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1. 发明申请

US20050163746A1 Hsp peptides and analogs for modulation of immune responses via antigen presenting cells 失效
标题翻译： Hsp肽和类似物用于通过抗原呈递细胞调节免疫应答
公开(公告)号：US20050163746A1
公开(公告)日：2005-07-28
申请号：US10902923
申请日：2004-07-30
申请人： Yoram Karmon , Ann Avron , Dana Elias
发明人： Yoram Karmon , Ann Avron , Dana Elias
IPC分类号： A61K38/00 , A61K38/19 , A61K45/00 , A61K49/00 , C07K14/47 , G01N33/50 , G01N33/53 , G01N33/567 , G01N33/68
CPC分类号： G01N33/6863 , A61K38/00 , A61K49/0004 , C07K14/47 , C07K14/4713 , C07K2319/00 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5047 , G01N33/505 , G01N33/5091
摘要： According to the present invention it is now disclosed that exposure of antigen presenting cells, particularly dendritic cells, to peptides or peptide analogs derived from heat shock proteins will subsequently activate T cells to produce immunomodulatory cytokines and will directly influence the cytokines, chemokines, and surface antigens produced by the exposed antigen presenting cells. The present invention relates to peptides and peptide analogs of heat shock proteins capable of interacting directly with dendritic cells. The present invention further relates to pharmaceutical compositions that include dendritic cells exposed to such peptides and analogs, useful for prevention or treatment of either inflammatory disorders and autoimmune diseases or malignancies, viral infections and allergy.
摘要翻译：根据本发明，现在公开了抗原呈递细胞，特别是树突状细胞暴露于衍生自热休克蛋白的肽或肽类似物随后将激活T细胞以产生免疫调节细胞因子，并将直接影响细胞因子，趋化因子和表面由暴露的抗原呈递细胞产生的抗原。本发明涉及能够与树突细胞直接相互作用的热休克蛋白的肽和肽类似物。本发明还涉及药物组合物，其包括暴露于此类肽和类似物的树突状细胞，其可用于预防或治疗炎症性疾病和自身免疫性疾病或恶性肿瘤，病毒感染和变态反应。

2. 发明授权

US07576177B2 Hsp peptides and analogs for modulation of immune responses via antigen presenting cells 失效
标题翻译： Hsp肽和类似物用于通过抗原呈递细胞调节免疫应答
公开(公告)号：US07576177B2
公开(公告)日：2009-08-18
申请号：US10902923
申请日：2004-07-30
申请人： Yoram Karmon , Ann Avron , Dana Elias
发明人： Yoram Karmon , Ann Avron , Dana Elias
IPC分类号： C07K14/00
CPC分类号： G01N33/6863 , A61K38/00 , A61K49/0004 , C07K14/47 , C07K14/4713 , C07K2319/00 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5047 , G01N33/505 , G01N33/5091
摘要： According to the present invention it is now disclosed that exposure of antigen presenting cells, particularly dendritic cells, to peptides or peptide analogs derived from heat shock proteins will subsequently activate T cells to produce immunomodulatory cytokines and will directly influence the cytokines, chemokines, and surface antigens produced by the exposed antigen presenting cells. The present invention relates to peptides and peptide analogs of heat shock proteins capable of interacting directly with dendritic cells. The present invention further relates to pharmaceutical compositions that include dendritic cells exposed to such peptides and analogs, useful for prevention or treatment of either inflammatory disorders and autoimmune diseases or malignancies, viral infections and allergy.
摘要翻译：根据本发明，现在公开了抗原呈递细胞，特别是树突状细胞暴露于衍生自热休克蛋白的肽或肽类似物随后将激活T细胞以产生免疫调节细胞因子，并将直接影响细胞因子，趋化因子和表面由暴露的抗原呈递细胞产生的抗原。本发明涉及能够与树突细胞直接相互作用的热休克蛋白的肽和肽类似物。本发明还涉及药物组合物，其包括暴露于此类肽和类似物的树突状细胞，其可用于预防或治疗炎症性疾病和自身免疫性疾病或恶性肿瘤，病毒感染和变态反应。

