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1. 发明申请

US20090047380A1 Catalase gene and use thereof 审中-公开
标题翻译：过氧化氢酶基因及其用途
公开(公告)号：US20090047380A1
公开(公告)日：2009-02-19
申请号：US11920006
申请日：2006-12-22
申请人： Yoshihiro Nakao , Yukiko Kodama , Tomoko Shimonaga , Fumihiko Omura
发明人： Yoshihiro Nakao , Yukiko Kodama , Tomoko Shimonaga , Fumihiko Omura
IPC分类号： C12C1/00 , C12N15/11 , C12N9/00 , C12N15/00 , C12N1/19 , C12G1/00 , C12C11/00 , C12Q1/00 , C12Q1/68
CPC分类号： C12N9/0065
摘要： The present invention relates to a gene encoding a catalase and use thereof, in particular, a brewery yeast having high sulfite-producing capability, alcoholic beverages produced with said yeast, and a method for producing said beverages. More particularly, the present invention relates to a yeast, whose capability of producing sulfite, that contribute to stability of flavor in products, is enhanced by amplifying expression level of CTA1 gene encoding a catalase Cta1p, especially non-ScCTA1 gene or ScCTA1 gene specific to a lager brewing yeast, and to a method for producing alcoholic beverages with said yeast.
摘要翻译：本发明涉及编码过氧化氢酶的基因及其用途，特别是具有高亚硫酸盐生产能力的啤酒酵母，用该酵母生产的酒精饮料及其制造方法。更具体地，本发明涉及通过扩增编码过氧化氢酶Cta1p的CTA1基因，特别是非ScCTA1基因或ScCTA1基因特异性的ScCTA1基因的表达水平来提高其产生亚硫酸盐的生产亚硫酸盐的能力，该酵母有助于产品中风味的稳定性啤酒酿造酵母，以及用所述酵母生产酒精饮料的方法。

2. 发明申请

US20090041889A1 Gene Encoding Protein With Vicinal Diketone or Diacetyl-Reducing Activity and Use Thereof 审中-公开
标题翻译：基因编码蛋白质与Vicinal Diketone或Diacetyl-Reducing活性及其用途
公开(公告)号：US20090041889A1
公开(公告)日：2009-02-12
申请号：US11918494
申请日：2006-11-21
申请人： Yoshihiro Nakao , Yukiko Kodama , Tomoko Shimonaga , Fumihiko Omura
发明人： Yoshihiro Nakao , Yukiko Kodama , Tomoko Shimonaga , Fumihiko Omura
IPC分类号： C12C1/00 , C07H21/04 , C07K14/00 , C12G1/00 , C12Q1/02 , C12Q1/68 , C12N15/63 , C12N1/19
CPC分类号： C12C12/004 , C07K14/395 , C12C12/006 , C12G1/0203 , C12N9/00 , C12N9/0004
摘要： The present invention relates to a gene encoding a protein having a vicinal diketone or diacetyl-reducing activity and use thereof, in particular, a brewery yeast for producing alcoholic beverages with superior flavor, alcoholic beverages produced with said yeast, and a method for producing said beverages. More particularly, the present invention relates to a yeast, whose capability of producing vicinal diketones, especially diacetyl, that are responsible for off-flavors in products, is reduced by amplifying expression level of MMF1 gene encoding a protein (Mmflp) having a vicinal diketone or diacetyl-reducing activity, especially the non-ScMMF1 gene or ScMMF1 gene specific to a lager brewing yeast, and to a method for producing alcoholic beverages with said yeast.
摘要翻译：本发明涉及编码具有邻位二酮或二乙酰还原活性的蛋白质的基因及其用途，特别是用于生产具有优良风味的酒精饮料的啤酒酵母，用所述酵母生产的含酒精饮料的方法及其制备方法饮料。更具体地，本发明涉及通过扩增编码具有邻位二酮的蛋白质（Mmflp）的MMF1基因的表达水平来降低其产生邻位二酮，特别是二乙酰基的负责产品异味的能力的酵母或二乙酰基还原活性，特别是对大啤酒酵母特异性的非ScMMF1基因或ScMMF1基因，以及用所述酵母生产酒精饮料的方法。

