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1. 发明授权

US07058650B2 Methods for establishing a pathways database and performing pathway searches 失效
公开(公告)号：US07058650B2
公开(公告)日：2006-06-06
申请号：US10081904
申请日：2002-02-20
申请人： Yonghong Yang , John Tillinghast , Christopher Piercy
发明人： Yonghong Yang , John Tillinghast , Christopher Piercy
IPC分类号： G06F7/00 , G01N33/48 , C12Q1/68 , G06G7/48
CPC分类号： G06F19/28 , G06F19/12 , Y10S707/954 , Y10S707/99931 , Y10S707/99943
摘要： The invention provides a computerized storage and retrieval system for storing biological information organized as a protein pathways database and methods for performing pathway searches on nodes (proteins or other molecules), modes (interactions), and nodes-and-modes. The protein pathways database is a relational database that integrates protein sequence, genomic sequence, gene-expression, protein interactions, protein-protein association and pathway data and can be searched using a query pathway to predict homologous or orthologous nodes, modes, and pathways.

2. 发明授权

US08748377B2 Pharmaceutical compositions 有权
标题翻译：药物组合物
公开(公告)号：US08748377B2
公开(公告)日：2014-06-10
申请号：US13133976
申请日：2009-12-10
申请人： Mark A. Bush , Murray W. Stewart , Yonghong Yang
发明人： Mark A. Bush , Murray W. Stewart , Yonghong Yang
IPC分类号： A61P7/12 , A61K38/00 , A61K38/22 , A61K39/00
CPC分类号： A61K38/26 , A61K45/06 , C07K14/605
摘要： The present invention provides pharmaceutical compositions comprising at least one polypeptide having GLP-1 activity wherein an effective dose of said pharmaceutical composition comprises 15 mg, 30 mg, 50 mg or 100 mg of said polypeptide having GLP-1 activity. Also provided are methods of administering the pharmaceutical compositions of the invention.
摘要翻译：本发明提供包含至少一种具有GLP-1活性的多肽的药物组合物，其中所述药物组合物的有效剂量包含15mg，30mg，50mg或100mg所述具有GLP-1活性的多肽。还提供了施用本发明的药物组合物的方法。

3. 发明申请

US20050170374A1 Novel nucleic acids and polypeptides 审中-公开
公开(公告)号：US20050170374A1
公开(公告)日：2005-08-04
申请号：US10945678
申请日：2004-09-20
申请人： Y. Tang , Zhi Wang , Ping Zhou , Chongjun Xu , Feiyan Ren , Rui-Hong Chen , Jian-Rui Wang , Yonghong Yang , Radoje Drmanac
发明人： Y. Tang , Zhi Wang , Ping Zhou , Chongjun Xu , Feiyan Ren , Rui-Hong Chen , Jian-Rui Wang , Yonghong Yang , Radoje Drmanac
IPC分类号： A61K38/00 , C07K14/47 , C07K14/81 , C07K16/00 , C12N9/16 , C12N9/64 , C12Q1/68 , C07H21/04 , C07K16/18
CPC分类号： C12N9/6432 , A01K2217/05 , A61K38/00 , A61K2039/505 , C07K14/47 , C07K14/8107 , C07K16/00 , C07K2319/00 , C12N9/16 , C12Y304/21006
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.

4. 发明授权

US08906354B2 Loaded latex optical molecular imaging probes containing lipophilic large stokes shift dyes 有权
标题翻译：装载胶乳光学分子成像探针，含有亲脂性大型斯托克斯位移染料
公开(公告)号：US08906354B2
公开(公告)日：2014-12-09
申请号：US13043057
申请日：2011-03-08
申请人： Tao Ji , Hans F. Schmitthenner , Yonghong Yang , John W. Harder , Jeffrey W. Leon , William J. Harrison , Brian J. Kelley , James R. Bennett , David A. Stegman , Ruizheng Wang
发明人： Tao Ji , Hans F. Schmitthenner , Yonghong Yang , John W. Harder , Jeffrey W. Leon , William J. Harrison , Brian J. Kelley , James R. Bennett , David A. Stegman , Ruizheng Wang
IPC分类号： A61K49/00 , B82Y15/00
CPC分类号： A61K49/0054 , A61K49/0032 , A61K49/0093 , B82Y15/00
摘要： The present invention relates to a loaded particle comprising at least one fluorescent dye, and in particular, a fluorescent dye with a large Stokes shift. The invention further relates to a method for producing an loaded latex particle, loaded with a fluorescent dye having a large stokes shift. In addition, the present invention relates to latex particles loaded with fluorescent dyes that are organic solvent soluble and insoluble in water. In a preferred embodiment, when the dyes are loaded into the water soluble latex particle, an increase is observed in quantum yield of fluorescence as compared to the quantum yield of the dye in aqueous solvent.
摘要翻译：本发明涉及包含至少一种荧光染料的负载颗粒，特别是具有大的斯托克斯位移的荧光染料。本发明还涉及一种负载胶乳粒子的方法，该方法装载有具有较大的斯托克斯位移的荧光染料。此外，本发明涉及装有荧光染料的胶乳颗粒，其是可溶于和不溶于水的有机溶剂。在优选的实施方案中，当将染料加载到水溶性胶乳颗粒中时，与水性溶剂中染料的量子产率相比，观察到荧光量子产率的增加。

