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1. 发明授权

US09539418B2 Proteoglycan-containing microneedle array 有权
标题翻译：含蛋白多糖的微针阵列
公开(公告)号：US09539418B2
公开(公告)日：2017-01-10
申请号：US13635813
申请日：2011-03-18
申请人： Ying-shu Quan , Fumio Kamiyama , Takao Taki , Kazuyoshi Kawai , Tadayoshi Takemoto , Takuya Hamabuchi , Kazuhide Ohta
发明人： Ying-shu Quan , Fumio Kamiyama , Takao Taki , Kazuyoshi Kawai , Tadayoshi Takemoto , Takuya Hamabuchi , Kazuhide Ohta
IPC分类号： A61M37/00 , A61K9/00 , A61Q19/00 , A61Q19/08 , A61K8/98
CPC分类号： A61M37/0015 , A61K8/981 , A61K8/987 , A61K9/0021 , A61K2800/87 , A61K2800/91 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053 , A61Q19/00 , A61Q19/08
摘要： A microneedle array is provided which has (1) the strength to withstand insertion into the skin surface layer and/or stratum corneum, (2) the fineness and flexibility to cause no pain or bleeding in the skin surface layer and/or stratum corneum at the insertion site of the microneedles, and (3) solubility or biodegradability of the microneedle portions under the skin. The microneedle array is produced by forming microneedles using proteoglycan as a base material.
摘要翻译：提供了一种微针阵列，其具有（1）抵抗插入皮肤表面层和/或角质层的强度，（2）在皮肤表面层和/或角质层中不产生疼痛或出血的细度和柔韧性微针的插入部位，（3）皮肤下的微针部分的溶解度或生物降解性。微针阵列通过使用蛋白多糖作为基材形成微针来制造。

2. 发明申请

US20130012882A1 PROTEOGLYCAN-CONTAINING MICRONEEDLE ARRAY 有权
标题翻译：含蛋白质包含微阵列
公开(公告)号：US20130012882A1
公开(公告)日：2013-01-10
申请号：US13635813
申请日：2011-03-18
申请人： Ying-shu Quan , Fumio Kamiyama , Takao Taki , Kazuyoshi Kawai , Tadayoshi Takemoto , Takuya Hamabuchi , Kazuhide Ohta
发明人： Ying-shu Quan , Fumio Kamiyama , Takao Taki , Kazuyoshi Kawai , Tadayoshi Takemoto , Takuya Hamabuchi , Kazuhide Ohta
IPC分类号： A61M5/00 , B29C47/06
CPC分类号： A61M37/0015 , A61K8/981 , A61K8/987 , A61K9/0021 , A61K2800/87 , A61K2800/91 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053 , A61Q19/00 , A61Q19/08
摘要： An object of the present invention is to provide a novel microneedle array that has (1) the strength to withstand insertion into the skin surface layer and/or stratum corneum, (2) the fineness and flexibility to cause no pain or bleeding in the skin surface layer and/or stratum corneum at the insertion site of the microneedles, and (3) solubility or biodegradability of the microneedle portions under the skin.[Method for Achieving the Object]The microneedle array is produced by forming microneedles using proteoglycan as a base material.
摘要翻译：本发明的目的是提供一种新颖的微针阵列，其具有（1）抵抗插入皮肤表面层和/或角质层的强度，（2）细度和柔韧性，使皮肤无疼痛或出血表面层和/或角质层在微针的插入位置，和（3）皮肤下的微针部分的溶解度或生物降解性。 [实现对象的方法]微针阵列通过使用蛋白多糖作为基材形成微针来制造。

