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1. 发明申请

WO2008120207A2 COMPOSITIONS FOR NASAL DELIVERY 审中-公开
标题翻译： NASAL交货的组合
公开(公告)号：WO2008120207A2
公开(公告)日：2008-10-09
申请号：PCT/IL2008/000445
申请日：2008-03-30
申请人： YISSUM, Research Development Company of the Hebrew University of Jerusalem , TOUITOU, Elka , GODIN, Biana , DUCHI, Shaher
发明人： TOUITOU, Elka , GODIN, Biana , DUCHI, Shaher
IPC分类号： A61K9/00 , A61K47/10 , A61K47/24 , A61K47/34 , A61K31/352
CPC分类号： A61K9/0043 , A61K9/0019 , A61K31/05 , A61K31/196 , A61K31/5513 , A61K38/02 , A61K38/16 , A61K47/10 , A61K47/24 , A61K47/34 , Y02A50/411 , A61K2300/00
摘要： A pharmaceutical composition comprising the combination of cannabidiol and glatiramer acetate, and a pharmaceutically acceptable carrier.
摘要翻译：包含大麻二醇和醋酸格拉默的组合的药物组合物和药学上可接受的载体。

2. 发明申请

WO2007043057A2 COMPOSITIONS FOR NASAL DELIVERY 审中-公开
标题翻译：供鼻用组合物
公开(公告)号：WO2007043057A2
公开(公告)日：2007-04-19
申请号：PCT/IL2006/001187
申请日：2006-10-15
申请人： Yissum, Research Development Company of the Hebrew University of Jerusalem , TOUITOU, Elka , GODIN, Biana , DUCHI, Shaher
发明人： TOUITOU, Elka , GODIN, Biana , DUCHI, Shaher
IPC分类号： A61K9/00 , A61K47/24 , A61K47/10 , A61K47/32 , A61K47/28 , A61K47/26
CPC分类号： A61K47/26 , A61K9/0043 , A61K47/10 , A61K47/14 , A61K47/18 , A61K47/24 , A61K47/28 , A61K47/32 , Y02A50/411
摘要： Use of phospholipids, one or more C2-C4 alcohols and water in the preparation of a vesicular composition adapted for intranasal administration of an active agent, wherein the concentrations of said phospholipids and said one or more alcohols in said composition are in the ranges of 0.2 to 10% and 12 to 30% by weight, respectively, with the water content of said composition being not less than 30% by weight.
摘要翻译：使用磷脂，一种或多种C 2 -C 4醇和水在制备适用于鼻内给予活性剂的囊泡组合物中的用途，其中所述磷脂和所述一种或多种醇在所述组合物分别在0.2至10重量％和12至30重量％的范围内，所述组合物的水含量不小于30重量％。

3. 发明申请

WO2004037160A2 IN VITRO TEST FOR STUDYING COMPOUND PREDICTING PHARMACOLOGIC AND/OR PHARMACOKINETIC AND/OR PHARMACODYNAMIC PARAMETERS OF A COMPOUND 审中-公开
标题翻译：用于研究化合物的化合物预防药物和/或药物动力学和/或药物动力学参数的体外试验
公开(公告)号：WO2004037160A2
公开(公告)日：2004-05-06
申请号：PCT/IL2003/000876
申请日：2003-10-23
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , TOUITOU, Elka , GODIN, Biana
发明人： TOUITOU, Elka , GODIN, Biana
IPC分类号： A61K
CPC分类号： C12Q1/025 , C12Q1/18
摘要： The invention provides a method and an assay for predicting the pharmacologic and/or pharmacokinetic and/or pharmacodynamic activity and/or effective concentration of a test material using cell and/or protozoa and/or micro-organism by assessing the effect of the test material on the and/or protozoa and/or micro-organism. Further, the invention provides an apparatus or a system, which comprises a donor and a receiver compartments, separated by membrane, wherein cell and/or protozoa and/or micro-organism are present in the receiver compartments, for predicting the pharmacologic of pharmacokinetic effects such as effective concentration of a test material, by assessing the effect of the test material, on the cell and/or protozoa and/or micro-organism. In addition, the invention provides use of an artificial human skin for measuring the diffusion or the penetration of a test material through the skin.
摘要翻译：本发明提供了一种用于通过评估测试材料的效果来预测使用细胞和/或原生动物和/或微生物的测试材料的药物和/或药物动力学和/或药效学活性和/或有效浓度的方法和测定法在和/或原生动物和/或微生物上。此外，本发明提供了一种装置或系统，其包括由膜分离的供体和接收器隔室，其中细胞和/或原生动物和/或微生物存在于接收器室中，用于预测药代动力学效应的药理学例如通过评估测试材料对细胞和/或原生动物和/或微生物的影响来测试材料的有效浓度。此外，本发明提供人造人皮肤用于测量测试材料通过皮肤的扩散或穿透的用途。

