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1. 发明授权

US07524292B2 Method and apparatus for detecting respiratory disturbances 有权
标题翻译：用于检测呼吸障碍的方法和装置
公开(公告)号：US07524292B2
公开(公告)日：2009-04-28
申请号：US11565092
申请日：2006-11-30
申请人： Yong K. Cho , Steven L. Ning , Luc R. Mongeon , Scott W. Davie , Todd J. Sheldon , Mark K. Erickson , H. Toby Markowitz
发明人： Yong K. Cho , Steven L. Ning , Luc R. Mongeon , Scott W. Davie , Todd J. Sheldon , Mark K. Erickson , H. Toby Markowitz
IPC分类号： A61B5/08 , A61B5/02 , A61B5/00 , A61B5/103 , A61B5/05
CPC分类号： A61B5/0809 , A61B5/0205 , A61B5/0215 , A61B5/0402 , A61B5/1459 , A61B5/4818 , G06F19/00
摘要： A system and method for monitoring respiration including sensing a signal that varies with respiration, deriving a respiration parameter, applying criteria for detecting a respiration disturbance and determining one or more respiratory disturbance metrics. The system preferably includes an implantable sensor with an associated implantable medical device such that chronic respiration monitoring is possible. The implantable medical device may execute methods for detecting and measuring respiratory disturbances or may store data to be transferred to an external device for detecting and measuring respiratory disturbances. Respiratory disturbance detection may trigger a responsive action such as physiological data storage, a change in therapy delivery, or a clinician warning. Assessment of cardiac function may be made based on metrics of respiratory disturbances or a measure of circulatory delay time following detection of a respiratory disturbance.
摘要翻译：一种用于监测呼吸的系统和方法，包括感测随呼吸变化的信号，导出呼吸参数，应用用于检测呼吸障碍的标准和确定一个或多个呼吸障碍度量。该系统优选地包括具有相关联的可植入医疗装置的可植入传感器，使得可以进行慢性呼吸监测。可植入医疗装置可以执行用于检测和测量呼吸障碍的方法，或者可以将要传送到外部设备的数据存储以检测和测量呼吸障碍。呼吸道干扰检测可能会触发响应动作，如生理数据存储，治疗传递的变化或临床医生的警告。心脏功能的评估可以基于呼吸紊乱的度量或检测到呼吸障碍之后的循环延迟时间的量度进行。

2. 发明授权

US07025730B2 System and method for automatically monitoring and delivering therapy for sleep-related disordered breathing 失效
标题翻译：用于自动监测和输送睡眠相关无序呼吸治疗的系统和方法
公开(公告)号：US07025730B2
公开(公告)日：2006-04-11
申请号：US10419465
申请日：2003-04-21
申请人： Yong K. Cho , Mark K. Erickson , H. Toby Markowitz
发明人： Yong K. Cho , Mark K. Erickson , H. Toby Markowitz
IPC分类号： A61B5/08
CPC分类号： A61N1/3601 , A61N1/36514
摘要： The invention relates generally to a system and method for monitoring and automatically delivering a therapy for sleep-related disordered breathing. In one form the present invention relates to an external device for monitoring for sleep-related disordered breathing in communication with an implantable medical device for delivering an electrical stimulation therapy. In another form the present invention relates to an implantable medical device for detecting sleep-related disordered breathing episode(s) and an external apparatus (e.g., a CPAP machine) for providing therapy to terminate, and/or reduce, said episode(s). In this form of the invention, the implantable medical device communicates with the external apparatus so that the therapy provided corresponds in magnitude and duration to the severity and/or length of the episode(s). In yet another form, an implantable apparatus detects said disordered breathing episode(s) and a hybrid therapy is provided by both the implantable apparatus and an external apparatus.
摘要翻译：本发明一般涉及用于监测和自动递送针对睡眠相关无序呼吸的治疗的系统和方法。在一种形式中，本发明涉及一种用于监测与可植入医疗装置进行通信以进行电刺激治疗的与睡眠有关的无序呼吸的外部装置。在另一种形式中，本发明涉及一种用于检测睡眠相关的无序呼吸发作的可植入医疗装置和用于提供终止和/或减少所述发作的治疗的外部装置（例如，CPAP机）。在本发明的这种形式中，可植入医疗装置与外部装置通信，使得所提供的治疗的大小和持续时间与发作的严重性和/或长度相对应。在另一种形式中，可植入装置检测所述无序呼吸事件，并且可植入装置和外部装置都提供混合治疗。

