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1. 发明授权

US4460502A Peptide, process for preparation thereof and use thereof 失效
标题翻译：肽，其制备方法及其用途
公开(公告)号：US4460502A
公开(公告)日：1984-07-17
申请号：US316653
申请日：1981-10-30
申请人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Satoshi Yonishi , Hidekazu Takeno , Satoshi Kada , Masashi Hashimoto
发明人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Satoshi Yonishi , Hidekazu Takeno , Satoshi Kada , Masashi Hashimoto
IPC分类号： A61K38/00 , C07K5/02 , C07C103/52
CPC分类号： C07K5/0215 , A61K38/00 , Y02P20/55
摘要： The invention deals with novel peptides useful for the therapeutic treatment of infectious diseases caused by pathogenic microorganisms, having the structure ##STR1## wherein R.sup.1 is substituted or unsubstituted lower alkanoyl, or substituted or unsubstituted aralkanoyl,R.sup.2 and R.sup.3 are each carboxy or protected carboxy,R.sup.4 is hydrogen or an amino protective group, andR.sup.5 is hydrogen or lower alkyl, and their pharmaceutically acceptable salts.
摘要翻译：本发明涉及可用于治疗由病原微生物引起的感染性疾病的治疗性治疗的新型肽，其具有以下结构：其中R 1为取代或未取代的低级烷酰基或取代或未取代的芳烷酰基，R 2和R 3各自为羧基或被保护的羧基， R4是氢或氨基保护基，R5是氢或低级烷基，以及它们的药学上可接受的盐。

2. 发明授权

US4493794A Peptide, process for preparation thereof and use thereof 失效
标题翻译：肽，其制备方法及其用途
公开(公告)号：US4493794A
公开(公告)日：1985-01-15
申请号：US328997
申请日：1981-12-09
申请人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Satoshi Yonishi , Hidekazu Takeno , Satoshi Okada , Masashi Hashimoto
发明人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Satoshi Yonishi , Hidekazu Takeno , Satoshi Okada , Masashi Hashimoto
IPC分类号： C07D263/44 , A61K31/195 , A61K31/22 , A61K31/27 , A61K38/00 , A61P31/04 , A61P35/00 , A61P37/04 , C07C231/02 , C07C237/10 , C07C237/12 , C07C237/22 , C07C271/22 , C07K5/02 , C07C103/52
CPC分类号： C07K5/0215 , A61K38/00 , Y02P20/55
摘要： The invention deals with novel peptides useful for the therapeutic treatment of infectious diseases caused by pathogenic microorganisms, having the structure: ##STR1## wherein R.sup.1 is hydrogen, substituted or unsubstituted alkanoyl, or substituted or unsubstituted aralkanoyl,R.sup.2 is carboxy or protected carboxy,R.sup.3 is carboxy, protected carboxy, carbamoyl, or carboxy or protected carboxy(lower)alkylcarbamoyl,R.sup.4 is carboxy, protected carboxy or carbamoyl, andR.sup.5 is hydrogen or an amino protective group, with proviso that at least one of R.sup.3 and R.sup.4 is always carbamoyl and their pharmaceutically acceptable salts.
摘要翻译：本发明涉及可用于治疗由病原微生物引起的感染性疾病的新型肽，其具有以下结构：其中R 1为氢，取代或未取代的烷酰基或取代或未取代的芳烷酰基，R 2为羧基或被保护的羧基，R 3 羧基，保护的羧基，氨基甲酰基或羧基或受保护的羧基（低级）烷基氨基甲酰基，R4是羧基，保护的羧基或氨基甲酰基，R5是氢或氨基保护基，条件是R3和R4中的至少一个总是氨基甲酰基及其药学上可接受的盐。