3. 发明申请

US20090130255A1 Catalase Gene and Use Thereof 审中-公开
标题翻译：过氧化氢酶基因及其用途
公开(公告)号：US20090130255A1
公开(公告)日：2009-05-21
申请号：US11919226
申请日：2006-12-22
申请人： Yoshihiro Nakao , Yukiko Kadama , Tomoko Shimonaga , Fumihiko Omura
发明人： Yoshihiro Nakao , Yukiko Kadama , Tomoko Shimonaga , Fumihiko Omura
IPC分类号： C12C11/00 , C12G1/00 , C12P21/06 , C12N9/02 , C12N1/18 , C07H21/04
CPC分类号： C12C12/006 , C12C12/004 , C12G1/0203 , C12N9/0065 , C12Y111/01006
摘要： The present invention relates to a gene encoding a catalase and use thereof, in particular, a brewery yeast having high sulfite-producing capability, alcoholic beverages produced with said yeast, and a method for producing said beverages. More particularly, the present invention relates to a yeast, whose capability of producing sulfite, that contribute to stability of flavor in products, is enhanced by amplifying expression level of CTT1 gene encoding a catalase Ctt1p, especially non-ScCTT1 gene or ScCTT1 gene specific to a lager brewing yeast, and to a method for producing alcoholic beverages with said yeast.
摘要翻译：本发明涉及编码过氧化氢酶的基因及其用途，特别是具有高亚硫酸盐生产能力的啤酒酵母，用该酵母生产的酒精饮料及其制造方法。更具体地，本发明涉及通过扩增编码过氧化氢酶Ctt1p的CTT1基因，特别是非ScCTT1基因或ScCTT1基因特异性的ScCTT1基因的表达水平来提高其产生亚硫酸盐的能力，其有助于产品中风味稳定性的酵母啤酒酿造酵母，以及用所述酵母生产酒精饮料的方法。

4. 发明授权

US08043638B2 Mutant ILV5 gene and use thereof 有权
标题翻译：突变型ILV5基因及其用途
公开(公告)号：US08043638B2
公开(公告)日：2011-10-25
申请号：US12303266
申请日：2007-12-17
申请人： Fumihiko Omura
发明人： Fumihiko Omura
IPC分类号： C12C11/00 , C12H1/14 , C12N1/00 , C12N15/00 , C12N9/90 , C12P21/06 , C07K1/00 , C07H21/04
CPC分类号： C12C13/02 , C12C12/004 , C12C12/006 , C12G1/02 , C12G2200/11 , C12N9/0006
摘要： The present invention relates to a mutant acetohydroxy-acid reductoisomerase gene (mutant ILV5 gene) and use thereof, in particular, a brewery yeast for producing alcoholic beverages with superior flavor, alcoholic beverages produced with said yeast, and a method for producing said beverages. According to the method for producing alcoholic beverages of the present invention, because of reduction of the production of VDKs, especially DA, which are responsible for off-flavors in products, alcoholic beverages with superior flavor can be produced.
摘要翻译：本发明涉及突变型乙酰羟酸还原异构酶基因（突变型ILV5基因）及其用途，特别是用于生产具有优良风味的酒精饮料的酿酒酵母，用所述酵母生产的酒精饮料及其制备方法。根据本发明的含酒精饮料的制造方法，由于减少了产品中异味的VDK，特别是DA的生产，因此可以生产具有优良风味的酒精饮料。

5. 发明申请

US20080032386A1 Stabilized Proline Transporter 审中-公开
标题翻译：稳定的脯氨酸转运蛋白
公开(公告)号：US20080032386A1
公开(公告)日：2008-02-07
申请号：US11629683
申请日：2005-06-17
申请人： Fumihiko Omura , Nobuyuki Fukui , Hiroto Kondo
发明人： Fumihiko Omura , Nobuyuki Fukui , Hiroto Kondo
IPC分类号： C07H21/04 , C07K16/00 , C12C11/00 , C12N1/00 , C12N15/00
CPC分类号： C07K14/395 , C12C12/004 , C12C12/006
摘要： The present invention relates to a stabilized proline transporter Put4 obtained by gene mutation and a gene encoding the same, as well as a Saccharomyces yeast strain which is obtained by yeast transformation with the gene and is capable of efficiently using proline in a source material such as wort. The stabilized mutated proline transporter Put4 can be used to achieve efficient use of nitrogen sources such as poorly assimilable proline contained in source materials (e.g., wort) for alcohol beverages. Fermentation using yeast capable of taking up a wide variety and large amounts of nitrogen sources facilitates carbon source assimilation and allows improvement of productivity for alcohol beverages. Moreover, the use of poorly assimilable nitrogen sources leads to resource savings and enables environmentally friendly production of alcohol beverages.
摘要翻译：本发明涉及通过基因突变获得的稳定的脯氨酸转运蛋白Put4和编码该基因突变的基因，以及通过用该基因进行酵母转化而获得的酵母菌酵母菌株，并且能够有效地使用源材料中的脯氨酸麦芽汁稳定的突变脯氨酸转运蛋白Put4可用于实现氮源的有效利用，例如酒精饮料的原料（例如麦芽汁）中所含的不良可同化的脯氨酸。使用能够吸收多种和大量氮源的酵母的发酵有助于碳源同化，并且可以提高酒精饮料的生产率。此外，使用不良的可吸收的氮源导致资源节约并且能够环保地生产酒精饮料。

