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    • 1. 发明申请
    • METHOD OF PRODUCING A DRY EARTHWORM POWDER
    • 生产干土粉的方法
    • US20110086106A1
    • 2011-04-14
    • US12903615
    • 2010-10-13
    • Yoichi ISHIIKazuyuki IshiiHiroyuki SumiEtsuo YoshidaSayaka Ishii
    • Yoichi ISHIIKazuyuki IshiiHiroyuki SumiEtsuo YoshidaSayaka Ishii
    • A61K35/56
    • A61K35/62
    • Provided is a simple and easy method of producing an innoxious dry earthworm powder, while suppressing inactivation of the enzymes contained in earthworms. In the method, a homogenate obtained by grinding living earthworms is freeze-dried and the dried product is heat-treated at a temperature of 110° C. or higher but lower than 130° C. Preferably, the method according to the present invention comprises further a process for preparation of the living earthworms, which precedes the grinding step, comprising the steps of: standing the living earthworms under light for 10 to 50 hours; removing the dirt formed on the skin thereof, bringing the earthworms into contact with an organic acid for 30 seconds or less; diluting the acid with addition of water to adjust the pH of the aqueous acidic solution to a pH in the range of 2 to 5; standing the earthworm mixture under the pH condition for 3 to 180 minutes; and then washing the earthworms with water.
    • 提供了一种简单易行的生产无嗅干蚯蚓粉的方法,同时抑制蚯蚓中含有的酶的失活。 在该方法中,通过研磨活蚯蚓获得的匀浆物被冷冻干燥,干燥产物在110℃以上且低于130℃的温度下进行热处理。优选地,根据本发明的方法包括 进一步的在研磨步骤之前制备活蚯蚓的方法,包括以下步骤:将活蚯蚓放在灯下10-50小时; 除去形成在其皮肤上的污垢,使蚯蚓与有机酸接触30秒以下; 通过添加水稀释酸,以将酸性水溶液的pH调节至2至5范围内的pH; 在pH条件下静置蚯蚓混合物3〜180分钟; 然后用水洗蚯蚓。
    • 2. 发明授权
    • Method of producing a dry earthworm powder
    • 生产干蚯蚓粉的方法
    • US08394417B2
    • 2013-03-12
    • US12903615
    • 2010-10-13
    • Yoichi IshiiKazuyuki IshiiHiroyuki SumiEtsuo YoshidaSayaka Ishii
    • Yoichi IshiiKazuyuki IshiiHiroyuki SumiEtsuo YoshidaSayaka Ishii
    • A61K35/56
    • A61K35/62
    • Provided is a simple and easy method of producing an innoxious dry earthworm powder, while suppressing inactivation of the enzymes contained in earthworms. In the method, a homogenate obtained by grinding living earthworms is freeze-dried and the dried product is heat-treated at a temperature of 110° C. or higher but lower than 130° C. Preferably, the method according to the present invention comprises further a process for preparation of the living earthworms, which precedes the grinding step, comprising the steps of: standing the living earthworms under light for 10 to 50 hours; removing the dirt formed on the skin thereof, bringing the earthworms into contact with an organic acid for 30 seconds or less; diluting the acid with addition of water to adjust the pH of the aqueous acidic solution to a pH in the range of 2 to 5; standing the earthworm mixture under the pH condition for 3 to 180 minutes; and then washing the earthworms with water.
    • 提供了一种简单易行的生产无嗅干蚯蚓粉的方法,同时抑制蚯蚓中含有的酶的失活。 在该方法中,通过研磨活蚯蚓获得的匀浆物被冷冻干燥,干燥产物在110℃以上且低于130℃的温度下进行热处理。优选地,根据本发明的方法包括 进一步的在研磨步骤之前制备活蚯蚓的方法,包括以下步骤:将活蚯蚓放在灯下10-50小时; 除去形成在其皮肤上的污垢,使蚯蚓与有机酸接触30秒以下; 通过添加水稀释酸,以将酸性水溶液的pH调节至2至5范围内的pH; 在pH条件下静置蚯蚓混合物3〜180分钟; 然后用水洗蚯蚓。
    • 3. 发明授权
    • Method of producing a dry earthworm powder
    • 生产干蚯蚓粉的方法
    • US08137701B2
    • 2012-03-20
    • US12076738
    • 2008-03-21
    • Yoichi IshiiHiroyuki SumiEtsuo Yoshida
    • Yoichi IshiiHiroyuki SumiEtsuo Yoshida
    • A61K35/56
    • A61K35/62
    • Provided is a method of producing a dry earthworm powder without deterioration in useful pharmacological action, by removing dirt on the skin of earthworms while allowing the earthworms to excrete the digest remaining in the digestive tracts efficiently without weakening the earthworms, which comprises the steps of: standing living earthworms under light for 10 to 50 hours, removing the dirt formed on the skin thereof, adding an organic acid to the living earthworms, diluting the acid rapidly with addition of water, adjusting the pH of the aqueous acidic solution to 2 to 5, standing the earthworm mixture for 3 to 180 minutes under the pH condition, washing the earthworms with water, grinding the earthworms into a homogenate, freezing the homogenate at −18° C. to −35° C., keeping the frozen homogenate for 20 to 240 hours, and freeze-drying and degassing the frozen homogenate under vacuum simultaneously.
    • 本发明提供一种干燥蚯蚓粉的制造方法,其不会劣化有用的药理作用,通过去除蚯蚓皮肤上的污物,同时允许蚯蚓有效排出消化道中残留的消化物而不削弱蚯蚓,这包括以下步骤: 静置蚯蚓在灯下10〜50小时,除去皮肤上形成的污垢,向活蚯蚓加入有机酸,加入水快速稀释酸,将酸性水溶液的pH调节至2〜5 ,在pH条件下将蚯蚓混合物静置3〜180分钟,用水洗涤蚯蚓,将蚯蚓粉碎成匀浆,将匀浆在-18℃冷冻至-35℃,保持冷冻匀浆20 至240小时,同时在真空下对冷冻匀浆进行冷冻干燥脱气。