4. 发明申请

WO2011064769A1 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF HOT FLASHES 审中-公开
标题翻译：用于治疗烫伤的方法和药物组合物
公开(公告)号：WO2011064769A1
公开(公告)日：2011-06-03
申请号：PCT/IL2010/000976
申请日：2010-11-22
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. , TOUITOU, Elka , SHUMILOV, Margarita
发明人： TOUITOU, Elka , SHUMILOV, Margarita
IPC分类号： A61K9/00 , A61K9/70 , A61K31/506 , A61P5/24
CPC分类号： A61K31/506 , A61K9/0014 , A61K9/0043 , A61K9/0056 , A61K9/0058 , A61K9/006 , A61K9/7061 , A61K9/7084 , A61K47/10 , A61K47/14 , A61K47/24 , A61K47/38
摘要： Certain embodiments disclosed herein relate to uses, methods and compositions comprising azapirones for the treatment of hot flashes. In specific embodiments, the compositions comprise buspirone as the active ingredient. The invention further provides nasal compositions, and appropriate uses and methods especially suitable for administration of buspirone for the treatment of hot flashes.
摘要翻译：本文公开的某些实施方案涉及包含用于治疗潮热的azapirones的用途，方法和组合物。在具体实施方案中，组合物包含丁螺环酮作为活性成分。本发明还提供了鼻用组合物，以及特别适用于治疗热潮红的丁螺环酮的适当用途和方法。

5. 发明申请

WO2005084632A1 METHOD AND COMPOSITION FOR BURNED SKIN 审中-公开
标题翻译：烧伤皮肤的方法和组成
公开(公告)号：WO2005084632A1
公开(公告)日：2005-09-15
申请号：PCT/IL2005/000249
申请日：2005-03-03
申请人： YISSUM, RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , TOUITOU, Elka
发明人： TOUITOU, Elka
IPC分类号： A61K7/48
CPC分类号： A61K31/78 , A61K9/0014 , A61K31/045 , A61K47/02 , A61K47/10
摘要： The present invention is directed to the use of an agent selected from ethyl alcohol, isopropyl alcohol or a mixture thereof and a topically acceptable polymeric carrier in the preparation of a composition for the treatment of burns.
摘要翻译：本发明涉及选自乙醇，异丙醇或其混合物和局部可接受的聚合物载体的制剂在制备用于治疗烧伤的组合物中的用途。

6. 发明申请

WO2010086725A1 COMPOSITIONS FOR NAIL AND SKIN TREATMENT 审中-公开
标题翻译：用于指甲和皮肤治疗的组合物
公开(公告)号：WO2010086725A1
公开(公告)日：2010-08-05
申请号：PCT/IB2010/000170
申请日：2010-01-29
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD , TOUITOU, Elka
发明人： TOUITOU, Elka
IPC分类号： A01N33/02 , A61K31/135
CPC分类号： A61K31/137 , A61K9/0014 , A61K9/127 , A61K9/70 , A61K9/7015
摘要： Provided are novel topical compositions for the treatment of nail and skin afflictions comprising terbinafine and/or terbinafine salt(s), at least 61% (w/w) of one or more volatile solvents, one or more film-forming ingredients and one or more phospholipids, processes for their preparation and methods of treatment of nail and skin afflictions. After application of the compositions of the invention on a nail or skin surface, following evaporation of volatile solvents, the composition forms a film, which exhibits web-like structures containing the active(s).
摘要翻译：提供了用于治疗指甲和皮肤疾病的新型局部组合物，其包含特比萘芬和/或特比萘芬盐，至少61％（w / w）的一种或多种挥发性溶剂，一种或多种成膜成分和一种或多种成膜成分更多的磷脂，其制备方法和治疗指甲和皮肤疾病的方法。在本发明的组合物在指甲或皮肤表面上施用之后，挥发性溶剂蒸发后，组合物形成膜，其显示含有活性物质的网状结构。

