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1. 发明授权

US07715901B2 Sensitized online BOLD-MRI imaging method 失效
标题翻译：敏感的在线BOLD-MRI成像方法
公开(公告)号：US07715901B2
公开(公告)日：2010-05-11
申请号：US10513656
申请日：2003-05-08
申请人： Yoram Salomon , Michal Neeman , Avigdor Scherz , Shimon Gross , Assaf Gilead
发明人： Yoram Salomon , Michal Neeman , Avigdor Scherz , Shimon Gross , Assaf Gilead
IPC分类号： A61B5/05
CPC分类号： A61B5/055 , A61B5/4839 , A61K41/0061 , A61K41/0071 , A61K41/0076 , A61N5/062 , G01R33/4806
摘要： An online Blood Oxygenation Level-Dependent (BOLD)-magnetic resonance imaging (MRI) method for functional clinical guidance or monitoring a therapeutic modality involving treatment by a sensitizer which, upon excitation by the appropriate sensitizing radiation, initiates local oxygen consumption, comprising: (i) generating a BOLD-weighted MR-image of the target region of interest within the patient's body (time t0); (ii) administering said sensitizer to the patient; (iii) irradiating the target region while the patient is subjected to continuous MR imaging; (iv) generating a sole or a plurality of T2* weighted sequential BOLD MR-images during and/or after irradiation (time t); (v) processing the data generated at time t0 and time t and generating a color-coded difference or ratio map on a pixel by pixel basis; and (vi) analyzing the processed data. The method is preferably applied to photodynamic therapy (PDT).
摘要翻译：一种用于功能性临床指导或监测涉及由敏化剂治疗的治疗方式的在线血液氧合依赖性（BOLD） - 磁共振成像（MRI）方法，其在通过适当的敏化辐射激发时引发局部耗氧，包括： i）产生患者体内目标区域的BOLD加权MR图像（时间t0）; （ii）将所述致敏剂施用于患者; （iii）在患者进行连续MR成像的同时照射目标区域; （iv）在照射期间和/或之后产生唯一或多个T2 *加权顺序BOLD MR图像（时间t）; （v）处理在时间t0和时间t产生的数据，并逐个像素地产生颜色编码的差分或比例图; 和（vi）分析处理后的数据。该方法优选应用于光动力疗法（PDT）。

2. 发明申请

US20060135868A1 Sensitized online bold-mri imaging method 失效
标题翻译：敏感的在线大胆成像方法
公开(公告)号：US20060135868A1
公开(公告)日：2006-06-22
申请号：US10513656
申请日：2006-01-20
申请人： Yoram Salomon , Michal Neeman , Avigdor Scherz , Shimon Gross , Assaf Gilad
发明人： Yoram Salomon , Michal Neeman , Avigdor Scherz , Shimon Gross , Assaf Gilad
IPC分类号： A61B5/05 , A61B6/00 , A61M25/00
CPC分类号： A61B5/055 , A61B5/4839 , A61K41/0061 , A61K41/0071 , A61K41/0076 , A61N5/062 , G01R33/4806
摘要： An online Blood Oxygenation Level-Dependent (BOLD)-magnetic resonance imaging (MRI) method for functional clinical guidance or monitoring a therapeutic modality involving treatment by a sensitizer which, upon excitation by the appropriate sensitizing radiation, initiates local oxygen consumption, comprising: (i) generating a BOLD-weighted MR-image of the target region of interest within the patient's body (time t0); (ii) administering said sensitizer to the patient; (iii) irradiating the target region while the patient is subjected to continuous MR imaging; (iv) generating a sole or a plurality of T2* weighted sequential BOLD MR-images during and/or after irradiation (time t); (v) processing the data generated at time t0 and time t and generating a color-coded difference or ratio map on a pixel by pixel basis; and (vi) analyzing the processed data. The method is preferably applied to photodynamic therapy (PDT).
摘要翻译：一种用于功能性临床指导或监测涉及由敏化剂治疗的治疗方式的在线血液氧合依赖性（BOLD） - 磁共振成像（MRI）方法，其在通过适当的敏化辐射激发时引发局部耗氧，包括： i）生成患者身体内的目标感兴趣区域的BOLD加权MR图像（时间t <0>）; （ii）将所述致敏剂施用于患者; （iii）在患者进行连续MR成像的同时照射目标区域; （iv）在照射期间和/或之后产生唯一或多个T2 *加权顺序BOLD MR图像（时间t）; （v）处理在时间t 0和时间t产生的数据，并逐个像素地生成彩色差分或比例图; 和（vi）分析处理后的数据。该方法优选应用于光动力疗法（PDT）。