3. 发明授权

US07160252B2 Method and apparatus for detecting respiratory disturbances 有权
标题翻译：用于检测呼吸障碍的方法和装置
公开(公告)号：US07160252B2
公开(公告)日：2007-01-09
申请号：US10419467
申请日：2003-04-21
申请人： Yong K. Cho , Steven L. Ning , Luc R. Mongeon , Scott W. Davie , Todd J. Sheldon , Mark K. Erickson , H. Toby Markowitz
发明人： Yong K. Cho , Steven L. Ning , Luc R. Mongeon , Scott W. Davie , Todd J. Sheldon , Mark K. Erickson , H. Toby Markowitz
IPC分类号： A61B5/02 , A61B5/05 , A61B5/00
CPC分类号： A61B5/145 , A61B5/0205 , A61B5/029 , A61B5/0809 , A61B5/0816 , A61B5/091 , A61B5/4818 , A61M2016/0021 , A61M2230/04 , A61M2230/205 , A61M2230/60 , A61M2230/63 , A61M2230/65 , G06F19/00
摘要： A system and method for monitoring respiration including sensing a signal that varies with respiration, deriving a respiration parameter, applying criteria for detecting a respiration disturbance and determining one or more respiratory disturbance metrics. The system preferably includes an implantable sensor with an associated implantable medical device such that chronic respiration monitoring is possible. The implantable medical device may execute methods for detecting and measuring respiratory disturbances or may store data to be transferred to an external device for detecting and measuring respiratory disturbances. Respiratory disturbance detection may trigger a responsive action such as physiological data storage, a change in therapy delivery, or a clinician warning. Assessment of cardiac function may be made based on metrics of respiratory disturbances or a measure of circulatory delay time following detection of a respiratory disturbance.
摘要翻译：一种用于监测呼吸的系统和方法，包括感测随呼吸变化的信号，导出呼吸参数，应用用于检测呼吸障碍的标准和确定一个或多个呼吸障碍度量。该系统优选地包括具有相关联的可植入医疗装置的可植入传感器，使得可以进行慢性呼吸监测。可植入医疗装置可以执行用于检测和测量呼吸障碍的方法，或者可以将要传送到外部设备的数据存储以检测和测量呼吸障碍。呼吸道干扰检测可能会触发响应动作，如生理数据存储，治疗传递的变化或临床医生的警告。心脏功能的评估可以基于呼吸紊乱的度量或检测到呼吸障碍之后的循环延迟时间的量度进行。

4. 发明授权

US07315759B2 Implantable medical device with circulation delay measurement and therapy control 有权
标题翻译：具有循环延迟测量和治疗控制的植入式医疗设备
公开(公告)号：US07315759B2
公开(公告)日：2008-01-01
申请号：US10945639
申请日：2004-09-21
申请人： H. Toby Markowitz , Pooja Mehta , Chad T. Giese , Mark K. Erickson , Yong K. Cho , Marina Jovanovic , Sameh Sowelam
发明人： H. Toby Markowitz , Pooja Mehta , Chad T. Giese , Mark K. Erickson , Yong K. Cho , Marina Jovanovic , Sameh Sowelam
IPC分类号： A61N1/08
CPC分类号： A61N1/3601 , A61N1/36557 , A61N1/3962
摘要： Oxygen saturation data is monitored during a predefined window to obtain a measurement of circulation delay. The measured circulation delay is used as a basis for determining therapies, including overdrive pacing. In some embodiments, circulation delay is used to identify patients that will benefit from overdrive pacing as a therapy for sleep disordered breathing.
摘要翻译：在预定窗口期间监测氧饱和度数据，以获得循环延迟的测量。测量的循环延迟被用作确定治疗的基础，包括超速起搏。在一些实施例中，循环延迟用于识别将受益于过度起搏起搏作为睡眠无序呼吸治疗的患者。

