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1. 发明申请

US20110034684A1 Process For Preparing Crosslinked Hyaluronic Acid Gel 审中-公开
标题翻译：制备交联透明质酸凝胶的方法
公开(公告)号：US20110034684A1
公开(公告)日：2011-02-10
申请号：US12890808
申请日：2010-09-27
申请人： Yoshihiro Yokokawa , Takashi Oka , Yuichiro Mori , Norio Ueno
发明人： Yoshihiro Yokokawa , Takashi Oka , Yuichiro Mori , Norio Ueno
IPC分类号： C08B37/08
CPC分类号： A61K8/042 , A61K8/735 , A61K31/728 , A61K47/36 , A61Q19/00 , C08B37/0072
摘要： A novel process which can simply prepare a crosslinked hyaluronic acid gel having a small crosslinking agent content and exhibiting excellent viscoelasticity is provided.A process for preparing a crosslinked hyaluronic acid gel, comprising stirring and mixing a mixture containing 10 W/V % or more of hyaluronic acid, a crosslinking agent and water under acidic or alkaline condition.
摘要翻译：提供了可以简单地制备交联剂含量小且显示出优异的粘弹性的交联透明质酸凝胶的新方法。一种制备交联透明质酸凝胶的方法，包括在酸性或碱性条件下搅拌和混合含有10W / V％或更多透明质酸，交联剂和水的混合物。

2. 发明申请

US20060105022A1 Process for preparing crosslinked hyaluronic acid gel 审中-公开
标题翻译：制备交联透明质酸凝胶的方法
公开(公告)号：US20060105022A1
公开(公告)日：2006-05-18
申请号：US11272914
申请日：2005-11-14
申请人： Yoshihiro Yokokawa , Takashi Oka , Yuichiro Mori , Norio Ueno
发明人： Yoshihiro Yokokawa , Takashi Oka , Yuichiro Mori , Norio Ueno
IPC分类号： A61K31/728 , C08B37/00 , A61K47/00
CPC分类号： A61K8/042 , A61K8/735 , A61K31/728 , A61K47/36 , A61Q19/00 , C08B37/0072
摘要： [PROBLEMS] A novel process which can simply prepare a crosslinked hyaluronic acid gel having a small crosslinking agent content and exhibiting excellent viscoelasticity is provided. [MEANS TO SOLVE] A method of producing cross-linking hyaluronic acid gel, comprising stirring and mixing a mixture containing 20 W/V % or more of hyaluronic acid, a crosslinking agent and water under acidic or alkaline condition.
摘要翻译： [问题]提供了可以简单地制备交联剂含量小且显示出优异的粘弹性的交联透明质酸凝胶的新方法。解决方案一种制备交联透明质酸凝胶的方法，包括在酸性或碱性条件下搅拌混合含有20W / V％以上的透明质酸，交联剂和水的混合物。

3. 发明授权

US07943596B2 Medicinal composition for ophthal use containing acetylated hyaluronic acid 失效
标题翻译：含有乙酰化透明质酸的眼用药物组合物
公开(公告)号：US07943596B2
公开(公告)日：2011-05-17
申请号：US12151702
申请日：2008-05-08
申请人： Norio Ueno , Takashi Oka
发明人： Norio Ueno , Takashi Oka
IPC分类号： A61K31/728 , C07H5/06 , C07H13/04 , C08B37/00
CPC分类号： A61K31/728 , C08B37/0072
摘要： The present invention provides an ophthalmic pharmaceutical composition containing acetylated hyaluronic acid and a pharmacologically acceptable carrier. Preferably, the average molecular weight of the acetylated hyaluronic acid is 10,000 to 1,000,000, and the acetyl group substitution number is from 2.0 to 4.0. In a preferred embodiment, this ophthalmic pharmaceutical composition is used in the treatment or prevention of dry eye, and in an even more preferred embodiment it is a dry-eye instillation.
摘要翻译：本发明提供含有乙酰化透明质酸和药理学上可接受的载体的眼用药物组合物。优选地，乙酰化透明质酸的平均分子量为10,000〜1,000,000，乙酰基取代数为2.0〜4.0。在优选的实施方案中，该眼用药物组合物用于治疗或预防干眼症，并且在甚至更优选的实施方案中，它是干眼滴注。

4. 发明申请

US20080221064A1 Medicinal composition for ophthal use containing acetylated hyaluronic acid 失效
标题翻译：含有乙酰化透明质酸的眼用药物组合物
公开(公告)号：US20080221064A1
公开(公告)日：2008-09-11
申请号：US12151702
申请日：2008-05-08
申请人： Norio Ueno , Takashi Oka
发明人： Norio Ueno , Takashi Oka
IPC分类号： A61K31/728 , A61P27/04
CPC分类号： A61K31/728 , C08B37/0072
摘要： The present invention provides an ophthalmic pharmaceutical composition containing acetylated hyaluronic acid and a pharmacologically acceptable carrier. Preferably, the average molecular weight of the acetylated hyaluronic acid is 10,000 to 1,000,000, and the acetyl group substitution number is from 2.0 to 4.0. In a preferred embodiment, this ophthalmic pharmaceutical composition is used in the treatment or prevention of dry eye, and in an even more preferred embodiment it is a dry-eye instillation.
摘要翻译：本发明提供含有乙酰化透明质酸和药理学上可接受的载体的眼用药物组合物。优选地，乙酰化透明质酸的平均分子量为10,000〜1,000,000，乙酰基取代数为2.0〜4.0。在优选的实施方案中，该眼用药物组合物用于治疗或预防干眼症，并且在甚至更优选的实施方式中，其是干眼滴注。