6. 发明授权

US08048667B2 Hybrid alpha-glucoside transporter 有权
标题翻译：杂交α-葡萄糖苷转运蛋白
公开(公告)号：US08048667B2
公开(公告)日：2011-11-01
申请号：US12442131
申请日：2008-09-09
申请人： Haruyo Hatanaka , Fumihiko Omura
发明人： Haruyo Hatanaka , Fumihiko Omura
IPC分类号： C12N1/19 , C12N15/63 , C07H21/04
CPC分类号： C07K14/395 , C12C12/004 , C12C12/006 , C12G1/0203 , C12G2200/11
摘要： The present invention relates to alpha-glucoside transporters which can promote assimilation of maltose/maltotriose contained in wort, etc., and so on. Especially in relation to glucose-induced inactivation/degradation, the present invention relates to alpha-glucoside transporters which are less susceptible to glucose-induced inactivation/degradation and can take up maltotriose like AGT1, by constructing the hybrid of AGT1 and MAL21. By using, e.g., a yeast expressing the alpha-glucoside transporter of the present invention, the fermentation rate of moromi mash containing oligosaccharides such as maltose/maltotriose can be accelerated.
摘要翻译：本发明涉及能够促进麦芽汁等中包含的麦芽糖/麦芽三糖的同化的α-葡萄糖苷转运体等。特别是关于葡萄糖诱导的失活/降解，本发明涉及通过构建AGT1和MAL21的杂交体，其对葡萄糖诱导的失活/降解较不敏感且可以摄取麦芽三糖如AGT1的α-葡萄糖苷转运蛋白。通过使用例如表达本发明的α-葡萄糖苷转运蛋白的酵母，可以加速含有寡糖如麦芽糖/麦芽三糖的醪液的发酵速度。

7. 发明申请

US20110027414A1 MUTANT ILV5 GENE AND USE THEREOF 有权
标题翻译：突变ILV5基因及其用途
公开(公告)号：US20110027414A1
公开(公告)日：2011-02-03
申请号：US12303266
申请日：2007-12-17
申请人： Fumihiko Omura
发明人： Fumihiko Omura
IPC分类号： C12N15/63 , C07H21/04 , C07K14/395 , C12N1/19 , C12C11/00 , C12G1/00
CPC分类号： C12C13/02 , C12C12/004 , C12C12/006 , C12G1/02 , C12G2200/11 , C12N9/0006
摘要： The present invention relates to a mutant acetohydroxy-acid reductoisomerase gene (mutant ILV5 gene) and use thereof, in particular, a brewery yeast for producing alcoholic beverages with superior flavor, alcoholic beverages produced with said yeast, and a method for producing said beverages. According to the method for producing alcoholic beverages of the present invention, because of reduction of the production of VDKs, especially DA, which are responsible for off-flavors in products, alcoholic beverages with superior flavor can be produced.
摘要翻译：本发明涉及突变型乙酰羟酸还原异构酶基因（突变型ILV5基因）及其用途，特别是用于生产具有优良风味的酒精饮料的酿酒酵母，用所述酵母生产的酒精饮料及其制备方法。根据本发明的含酒精饮料的制造方法，由于减少了产品中异味的VDK，特别是DA的生产，因此可以生产具有优良风味的酒精饮料。

8. 发明授权

US08735092B2 Glucose-induced inactivation/degradation-resistant transporter gene and use thereof 有权
标题翻译：葡萄糖诱导的灭活/降解抗性转运蛋白基因及其用途
公开(公告)号：US08735092B2
公开(公告)日：2014-05-27
申请号：US12442143
申请日：2008-09-09
申请人： Haruyo Hatanaka , Fumihiko Omura
发明人： Haruyo Hatanaka , Fumihiko Omura
IPC分类号： A61K38/00 , C12G1/022 , C12C12/00 , C07K14/395
CPC分类号： C07K14/395 , C12C12/004 , C12C12/006 , C12G1/0203 , C12G2200/11 , C12N15/81
摘要： The present invention relates to a glucose-induced inactivation- or degradation-resistant transporter gene and use thereof, and more particularly, to a brewing yeast having excellent assimilation of oligosaccharides (e.g., maltose or maltotriose), an alcoholic beverage prepared using the yeast, and a method of producing the alcoholic beverage. More specifically, the present invention relates to a glucose-induced inactivation- or degradation-resistant transporter including, for example, Mal21p, mutant Mal31p, mutant Mal61p, mutant Mtt1p or mutant Agt1p, a gene encoding the transporter, and a method of producing an alcoholic beverage using the same.
摘要翻译：本发明涉及葡萄糖诱导的灭活或降解抗性转运蛋白基因及其用途，更具体地，涉及具有优异的寡糖同化的酿造酵母（例如麦芽糖或麦芽三糖），使用酵母制备的酒精饮料，以及生产酒精饮料的方法。更具体地，本发明涉及葡萄糖诱导的灭活或降解抗性转运蛋白，其包括例如Mal21p，突变体Mal31p，突变体Mal61p，突变体Mtt1p或突变体Agt1p，编码转运蛋白的基因，以及生产酒精饮料使用相同。