3. 发明申请

US20080218345A1 Intermediate Attachment Mechanism and Use Thereof in Rfid Transponder 失效
标题翻译：中级附件机制及其在Rfid应答器中的应用
公开(公告)号：US20080218345A1
公开(公告)日：2008-09-11
申请号：US11997434
申请日：2006-07-31
申请人： Zvi Nitzan , Yoram Karmon
发明人： Zvi Nitzan , Yoram Karmon
IPC分类号： G06K19/077
CPC分类号： G06K19/0702 , G06K19/07749 , G06K19/0775
摘要： The present invention provides an intermediate attachment mechanism, called a powerposer (10), which includes at least one power source (16) coupled to an integrated circuit (14), at least one integrated circuit, which is arranged to store a code comprising information and powered with energy provided by the power source and a substrate (12) on which the at least one power source and the at least one integrated circuit are disposed, and wherein the substrate comprises connection means (22) for connecting to an application device and attachment means for attaching to the application device. Further, the present invention provides a battery assisted or active RFID transponder featuring a transponder substrate, at least one antenna disposed on the transponder substrate and a powerposer disposed on the transponder substrate. Still further the present invention provides methods of production of a powerposer and an active or battery assisted RFID transponder comprising a powerposer.
摘要翻译：本发明提供一种称为动力牵引器（10）的中间连接机构，其包括耦合到集成电路（14）的至少一个电源（16），至少一个集成电路，其被设置为存储包括信息的代码并且由电源提供的能量和其上设置有至少一个电源和至少一个集成电路的基板（12）供电，并且其中所述基板包括用于连接到应用装置的连接装置（22）用于附接到应用装置的附接装置。此外，本发明提供了一种电池辅助或有源的RFID应答器，其特征在于应答器基板，设置在应答器基板上的至少一个天线和设置在应答器基板上的电源接头。本发明进一步提供了一种制造动力装置的方法以及包括动力装置的主动或电池辅助的RFID应答器。

4. 发明申请

US20070024425A1 Active capacitive coupling RFID device, system and method of production thereof 审中-公开
标题翻译：有源电容耦合RFID器件，系统及其生产方法
公开(公告)号：US20070024425A1
公开(公告)日：2007-02-01
申请号：US11495556
申请日：2006-07-31
申请人： Zvi Nitzan , Doron Lavee , Yoram Karmon
发明人： Zvi Nitzan , Doron Lavee , Yoram Karmon
IPC分类号： H04Q5/22
CPC分类号： G06K19/0723
摘要： The present invention is of an active RFID system configured for SIMPLEX two way communication based on conductive coupling, wherein two way communication is non-simultaneous and can operate on a single frequency comprising at least one capacitive coupling reader, wherein the reader is configured to transmit modulated or unmodulated RF electric signals and to receive and decode data transmitted by the transponder; at least one active capacitive coupling RFID transponder comprising at least one integrated circuit, which is arranged to store a code comprising information and which is configured for capacitive coupled RFID transponder application; at least one antenna configured to receive signal from the at least one reader, and transmit the transponder code comprising information; and at least one power source for providing energy to operate the at least one integrated circuit and transponder transmission; and at least one data processing device for processing the data received from the reader. The fully active transponder includes a carrier frequency control circuit wherein the carrier frequency generator is configured to facilitate correction of frequency error in comparison to the reader transmitter carrier frequency.
摘要翻译：本发明是一种有源RFID系统，其被配置用于基于导电耦合的SIMPLEX双向通信，其中双向通信是非同时的并且可以在包括至少一个电容耦合读取器的单个频率上操作，其中读取器被配置为传输调制或未调制的RF电信号并且接收和解码由应答器发送的数据; 至少一个有源电容耦合RFID应答器，其包括至少一个集成电路，其被布置为存储包括信息的代码，并且被配置用于电容耦合RFID应答器应用; 至少一个天线被配置为从所述至少一个读取器接收信号，并且发送包括信息的所述应答器代码; 以及用于提供能量以操作所述至少一个集成电路和应答器传输的至少一个电源; 以及用于处理从读取器接收的数据的至少一个数据处理装置。完全有效的应答器包括载波频率控制电路，其中载波频率发生器被配置为便于与读取器发射机载波频率相比频率误差的校正。