5. 发明申请

US20060166930A1 Medicinal composition for ophthal use containing acetylated hyaluronic acid 审中-公开
标题翻译：含有乙酰化透明质酸的眼用药物组合物
公开(公告)号：US20060166930A1
公开(公告)日：2006-07-27
申请号：US10545409
申请日：2004-02-27
申请人： Norio Ueno , Takashi Oka
发明人： Norio Ueno , Takashi Oka
IPC分类号： A61K31/728
CPC分类号： A61K31/728 , C08B37/0072
摘要： The present invention provides an ophthalmic pharmaceutical composition containing acetylated hyaluronic acid and a pharmacologically acceptable carrier. Preferably, the average molecular weight of the acetylated hyaluronic acid is 10,000 to 1,000,000, and the acetyl group substitution number is from 2.0 to 4.0. In a preferred embodiment, this ophthalmic pharmaceutical composition is used in the treatment or prevention of dry eye, and in an even more preferred embodiment it is a dry-eye instillation.
摘要翻译：本发明提供含有乙酰化透明质酸和药理学上可接受的载体的眼用药物组合物。优选地，乙酰化透明质酸的平均分子量为10,000〜1,000,000，乙酰基取代数为2.0〜4.0。在优选的实施方案中，该眼用药物组合物用于治疗或预防干眼症，并且在甚至更优选的实施方案中，它是干眼滴注。

6. 发明申请

US20060024068A1 Light output control circuit 有权
标题翻译：光输出控制电路
公开(公告)号：US20060024068A1
公开(公告)日：2006-02-02
申请号：US11203544
申请日：2005-08-15
申请人： Tadao Inoue , Tadashi Ikeuchi , Hiroyuki Rokugawa , Masaaki Kawai , Norio Ueno , Norio Murakami , Toru Matsuyama , Makoto Miki , Toshiyuki Takauji
发明人： Tadao Inoue , Tadashi Ikeuchi , Hiroyuki Rokugawa , Masaaki Kawai , Norio Ueno , Norio Murakami , Toru Matsuyama , Makoto Miki , Toshiyuki Takauji
IPC分类号： H04B10/04 , H04B10/12
CPC分类号： H01S5/0683 , H01S5/06825
摘要： Using a switching signal from a coarse/fine switching and operation mode switching circuit, the width of change of a counter control value during power up is increased, and the width of change is reduced once a steady state is reached. In the steady state, the frequency of updating is limited by a control signal from an update permit control circuit. In the steady state, the frequency band of a current source in an LD driving circuit is reduced in width.
摘要翻译：使用来自粗/精切换和动作模式切换电路的切换信号，上电期间的计数器控制值的变化幅度增大，一旦达到稳定状态，则变化幅度减小。在稳定状态下，更新频率受来自更新许可控制电路的控制信号的限制。在稳态中，LD驱动电路中的电流源的频带宽度减小。

7. 发明授权

US5512853A Interface circuit adaptive to high speed and low voltage operation 失效
标题翻译：接口电路适应于高速和低电压工作
公开(公告)号：US5512853A
公开(公告)日：1996-04-30
申请号：US320068
申请日：1994-10-07
申请人： Norio Ueno , Toru Matsuyama
发明人： Norio Ueno , Toru Matsuyama
IPC分类号： G06F15/78 , H03K19/0175 , H03K19/0185 , H03L5/00 , H01L25/00 , H03B1/00 , H03K17/16
CPC分类号： H03K19/018514
摘要： An interface circuit for interfacing between an integrated circuit (IC) on a transmitting side and an IC on a receiving side over a line on a printed circuit board comprises an output circuit implemented in the IC on the transmitting side and composed of a current source for supplying a given current and a switching circuit for cutting off the given current according to a binary signal and delivering the given current as a current signal to the line, and an input circuit implemented in the IC on the receiving side and composed of a transimpedance circuit whose input impedance is equal to the one of the line and which converts the current signal into a voltage signal, and a comparator for identifying the voltage signal relative to a given threshold voltage and reproducing the binary signal. This circuitry makes it possible to provide an interface circuit that can be implemented in a CMOS IC during CMOS processing and operated at a low voltage. A threshold voltage for use in identifying a signal on the receiving side is stabilized, thus realizing an interface circuit unsusceptible to influence of a change in CMOS processing or the like.
摘要翻译：用于在发送侧的集成电路（IC）和印刷电路板上的线路上的接收侧的IC之间进行接口的接口电路包括在发送侧的IC中实现的输出电路，并且由电流源提供给定的电流和切换电路，用于根据二进制信号切断给定的电流，并将给定的电流作为电流信号传送到线路，以及在接收侧的IC中实现并由跨阻电路其输入阻抗等于线路中的一个，并将电流信号转换为电压信号;以及比较器，用于识别相对于给定阈值电压的电压信号并再现二进制信号。该电路使得可以提供在CMOS处理期间可以在CMOS IC中实现并在低电压下操作的接口电路。用于识别接收侧的信号的阈值电压是稳定的，因此实现了不能影响CMOS处理等的改变的接口电路。