3. 发明授权

US4476050A Peptide, process for preparation thereof and use thereof 失效
标题翻译：肽，其制备方法及其用途
公开(公告)号：US4476050A
公开(公告)日：1984-10-09
申请号：US341057
申请日：1982-01-20
申请人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Satoshi Yonishi , Hidekazu Takeno , Satoshi Okada , Masashi Hashimoto
发明人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Satoshi Yonishi , Hidekazu Takeno , Satoshi Okada , Masashi Hashimoto
IPC分类号： C07K1/113 , A61K38/00 , A61P31/04 , A61P37/04 , C07K5/02 , C07C103/52
CPC分类号： C07K5/0215 , A61K38/00 , Y02P20/55
摘要： The invention deals with novel peptides useful in the therapeutic treatment of infectious diseases caused by pathogenic microorganisms having the structure: ##STR1## wherein, R.sup.1 is hydrogen or acyl,R.sup.2 is lower alkyl,R.sup.3 is carboxy or protected carboxy,R.sup.4 is hydrogen or lower alkyl,R.sup.5 is hydrogen, alkyl or ar(lower)alkyl,R.sup.6 is carboxy or protected carboxy, andR.sup.7 is hydrogen or an amino protective group,and their pharmaceutically acceptable salts.
摘要翻译：本发明涉及用于治疗由具有以下结构的病原微生物引起的感染性疾病的新型肽：其中R1为氢或酰基，R2为低级烷基，R3为羧基或被保护的羧基，R4为氢或低级烷基，R 5为氢，烷基或芳（低级）烷基，R 6为羧基或被保护的羧基，R 7为氢或氨基保护基，及其药学上可接受的盐。

4. 发明授权

US4497729A Peptide, process for preparation thereof and use thereof 失效
标题翻译：肽，其制备方法及其用途
公开(公告)号：US4497729A
公开(公告)日：1985-02-05
申请号：US322902
申请日：1981-11-19
申请人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Satoshi Yonishi , Hidekazu Takeno
发明人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Satoshi Yonishi , Hidekazu Takeno
IPC分类号： A61K38/00 , C07K5/02 , C07C103/52
CPC分类号： C07K5/0215 , A61K38/00
摘要： This invention relates to novel peptides, of pharmacological activity, of the formula: ##STR1## wherein R.sup.1 is heptanoyl, stearoyl, 2-hydroxypropionyl or 2-acetoxypropionyl,R.sup.2 is hydrogen or methyl,R.sup.3 is carboxy, benzyloxycarbonyl or hydroxymethyl,R.sup.4 is hydrogen or methyl,R.sup.5 is carboxy or hydroxymethyl,R.sup.6 is carboxy, methoxycarbonyl, 3-t-butoxycarbonylcarbazoyl or hydroxymethyl,R.sup.7 is hydrogen, 3-t-butoxycarbonyl or benzyloxycarbonyl, andn is an integer 0 or 1, with the proviso that when each of R.sup.3 and R.sup.6 is not simultaneously hydroxymethyl, then R.sup.5 is hydroxymethyl.
摘要翻译：本发明涉及具有下式的新颖的药物活性肽：其中R1是庚酰基，硬脂酰基，2-羟基丙酰基或2-乙酰氧基丙酰基，R2是氢或甲基，R3是羧基，苄氧羰基或羟甲基，R4是氢或甲基，R 5为羧基或羟甲基，R 6为羧基，甲氧基羰基，3-叔丁氧基羰基咔唑基或羟甲基，R7为氢，3-叔丁氧基羰基或苄氧基羰基，n为0或1的整数，条件是的R3和R6不同时为羟甲基，则R5为羟甲基。