5. 发明授权

US07884720B2 Intermediate attachment mechanism and use thereof in RFID transponder 失效
标题翻译：中间附件机构及其在RFID应答器中的应用
公开(公告)号：US07884720B2
公开(公告)日：2011-02-08
申请号：US11997434
申请日：2006-07-31
申请人： Zvi Nitzan , Yoram Karmon
发明人： Zvi Nitzan , Yoram Karmon
IPC分类号： G08B13/14
CPC分类号： G06K19/0702 , G06K19/07749 , G06K19/0775
摘要： The present invention provides an intermediate attachment mechanism, called a powerposer (10), which includes at least one power source (16) coupled to an integrated circuit (14), at least one integrated circuit, which is arranged to store a code comprising information and powered with energy provided by the power source and a substrate (12) on which the at least one power source and the at least one integrated circuit are disposed, and wherein the substrate comprises connection means (22) for connecting to an application device and attachment means for attaching to the application device. Further, the present invention provides a battery assisted or active RFID transponder featuring a transponder substrate, at least one antenna disposed on the transponder substrate and a powerposer disposed on the transponder substrate. Still further the present invention provides methods of production of a powerposer and an active or battery assisted RFID transponder comprising a powerposer.
摘要翻译：本发明提供一种称为动力牵引器（10）的中间连接机构，其包括耦合到集成电路（14）的至少一个电源（16），至少一个集成电路，其被设置为存储包括信息的代码并且由电源提供的能量和其上设置有至少一个电源和至少一个集成电路的基板（12）供电，并且其中所述基板包括用于连接到应用装置的连接装置（22）用于附接到应用装置的附接装置。此外，本发明提供了一种电池辅助或有源的RFID应答器，其特征在于应答器基板，设置在应答器基板上的至少一个天线和设置在应答器基板上的电源接头。本发明进一步提供了一种制造动力装置的方法以及包括动力装置的主动或电池辅助的RFID应答器。

6. 发明申请

US20060264804A1 Device and kit for delivery of encapsulated substances and methods of use thereof 审中-公开
标题翻译：用于递送包封物质的装置和试剂盒及其使用方法
公开(公告)号：US20060264804A1
公开(公告)日：2006-11-23
申请号：US11397864
申请日：2006-04-05
申请人： Yoram Karmon , Nurit Harel , Daniela Mavor , Michal Shahar
发明人： Yoram Karmon , Nurit Harel , Daniela Mavor , Michal Shahar
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/0412 , A61N1/042 , A61N1/0428 , A61N1/0436
摘要： The present invention is of a kit and electricity generating device for delivery of an encapsulated composition or mixture of compositions, including an electricity generating device and at least one composition in an encapsulated carrier vehicle which is contacted or applied to the electricity generating device. In some embodiments the device includes a means for maintaining stability of the encapsulated composition prior to bio-membrane penetration. The present invention also provides methods of use thereof. Furthermore, the present invention provides a device and method for delivering a fixed ratio of compounds from a mixture to a bio-membrane comprising the step of electro-transporting an encapsulated mixture of compounds. Still further, the present invention is of a device and method for delivering each compound of a mixture of compounds to the same penetration depth.
摘要翻译：本发明是用于递送包封的组合物或组合物混合物的套件和发电装置，其包括发电装置和与发电装置接触或应用于封装载体车辆中的至少一种组合物。在一些实施方案中，该装置包括用于在生物膜渗透之前保持包封的组合物的稳定性的装置。本发明还提供了其使用方法。此外，本发明提供了一种用于将固体比例的化合物从混合物输送到生物膜的装置和方法，包括电转移化合物的包封混合物的步骤。此外，本发明是将化合物的混合物的每种化合物输送到相同穿透深度的装置和方法。

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