专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US6066318A Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors 失效
标题翻译：序列重排C-MPL受体激动剂与其他造血因子之间的多功能造血融合蛋白
公开(公告)号：US6066318A
公开(公告)日：2000-05-23
申请号：US835162
申请日：1997-04-04
申请人： Yiqing Feng , Nicholas R. Staten , Charles M. Baum , Neena L. Summers , Maire Helena Caparon , S. Christopher Bauer , Linda L. Zurfluh , John P. McKearn , Barbara K. Klein , Stephen C. Lee , Charles A. McWherter , Judith G. Giri
发明人： Yiqing Feng , Nicholas R. Staten , Charles M. Baum , Neena L. Summers , Maire Helena Caparon , S. Christopher Bauer , Linda L. Zurfluh , John P. McKearn , Barbara K. Klein , Stephen C. Lee , Charles A. McWherter , Judith G. Giri
IPC分类号： A61K35/12 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/52 , C07K14/53 , C07K14/54 , C12N15/12 , C12N15/62
CPC分类号： C07K14/5403 , C07K14/524 , C07K14/53 , C12N15/62 , A61K2035/124 , A61K2039/51 , A61K38/00 , A61K48/00 , C07K2319/00 , C07K2319/75
摘要： Disclosed are novel multi-functional hematopoietic receptor agonist proteins, DNAs which encode the multi-functional hematopoietic receptor agonists proteins, methods of making the multi-functional hematopoietic receptor agonists proteins and methods of using the multi-functional hematopoietic receptor agonists proteins.
摘要翻译：公开了新型多功能造血受体激动剂蛋白质，编码多功能造血受体激动剂蛋白质的DNA，制备多功能造血受体激动剂蛋白质的方法和使用多功能造血受体激动剂蛋白质的方法。

2. 发明授权

US06730303B1 Fused G-CSF and IL-3 proteins and uses thereof 失效
标题翻译：融合的G-CSF和IL-3蛋白及其用途
公开(公告)号：US06730303B1
公开(公告)日：2004-05-04
申请号：US09510238
申请日：2000-02-22
申请人： Yiqing Feng , Nicholas R. Staten , Charles M. Baum , Neena L. Summers , Maire Helena Caparon , S. Christopher Bauer , Linda L. Zurfluh , John P. McKearn , Barbara K. Klein , Stephen C. Lee , Charles A. McWherter , Judith G. Giri
发明人： Yiqing Feng , Nicholas R. Staten , Charles M. Baum , Neena L. Summers , Maire Helena Caparon , S. Christopher Bauer , Linda L. Zurfluh , John P. McKearn , Barbara K. Klein , Stephen C. Lee , Charles A. McWherter , Judith G. Giri
IPC分类号： C07K1900
CPC分类号： C07K14/5403 , A61K38/00 , A61K48/00 , A61K2035/124 , A61K2039/51 , C07K14/524 , C07K14/53 , C07K2319/00 , C07K2319/75 , C12N15/62
摘要： Disclosed are novel multi-functional hematopoietic receptor agonist proteins, DNAs which encode the multi-functional hematopoietic receptor agonists proteins, methods of making the multi-functional hematopoietic receptor agonists proteins and methods of using the multi-functional hematopoietic receptor agonists proteins.
摘要翻译：公开了新型多功能造血受体激动剂蛋白质，编码多功能造血受体激动剂蛋白质的DNA，制备多功能造血受体激动剂蛋白质的方法和使用多功能造血受体激动剂蛋白质的方法。

3. 发明授权

US6100070A G-CSF receptor agonists 失效
公开(公告)号：US6100070A
公开(公告)日：2000-08-08
申请号：US833167
申请日：1997-04-04
申请人： Linda L. Zurfluh , Barbara K. Klein , Charles A. McWherrter , Yiqing Feng , John P. McKearn , Sarah Ruth Braford-Goldberg
发明人： Linda L. Zurfluh , Barbara K. Klein , Charles A. McWherrter , Yiqing Feng , John P. McKearn , Sarah Ruth Braford-Goldberg
IPC分类号： A61C7/06 , C07K14/53 , C12N15/27 , C07K14/535 , C12N15/63
CPC分类号： C07K14/535 , A61C7/06 , C07K14/53 , A61K38/00
摘要： Disclosed are novel G-CSF receptor agonist proteins, DNAs which encode the multi-functional hematopoietic receptor agonists proteins, methods of making the multi-functional hematopoietic receptor agonists proteins and methods of using the multi-functional hematopoietic receptor agonists proteins.

