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1. 发明授权

US08497271B2 Modulators of G protein-coupled receptor 88 有权
标题翻译： G蛋白偶联受体的调节剂88
公开(公告)号：US08497271B2
公开(公告)日：2013-07-30
申请号：US12895916
申请日：2010-10-01
申请人： Yingzhi Bi , Carolyn Diane Dzierba , Joanne J. Bronson , Kenneth Carson , Giovanni Cianchetta , Li Dong , Cynthia Fink , Michael Green , David Kimball , John E. Macor , Soojin Kwon , Jiancheng Wang , Yulian Zhang , Greg Zipp
发明人： Yingzhi Bi , Carolyn Diane Dzierba , Joanne J. Bronson , Kenneth Carson , Giovanni Cianchetta , Li Dong , Cynthia Fink , Michael Green , David Kimball , John E. Macor , Soojin Kwon , Jiancheng Wang , Yulian Zhang , Greg Zipp
IPC分类号： A61K31/496 , A61K31/165 , A61K31/381 , A61P25/16 , A61P25/18 , A61P25/28 , A61P25/30 , C07C233/60 , C07D333/24 , C07D409/12
CPC分类号： C07D333/24 , C07C233/60 , C07C2601/02
摘要： The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled receptor 88.
摘要翻译：本公开一般涉及可以调节G蛋白偶联受体88的化合物，包含这些化合物的组合物，以及调节G蛋白偶联受体88的方法。

2. 发明申请

US20110245264A1 Modulators of G Protein-Coupled Receptor 88 有权
公开(公告)号：US20110245264A1
公开(公告)日：2011-10-06
申请号：US12895916
申请日：2010-10-01
申请人： Yingzhi Bi , Carolyn Diane Dzierba , Joanne J. Bronson , Kenneth Carson , Giovanni Cianchetta , Li Dong , Cynthia Fink , Michael Green , David Kimball , John E. Macor , Soojin Kwon , Jiancheng Wang , Yulian Zhang , Greg Zipp
发明人： Yingzhi Bi , Carolyn Diane Dzierba , Joanne J. Bronson , Kenneth Carson , Giovanni Cianchetta , Li Dong , Cynthia Fink , Michael Green , David Kimball , John E. Macor , Soojin Kwon , Jiancheng Wang , Yulian Zhang , Greg Zipp
IPC分类号： A61K31/496 , C07D333/24 , A61K31/381 , C07D409/12 , C07C233/60 , A61K31/165 , A61P25/28 , A61P25/18 , A61P25/16 , A61P25/30
CPC分类号： C07D333/24 , C07C233/60 , C07C2601/02
摘要： The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled receptor 88.

3. 发明申请

US20060258691A1 Methods and compositions for improving cognition 审中-公开
标题翻译：改善认知的方法和组合
公开(公告)号：US20060258691A1
公开(公告)日：2006-11-16
申请号：US11433626
申请日：2006-05-12
申请人： Joseph Barbosa , Li Dong , Cynthia Fink , Thomas Lanthorn , Jiancheng Wang , G. Zipp
发明人： Joseph Barbosa , Li Dong , Cynthia Fink , Thomas Lanthorn , Jiancheng Wang , G. Zipp
IPC分类号： A61K31/519 , A61K31/4745
CPC分类号： A61K31/437 , A61K31/4745 , A61K31/496 , A61K31/506 , A61K31/519 , A61K31/551
摘要： This invention encompasses methods of improving cognitive performance and of treating, preventing and managing various diseases and disorders, such as Alzheimer's disease, autism, cognitive disorders, dementia, learning disorders, and short- and long-term memory loss.
摘要翻译：本发明包括改善认知表现以及治疗，预防和控制诸如阿尔茨海默病，自闭症，认知障碍，痴呆，学习障碍以及短期和长期记忆丧失的各种疾病和病症的方法。

4. 发明申请

US20060258672A1 Multicyclic compounds and methods of their use 审中-公开
标题翻译：多环化合物及其使用方法
公开(公告)号：US20060258672A1
公开(公告)日：2006-11-16
申请号：US11433057
申请日：2006-05-12
申请人： Joseph Barbosa , Li Dong , Cynthia Fink , Jiancheng Wang , G. Zipp
发明人： Joseph Barbosa , Li Dong , Cynthia Fink , Jiancheng Wang , G. Zipp
IPC分类号： A61K31/496 , A61K31/4545 , C07D403/02 , C07D401/02
CPC分类号： C07D239/42 , C07D277/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D417/04 , C07D451/02 , C07D471/08 , C07D487/04
摘要： This invention relates to multicyclic compounds, pharmaceutical compositions comprising them, and methods of their use in, for example, the treatment of cognitive disorders.
摘要翻译：本发明涉及多环化合物，包含它们的药物组合物及其在例如认知障碍治疗中的应用。