5. 发明申请

US20110301080A1 PHARMACEUTICAL COMPOSITIONS 有权
标题翻译：药物组合物
公开(公告)号：US20110301080A1
公开(公告)日：2011-12-08
申请号：US13133976
申请日：2009-12-10
申请人： Mark A. Bush , Murray W. Stewart , Yonghong Yang
发明人： Mark A. Bush , Murray W. Stewart , Yonghong Yang
IPC分类号： A61K38/22 , A61P9/00 , A61P3/04 , A61K38/28 , A61P3/10
CPC分类号： A61K38/26 , A61K45/06 , C07K14/605
摘要： The present invention provides pharmaceutical compositions comprising at least one polypeptide having GLP-1 activity wherein an effective dose of said pharmaceutical composition comprises 15 mg, 30 mg, 50 mg or 100 mg of said polypeptide having GLP-1 activity. Also provided are methods of administering the pharmaceutical compositions of the invention.
摘要翻译：本发明提供包含至少一种具有GLP-1活性的多肽的药物组合物，其中所述药物组合物的有效剂量包含15mg，30mg，50mg或100mg所述具有GLP-1活性的多肽。还提供了施用本发明的药物组合物的方法。

6. 发明申请

US20080077570A1 Full Text Query and Search Systems and Method of Use 审中-公开
标题翻译：全文查询和搜索系统及其使用方法
公开(公告)号：US20080077570A1
公开(公告)日：2008-03-27
申请号：US11740247
申请日：2007-04-25
申请人： Yuanhua Tang , Qianjin Hu , Yonghong Yang , Chunnuan Chen , Minghua Mei
发明人： Yuanhua Tang , Qianjin Hu , Yonghong Yang , Chunnuan Chen , Minghua Mei
IPC分类号： G06F17/30
CPC分类号： G06F16/3346 , G06F16/3344 , G06F16/951
摘要： Roughly described, a database searching method for searching a database, in which hits are ranked in dependence upon an information measure of itoms shared by both the hit and the query. The information measure can be a Shannon information score, or another measure which indicates the information value of the shared itoms. An itom can be a word or other token, or a multi-word phrase, and can overlap with each other. Synonyms can be substituted for itoms in the query, with the information measure of substituted itoms being derated in accordance with a predetermined measure of the synonyms' similarity. Indirect searching methods are described in which hit from other search engines are re-ranked in dependence upon the information measures of shared itoms. Structured and completely unstructured databases may be searched, with hits being demarcated dynamically. Hits may be clustered based upon distances in an information-measure-weighted distance space.
摘要翻译：粗略地描述了一种用于搜索数据库的数据库搜索方法，其中命中根据命中和查询共享的itom的信息度量进行排名。信息度量可以是香农信息评分，或者指示共享信息的信息值的另一个度量。 itom可以是单词或其他令牌，或多个单词的短语，并且可以相互重叠。同义词可以替代查询中的itom，根据同义词相似性的预定度量，取代的itom的信息度量被降级。描述间接搜索方法，其中来自其他搜索引擎的命中根据共享itom的信息度量重新排序。可以搜索结构化和完全非结构化的数据库，动态地划分命中。点击可以基于信息测量加权距离空间中的距离进行聚类。

7. 发明申请

US20060212441A1 Full text query and search systems and methods of use 审中-公开
标题翻译：全文查询和搜索系统及使用方法
公开(公告)号：US20060212441A1
公开(公告)日：2006-09-21
申请号：US11259468
申请日：2005-10-25
申请人： Yuanhua Tang , Qianjin Hu , Yonghong Yang
发明人： Yuanhua Tang , Qianjin Hu , Yonghong Yang
IPC分类号： G06F17/30
CPC分类号： G06F16/3346 , G06F16/951
摘要： The invention is a method for textual searching of text-based databases including databases of compiled internet content, scientific literature, abstracts for books and articles, newspapers, journals, and the like. Specifically, the algorithm supports searches using full-text or webpage as query and keyword searches allowing multiple entries and an information-content based ranking system (Shannon Information score) that uses p-values to represent the likelihood that a hit is due to random matches. Additionally, users can specify the parameters that determine hits and their ranking with scoring based on phrase matches and sentence similarities.
摘要翻译：本发明是一种用于文本搜索文本搜索方法，包括编译的互联网内容，科学文献，图书和文章摘要，报纸，期刊等的数据库。具体来说，该算法支持使用全文或网页的搜索，作为允许多个条目的查询和关键词搜索以及使用p值的基于信息内容的排名系统（Shannon Information score）来表示命中是由于随机匹配的可能性。此外，用户可以根据短语匹配和句子相似性指定确定匹配及其排名的参数。