7. 发明申请

WO2003000174A2 COMPOSITIONS AND METHODS FOR INTRACELLULAR DELIVERY 审中-公开
标题翻译：用于细胞内递送的组合物和方法
公开(公告)号：WO2003000174A2
公开(公告)日：2003-01-03
申请号：PCT/IL2002/000516
申请日：2002-06-26
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , TOUITOU, Elka
发明人： TOUITOU, Elka
IPC分类号： A61K
CPC分类号： A61Q5/00 , A61K8/553 , A61K9/127 , A61K47/10 , A61K47/24 , A61K48/0033 , A61K2800/83 , A61Q7/00 , A61Q19/00 , C12N15/87 , C12N15/89
摘要： The invention relates to intracellular deliver alcoholic lipid compositions for medical, cosmetic, research, diagnostic, veterinary, agriculture or pharmaceutical use containing phospholipid(s), ethanol (or other C2-C4 such volatile alcohols), water, at least one active molecule, optional addition of glycols or/and other additions for delivery to cells of an entrapped, attached, adsorbed, complexed molecule(s).
摘要翻译：本发明涉及用于医疗，化妆品，研究，诊断，兽医，农业或医药用途的含有磷脂，乙醇（或其他C2-C4如挥发性醇）的细胞内递送酒精脂质组合物，水，至少一种活性分子，任选添加乙二醇或/和其他添加物以递送至包埋的，附着的，吸附的复合分子的细胞。

8. 发明申请

WO2010086732A1 STABLE COMPOSITIONS FOR NAIL AND SKIN TREATMENT 审中-公开
标题翻译：稳定的组合物用于指甲和皮肤治疗
公开(公告)号：WO2010086732A1
公开(公告)日：2010-08-05
申请号：PCT/IB2010/000179
申请日：2010-01-30
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD , TOUITOU, Elka
发明人： TOUITOU, Elka
IPC分类号： A01N33/02 , A61K31/135
CPC分类号： A61K9/0014 , A61K47/10 , A61K47/24
摘要： Provided are novel stable and highly effective antifungal compositions comprising acidic actives, processes for their preparation and methods of treating nail and skin fungal infections, wherein the pH of the compositions is raised by 1.0-3.0 pH units by addition of a base the composition further includes one or more phospholipids.
摘要翻译：提供了包含酸性活性物质的新型稳定和高效抗真菌组合物，其制备方法和治疗指甲和皮肤真菌感染的方法，其中组合物的pH通过加入碱增加1.0-3.0 pH单位，该组合物还包括一种或多种磷脂。

9. 发明申请

WO2010086723A1 TERBINAFINE COMPOSITIONS FOR ONYCHOMYCOSIS TREATMENT 审中-公开
标题翻译：用于结核病治疗的苦参碱组合物
公开(公告)号：WO2010086723A1
公开(公告)日：2010-08-05
申请号：PCT/IB2010/000168
申请日：2010-01-30
申请人： GALDERMA PHARMA SA , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD , TOUITOU, Elka
发明人： TOUITOU, Elka
IPC分类号： A01N33/02 , A61K31/135
CPC分类号： A61K31/137 , A61K9/0014 , A61K9/127 , A61K9/70 , A61K9/7015
摘要： Novel terbinafine topical compositions for the treatment of nail onychomycosis comprising terbinafine or a terbinafine salt, up to 60% (w/w) of at least one volatile solvent selected from ethanol, isopropanol, n-propanol, butanol, and combinations thereof, water, at least one film-forming ingredient and at least one phospholipid, forming an ethosome lipid system, processes for their preparation and methods for treating onychomycosis, wherein after the application of the compositions on the treated nail surface and evaporation of volatile solvents, the film formed exhibits web-like structures containing the terbinafine or salt thereof.
摘要翻译：用于治疗指甲甲癣的新型特比萘芬局部组合物，其包含特比萘芬或特比萘芬盐，高达60％（w / w）的选自乙醇，异丙醇，正丙醇，丁醇及其组合的至少一种挥发性溶剂，水，至少一种成膜成分和至少一种形成精神病药物脂质体的磷脂，其制备方法和治疗甲真菌病的方法，其中在将组合物施用于经处理的指甲表面和蒸发挥发性溶剂后，形成膜表现出含有特比萘芬或其盐的网状结构。

10. 发明申请

WO2002079121A3 PRODUCTS FOR PREVENTING PENETRATION INTO THE SKIN 审中-公开
公开(公告)号：WO2002079121A3
公开(公告)日：2002-10-10
申请号：PCT/IL2002/000254
申请日：2002-03-26
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , TOUITOU, Elka , BERGELSON, Lev
发明人： TOUITOU, Elka , BERGELSON, Lev
IPC分类号： A61K7/42
摘要： The present invention relates to novel cosmetic and/or dermatological compounds and compositions for the photoprotection of human skin and/or hair against the damaging effects of UV radiation, in particular solar radiation. In another embodiment the invention relates to compositions and compounds for topical application comprising at least one photoprotective compound for topical application comprising of hydroxylated derivatives of natural Jojoba wax/oil or its synthetic substitute, esterified with carboxylic acids or aminoacids bearing UV-absorbing groups.

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