8. 发明授权

US06975813B1 Light output control device 失效
标题翻译：光输出控制装置
公开(公告)号：US06975813B1
公开(公告)日：2005-12-13
申请号：US09505783
申请日：2000-02-17
申请人： Tadao Inoue , Tadashi Ikeuchi , Hiroyuki Rokugawa , Masaaki Kawai , Norio Ueno , Norio Murakami , Toru Matsuyama , Makoto Miki , Toshiyuki Takauji
发明人： Tadao Inoue , Tadashi Ikeuchi , Hiroyuki Rokugawa , Masaaki Kawai , Norio Ueno , Norio Murakami , Toru Matsuyama , Makoto Miki , Toshiyuki Takauji
IPC分类号： H01L33/00 , H01S5/00 , H01S5/068 , H01S5/0683 , H04B10/04 , H01S3/00 , H01S3/13
CPC分类号： H01S5/0683 , H01S5/06825
摘要： Using a switching signal from a coarse/fine switching and operation mode switching circuit, the width of change of a counter control value during power up is increased, and the width of change is reduced once a steady state is reached. In the steady state, the frequency of updating is limited by a control signal from an update permit control circuit. In the steady state, the frequency band of a current source in an LD driving circuit is reduced in width.
摘要翻译：使用来自粗/精切换和动作模式切换电路的切换信号，上电期间的计数器控制值的变化幅度增大，一旦达到稳定状态，则变化幅度减小。在稳定状态下，更新频率受来自更新许可控制电路的控制信号的限制。在稳态中，LD驱动电路中的电流源的频带宽度减小。

9. 发明授权

US4468749A Adjustable attenuator circuit 失效
标题翻译：可调衰减器电路
公开(公告)号：US4468749A
公开(公告)日：1984-08-28
申请号：US292275
申请日：1981-08-12
申请人： Seiji Kato , Norio Ueno , Mitsuo Kakuishi
发明人： Seiji Kato , Norio Ueno , Mitsuo Kakuishi
IPC分类号： H03H19/00 , H03G3/00
CPC分类号： H03H19/004
摘要： An adjustable attenuator circuit in which sampled electric charges are partially transferred from a sampling capacitor to a charge dividing capacitor during a short time within each sampling period, and electric charges stored in the charge dividing capacitor are additively transferred to an integrating capacitor or are discharged to ground according to the content of a weighting coefficient which determines the attenuation factor of the adjustable attenuator circuit.
摘要翻译：一种可调衰减器电路，其中在每个采样周期内短时间内采样电荷被部分地从采样电容器转移到充电分压电容器，并且存储在电荷分配电容器中的电荷被相加地传递到积分电容器或被放电到根据确定可调衰减器电路的衰减系数的加权系数的内容来接地。

10. 发明授权

US07266308B2 Light output control circuit 有权
标题翻译：光输出控制电路
公开(公告)号：US07266308B2
公开(公告)日：2007-09-04
申请号：US11203544
申请日：2005-08-15
申请人： Tadao Inoue , Tadashi Ikeuchi , Hiroyuki Rokugawa , Masaaki Kawai , Norio Ueno , Norio Murakami , Toru Matsuyama , Makoto Miki , Toshiyuki Takauji
发明人： Tadao Inoue , Tadashi Ikeuchi , Hiroyuki Rokugawa , Masaaki Kawai , Norio Ueno , Norio Murakami , Toru Matsuyama , Makoto Miki , Toshiyuki Takauji
IPC分类号： H04B10/04 , H04B10/12 , H01S3/13
CPC分类号： H01S5/0683 , H01S5/06825
摘要： Using a switching signal from a coarse/fine switching and operation mode switching circuit, the width of change of a counter control value during power up is increased, and the width of change is reduced once a steady state is reached. In the steady state, the frequency of updating is limited by a control signal from an update permit control circuit. In the steady state, the frequency band of a current source in an LD driving circuit is reduced in width.
摘要翻译：使用来自粗/精切换和动作模式切换电路的切换信号，上电期间的计数器控制值的变化幅度增大，一旦达到稳定状态，则变化幅度减小。在稳定状态下，更新频率受来自更新许可控制电路的控制信号的限制。在稳态中，LD驱动电路中的电流源的频带宽度减小。

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