5. 发明申请

US20070049608A1 Pyrrolopyridine, pyrrolopyrimidine and pyrazolopyridine compounds, compositions comprising them, and methods of their use 审中-公开
标题翻译：吡咯并吡啶，吡咯并嘧啶和吡唑并吡啶化合物，包含它们的组合物及其使用方法
公开(公告)号：US20070049608A1
公开(公告)日：2007-03-01
申请号：US11508116
申请日：2006-08-22
申请人： Cynthia Fink , Joseph Barbosa , G. Zipp , Jiancheng Wang
发明人： Cynthia Fink , Joseph Barbosa , G. Zipp , Jiancheng Wang
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D471/04 , A61K31/437 , A61K31/519 , C07D487/04
摘要： Disclosed are pyrrolopyridine, pyrrolopyrimidine and pyrazolopyridine compounds, compositions comprising them, and methods of their use.
摘要翻译：公开了吡咯并吡啶，吡咯并嘧啶和吡唑并吡啶化合物，包含它们的组合物及其用途。

6. 发明授权

US08772291B2 Multicyclic compounds and methods of their use 有权
标题翻译：多环化合物及其使用方法
公开(公告)号：US08772291B2
公开(公告)日：2014-07-08
申请号：US12633453
申请日：2009-12-08
申请人： Joseph Barbosa , Li Dong , Cynthia Anne Fink , Jiancheng Wang , G. Gregory Zipp
发明人： Joseph Barbosa , Li Dong , Cynthia Anne Fink , Jiancheng Wang , G. Gregory Zipp
IPC分类号： A01N43/64 , A61K31/53 , A61K31/497 , A01N43/54 , C07D239/42 , C07D401/04 , A01N43/40 , A61K31/445 , C07D253/00 , C07D401/00 , C07D403/00 , C07D409/00 , C07D405/00 , C07D239/00 , C07D239/02 , C07D241/00 , C07D241/02 , C07D211/20
CPC分类号： C07D239/42 , C07D277/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D417/04 , C07D451/02 , C07D471/08 , C07D487/04
摘要： This invention relates to multicyclic compounds, pharmaceutical compositions comprising them, and methods of their use in, for example, the treatment of cognitive disorders.
摘要翻译：本发明涉及多环化合物，包含它们的药物组合物及其用于例如认知障碍治疗的方法。

7. 发明申请

US20100081691A1 MULTICYCLIC COMPOUNDS AND METHODS OF THEIR USE 有权
标题翻译：多种化合物及其使用方法
公开(公告)号：US20100081691A1
公开(公告)日：2010-04-01
申请号：US12633453
申请日：2009-12-08
申请人： Joseph Barbosa , Li Dong , Cynthia Anne Fink , Jiancheng Wang , G. Gregory Zipp
发明人： Joseph Barbosa , Li Dong , Cynthia Anne Fink , Jiancheng Wang , G. Gregory Zipp
IPC分类号： A61K31/4545 , C07D401/04
CPC分类号： C07D239/42 , C07D277/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D417/04 , C07D451/02 , C07D471/08 , C07D487/04
摘要： This invention relates to multicyclic compounds, pharmaceutical compositions comprising them, and methods of their use in, for example, the treatment of cognitive disorders.
摘要翻译：本发明涉及多环化合物，包含它们的药物组合物及其用于例如认知障碍治疗的方法。

8. 发明申请

US20090281088A1 BICYCLIC NITROIMIDAZOLE-SUBSTITUTED PHENYL OXAZOLIDINONES 有权
标题翻译：双环硝基咪唑取代苯基氧杂环己烷
公开(公告)号：US20090281088A1
公开(公告)日：2009-11-12
申请号：US12411220
申请日：2009-03-25
申请人： Charles Z. Ding , Genliang Lu , Keith Combrink , Dianjun D. Chen , Minsoo Song , Jiancheng Wang , Zhenkun Ma , Brian Desmond Palmer , Adrian Blaser , Andrew M. Thompson , Iveta Kmentova , Hamish Scott Sutherland , William Alexander Denny
发明人： Charles Z. Ding , Genliang Lu , Keith Combrink , Dianjun D. Chen , Minsoo Song , Jiancheng Wang , Zhenkun Ma , Brian Desmond Palmer , Adrian Blaser , Andrew M. Thompson , Iveta Kmentova , Hamish Scott Sutherland , William Alexander Denny
IPC分类号： A61K31/5365 , C07D498/04 , A61K31/551 , A61K31/496 , A61K31/4439 , A61K31/506 , A61P31/04
CPC分类号： C07D498/04
摘要： The current invention provides a series of bicyclic nitroimidazole-substituted phenyl oxazolidinones in which a bicyclic nitroimidazole pharmacophore is covalently bonded to a phenyl oxazolidinone, their pharmaceutical compositions, and the method of use of the compositions for prevention and treatment of bacterial infections. The bicyclic nitroimidazole-substituted phenyl oxazolidinones possess surprising antibacterial activity against wild-type and resistant strains of pathogens, and are therefore useful for the prevention, control and treatment of a number of human and veterinary bacterial infections caused by these pathogens, such as Mycobacterium tuberculosis.
摘要翻译：本发明提供了一系列双环硝基咪唑取代的苯基恶唑烷酮，其中双环硝基咪唑药效团与苯基恶唑烷酮共价键合，其药物组合物，以及组合物用于预防和治疗细菌感染的方法。双环硝基咪唑取代的苯基恶唑烷酮对于野生型和抗性病原体菌株具有惊人的抗菌活性，因此可用于预防，控制和治疗由这些病原体引起的许多人和兽医细菌感染如结核分枝杆菌。