4. 发明授权

US5604116A Interleukin-3 (IL-3) multiple mutation polypeptides, recombinant production of the same, and corresponding therapeutic methods 失效
标题翻译：白细胞介素-3（IL-3）多重突变多肽，重组生产相同，及相应的治疗方法
公开(公告)号：US5604116A
公开(公告)日：1997-02-18
申请号：US411795
申请日：1995-04-06
申请人： S. Christopher Bauer , Mark A. Abrams , Sarah R. Braford-Goldberg , Maire H. Caparon , Alan M. Easton , Barbara K. Klein , John P. McKearn , Peter Olins , Kumnan Paik , John W. Thomas
发明人： S. Christopher Bauer , Mark A. Abrams , Sarah R. Braford-Goldberg , Maire H. Caparon , Alan M. Easton , Barbara K. Klein , John P. McKearn , Peter Olins , Kumnan Paik , John W. Thomas
IPC分类号： C12N15/09 , A61K38/00 , A61K38/20 , A61K45/00 , A61P7/00 , A61P43/00 , C07H21/04 , C07K1/00 , C07K14/00 , C07K14/54 , C07K17/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/08 , C12N5/10 , C12N15/24 , C12N15/61 , C12P21/02 , C12P21/04 , C12R1/19 , C12N15/27
CPC分类号： C07K14/5403 , A61K38/00 , C07K2319/00 , C07K2319/02 , Y10S930/141
摘要： The present invention relates to recombinant human interleukin-3 (hIL-3) variant or mutant proteins (muteins). These hIL-3 muteins contain amino acid substitutions and may also have amino acid deletions at both the N- and C- termini. The invention also relates to pharmaceutical compositions containing the hIL-3 muteins and methods for using them. Additionally, the present invention relates to recombinant expression vectors comprising nucleotide sequences encoding the hIL-3 muteins, related microbial expression systems, and processes for making the hIL-3 muteins using the microbial expression systems. Included in the present invention are deletion mutants of hIL-3 in which from 1 to 14 amino acids have been deleted from the N-terminus, and from 1 to 15 amino acids 119 to 133 have been deleted from the C-terminus, and which also contain amino acid substitutions in the polypeptide. These hIL-3 multiple mutation polypeptides may have biological activities similar to or better than hIL-3 and, in some cases, may also have an improved side effect profile.
摘要翻译： PCT No.PCT / US93 / 11197 Sec。 371日期：1995年4月6日 102（e）日期1995年4月6日PCT 1993年11月22日PCT公布。公开号WO94 / 12638 日期：1994年6月9日本发明涉及重组人白细胞介素-3（hIL-3）变体或突变蛋白（突变蛋白）。这些hIL-3突变蛋白含有氨基酸取代，并且在N-和C-末端也可具有氨基酸缺失。本发明还涉及含有hIL-3突变蛋白的药物组合物及其使用方法。另外，本发明涉及包含编码hIL-3突变蛋白的核苷酸序列，相关微生物表达系统和使用微生物表达系统制备hIL-3突变蛋白的方法的重组表达载体。本发明包括hIL-3的缺失突变体，其中从N末端缺失1至14个氨基酸，从C末端缺失1至15个氨基酸119至133，其中还含有多肽中的氨基酸取代。这些hIL-3多重突变多肽可具有类似于或优于hIL-3的生物学活性，并且在一些情况下也可具有改善的副作用特征。