3. 发明申请

US20110250145A1 BIOLUMINESCENCE IMAGING OF MYELOPEROXIDASE ACTIVITY IN VIVO, METHODS, COMPOSITIONS AND APPARATUSES THEREFOR 有权
标题翻译：血液中的多酚氧化酶活性的生物荧光成像，方法，组合物及其装置
公开(公告)号：US20110250145A1
公开(公告)日：2011-10-13
申请号：US13127448
申请日：2009-11-03
申请人： Vijay Sharma , Seth Gammon , David Piwnica-Worms , Shimon Gross
发明人： Vijay Sharma , Seth Gammon , David Piwnica-Worms , Shimon Gross
IPC分类号： A61K49/00 , C07D413/14 , C07D405/12 , C07D403/14 , C07D237/32 , C07D491/22
CPC分类号： C12Q1/28 , A61K49/0013
摘要： Methods of imaging distribution of myeloperoxidase activity in a subject are disclosed. These methods include the use of bioluminescent substrates, including luminol and wavelength-shifted analogues of luminol. Bioluminescent myeloperoxidase substrates that emit light at longer wavelengths compared to luminol are shown to be useful for imaging myeloperoxidase activity in vivo. The disclosed methods can be used for imaging sites of inflammation and other pathological conditions associated with abnormal levels of MPO activity in vivo. Methods of synthesis of luminol analogues are also disclosed.
摘要翻译：公开了在受试者中成像骨髓过氧化物酶活性分布的方法。这些方法包括使用生物发光底物，包括鲁米诺和鲁米诺的波长偏移类似物。显示出比鲁米诺更长波长发光的生物发光髓过氧化物酶底物可用于体内髓过氧化物酶活性成像。所公开的方法可用于与体内MPO活性异常水平相关的炎症和其他病理状况的成像部位。还公开了鲁米诺类似物的合成方法。

4. 发明授权

US08652442B2 Bioluminescence imaging of myeloperoxidase activity in vivo, methods, compositions and apparatuses therefor 有权
标题翻译：骨髓过氧化物酶活性的生物发光成像，其方法，组合物和装置
公开(公告)号：US08652442B2
公开(公告)日：2014-02-18
申请号：US13127448
申请日：2009-11-03
申请人： David Piwnica-Worms , Shimon Gross , Vijay Sharma , Seth Gammon
发明人： David Piwnica-Worms , Shimon Gross , Vijay Sharma , Seth Gammon
IPC分类号： A61B5/00 , C07D237/30
CPC分类号： C12Q1/28 , A61K49/0013
摘要： Methods of imaging distribution of myeloperoxidase activity in a subject are disclosed. These methods include the use of bioluminescent substrates, including luminol and wavelength-shifted analogues of luminol. Bioluminescent myeloperoxidase substrates that emit light at longer wavelengths compared to luminol are shown to be useful for imaging myeloperoxidase activity in vivo. The disclosed methods can be used for imaging sites of inflammation and other pathological conditions associated with abnormal levels of MPO activity in vivo. Methods of synthesis of luminol analogues are also disclosed.
摘要翻译：公开了在受试者中成像骨髓过氧化物酶活性分布的方法。这些方法包括使用生物发光底物，包括鲁米诺和鲁米诺的波长偏移类似物。显示出比鲁米诺更长波长发光的生物发光髓过氧化物酶底物可用于体内髓过氧化物酶活性成像。所公开的方法可用于与体内MPO活性异常水平相关的炎症和其他病理状况的成像部位。还公开了鲁米诺类似物的合成方法。

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