5. 发明授权

US07896813B2 System and method for monitoring periodic breathing associated with heart failure 有权
标题翻译：用于监测与心力衰竭相关的周期性呼吸的系统和方法
公开(公告)号：US07896813B2
公开(公告)日：2011-03-01
申请号：US11278187
申请日：2006-03-31
申请人： Sameh Sowelam , H. Toby Markowitz , Mark K. Erickson , Ioana Nicolaescu
发明人： Sameh Sowelam , H. Toby Markowitz , Mark K. Erickson , Ioana Nicolaescu
IPC分类号： A61B5/08
CPC分类号： A61B5/08 , A61B5/021 , A61B5/087 , A61B5/1135 , A61B5/1455 , A61B5/4818 , A61B7/003
摘要： A system and method for monitoring in a patient includes producing sensor signals representative of a physiologic parameter associated with respiration. A periodic breathing cycle is detected based on the sensor signals. An output is produced as a function of the cycle length.
摘要翻译：用于在患者中监测的系统和方法包括产生代表与呼吸相关的生理参数的传感器信号。基于传感器信号检测周期性呼吸周期。作为循环长度的函数产生输出。

6. 发明授权

US07027865B2 Pacemaker with vasovagal syncope detection and therapy 有权
标题翻译：起搏器与血管迷走性晕厥检测和治疗
公开(公告)号：US07027865B2
公开(公告)日：2006-04-11
申请号：US10414908
申请日：2003-04-16
申请人： Mark K. Erickson , H. Toby Markowitz
发明人： Mark K. Erickson , H. Toby Markowitz
IPC分类号： A61N1/36
CPC分类号： A61N1/365
摘要： A method and apparatus for cardiac pacing are provided in which pacing pulses are delivered at an increased rate in response to a detected intrinsic heart rate drop and a special rate drop response detection scheme is temporarily disabled until an intrinsic heart rate exceeds a predetermined threshold value. If the pacing rate reaches the lower pacing rate without sensing intrinsic activity, heart rate drop detection remains disabled and lower rate pacing continues. Rate drop detection is re-enabled whenever sufficient sensed intrinsic activity indicates that a sudden intrinsic rate drop could occur again. Thus, the subsequent reduction in heart rate requiring therapy is declared only if a sensed intrinsic heart rate drops from above an intermediate value (herein defined as a re-enable rate) that is set above the lower pacing rate and an upper pacing rate.
摘要翻译：提供了一种用于心脏起搏的方法和装置，其中响应于检测到的固有心率下降，以增加的速率递送起搏脉冲，并且临时禁用特殊速率下降响应检测方案，直到内在心率超过预定阈值。如果起搏速率达不到较低的起搏速率，而不检测内在活动，心率下降检测仍然被禁用，并且较低的起搏速度继续下去。只要足够的感知内在活动表明突然内在速率下降可能再次发生，速率下降检测就会重新启用。因此，仅当感测到的固有心率从设定在较低起搏速率和较高起搏速率以上的中间值（在此被定义为重新启用率）上降低时才宣布要求治疗的心率的随后降低。

7. 发明授权

US06641542B2 Method and apparatus to detect and treat sleep respiratory events 有权
公开(公告)号：US06641542B2
公开(公告)日：2003-11-04
申请号：US10133009
申请日：2002-04-26
申请人： Yong Kyun Cho , Luc R. Mongeon , Mark K. Erickson , H. Toby Markowitz
发明人： Yong Kyun Cho , Luc R. Mongeon , Mark K. Erickson , H. Toby Markowitz
IPC分类号： A61B508
CPC分类号： A61B5/08 , A61B5/0205 , A61B5/4818 , A61N1/3601
摘要： The present invention provides a method and apparatus for detecting and treating sleep respiratory events that includes a plurality of sensors gathering physiological data related to sleep respiratory events. A processor extracts an average cycle length and a frequency of at least one of Cheyne-Stokes respiration and periodic breathing based upon the physiological data, and determines whether therapy is required based on the average cycle length and the frequency.