3. 发明申请

US20100136092A1 TRANSDERMAL IMMUNE PREPARATION, METHOD FOR PRODUCTION OF THE SAME, AND TRANSDERMAL IMMUNIZATION METHOD USING THE SAME 审中-公开
标题翻译：透皮免疫制剂，其制造方法和使用该抗体的透皮免疫方法
公开(公告)号：US20100136092A1
公开(公告)日：2010-06-03
申请号：US12529200
申请日：2008-02-28
申请人： Shinsaku Nakagawa , Naoki Okada , Takuya Fujita , Fumio Kamiyama , Ying-shu Quan
发明人： Shinsaku Nakagawa , Naoki Okada , Takuya Fujita , Fumio Kamiyama , Ying-shu Quan
IPC分类号： A61K9/70 , A61K31/7088 , A61K39/00 , A61K39/12 , A61K31/7105 , A61K38/43 , A61P31/04 , A61P31/12 , A61P31/10 , A61P33/00 , A61P37/04
CPC分类号： A61K31/7088 , A61K9/7053 , A61K9/7061 , A61K39/00 , A61K39/12 , A61K39/235 , A61K39/292 , A61K39/35 , A61K48/0041 , A61K48/005 , A61K48/0075 , A61K2039/53 , A61K2039/54 , A61K2039/555 , C12N2710/10034 , C12N2730/10134
摘要： This invention is concerned with transdermal immune preparations which can exhibit a high immunological activity without containing any adjuvant, methods for producing the preparation, and transdermal immunization methods using the preparation.The transdermal immune preparations can regulate the immune response by applying the preparation to an intact skin, and which comprises a base material and an antigen or artificial synthetic nucleic acid laminated on the surface of the base material; the methods for producing transdermal immune preparations which comprises putting drops of an aqueous solution or suspension prepared by dissolving or suspending an antigen in water or a water-containing alcohol on the surface of a base material in order for the water or the water-containing alcohol to be absorbed in the base material, thereby forming an layer containing the antigen in a concentrated state on the surface of the base material; and the transdermal immunization methods which is characterized by applying the transdermal immune preparation to an intact skin to regulate the immune response.
摘要翻译：本发明涉及可以在不含任何佐剂的情况下表现出高免疫学活性，制备该制剂的方法和使用该制剂的透皮免疫方法的透皮免疫制剂。透皮免疫制剂可以通过将制剂应用于完整皮肤来调节免疫应答，其包含层压在基材表面上的基材和抗原或人造合成核酸; 用于生产透皮免疫制剂的方法，其包括将通过将抗原溶解或悬浮在水或含水醇中而制备的水溶液或悬浮液滴在基材的表面上，以使水或含水醇被吸收在基材中，从而在基材的表面上形成浓缩状态的含有抗原的层; 和经皮免疫方法，其特征在于将透皮免疫制剂应用于完整的皮肤以调节免疫应答。

4. 发明申请

US20140257189A1 MICRONEEDLE DEPOSITION METHOD 有权
标题翻译： MICRONEEDLE沉积方法
公开(公告)号：US20140257189A1
公开(公告)日：2014-09-11
申请号：US14352397
申请日：2011-10-20
申请人： Ying-shu Quan , Fumio Kamiyama
发明人： Ying-shu Quan , Fumio Kamiyama
IPC分类号： A61K9/00 , A61M37/00
CPC分类号： A61K9/0021 , A61K9/08 , A61M37/0015 , A61M2037/0046 , A61M2037/0053
摘要： The present invention provides a microneedle array which holds a drug only in the microneedle portions, and a method of manufacturing the same.The microneedle array 2A which holds the drug only on the tips of the microneedles can be manufactured by the microneedle deposition method, i.e. a) the microneedle array 2 is prepared using an water-soluble polymer as a base material; b) a drug solution 1 to be applied to the tips of the microneedle array 2 is prepared; and c) the tips of the microneedle array 2 are contacted with the drug solution 1 for a short time. When the drug solution 1 is a water solution, the biodegradable polymer is of water-soluble, and in addition to the drug, the biodegradable polymer is dissolved in the solution at high concentration, the applied drug is integrated with the microneedle so that only the drug does not fall away during insertion.
摘要翻译：本发明提供了仅在微针部分中保持药物的微针阵列及其制造方法。可以通过微针沉积法制造仅存在微针尖端的微针阵列2A，即a）使用水溶性聚合物作为基材制备微针阵列2; b）制备施加到微针阵列2的末端的药液1; 和c）微针阵列2的尖端与药物溶液1短时间接触。当药物溶液1为水溶液时，生物降解性聚合物是水溶性的，除了药物之外，可生物降解的聚合物以高浓度溶解在溶液中，所施用的药物与微针一体化，使得只有药物在插入过程中不会脱落。

5. 发明申请

US20100076112A1 Crosslinkable pressure-sensitive adhesive for skin 有权
标题翻译：可交联的皮肤粘合剂
公开(公告)号：US20100076112A1
公开(公告)日：2010-03-25
申请号：US12592348
申请日：2009-11-24
申请人： Fumio Kamiyama , Ying Shu Quan , