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    • 4. 发明授权
    • Optical telephone using optical modulator
    • 光电话使用光调制器
    • US5357362A
    • 1994-10-18
    • US59467
    • 1993-05-07
    • Yuji AzumaYoshihiro ShibataShinji TamuraNobuo KuwakiNobuhiro IkawaAkira FukudaAkio Kuwahara
    • Yuji AzumaYoshihiro ShibataShinji TamuraNobuo KuwakiNobuhiro IkawaAkira FukudaAkio Kuwahara
    • G02B6/28G02B26/02H04B10/155H04B10/213H04B10/12G02B6/26H04B10/04
    • H04B10/505G02B26/02G02B6/2852
    • An optical modulation method operable in an optical transmission path using an optical fiber, wherein an optical fiber bending region is formed by bending a portion of the optical fiber into a U shape having a predetermined bending width. A bending width set point is set in correspondence with a predetermined inclined portion of a characteristic curve representing a dependency ratio of insertion loss of light propagating in said optical fiber bending region relative to the bending width thereof, said predetermined inclined portion of said characteristic curve being located between a predetermined maximum and minimum portion thereof. Intensity modulation of light propagating in the optical fiber is performed using a signal to be transmitted by adjusting the bending width of the optical fiber bending region in correspondence with the signal to be transmitted with reference to the bending width set point as a center. An optical telephone uses an optical modulator including an optical fiber having a U-shaped bending region and a transducer for vibrating one straight portion of the optical fiber.
    • 一种光学调制方法,其在使用光纤的光传输路径中可操作,其中通过将所述光纤的一部分弯曲成具有预定弯曲宽度的U形形成光纤弯曲区域。 弯曲宽度设定点对应于表示在所述光纤弯曲区域中传播的光的插入损耗相对于其弯曲宽度的依赖比的特性曲线的预定倾斜部分,所述特征曲线的所述预定倾斜部分为 位于其预定的最大和最小部分之间。 通过以相对于弯曲宽度设定点为中心的要发送的信号调整光纤弯曲区域的弯曲宽度,通过使用要发送的信号来进行在光纤中传播的光的强度调制。 光电话机使用包括具有U形弯曲区域的光纤的光学调制器和用于振动光纤的一个直线部分的换能器。
    • 6. 发明申请
    • NOVEL SPIROCHROMANONE CARBOXYLIC ACIDS
    • 新型螺环酮羧酸
    • US20110077262A1
    • 2011-03-31
    • US12997263
    • 2009-06-29
    • Hideki JonaYoshihiro ShibataTakeru Yamakawa
    • Hideki JonaYoshihiro ShibataTakeru Yamakawa
    • A61K31/438C07D491/107A61P3/00A61P3/04A61P3/10A61P31/00
    • C07D491/107A61K31/438A61K31/444A61K31/4545A61K31/4709
    • The invention relates to a compound of a general formula (I): wherein A represents a linking group; Ar1 represents a group formed from an aromatic ring; R1 and R2 each independently represent a hydrogen atom, a halogen atom, a cyano group, a C2-C6 alkenyl group, a C1-C6 alkoxy group, a halo-C1-C6 alkoxy group, a cyclo-C3-C6 alkyloxy group, a C2-C7 alkanoyl group, a halo-C2-C7 alkanoyl group, a C2-C7 alkoxycarbonyl group, a halo-C2-C7 alkoxycarbonyl group, a cyclo-C3-C6 alkyloxycarbonyl group, an aralkyloxycarbonyl group, a carbamoyl-C1-C6 alkoxy group, a carboxy-C2-C6 alkenyl group, or a group of -Q1-N(Ra)-Q2-Rb; a C1-C6 alkyl group optionally having substituent(s); an aryl or heterocyclic group optionally having substituent(s); or a C1-C6 alkyl group or a C2-C6 alkenyl group having the aryl or heterocyclic group; T and U each independently represent a nitrogen atom or a methine group; and V represents an oxygen atom, a sulfur atom or an imino group. The compound of the invention is useful as therapeutical agents for various ACC-related diseases.
    • 本发明涉及通式(I)的化合物:其中A表示连接基团; Ar 1表示由芳香环形成的基团; R 1和R 2各自独立地表示氢原子,卤素原子,氰基,C 2 -C 6烯基,C 1 -C 6烷氧基,卤代-C 1 -C 6烷氧基,环-C 3 -C 6烷氧基, C2-C7烷酰基,卤代-C2-C7烷酰基,C2-C7烷氧基羰基,卤代-C2-C7烷氧基羰基,环-C3-C6烷氧基羰基,芳烷氧基羰基,氨基甲酰基C1- C6烷氧基,羧基-C2-C6烯基或-Q1-N(Ra)-Q2-Rb的基团; 任选具有取代基的C1-C6烷基; 任选具有取代基的芳基或杂环基; 或具有芳基或杂环基的C 1 -C 6烷基或C 2 -C 6烯基; T和U各自独立地表示氮原子或次甲基; V表示氧原子,硫原子或亚氨基。 本发明的化合物可用作各种ACC相关疾病的治疗剂。