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1. 发明授权

US08530491B2 Antimalarial compounds with flexible side-chains 有权
标题翻译：具有柔性侧链的抗疟药化合物
公开(公告)号：US08530491B2
公开(公告)日：2013-09-10
申请号：US12247953
申请日：2008-10-08
申请人： Yongyuth Yuthavong , Tirayut Vilaivan , Sumalee Kamchonwongpaisan , Bongkoch Tarnchompoo , Chawanee Thongpanchang , Penchit Chitnumsub , Jirundon Yuvaniyama , David Matthews , William Charman , Susan Charman , Livia Vivas , Sanjay Babu Katiyar
发明人： Yongyuth Yuthavong , Tirayut Vilaivan , Sumalee Kamchonwongpaisan , Bongkoch Tarnchompoo , Chawanee Thongpanchang , Penchit Chitnumsub , Jirundon Yuvaniyama , David Matthews , William Charman , Susan Charman , Livia Vivas , Sanjay Babu Katiyar
IPC分类号： A61K31/505 , C07D401/02
CPC分类号： C07D401/04 , C07D239/48 , C07D401/12
摘要： The present invention relates to novel compounds that are inhibitors of wild type and mutant dihydrofolate reductase (DHFR) of Plasmodium falciparum, which are useful for the treatment of malaria. It also relates to processes of making and using such compounds. The antimalarial compounds of the present invention have low toxicity to a host infected with the malarial parasite, and are potent when administered in pharmaceutical compositions.
摘要翻译：本发明涉及作为恶性疟原虫的野生型抑制剂和突变型二氢叶酸还原酶（DHFR）的新型化合物，其可用于治疗疟疾。它还涉及制备和使用这些化合物的方法。本发明的抗疟疾化合物对感染疟疾寄生虫的宿主具有低毒性，并且在药物组合物中施用时是有效的。

2. 发明申请

US20090099220A1 ANTIMALARIAL COMPOUNDS WITH FLEXIBLE SIDE-CHAINS 有权
标题翻译：具有柔性侧链的抗微生物化合物
公开(公告)号：US20090099220A1
公开(公告)日：2009-04-16
申请号：US12247953
申请日：2008-10-08
申请人： Yongyuth YUTHAVONG , Tirayut Vilaivan , Sumalee Kamchonwongpaisan , Bongkoch Tarnchompoo , Chawanee Thongpanchang , Penchit Chitnumsub , Jirundon Yuvaniyama , David Matthews , William Charman , Susan Charman , Livia Vivas , Sanjay Babu Katiyar
发明人： Yongyuth YUTHAVONG , Tirayut Vilaivan , Sumalee Kamchonwongpaisan , Bongkoch Tarnchompoo , Chawanee Thongpanchang , Penchit Chitnumsub , Jirundon Yuvaniyama , David Matthews , William Charman , Susan Charman , Livia Vivas , Sanjay Babu Katiyar
IPC分类号： A61K31/505 , C07D239/12 , C07D401/04 , A61P33/06 , A61K31/506
CPC分类号： C07D401/04 , C07D239/48 , C07D401/12
摘要： The present invention relates to novel compounds that are inhibitors of wild type and mutant dihydrofolate reductase (DHFR) of Plasmodium falciparum, which are useful for the treatment of malaria. It also relates to processes of making and using such compounds. The antimalarial compounds of the present invention have low toxicity to a host infected with the malarial parasite, and are potent when administered in pharmaceutical compositions.
摘要翻译：本发明涉及作为恶性疟原虫的野生型抑制剂和突变型二氢叶酸还原酶（DHFR）的新型化合物，其可用于治疗疟疾。它还涉及制备和使用这些化合物的方法。本发明的抗疟疾化合物对感染疟疾寄生虫的宿主具有低毒性，并且在药物组合物中施用时是有效的。

3. 发明授权

US07098321B2 Homologous peptide nucleic acids 有权
公开(公告)号：US07098321B2
公开(公告)日：2006-08-29
申请号：US10357589
申请日：2003-02-04
申请人： Gordon Lowe , Tirayut Vilaivan
发明人： Gordon Lowe , Tirayut Vilaivan
IPC分类号： C07H21/00 , C07H21/02 , C07H21/04 , C12Q1/68
CPC分类号： C07K14/003 , Y02P20/55
摘要： The invention discloses compounds of the formula: where n is 1, or 2 to 200 in which case each recurring unit can be the same or different, B is a protected or unprotected base capable of Watson-Crick or of Hoogsteen pairing. C is OH or OR′″ where R′″ is a protecting group or an activating group or a lipophilic group or an amino acid or amino amide or nucleoside, D is H or a protecting group or a lipophilic group or an amino acyl group or nucleoside, each of R′ and R″, which may be the same or different, is an alkyl or aryl group or R′ and R″ together represent 2 or more chain atoms necessary to complete an unsaturated or saturated ring with X and Y, said ring being optionally substituted and optionally being fused to at least one other ring, X represents and Y represents or wherein Y′ represents hydrogen or additionally, when R′ and R″ do not together complete a ring, an alkyl or aryl group, and X′, when R′ and R″ together complete a ring, represents hydrogen or forms a bridge with another atom of the ring, or when R′ and R″ do not together complete a ring, represents hydrogen or an alkyl or aryl group as well as a method of analysing a polynucleotide sequence comprising incubating the sequence with a probe comprising a compound of the above invention in which n is 2 or more under suitable hybridisation conditions, and detecting the presence or absence of any hybrid formed.

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