5. 发明授权

US5543141A Therapeutic methods using interleukin-3 (IL-3) human/murine hybrid polypeptides 失效
标题翻译：使用白细胞介素-3（IL-3）人/鼠杂交多肽的治疗方法
公开(公告)号：US5543141A
公开(公告)日：1996-08-06
申请号：US466647
申请日：1995-06-06
申请人： Sarah R. Braford-Goldberg , Alan M. Easton , Barbara K. Klein , John P. McKearn , Peter O. Olins
发明人： Sarah R. Braford-Goldberg , Alan M. Easton , Barbara K. Klein , John P. McKearn , Peter O. Olins
IPC分类号： A61K38/00 , C07K14/54 , C12N15/24 , A61K38/20
CPC分类号： C07K14/5403 , A61K38/00
摘要： The present invention relates to recombinant human interleukin-3 (hIL-3) variant or mutant proteins (muteins) in which segments of the polypeptide sequence of the human IL-3 polypeptide have been replaced by segments of the murine (mouse) interleukin-3 (mIL-3) polypeptide to form human/murine chimeric hybrid polypeptides. The human/mouse IL-3 may have amino acid deletions at the N-terminus or the C-terminus or at both the N- and C- termini and in some cases may also contain additional amino acid substitutions or deletions. The human/murine IL-3 muteins retain at least one biological activity of native hIL-3 and may also exhibit an improved side effects profile such as a reduction in the stimulation of leukotriene release or histamine release. The invention also relates to pharmaceutical compositions containing the h/m IL-3 hybrids and methods for using them. Additionally, the present invention relates to recombinant expression vectors comprising nucleotide sequences encoding the IL-3 hybrid muteins, related microbial expression systems, and processes for making the IL-3 hybrids using the microbial expression systems.
摘要翻译：本发明涉及重组人白细胞介素-3（hIL-3）变体或突变蛋白（突变蛋白），其中人IL-3多肽的多肽序列的片段已被鼠（小鼠）白介素-3 （mIL-3）多肽以形成人/鼠嵌合杂合多肽。人/小鼠IL-3可以在N末端或C末端或在N-和C-末端具有氨基酸缺失，并且在一些情况下也可能含有额外的氨基酸取代或缺失。人/鼠IL-3突变蛋白保留天然hIL-3的至少一种生物活性，并且还可以表现出改善的副作用特征，例如减少刺激白三烯释放或组胺释放。本发明还涉及含有h / m IL-3杂交体的药物组合物及其使用方法。此外，本发明涉及包含编码IL-3杂交突变蛋白的核苷酸序列，相关的微生物表达系统和使用微生物表达系统制备IL-3杂交体的方法的重组表达载体。

6. 发明授权

US5501962A Interleuken-3 (IL-3) human/murine hybrid polypeptides and recombinant production of the same 失效
标题翻译：白细胞介素-3（IL-3）人/鼠杂交多肽及其重组生产
公开(公告)号：US5501962A
公开(公告)日：1996-03-26
申请号：US081539
申请日：1993-06-21
申请人： Sarah R. Braford-Goldberg , Alan M. Easton , Barbara K. Klein , John P. McKearn , Peter O. Olins
发明人： Sarah R. Braford-Goldberg , Alan M. Easton , Barbara K. Klein , John P. McKearn , Peter O. Olins
IPC分类号： A61K38/00 , C07K14/54 , C12N15/24 , A61K38/20 , C12N15/27
CPC分类号： C07K14/5403 , A61K38/00
摘要： The present invention relates to recombinant human interleukin-3 (hIL-3) variant or mutant proteins (muteins) in which segments of the polypeptide sequence of the human IL-3 polypeptide have been replaced by segments of the murine (mouse) interleukin-3 (mIL-3) polypeptide to form human/murine chimeric hybrid polypeptides. The human/mouse hybrid IL-3 may have amino acid deletions at the N-terminus or the C-terminus or at both the N- and C- termini and in some cases may also contain additional amino acid substitutions or deletions. The human/murine IL-3 muteins retain at least one biological activity of native hIL-3 and may also exhibit an improved side effects profile such as a reduction in the stimulation of leukotriene release or histamine release. The invention also relates to pharmaceutical compositions containing the h/m IL-3 hybrids and methods for using them. Additionally, the present invention relates to recombinant expression vectors comprising nucleotide sequences encoding the IL-3 hybrid muteins, related microbial expression systems, and processes for making the IL-3 hybrids using the microbial expression systems.
摘要翻译：本发明涉及重组人白细胞介素-3（hIL-3）变体或突变蛋白（突变蛋白），其中人IL-3多肽的多肽序列的片段已被鼠（小鼠）白介素-3 （mIL-3）多肽以形成人/鼠嵌合杂合多肽。人/小鼠混合IL-3可以在N-末端或C-末端或在N-和C-末端具有氨基酸缺失，并且在一些情况下也可能含有额外的氨基酸取代或缺失。人/鼠IL-3突变蛋白保留天然hIL-3的至少一种生物活性，并且还可以表现出改善的副作用特征，例如减少刺激白三烯释放或组胺释放。本发明还涉及含有h / m IL-3杂交体的药物组合物及其使用方法。此外，本发明涉及包含编码IL-3杂交突变蛋白的核苷酸序列，相关的微生物表达系统和使用微生物表达系统制备IL-3杂交体的方法的重组表达载体。