5. 发明授权

US4487763A Peptide, process for preparation thereof and use thereof 失效
标题翻译：肽，其制备方法及其用途
公开(公告)号：US4487763A
公开(公告)日：1984-12-11
申请号：US402440
申请日：1982-07-28
申请人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Matsuhiko Aratani , Hidekazu Takeno , Satoshi Okada , Hirokazu Tanaka , Masashi Hashimoto
发明人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Matsuhiko Aratani , Hidekazu Takeno , Satoshi Okada , Hirokazu Tanaka , Masashi Hashimoto
IPC分类号： A61K38/00 , A61P31/04 , A61P37/00 , A61P37/04 , C07C237/22 , C07K1/06 , C07K1/113 , C07K5/02 , C07K5/04 , C07K7/02 , C07K9/00 , C07C103/52 , A61K37/02
CPC分类号： C07C243/00 , C07K5/0215 , C07K9/005 , C12R1/465 , A61K38/00
摘要： The invention relates to novel peptides and their pharmaceutically acceptable salts, particularly useful for pharmaceutical purposes such as in the therapeutic treatment of infectious diseases caused by pathogenic microorganisms. The compounds have the structure ##STR1## wherein R.sup.1 is hydrogen or acyl;R.sup.2 is carboxy or protected carboxy or a group of the formula: --COHN--R.sub.a.sup.2 wherein R.sub.a.sup.2 is carboxy (lower) alkyl or protected carboxy (lower) alkyl;R.sup.3 is carboxy, protected carboxy, lower alkyl, hydroxyphenyl, carbamoyl or a group of the formula: ##STR2## wherein R.sub.a.sup.3 is hydrogen, amino, protected amino or acylamino, R.sub.b.sup.3 is carboxy or protected carboxy,R.sup. is carboxy, protected carboxy, carbamoyl, carboxy (lower) alkyl or protected carboxy (lower) alkyl;l is an integer 2,m is an integer 0 to 2 andn is an integer 1, provided that, whenR.sup.1 is hydrogen or acyl,R.sup.2 is carboxy, protected carboxy or a group of the formula: --CONHR.sub.a.sup.2 wherein R.sub.a.sup.2 is carboxy (lower) alkyl or protected carboxy (lower) alkyl,R.sup.P is carboxy, or protected carboxy, m is an integer 2, thenR.sup.3 is carbamoyl, lower alkyl or hydroxyphenyl or a group of the formula: ##STR3## wherein R.sub.a.sup.3 is hydrogen or acylamino and R.sub.b.sup.3 is carboxy or protected carboxy, and whenR.sup.P is carbamoyl, thenR.sup.1 is acyl.

6. 发明授权

US4666890A Peptide, process for preparation thereof and use thereof 失效
标题翻译：肽，其制备方法及其用途
公开(公告)号：US4666890A
公开(公告)日：1987-05-19
申请号：US380061
申请日：1982-05-20
申请人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Matsuhiko Aratani , Hidekazu Takeno , Satoshi Okada , Hirokazu Tanaka , Masashi Hashimoto , Yoshio Kuroda , Eiko Iguchi , Masanobu Kohsaka , Hatsuo Aoki , Hiroshi Imanaka
发明人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Matsuhiko Aratani , Hidekazu Takeno , Satoshi Okada , Hirokazu Tanaka , Masashi Hashimoto , Yoshio Kuroda , Eiko Iguchi , Masanobu Kohsaka , Hatsuo Aoki , Hiroshi Imanaka
IPC分类号： A61K38/00 , C07K5/02 , C07K5/06 , C07K5/062 , C07K5/072 , C07K9/00 , C07K5/08 , C07K5/10
CPC分类号： C07C243/00 , C07K5/0215 , C07K5/06026 , C07K5/06052 , C07K5/06069 , C07K5/06078 , C07K9/005 , C12R1/465 , A61K38/00 , Y02P20/55
摘要： The invention relates to novel peptides of enhanced pharmacological activity of the formula: ##STR1## wherein R.sup.1 is alkanoyl;R.sup.2 and R.sup.q are each hydrogen, carboxy, protected carboxy, or a group of the formula: ##STR2## wherein R.sub.a.sup.2 is mono- or di-carboxy (or protected carboxy) lower alkyl or ar(carboxy or protected carboxy) lower alkyl whose aryl moiety may be substituted by hydroxy,R.sub.b.sup.2 is hydrogen or lower alkyl;R.sup.P is hydrogen, carboxy, protected carboxy, with proviso that when one of R.sup.2 and R.sup.q is hydrogen, then the other is carboxy or protected carboxy or a group of the formula: ##STR3## wherein R.sub.a.sup.2 and R.sub.b.sup.2 are each as defined above; R.sup.r is hydrogen or amino protective group;m is an integer 1 to 3;or its pharmaceutically acceptable salt.
摘要翻译：本发明涉及增强的药理活性的新肽，其具有下式：其中R1是烷酰基; R 2和R q各自为氢，羧基，被保护的羧基或下式的基团：其中R 2a是单或二羧基（或保护的羧基）低级烷基或芳（羧基或保护的羧基）低级烷基，其芳基部分可以被羟基取代，Rb2是氢或低级烷基; RP是氢，羧基，保护的羧基，条件是当R 2和R q中的一个是氢时，另一个是羧基或被保护的羧基或下式的基团：其中Ra2和Rb2各自如上所定义; Rr为氢或氨基保护基; m为整数1〜3; 或其药学上可接受的盐。

