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1. 发明申请

US20110046400A1 PREPARATION METHOD OF (3S,4S)-3-HEXYL-4-((R)-2-HYDROXYTRIDECYL)-OXETAN-2-0NE AND THE PRODUCT OF THAT METHOD 有权
标题翻译：（3S，4S）-3-甲基-4 - （（R）-2-羟基吡啶基） - 异-2-烯的制备方法及其制法
公开(公告)号：US20110046400A1
公开(公告)日：2011-02-24
申请号：US12990111
申请日：2008-05-26
申请人： Yong Qin , Xianglin Deng , Xuan Zhou , Guofeng Yu , Ke Wang , Hao Song , Xiaolin Wang , Shan Huang
发明人： Yong Qin , Xianglin Deng , Xuan Zhou , Guofeng Yu , Ke Wang , Hao Song , Xiaolin Wang , Shan Huang
IPC分类号： C07D305/12
CPC分类号： C07D305/12 , C07D213/70
摘要： The present invention relates to a method for the preparation of (3S,4S)-3-hexyl-4-((R)-2-hydroxytridecyl)-oxetan-2-one and a product of the method. The method includes the following steps: a) reducing a substance represented by formula (II) to obtain a substance represented by formula (III), and then oxidizing the substance represented by formula (III) to form a substance represented by formula (IV); b) acylating n-octanoic acid to obtain n-octanoyl chloride using thionyl dichloride, then condensing the obtained n-octanoyl chloride with 2-mercapto-pyridine under basic condition to form a substance represented by formula (V), and then converting the substance represented by formula (V) to a substance represented by formula (VI); c) reacting the substance obtained in the step a) with the substance obtained in the step b) under catalytic condition of Lewis acid to generate a substance represented by formula (VII), and then reacting with a Lewis acid. The meanings of the signs in these formulas are the same as those in the description.
摘要翻译：本发明涉及制备（3S，4S）-3-己基-4 - （（R）-2-羟基十三烷基）氧杂环丁烷-2-酮的方法和该方法的产物。该方法包括以下步骤：a）还原由式（II）表示的物质以获得由式（III）表示的物质，然后氧化由式（III）表示的物质以形成由式（IV）表示的物质， ; b）用正辛酸酰化得到正辛酰氯，然后在碱性条件下将所得的正辛酰氯与2-巯基 - 吡啶缩合形成式（Ⅴ）表示的物质，然后转化成物质由式（Ⅴ）代表由式（Ⅵ）表示的物质; c）在路易斯酸的催化条件下，使步骤a）中获得的物质与步骤b）中获得的物质反应，生成由式（Ⅶ）表示的物质，然后与路易斯酸反应。这些公式中的符号的含义与描述中的符号的含义相同。

2. 发明授权

US08431726B2 Preparation method of (3S,4S)-3-hexyl-4-((R)-2-hydroxytridecyl)-oxetan-2-one and the product of that method 有权
标题翻译：（3S，4S）-3-己基-4 - （（R）-2-羟基十三烷基） - 氧杂环丁烷-2-酮的制备方法和该方法的产物
公开(公告)号：US08431726B2
公开(公告)日：2013-04-30
申请号：US12990111
申请日：2008-05-26
申请人： Yong Qin , Xianglin Deng , Xuan Zhou , Guofeng Yu , Ke Wang , Hao Song , Xiaolin Wang , Shan Huang
发明人： Yong Qin , Xianglin Deng , Xuan Zhou , Guofeng Yu , Ke Wang , Hao Song , Xiaolin Wang , Shan Huang
IPC分类号： C07D305/12
CPC分类号： C07D305/12 , C07D213/70
摘要： The present invention relates to a method for the preparation of (3S,4S)-3-hexyl-4-((R)-2-hydroxytridecyl)-oxetan-2-one and a product of the method. The method includes the following steps: a) reducing a substance represented by formula (II) to obtain a substance represented by formula (III), and then oxidizing the substance represented by formula (III) to form a substance represented by formula (IV); b) acylating n-octanoic acid to obtain n-octanoyl chloride using thionyl dichloride, then condensing the obtained n-octanoyl chloride with 2-mercapto-pyridine under basic condition to form a substance represented by formula (V), and then converting the substance represented by formula (V) to a substance represented by formula (VI); c) reacting the substance obtained in the step a) with the substance obtained in the step b) under catalytic condition of Lewis acid to generate a substance represented by formula (VII), and then reacting with a Lewis acid. The meanings of the signs in these formulas are the same as those in the description.
摘要翻译：本发明涉及制备（3S，4S）-3-己基-4 - （（R）-2-羟基十三烷基）氧杂环丁烷-2-酮的方法和该方法的产物。该方法包括以下步骤：a）还原由式（II）表示的物质以获得由式（III）表示的物质，然后氧化由式（III）表示的物质以形成由式（IV）表示的物质， ; b）用正辛酸酰化得到正辛酰氯，然后在碱性条件下将所得正辛酰氯与2-巯基 - 吡啶缩合形成式（Ⅴ）表示的物质，然后转化成物质由式（Ⅴ）代表由式（Ⅵ）表示的物质; c）在路易斯酸的催化条件下，使步骤a）中获得的物质与步骤b）中获得的物质反应，生成由式（Ⅶ）表示的物质，然后与路易斯酸反应。这些公式中的符号的含义与描述中的符号的含义相同。

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