matsuo , Masahiro Sakata , Wataru Kondo
发明人： Yoshihisa Koga , Shinji Yata , Takashi Watanabe , Takuya Matsuo , Masahiro Sakata , Wataru Kondo
IPC分类号： A61K31/455 , A61K31/165
CPC分类号： C07C237/40 , C07D213/74 , C07D213/82 , C07D401/12 , C07D413/04
摘要： The present invention relates to a novel 3-aminobenzamide compound represented by the following formula which effectively inhibits vanilloid receptor subtype 1 (VR1) activity (wherein, for example, R1 is a C1-6 alkyl group which may be substituted, R2 is a hydrogen atom, a C1-6 alkyl group or a C1-6 alkoxy group which may be substituted, R3 is a hydrogen atom or a C1-6 alkyl group, R4 is a C1-6 alkyl group, a C1-6 alkoxy group, or a halo C1-6 alkyl group, m is an integer of 1 to 5 and P is a carbon or hetero ring) or a pharmaceutically acceptable salt thereof. The pharmaceutical composition comprising as active ingredients the 3-aminobenzamide compound or a pharmaceutically acceptable salt thereof is useful for treating diseases involved in VR1 activity such as pain, acute pain, chronic pain, neuropathic pain, rheumatoid arthritis pain, and neuralgia.
摘要翻译：本发明涉及有效抑制香草素受体亚型1（VR1）活性的下式所示的新型3-氨基苯甲酰胺化合物（其中，例如R 1是C 1-6烷基，可以被取代，R 2是氢原子，可以被取代的C 1-6烷基或C 1-6烷氧基，R 3是氢原子或 C 1-6烷基，R 4是C 1-6烷基，C 1-6烷氧基或卤代C 1-6烷基，m是1〜5的整数，P 是碳或杂环）或其药学上可接受的盐。包含3-氨基苯甲酰胺化合物或其可药用盐作为活性成分的药物组合物可用于治疗涉及VR1活性的疾病，例如疼痛，急性疼痛，慢性疼痛，神经性疼痛，类风湿性关节炎疼痛和神经痛。

7. 发明申请

US20120115827A1 3-AMINOBENZAMIDE COMPOUNDS AND VANILLOID RECEPTOR SUBTYPE 1 (VR1) INHIBITORS 审中-公开
标题翻译： 3-氨基苯甲酸化合物和VANILLOID受体亚型1（VR1）抑制剂
公开(公告)号：US20120115827A1
公开(公告)日：2012-05-10
申请号：US13155143
申请日：2011-06-07
申请人： Yoshihisa Koga , Shinji Yata , Takashi Watanabe , Takuya Matsuo , Masahiro Sakata , Wataru Kondo
发明人： Yoshihisa Koga , Shinji Yata , Takashi Watanabe , Takuya Matsuo , Masahiro Sakata , Wataru Kondo
IPC分类号： A61K31/56 , A61K31/44 , A61K31/4402 , C07D498/04 , A61K31/5383 , C07C237/40 , A61K31/167 , C07D413/04 , A61K31/538 , C07D401/12 , A61K31/4709 , A61K31/444 , A61K31/4545 , C07D213/79 , C07D213/81 , A61P29/00 , A61P25/00 , A61P25/28 , A61P9/00 , A61P17/00 , A61P17/04 , A61P11/06 , A61P11/00 , A61P13/10 , A61P1/00 , A61P1/04 , A61P31/12 , A61P25/08 , A61P9/06 , A61P23/00 , A61P11/02 , A61P25/06 , A61P19/02 , A61M37/00 , C07D213/74
CPC分类号： C07C237/40 , C07D213/74 , C07D213/82 , C07D401/12 , C07D413/04
摘要： The present invention relates to a novel 3-aminobenzamide, compound represented by the following formula which effectively inhibits vanilloid receptor subtype 1 (VR1) activity (wherein, for example, R1 is a C1-6 alkyl group which may be substituted, R2 is a hydrogen atom, a C1-6 alkyl group or a C1-6 alkoxy group which may be substituted, R3 is a hydrogen atom or a C1-6 alkyl group, R4 is a C1-6 alkyl group, a C1-6 alkoxy group, or a halo C1-6 alkyl group, m is an integer of 1 to 5 and P is a carbon or hetero ring) or a pharmaceutically acceptable salt thereof. The pharmaceutical composition comprising as active ingredients the 3-aminobenzamide, compound or a pharmaceutically acceptable salt thereof is useful for treating diseases involved in VR1 activity such as pain, acute pain, chronic pain, neuropathicpain, rheumatoid arthritis pain, and neuralgia.
摘要翻译：本发明涉及一种新的3-氨基苯甲酰胺，其由下式表示，其有效抑制香草素受体亚型1（VR1）活性（其中，例如，R 1为可被取代的C 1-6烷基，R 2为氢原子，可以被取代的C 1-6烷基或C 1-6烷氧基，R 3是氢原子或C 1-6烷基，R 4是C 1-6烷基，C 1-6烷氧基，或卤代C 1-6烷基，m为1〜5的整数，P为碳或杂环）或其药学上可接受的盐。包含3-氨基苯甲酰胺，化合物或其药学上可接受的盐作为活性成分的药物组合物可用于治疗涉及VR1活性的疾病，例如疼痛，急性疼痛，慢性疼痛，神经性疼痛，类风湿性关节炎疼痛和神经痛。