9. 发明授权

US09339553B2 Liquid compositions of insoluble drugs and preparation methods thereof 有权
标题翻译：不溶性药物的液体组合物及其制备方法
公开(公告)号：US09339553B2
公开(公告)日：2016-05-17
申请号：US13819407
申请日：2011-08-31
申请人： Qiang Zhang , Wenbing Dai , Jiancheng Wang , Xuan Zhang
发明人： Qiang Zhang , Wenbing Dai , Jiancheng Wang , Xuan Zhang
IPC分类号： A61K47/44 , A61K9/00 , A61K9/107 , A61K47/24 , A61K9/08
CPC分类号： A61K47/44 , A61K9/0019 , A61K9/08 , A61K9/107 , A61K47/24
摘要： A liquid composition of an insoluble medicament and a preparation method thereof are disclosed. The composition includes insoluble medicament, oil for injection, phospholipid, and solvent; the percentage by weight of each component is as follows: insoluble medicament 0.01-10%, oil for injection 0%-20%, phospholipid 10-80%, solvent 20-89%. The preparation method for the composition includes the following steps: dissolving an insoluble medicament into solvent or oil for injection or a mixture thereof firstly, and then adding other components, and mixing uniformly; or dissolving an insoluble medicament into a mixture of other components, and mixing uniformly; or dissolving an insoluble medicament into part of solvent firstly, and then adding into a mixed solvent of other components and the remaining solvent, and mixing uniformly.
摘要翻译：公开了不溶性药物的液体组合物及其制备方法。该组合物包括不溶性药物，注射用油，磷脂和溶剂; 每种成分的重量百分比如下：不溶性药物0.01-10％，注射用油0％-20％，磷脂10-80％，溶剂20-89％。组合物的制备方法包括以下步骤：首先将不溶性药物溶解于溶剂或注射用油或其混合物中，然后加入其它组分，均匀混合; 或将不溶性药物溶解到其它组分的混合物中，并均匀混合; 或首先将不溶性药物溶解在一部分溶剂中，然后加入到其他成分和剩余溶剂的混合溶剂中，并均匀混合。

10. 发明申请

US20130156853A1 Liquid Compositions of Insoluble Drugs and Preparation Methods Thereof 有权
标题翻译：不溶性药物的液体组合物及其制备方法
公开(公告)号：US20130156853A1
公开(公告)日：2013-06-20
申请号：US13819407
申请日：2011-08-31
申请人： Qiang Zhang , Wenbing Dai , Jiancheng Wang , Xuan Zhang
发明人： Qiang Zhang , Wenbing Dai , Jiancheng Wang , Xuan Zhang
IPC分类号： A61K47/44
CPC分类号： A61K47/44 , A61K9/0019 , A61K9/08 , A61K9/107 , A61K47/24
摘要： A liquid composition of an insoluble medicament and a preparation method thereof are disclosed. The composition includes insoluble medicament, oil for injection, phospholipid, and solvent; the percentage by weight of each component is as follows: insoluble medicament 0.01-10%, oil for injection 0%-20%, phospholipid 10-80%, solvent 20-89%. The preparation method for the composition includes the following steps: dissolving an insoluble medicament into solvent or oil for injection or a mixture thereof firstly, and then adding other components, and mixing uniformly; or dissolving an insoluble medicament into a mixture of other components, and mixing uniformly; or dissolving an insoluble medicament into part of solvent firstly, and then adding into a mixed solvent of other components and the remaining solvent, and mixing uniformly.
摘要翻译：公开了不溶性药物的液体组合物及其制备方法。该组合物包括不溶性药物，注射用油，磷脂和溶剂; 每种成分的重量百分比如下：不溶性药物0.01-10％，注射用油0％-20％，磷脂10-80％，溶剂20-89％。组合物的制备方法包括以下步骤：首先将不溶性药物溶解于溶剂或注射用油或其混合物中，然后加入其它组分，均匀混合; 或将不溶性药物溶解到其它组分的混合物中，并均匀混合; 或首先将不溶性药物溶解在一部分溶剂中，然后加入到其他成分和剩余溶剂的混合溶剂中，并均匀混合。

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