8. 发明授权

US07082186B2 Container inspection system using cobalt-60 γ-ray source and cesium iodide or cadmium tungstate array detector 失效
标题翻译：使用钴-60伽马射线源和碘化铯或钨酸镉阵列检测器的集装箱检验系统
公开(公告)号：US07082186B2
公开(公告)日：2006-07-25
申请号：US10480448
申请日：2002-06-28
申请人： Jinggi Zhao , Huimin Chen , Qifang Han , Zhicheng Huang , Li Chen , Yongging Li , Bo Meng , Hancheng Sun , Jinhan Luo , Yishan Wang , Hong Li , Chuan Jin , Guoping Dong , Xiaoyuan Huang , Mingwen Dong , Junqing Liu , Yonghong Yang , Dong Li , Xiaodong Yao , Quan Zhou
发明人： Jinggi Zhao , Huimin Chen , Qifang Han , Zhicheng Huang , Li Chen , Yongging Li , Bo Meng , Hancheng Sun , Jinhan Luo , Yishan Wang , Hong Li , Chuan Jin , Guoping Dong , Xiaoyuan Huang , Mingwen Dong , Junqing Liu , Yonghong Yang , Dong Li , Xiaodong Yao , Quan Zhou
IPC分类号： G01N23/04 , G21K1/00 , G21K1/02
CPC分类号： G01V5/0016
摘要： A container inspection equipment with cobalt-60 γ-ray source and cesium iodide or cadmium tungstate detector includes a cobalt-60 γ-ray source, a cask, a front collimator, a rear collimator, a cesium iodide or cadmium tungstate detector, signal and image processing systems, container trailer system, and automatic control system. The cask of the cobalt-60 γ-ray source, the beam shutter, and the front collimator are fixed on the same chassis to form an integration and placed in the source room. The rear collimator, cesium iodide or cadmium tungstate array detector and the radiation catcher are fixed on the same chassis to form an integration and placed in the detector room. A container inspection tunnel is formed between the source room and the detector room. The equipment is mainly used for inspecting smuggling goods and contrabands etc., in large containers, container trucks, train carriage and air containers. The equipment either can be installed in the sea port and land frontier customs or installed at the air port, vital communication line, and railway station.
摘要翻译：具有钴-60γ射线源和碘化铯或钨酸镉检测器的容器检查设备包括钴-60γ射线源，桶，前准直仪，后准直仪，碘化铯或钨酸镉检测器，信号和图像处理系统，集装箱拖车系统以及自动控制系统。钴-60伽马射线源，光束快门和前准直器的木桶固定在相同的底盘上，形成一体化并放置在源室中。后准直仪，碘化铯或钨酸镉阵列检测器和辐射捕获器固定在相同的底盘上，形成一体化并放置在检测室中。在源室和检测室之间形成容器检查通道。该设备主要用于大型集装箱，集装箱卡车，列车运输和空运集装箱的走私货物和违禁品等的检验。设备可以安装在海港和陆上海关，也可以安装在空港，重要通信线路和火车站。

9. 发明申请

US20050202422A1 Novel nucleic acids and polypeptides 审中-公开
公开(公告)号：US20050202422A1
公开(公告)日：2005-09-15
申请号：US10291128
申请日：2002-11-08
申请人： Y. Tang , Chenghua Liu , Vinod Asundi , Rui-Hong Chen , Feiyan Ren , Dunrui Wang , Jian-Rui Wang , Chongjun Xu , Aidong Xue , Yonghong Yang , Jie Zhang , Qing Zhao , Ping Zhou , Ryle Goodrich , Radoje Drmanac
发明人： Y. Tang , Chenghua Liu , Vinod Asundi , Rui-Hong Chen , Feiyan Ren , Dunrui Wang , Jian-Rui Wang , Chongjun Xu , Aidong Xue , Yonghong Yang , Jie Zhang , Qing Zhao , Ping Zhou , Ryle Goodrich , Radoje Drmanac
IPC分类号： A61K38/00 , C07K14/81 , C12Q1/68 , A61K38/17 , C07H21/04 , C07K14/47 , C12N9/00
CPC分类号： C07K14/8107 , A61K38/00
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.

10. 发明申请

US20050175607A1 Novel nucleic acids and polypeptides 审中-公开
公开(公告)号：US20050175607A1
公开(公告)日：2005-08-11
申请号：US10220335
申请日：2001-02-26
申请人： Y Tang , Chenghua Liu , Vinod Asundi , Chongjun Xu , Tom Wehrman , Feiyan Ren , Yunqing Ma , Ping Zhou , Qing Zha , Yonghong Yang , Radoje Drmanac , Jie Zhang , Rui-hong Chen , Jian-Rui Wang , Dunrui Wang , Aidong Xue
发明人： Y Tang , Chenghua Liu , Vinod Asundi , Chongjun Xu , Tom Wehrman , Feiyan Ren , Yunqing Ma , Ping Zhou , Qing Zha , Yonghong Yang , Radoje Drmanac , Jie Zhang , Rui-hong Chen , Jian-Rui Wang , Dunrui Wang , Aidong Xue
IPC分类号： C07K14/47 , C12Q1/68 , A61K39/395 , C07H21/04 , C07K14/52 , C07K16/24
CPC分类号： C07K14/47 , C12Q1/6886
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.

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