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    • 1. 发明授权
    • Pharmaceutical composition for preventing or treating ischemic diseases
    • 用于预防或治疗缺血性疾病的药物组合物
    • US08106009B2
    • 2012-01-31
    • US10371030
    • 2003-02-21
    • Yoshihiro YoshidaShinya IkematsuSadatoshi SakumaMunehiro Oda
    • Yoshihiro YoshidaShinya IkematsuSadatoshi SakumaMunehiro Oda
    • A61K38/18C07K14/475
    • A61K38/18A61K38/1825A61K38/185A61K38/204A61K2300/00
    • A pharmaceutical composition for treating or preventing cytopathy caused by ischemia, comprising a midkine family protein as an active ingredient, and a pharmaceutical composition for treating or preventing ischemic disorders, comprising a midkine family protein as an active ingredient, are provided. Midkine is efficacious in treating or preventing ischemic disorders and cytopathy caused by ischemia and can remarkably prevent, for example, the development of cerebral infarction, a representative of ischemic brain disorders. The pharmaceutical composition of the present invention is also efficacious against, for example, cerebral ischemic disorders such as cerebrovascular-spasm following a subarachnoid hemorrhage, Alzheimer's disease, senile dementia of Alzheimer's type, and cerebrovascular senile dementia, as well as cerebral ischemia, transient cerebral ischemic disease, and head trauma, and other cerebrovascular diseases such as Parkinson's disease, Huntington's chorea, and amyotrophic regressive disorders.
    • 提供了用于治疗或预防由缺血引起的细胞病变的药物组合物,其包含中期因子家族蛋白作为活性成分,以及用于治疗或预防缺血性疾病的药物组合物,其包含中期因子家族蛋白作为活性成分。 Midkine有效治疗或预防局部缺血引起的缺血性疾病和细胞病变,并且可以显着地预防例如缺血性脑病的代表性脑梗塞的发展。 本发明的药物组合物对于例如脑缺血障碍如蛛网膜下腔出血后的脑血管痉挛,阿尔茨海默氏病,老年痴呆型老年痴呆,脑血管性老年性痴呆,以及脑缺血,暂时性大脑 缺血性疾病和头部创伤,以及其他脑血管疾病如帕金森病,亨廷顿氏舞蹈病和肌萎缩性退行性疾病。