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1. 发明授权

US5256788A Moranoline derivatives and their production and the use of moranoline and its derivatives as a stabilizing agent for enzymes 失效
标题翻译：山梨醇衍生物及其制备及其用途作为酶的稳定剂
公开(公告)号：US5256788A
公开(公告)日：1993-10-26
申请号：US475158
申请日：1990-02-05
申请人： Yohji Ezure , Shigeaki Maruo , Hiroshi Yamashita , Katsunori Miyazaki , Makoto Sugiyama
发明人： Yohji Ezure , Shigeaki Maruo , Hiroshi Yamashita , Katsunori Miyazaki , Makoto Sugiyama
IPC分类号： C07D211/46 , C07H17/02 , C12N9/96 , C12P19/04 , C12P19/44 , C07P211/36
CPC分类号： C12P19/445 , C07D211/46 , C07H17/02 , C12N9/96 , C12P19/04
摘要： The present invention relates to stabilizing agents for enzymes which comprises an enzyme stabilizing amount of an N-substituted moranoline derivative of the formula (III): ##STR1## wherein R.sup.1 is phenyl lower alkynyl, phenoxy lower alkenyl or phenoxy lower alkynyl, wherein the phenyl moiety is unsubstituted, or a glucose oligomer thereof.

2. 发明授权

US5364794A Process for producing saccharides 失效
标题翻译：生产糖的方法
公开(公告)号：US5364794A
公开(公告)日：1994-11-15
申请号：US988111
申请日：1993-02-04
申请人： Yohji Ezure , Shigeaki Maruo , Katsunori Miyazaki , Naoyoshi Yamada
发明人： Yohji Ezure , Shigeaki Maruo , Katsunori Miyazaki , Naoyoshi Yamada
IPC分类号： A61K31/70 , A61K31/715 , C07H3/06 , C12P19/18 , C12P19/20 , C12P19/02 , C12P19/14
CPC分类号： C07H3/06 , A61K31/70 , A61K31/715 , C12P19/18
摘要： A simplified process is provided for producing saccharides of definite chain length, such as glucose, maltose and maltooligosaccharides, each in an isolated state and with a high purity.The process comprises transferring a saccharide chain, using a saccharide chain transferase, from a saccharide chain source to a substance substantially separable from the saccharides mentioned above and treating the thus-obtained oligosaccharide with an enzyme capable of excising the saccharide chain of definite chain length in an exo manner.
摘要翻译： PCT No.PCT / JP91 / 00984。 371日期：1993年2月4日 102（e）日期1993年2月4日PCT PCT 1991年7月24日PCT公布。公开号WO92 / 01805 日期为1992年2月6日。提供了一种制备具有确定链长度的糖的简化方法，例如葡萄糖，麦芽糖和麦芽低聚糖，各自处于分离状态并具有高纯度。该方法包括使用糖链转移酶将糖链从糖链源转移到基本上可与上述糖分离的物质，并用能够切割确定链长的糖链的酶处理由此获得的寡糖外在的方式。

3. 发明授权

US5612203A Process for producing saccharides 失效
标题翻译：生产糖的方法
公开(公告)号：US5612203A
公开(公告)日：1997-03-18
申请号：US244117
申请日：1994-08-08
申请人： Shigeaki Maruo , Noriyuke Tachikake , Yohji Ezure
发明人： Shigeaki Maruo , Noriyuke Tachikake , Yohji Ezure
IPC分类号： C12P19/04 , C12P19/14 , C12P19/12
CPC分类号： C12P19/14 , C12P19/04
摘要： Disclosed is a method for producing saccarides of definite chain length, such as glucose, maltose, malto-oligosaccharides and isomalto-oligosaccharides with a high purity. Saccharides such as starch, dextran and cellulose, and hydrolyzates thereof, are subjected to modification of the anomeric carbon at the reducing end of the molecule without modification of the non-reducing end of the molecule. The modification may be oxidation, for example by bromine to produce a carboxylic acid at the anomeric carbon, or amination, for example by phenylhydrazine to produce an osazone or osone of the saccharide. After modification, the modified saccharide can be adsorbed on an ion exchange resin and then repeatedly cleaved with a suitable enzyme, such as .beta.-amylase, to produce the desired saccharide of definite chain length.
摘要翻译： PCT No.PCT / JP92 / 01498 Sec。 371日期1994年8月8日 102（e）日期1994年8月8日PCT 1994年5月19日PCT PCT。公开号WO93 / 10256 日期1993年5月27日公开是生产具有高纯度的葡萄糖，麦芽糖，麦芽低聚糖和异麦芽低聚糖等确定链长的蛔虫的方法。糖类如淀粉，葡聚糖和纤维素及其水解产物在分子的还原端进行端基异构碳的修饰，而不改变分子的非还原性末端。修饰可以是氧化，例如通过溴在异头碳处产生羧酸，或胺化，例如通过苯肼来制备糖的奥扎酮或奥斯酮。改性后，可以将改性的糖类吸附在离子交换树脂上，然后用合适的酶例如β-淀粉酶重复切割，得到所需的具有确定链长度的糖。