7. 发明授权

US4311640A Peptide, process for preparation thereof and use thereof 失效
标题翻译：肽，其制备方法及其用途
公开(公告)号：US4311640A
公开(公告)日：1982-01-19
申请号：US93523
申请日：1979-11-13
申请人： Yoshio Kuroda , Eiko Iguchi , Masanobu Kohsaka , Hatsuo Aoki , Hiroshi Imanaka , Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Matsuhiko Aratani , Hidekazu Takeno , Satoshi Okada , Hirokazu Tanaka , Masashi Hashimoto
发明人： Yoshio Kuroda , Eiko Iguchi , Masanobu Kohsaka , Hatsuo Aoki , Hiroshi Imanaka , Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Matsuhiko Aratani , Hidekazu Takeno , Satoshi Okada , Hirokazu Tanaka , Masashi Hashimoto
IPC分类号： A61K38/00 , C07K5/02 , C07K7/02 , C07K9/00 , C07C103/52 , C07G7/00
CPC分类号： C07C243/00 , C07K5/0215 , C07K9/005 , C12R1/465 , A61K38/00 , Y02P20/55
摘要： The invention deals with novel peptides useful for the therapeutic treatment of infectious diseases caused by pathogenic microorganisms. Included is the peptide FR900156 having the structure: ##STR1## as well as the peptides of the structure ##STR2## wherein R.sup.1 is acyl;R.sub.b.sup.1 is hydrogen, methyl, isopropyl, hydroxymethyl, protected hydroxymethyl or benzyl;R.sup.2 is hydrogen, carboxy, protected carboxy, or a group of the formula: ##STR3## wherein R.sub.a.sup.2 is mono- or di-carboxy lower alkyl or ar(carboxy) lower alkyl whose aryl moiety may be substituted by hydroxy,R.sub.b.sup.2 is hydrogen or lower alkyl;R.sup.p and R.sup.q are each hydrogen, carboxy, protected carboxy, with proviso that when one of R.sup.2 and R.sup.q is hydrogen, then the other is carboxy or protected carboxy;R.sup.r is hydrogen or amino protective group; m is an integer 1 to 3; and n is 1 provided that when R.sup.1 is hydrogen, t-butoxycarbonyl or N-acetylmuramyl, R.sub.b.sup.1 is methyl, m is an integer 2 and n is an integer 1, then R.sup.2 is hydrogen, protected carboxy or a group of the formula: ##STR4## wherein R.sub.a.sup.2 is mono- or di-carboxy lower alkyl having 1 and 3 to 6, carbon atoms, .alpha.-carboxyethyl, ar(carboxy) lower alkyl whose aryl moiety may be substituted by hydroxy and R.sub.b.sup.2 is as defined above, or its pharmaceutically acceptable salt.
摘要翻译：本发明涉及可用于治疗由病原微生物引起的感染性疾病的新型肽。包括具有以下结构的肽FR900156：以及结构的肽，其中R 1是酰基; Rb1是氢，甲基，异丙基，羟甲基，保护的羟甲基或苄基; R2是氢，羧基，受保护的羧基或下式的基团：其中R 2a是其芳基部分可以被羟基取代的一或二羧基低级烷基或芳（羧基）低级烷基，R 2b是氢或低级烷基 Rp和Rq各自为氢，羧基，保护的羧基，条件是当R 2和R q中的一个为氢时，则另一个为羧基或被保护的羧基; Rr为氢或氨基保护基; m为整数1〜3; 并且n为1，条件是当R 1为氢时，叔丁氧基羰基或N-乙酰胞壁酰基，R 1b为甲基，m为整数2，n为整数1，则R 2为氢，被保护的羧基或下式基团：其中Ra2是具有1和3至6个碳原子的一或二羧基低级烷基，其α-芳基部分可以被羟基取代的α-羧乙基，芳（羧基）低级烷基，如上所定义，或其药学上可接受的盐。