9. 发明授权

US08053224B2 Glucose-induced inactivation/degradation-resistant transporter gene and use thereof 有权
标题翻译：葡萄糖诱导的灭活/降解抗性转运蛋白基因及其用途
公开(公告)号：US08053224B2
公开(公告)日：2011-11-08
申请号：US12442121
申请日：2008-09-09
申请人： Haruyo Hatanaka , Fumihiko Omura
发明人： Haruyo Hatanaka , Fumihiko Omura
IPC分类号： C12N1/19 , C12N15/63 , C07H21/04
CPC分类号： C07K14/395 , C12C12/004 , C12C12/006 , C12G1/0203 , C12G2200/11
摘要： The present invention relates to a glucose-induced inactivation/degradation resistant transporter gene and use thereof, and more particularly to a brewery yeast having excellent assimilability of oligosaccharides (maltose, maltotriose, etc.), an alcoholic beverage produced using the yeast, and so on. In particular, the present invention relates to a glucose-induced inactivation/degradation resistant transporter such as Mal21p, etc., a gene encoding the same, a method of producing an alcoholic beverage using the same; and so on.
摘要翻译：本发明涉及葡萄糖诱导的灭活/降解抗性转运蛋白基因及其用途，更具体地涉及具有优异的寡糖（麦芽糖，麦芽三糖等）的同化能力的啤酒酵母，使用酵母生产的酒精饮料等上。特别地，本发明涉及葡萄糖诱导的灭活/降解抗性转运体如Mal21p等，其编码基因，使用其的酒精饮料的制备方法; 等等。

10. 发明授权

US06753964B2 Axis determination apparatus, film-thickness measurement apparatus, deposition apparatus, axis determination method, and film-thickness measurement method 有权
标题翻译：轴确定装置，膜厚测量装置，沉积装置，轴线确定方法和膜厚测量方法
公开(公告)号：US06753964B2
公开(公告)日：2004-06-22
申请号：US10002000
申请日：2001-12-05
申请人： Kai Chen , Fumihiko Omura , Akihito Minamitsu , Shizuo Nakamura
发明人： Kai Chen , Fumihiko Omura , Akihito Minamitsu , Shizuo Nakamura
IPC分类号： G01B1100
CPC分类号： H01L21/681
摘要： A film-thickness measurement apparatus of the present invention includes a lifter, a support mount, a light-emitting device, and a light-receiving device. With the center of a wafer staying in alignment with that of the support mount, the lifter places the wafer onto the surface of the support mount to determine the center of the wafer. While the wafer is being rotated about the center of the wafer, the light-emitting device irradiates the circumferential portion of the wafer with a laser beam, thereby allowing the position of a notch to be detected depending on whether or not the laser beam passes through the notch. This makes it possible to detect the positions of the notch and the center of the wafer to determine the center axis line of the surface of the wafer, thereby allowing the coordinates of a given position on the surface of the wafer to be defined in accordance with the center axis line and the center of the wafer. The thickness of the thin film on the surface of the wafer at the predetermined positions can then be determined.
摘要翻译：本发明的薄膜厚度测量装置包括升降机，支撑架，发光装置和光接收装置。随着晶片的中心保持与支撑安装座的中心对准，升降器将晶片放置在支撑座的表面上以确定晶片的中心。当晶片围绕晶片的中心旋转时，发光器件用激光束照射晶片的圆周部分，从而根据激光束是否通过来检测凹口的位置缺口这使得可以检测晶片的凹口和中心的位置以确定晶片的表面的中心轴线，从而允许根据晶片的表面限定晶片表面上的给定位置的坐标中心轴线和晶圆的中心。然后可以确定晶片在预定位置的表面上的薄膜的厚度。

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