4. 发明授权

US4806633A Method of manufacturing moranoline derivatives 失效
标题翻译：山梨醇衍生物的制备方法
公开(公告)号：US4806633A
公开(公告)日：1989-02-21
申请号：US39012
申请日：1987-04-15
申请人： Yoji Ezure , Masashi Yamamoto , Shigeaki Maruo , Makoto Sugiyama
发明人： Yoji Ezure , Masashi Yamamoto , Shigeaki Maruo , Makoto Sugiyama
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7052 , A61P3/08 , A61P3/10 , C07H17/02 , A61K31/73 , C07H5/06 , C08B37/16
CPC分类号： C07H17/02 , Y10S514/866
摘要： A method of preparing a molecular compound of glucosylmoranoline of the formula I ##STR1## with methanol, which comprises stirring an aqueous solution comprising (I) and other moranoline derivatives with methanol, whereupon crystals of the molecular compound of (I) with methanol are formed.
摘要翻译：用甲醇制备式I（I）的葡糖基吗啉酸的分子化合物的方法，其包括用甲醇搅拌包含（I）和其它甲醇衍生物的水溶液，随后将（I）分子化合物的晶体与形成甲醇。

5. 发明授权

US4785018A Glycine derivatives 失效
标题翻译：甘氨酸衍生物
公开(公告)号：US4785018A
公开(公告)日：1988-11-15
申请号：US66820
申请日：1987-06-25
申请人： Masao Murase , Shigeaki Maruo
发明人： Masao Murase , Shigeaki Maruo
IPC分类号： C12N9/99 , A61K31/22 , A61K31/24 , A61K31/47 , A61P3/08 , A61P3/10 , A61P7/10 , A61P13/02 , A61P15/00 , A61P25/02 , A61P27/02 , A61P27/12 , A61P43/00 , C07C67/00 , C07C325/00 , C07C327/48 , C07D215/50 , C07D215/52 , C07C153/063
CPC分类号： A61K31/24 , C07D215/50
摘要： A compound of the formula (I): ##STR1## wherein R is hydrogen or unsubstituted or substituted 1-naphthyl. These compounds are useful to obtain inhibition of aldose reductase in animals, including humans.
摘要翻译：式（I）的化合物：其中R是氢或未取代的或取代的1-萘基。这些化合物可用于在动物（包括人）中获得抑制醛糖还原酶。

6. 发明授权

US4970214A Quinoline substituted oxomethyl or thioxomethyl glycine derivatives and aldose reductase inhibition therewith 失效
标题翻译：喹啉取代的氧代甲基或硫代甲基甘氨酸衍生物和醛糖还原酶抑制
公开(公告)号：US4970214A
公开(公告)日：1990-11-13
申请号：US281446
申请日：1988-12-08
申请人： Masao Murase , Shigeaki Maruo
发明人： Masao Murase , Shigeaki Maruo
IPC分类号： C12N9/99 , A61K31/22 , A61K31/24 , A61K31/47 , A61P3/08 , A61P3/10 , A61P7/10 , A61P13/02 , A61P15/00 , A61P25/02 , A61P27/02 , A61P27/12 , A61P43/00 , C07C67/00 , C07C325/00 , C07C327/48 , C07D215/50 , C07D215/52
CPC分类号： A61K31/24 , C07D215/50
摘要： A compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt thereof, wherein Y is S or O;R is hydrogen or alkyl having from about 1 to about 4 carbon atoms;R.sup.1 is hydrogen, alkyl having from about 1 to about 4 carbon atoms, alkoxy having from about 1 to about 4 carbon atoms, halogen or trifluoromethyl;R.sup.2 is hydrogen or unsubstituted or substituted alkyl having from about 1 to about 4 carbon atoms; andR.sup.3 is hydrogen, alkyl having from about 1 to about 6 carbon atoms, cycloalkyl having from about 3 to about 6 carbon atoms, alkoxy having from about 1 to about 4 carbon atoms, aryloxy having from about 6 to about 10 carbon atoms, alkylthio having from about 1 to about 4 carbon atoms, hydroxyalkoxy having from about 1 to about 4 carbon atoms, or unsubstituted or substituted phenyl is useful to obtain inhibition of aldose reduction in animals, including humans.

7. 发明授权

US4363802A Moranoline derivatives 失效
标题翻译：羊毛醇衍生物
公开(公告)号：US4363802A
公开(公告)日：1982-12-14
申请号：US325832
申请日：1981-11-30
申请人： Shingo Matsumura, deceased , Hiroshi Enomoto , Yoshiaki Aoyagi , Yoji Ezure , Yoshiaki Yoshikuni , Shigeaki Maruo , Nobutoshi Ojima , Kiyotaka Konno
发明人： Shingo Matsumura, deceased , Hiroshi Enomoto , Yoshiaki Aoyagi , Yoji Ezure , Yoshiaki Yoshikuni , Shigeaki Maruo , Nobutoshi Ojima , Kiyotaka Konno
IPC分类号： C07D211/46 , A61K31/70 , A61K31/7042 , A61K31/7052 , A61P3/08 , A61P3/10 , C07D405/14 , C07H17/02 , C12N9/10 , C12P19/60 , C08B37/00
CPC分类号： C12N9/1074 , C07H17/02 , C12P19/60 , Y10S514/866
摘要： Bisglucosyl moranoline of the formula (I) ##STR1## is useful in inhibiting increase of blood sugar in sugar-loaded animals and humans, and particularly for treatment of diabetes mellitus.
摘要翻译：式（I）的双葡萄糖基吗啉醇可以用于抑制糖负荷动物和人类的血糖升高，特别是用于治疗糖尿病。

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