8. 发明授权

US4512980A Peptide, process for preparation thereof and use thereof 失效
标题翻译：肽，其制备方法及其用途
公开(公告)号：US4512980A
公开(公告)日：1985-04-23
申请号：US402438
申请日：1982-07-28
申请人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Matsuhiko Aratani , Hidekazu Takeno , Satoshi Okada , Hirokazu Tanaka , Masashi Hashimoto
发明人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Matsuhiko Aratani , Hidekazu Takeno , Satoshi Okada , Hirokazu Tanaka , Masashi Hashimoto
IPC分类号： A61K38/00 , A61P31/04 , A61P37/00 , A61P37/04 , C07C237/22 , C07K1/06 , C07K1/113 , C07K5/02 , C07K5/04 , C07K7/02 , C07K9/00 , C07C103/52 , A61K37/02
CPC分类号： C07C243/00 , C07K5/0215 , C07K9/005 , C12R1/465 , A61K38/00
摘要： The invention relates to novel peptides of pharmacological activity, of the formula ##STR1## wherein R.sup.1 is hydrogen or acyl;R.sup.2 is carboxy or protected carboxy or a group of the formula: --COHN--R.sub.a.sup.2 wherein R.sub.a.sup.2 is carboxy (lower) alkyl or protected carboxy (lower) alkyl;R.sup.3 is carboxy, protected carboxy, lower alkyl, hydroxyphenyl, carbamoyl or a group of the formula: ##STR2## wherein R.sub.a.sup.3 is hydrogen, amino, protected amino or acylamino, R.sub.b.sup.3 is carboxy or protected carboxy;R.sup.p is carboxy, protected carboxy, carbamoyl, carboxy (lower) alkyl or protected carboxy (lower) alkyl;l is an integer 0;m is an interger 3; andn is an integer 1, provided that when R.sup.1 is hydrogen or acyl,R.sup.2 is carboxy, protected carboxy or a group of the formula:--CONHR.sub.a.sup.2 wherein R.sub.a.sup.2 is carboxy (lower) alkyl or protected carboxy (lower) alkyl,R.sup.p is carboxy, or protected carboxy,R.sup.3 is carbamoyl, lower alkyl or hydroxyphenyl or a group of the formula: ##STR3## wherein R.sub.a.sup.3 is hydrogen or acylamino and R.sub.b.sup.3 is carboxy or protected carboxy, andwhen R.sup.p is carbamoyl, thenR.sup.1 is acyl.

9. 发明授权

US4504584A Cultures of novel strains of Streptomyces 失效
标题翻译：链霉菌新菌株的培养
公开(公告)号：US4504584A
公开(公告)日：1985-03-12
申请号：US379851
申请日：1982-05-19
申请人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Matsuhiko Aratani , Hidekazu Takeno , Satoshi Okada , Hirokazu Tanaka , Masashi Hashimoto , Yoshio Kuroda , Eiko Iguchi , Masanobu Kohsaka , Hatsuo Aoki , Hiroshi Imanaka
发明人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Matsuhiko Aratani , Hidekazu Takeno , Satoshi Okada , Hirokazu Tanaka , Masashi Hashimoto , Yoshio Kuroda , Eiko Iguchi , Masanobu Kohsaka , Hatsuo Aoki , Hiroshi Imanaka
IPC分类号： A61K38/00 , C07K5/02 , C07K5/06 , C07K5/062 , C07K5/072 , C07K9/00 , C12N1/20 , C12R1/465
CPC分类号： C07C243/00 , C07K5/0215 , C07K5/06026 , C07K5/06104 , C07K9/005 , C12R1/465 , A61K38/00 , Y10S435/886 , Y10S930/19
摘要： The invention relates to a biologically pure culture of new strains of the microorganism Streptomyces which are capable upon fermentation of producing a peptide of pharmacological activity.
摘要翻译：本发明涉及生物学纯培养的新型菌株的微生物链霉菌，其能够在发酵时产生药理活性肽。