8. 发明授权

US07130687B2 Implantable medical device and method for delivering therapy for sleep-disordered breathing 有权
标题翻译：植入式医疗装置和方法，用于为睡眠呼吸障碍提供治疗
公开(公告)号：US07130687B2
公开(公告)日：2006-10-31
申请号：US10693375
申请日：2003-10-24
申请人： Yong K. Cho , H. Toby Markowitz
发明人： Yong K. Cho , H. Toby Markowitz
IPC分类号： A61N1/362
CPC分类号： A61N1/3601 , A61B5/08 , A61B5/082 , A61N1/36521 , A61N1/36557
摘要： An implantable medical device delivers augmentation therapy to intervene in a pattern of sleep-disordered breathing. Augmentation therapy includes the delivery of electrical stimulation to cardiac tissue above and/or below a capture threshold. PESP and NES/CCM are possible augmentation therapies that are used alone or in combination. In addition, augmentation therapies can be used with other pacing therapies such as atrial overdrive pacing and atrial coordinated pacing as a therapy for sleep-disordered breathing.
摘要翻译：可植入的医疗装置提供增强疗法以介入睡眠呼吸障碍的模式。增强疗法包括将电刺激递送到高于和/或低于捕获阈值的心脏组织。 PESP和NES / CCM是单独使用或组合使用的可能的增强疗法。此外，增强疗法可以与其他起搏疗法一起使用，例如心房超速起搏和心房协调起搏作为睡眠呼吸障碍的治疗方法。

9. 发明授权

US10568546B2 Devices and methods for sizing valve apertures and luminal organs 有权
公开(公告)号：US10568546B2
公开(公告)日：2020-02-25
申请号：US14742025
申请日：2015-06-17
申请人： 3DT Holdings, LLC , H. Toby Markowitz
发明人： Ghassan S. Kassab , H. Toby Markowitz
IPC分类号： A61B5/107 , A61B5/00 , A61B5/053 , A61B5/02
摘要： Devices and methods for sizing valve apertures and luminal organs. In at least one embodiment of a device for obtaining measurements within a luminal organ of the present disclosure, the device comprises an elongated body, and at least one sizing finger positioned at a distal end of the elongated body, the at least one sizing finger configured to move from a first position to a second position by way of adjustment of at least one movable device coupled thereto, wherein a dimensional measurement within the luminal organ can be determined based upon the first position and the second position.

10. 发明授权

US09179860B2 Determining a location of a member 有权
标题翻译：确定会员的位置
公开(公告)号：US09179860B2
公开(公告)日：2015-11-10
申请号：US12423466
申请日：2009-04-14
申请人： H. Toby Markowitz , Mustafa Karamanoglu , Pooja Mehta , Ioana Fleming , David A. Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Steven L. Waldhauser , Shangqian Peter Zhang , Jeff Jannicke , Phillip Falkner , Don Hefner , Eduardo N. Warman , James Steeves , Rogier Receveur , Koen Michels , Olaf Eick , Vincent Larik
发明人： H. Toby Markowitz , Mustafa Karamanoglu , Pooja Mehta , Ioana Fleming , David A. Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Steven L. Waldhauser , Shangqian Peter Zhang , Jeff Jannicke , Phillip Falkner , Don Hefner , Eduardo N. Warman , James Steeves , Rogier Receveur , Koen Michels , Olaf Eick , Vincent Larik
IPC分类号： A61B5/05 , A61B5/06 , A61B5/0432 , A61B5/044 , A61B5/042 , A61B5/053 , A61B19/00 , A61B5/0428 , A61B8/06 , A61B8/00 , A61B17/00 , A61B17/22
CPC分类号： A61B5/061 , A61B5/0422 , A61B5/04288 , A61B5/0432 , A61B5/044 , A61B5/05 , A61B5/053 , A61B5/0538 , A61B5/06 , A61B5/062 , A61B5/063 , A61B5/066 , A61B5/4836 , A61B5/742 , A61B8/06 , A61B8/4472 , A61B34/20 , A61B34/25 , A61B2017/00022 , A61B2017/00026 , A61B2017/00053 , A61B2017/00084 , A61B2017/00243 , A61B2017/00336 , A61B2017/22051 , A61B2034/105 , A61B2090/376 , A61B2090/378 , A61B2090/3983
摘要： An volume of a patient can be mapped with a system operable to identify a plurality of locations and save a plurality of locations of a mapping instrument. The mapping instrument can include one or more electrodes that can sense a voltage that can be correlated to a three dimensional location of the electrode at the time of the sensing or measurement. Therefore, a map of a volume can be determined based upon the sensing of the plurality of points without the use of other imaging devices. An implantable medical device can then be navigated relative to the mapping data.
摘要翻译：可以用可操作以识别多个位置并且存储映射仪器的多个位置的系统来映射患者的体积。映射仪器可以包括一个或多个电极，其可以感测在感测或测量时可以与电极的三维位置相关联的电压。因此，可以基于多个点的感测而不使用其它成像装置来确定体积的映射。然后可以相对于映射数据导航可植入医疗装置。

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