7. 发明授权

US08231894B2 Antimicrobial and immunostimulating composition 有权
标题翻译：抗微生物和免疫刺激组合物
公开(公告)号：US08231894B2
公开(公告)日：2012-07-31
申请号：US13156566
申请日：2011-06-09
申请人： Barbara K. Klein , Leo D. Katzner
发明人： Barbara K. Klein , Leo D. Katzner
IPC分类号： A61K9/70 , A61K39/00
CPC分类号： A61K31/716 , A61K33/38 , A61L15/44 , A61L15/46 , A61L31/16 , A61L2300/104 , A61L2300/232 , A61L2300/404 , A61L2300/426 , A61L2300/45 , Y02A50/473
摘要： A medical composition comprising an antimicrobially effective and immunostimulating amount of a combination of a β-glucan component and a silver-containing component is disclosed. The medical composition may be adapted for use topically or incorporated with a mesh material which may be further adapted for use as a wound dressing or as a surgical mesh. Methods for manufacturing the medical compositions described herein are also provided. The invention further provides methods for treating tissue damaged by wound or burn, and methods for treating or repairing tissue at a surgical site.
摘要翻译：公开了包含抗微生物和免疫刺激量的葡聚糖组分和含银组分的组合物的药物组合物。该医疗组合物可以适用于局部使用或与网状材料结合，所述网状材料可以进一步适合用作伤口敷料或外科手术网。还提供了用于制造本文所述医药组合物的方法。本发明还提供了用于治疗由伤口或烧伤损伤的组织的方法，以及在手术部位处理或修复组织的方法。

8. 发明授权

US06168799A &bgr;-D-glucan topical composition 有权
标题翻译： β-D-葡聚糖局部组合物
公开(公告)号：US06168799A
公开(公告)日：2001-01-02
申请号：US09231311
申请日：1999-01-13
申请人： Barbara K. Klein
发明人： Barbara K. Klein
IPC分类号： A61K700
CPC分类号： A61Q19/00 , A61K8/73 , A61K31/716 , A61Q19/007 , Y10S514/847 , Y10S514/887
摘要： A topical composition for healing treatment of burns and wounds and scarring therefrom has as the active ingredient cereal-derived (1-3) (1-4) &bgr;-D-glucan at about 0.5-15 w/w percent. The composition may be formulated in various forms with creams and gels being preferred for application to the skin.
摘要翻译：用于愈合治疗烧伤和伤口及其瘢痕形成的局部组合物以约0.5-15w / w％作为谷物来源的（1-3）（1-4）β-D-葡聚糖作为活性成分。组合物可以以各种形式配制，其中乳膏和凝胶优选用于施用于皮肤。

9. 发明授权

US07348021B2 Immunostimulating coating for surgical devices 有权
标题翻译：外科手术器械的免疫刺激涂层
公开(公告)号：US07348021B2
公开(公告)日：2008-03-25
申请号：US10347023
申请日：2003-01-17
申请人： Barbara K. Klein
发明人： Barbara K. Klein
IPC分类号： A61K31/716 , A61K9/70 , A61M31/00 , B32B27/12 , B32B27/04
CPC分类号： A61L27/20 , A61L31/042 , Y10T442/2525
摘要： The present invention discloses an immunostimulating agent that may be applied to various surgical devices to promote rapid healing and the ready acceptance and integration of the surgical devices with the body tissues at the surgical site.
摘要翻译：本发明公开了一种免疫刺激剂，其可应用于各种手术装置以促进手术部位的外科手术装置与身体组织的快速愈合和即时接受和整合。

10. 发明申请

US20110244021A1 ANTIMICROBIAL AND IMMUNOSTIMULATING COMPOSITION 有权
标题翻译：抗微生物和免疫组化
公开(公告)号：US20110244021A1
公开(公告)日：2011-10-06
申请号：US13156566
申请日：2011-06-09
申请人： Barbara K. Klein , Leo D. Katzner
发明人： Barbara K. Klein , Leo D. Katzner
IPC分类号： A61K9/70 , A61K39/00
CPC分类号： A61K31/716 , A61K33/38 , A61L15/44 , A61L15/46 , A61L31/16 , A61L2300/104 , A61L2300/232 , A61L2300/404 , A61L2300/426 , A61L2300/45 , Y02A50/473
摘要： A medical composition comprising an antimicrobially effective and immunostimulating amount of a combination of a β-glucan component and a silver-containing component is disclosed. The medical composition may be adapted for use topically or incorporated with a mesh material which may be further adapted for use as a wound dressing or as a surgical mesh. Methods for manufacturing the medical compositions described herein are also provided. The invention further provides methods for treating tissue damaged by wound or burn, and methods for treating or repairing tissue at a surgical site.
摘要翻译：公开了包含抗微生物和免疫刺激量的葡聚糖组分和含银组分的组合物的药物组合物。该医疗组合物可以适用于局部使用或与网状材料结合，所述网状材料可以进一步适合用作伤口敷料或外科手术网。还提供了用于制造本文所述医药组合物的方法。本发明还提供了用于治疗由伤口或烧伤损伤的组织的方法，以及在手术部位处理或修复组织的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式