10. 发明授权

US4354966A Peptides, process for preparation thereof and use thereof 失效
标题翻译：肽，其制备方法和用途
公开(公告)号：US4354966A
公开(公告)日：1982-10-19
申请号：US193453
申请日：1980-10-03
申请人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Matsuhiko Aratani , Hidekazu Takeno , Satoshi Okada , Hirokazu Tanaka , Masashi Hashimoto
发明人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Matsuhiko Aratani , Hidekazu Takeno , Satoshi Okada , Hirokazu Tanaka , Masashi Hashimoto
IPC分类号： A61K38/00 , C07K5/02 , C07K9/00 , C07C103/52
CPC分类号： C07C243/00 , C07K5/0215 , C07K9/005 , C12R1/465 , A61K38/00
摘要： The invention relates to novel peptides and their pharmaceutically acceptable salts, particularly useful for pharmaceutical purposes such as in the therapeutic treatment of infectious diseases caused by pathogenic microorganisms. The compounds have the structure ##STR1## wherein R.sup.1 is hydrogen or acyl;R.sup.2 is carboxy or protected carboxy or a group of the formula: --COHN--R.sub.a.sup.2 wherein R.sub.a.sup.2 is carboxy (lower) alkyl or protected carboxy (lower) alkyl;R.sup.3 is carboxy, protected carboxy, lower alkyl, hydroxyphenyl, carbamoyl or a group of the formula: ##STR2## wherein R.sub.a.sup.3 is hydrogen, amino, protected amino or acylamino, R.sub.b.sup.3 is carboxy or protected carboxy;R.sup.p is carboxy, protected carboxy, carbamoyl, carboxy (lower) alkyl or protected carboxy (lower) alkyl;l is an integer 2,m is an integer 0 to 2 andn is an integer 1,provided that,whenR.sup.1 is hydrogen or acyl,R.sup.2 is carboxy, protected carboxy or a group of the formula: --CONHR.sub.a.sup.2 wherein R.sub.a.sup.2 is carboxy (lower) alkyl or protected carboxy (lower) alkyl,R.sup.p is carboxy, or protected carboxy, m is an integer 2, thenR.sup.3 is carbamoyl, lower alkyl or hydroxyphenyl or a group of the formula: ##STR3## wherein R.sub.a.sup.3 is hydrogen or acylamino and R.sub.b.sup.3 is carboxy or protected caboxy, andwhenR.sup.p is carbamoyl, thenR.sup.1 is acyl.
摘要翻译：本发明涉及新型肽及其药学上可接受的盐，特别可用于药物目的，例如由病原微生物引起的感染性疾病的治疗性治疗。这些化合物具有结构，其中R 1是氢或酰基; R2是羧基或保护的羧基或下式基团-COHN-Ra2，其中Ra2是羧基（低级）烷基或被保护的羧基（低级）烷基; R 3是羧基，保护的羧基，低级烷基，羟基苯基，氨基甲酰基或下式的基团：其中R 3a是氢，氨基，被保护的氨基或酰氨基，R 3b是羧基或被保护的羧基; Rp是羧基，保护的羧基，氨基甲酰基，羧基（低级）烷基或被保护的羧基（低级）烷基; l为整数2，m为整数0〜2，n为整数1，条件是当R 1为氢或酰基时，R 2为羧基，被保护的羧基或式-CONHRa 2基团，其中Ra 2为羧基（低级）烷基或受保护的羧基（低级）烷基，Rp是羧基或受保护的羧基，m是整数2，则R3是氨基甲酰基，低级烷基或羟基苯基或下式的基团：其中R 3a是氢或酰基氨基并且R 3b是羧基或被保护的环氧基，当Rp是氨基甲酰基时，则R1是酰基。

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