8. 发明授权

US5362461A Method for recovering calcium fluoride from fluoroetchant 失效
标题翻译：从异氟醚中回收氟化钙的方法
公开(公告)号：US5362461A
公开(公告)日：1994-11-08
申请号：US953960
申请日：1992-10-01
申请人： Tadahiro Ohmi , Hiroyuki Harada , Nobuhiro Miki , Toshiro Fukutome , Matagoro Maeno , Norio Terasawa , Yoshihiro Eto , Masahiro Sakata
发明人： Tadahiro Ohmi , Hiroyuki Harada , Nobuhiro Miki , Toshiro Fukutome , Matagoro Maeno , Norio Terasawa , Yoshihiro Eto , Masahiro Sakata
IPC分类号： C01F11/22
CPC分类号： C01F11/22
摘要： Calcium fluoride with high purity of very small content of unreacted calcium carbonate and silica is recovered from an etchant mainly composed of hydrogen fluoride or hydrogen fluoride and ammonium fluoride. The etchant is reacted with calcium carbonate with transfer directions of the etchant and calcium carbonate being controlled within a composition region in which mole equivalent ratio of ammonium fluoride/hydrogen fluoride is specified.
摘要翻译：从主要由氟化氢或氟化氢和氟化铵组成的蚀刻剂回收具有非常小含量的未反应的碳酸钙和二氧化硅的高纯度的氟化钙。蚀刻剂与碳酸钙反应，其中蚀刻剂和碳酸钙的转移方向被控制在其中规定了氟化铵/氟化氢的摩尔当量比的组成区域内。

9. 发明授权

US6040807A Three-dimensional display 失效
标题翻译：三维显示
公开(公告)号：US6040807A
公开(公告)日：2000-03-21
申请号：US987140
申请日：1997-12-08
申请人： Goro Hamagishi , Keiichi Kanatani , Shunichi Kishimoto , Masahiro Sakata , Atsuhiro Yamashita , Naoki Matsushita , Ken Mashitani
发明人： Goro Hamagishi , Keiichi Kanatani , Shunichi Kishimoto , Masahiro Sakata , Atsuhiro Yamashita , Naoki Matsushita , Ken Mashitani
IPC分类号： G02B27/22 , H04N13/00 , G09G5/00
CPC分类号： H04N13/0409 , G02B27/2214 , H04N13/0418 , H04N13/0445 , H04N13/045
摘要： A three-dimensional display comprising a flat light source, a vertical striped filter having slits transmitting light from the light source and barriers screening the light from the light source alternately formed therein for partially transmitting the light from the light source, and an LCD panel arranged on the light emission side of the vertical striped filter and having left eye pixels and right eye pixels alternately formed therein, light passing through the left eye pixels in the LCD panel and light passing through the right eye pixels being emitted toward a observer in a separated state.
摘要翻译：一种三维显示器，包括平面光源，具有从所述光源透射光的狭缝的垂直条形滤光器，以及屏蔽来自其中交替形成的光源的光，用于部分透射来自所述光源的光;以及LCD板，在垂直条纹滤光片的发光侧并交替地形成左眼像素和右眼像素，通过LCD面板中的左眼像素的光和穿过右眼像素的光以分离的方式向观察者发射州。

10. 发明授权

US4896151A Simultaneous communication method and system 失效
标题翻译：同时通信方法和系统
公开(公告)号：US4896151A
公开(公告)日：1990-01-23
申请号：US112212
申请日：1987-10-26
申请人： Shoubu Kuranami , Masahiro Sakata
发明人： Shoubu Kuranami , Masahiro Sakata
IPC分类号： H04L1/18 , H04L12/403
CPC分类号： H04L12/403
摘要： In a simultaneous communication as in a POS system in which the same data including a multiplicity of data blocks is transmitted from a controller to a multiplicity of terminals all at once, the controller transmits all of the data blocks to the terminals without receiving any acknowledgement from each of the terminals in the course of data transmission. Each time the data block is received, the terminals hold information concerning the acknowledgement of the data block. After the termination of transmission of the whole of the data, the controller receives the acknowledgement information from each terminal into a management table. Based on the contents of the mangement table, the controller retransmits the data to a terminal(s) indicative of a negative acknowledgement in a similar manner to the above-mentioned data transmission or while taking acknowledgement for each data block.
摘要翻译：在与包括多个数据块的相同数据从控制器一次发送到多个终端的POS系统中的同时通信中，控制器将所有数据块发送到终端，而不接收任何来自每个终端在数据传输过程中。每次接收到数据块时，终端保存关于数据块确认的信息。在整个数据传输结束后，控制器从每个终端接收到确认信息到一个管理表中。基于管理表的内容，控制器以与上述数据传输类似的方式或在对每个数据块进行确认时将数据重新发送到指示否定确认的终端。

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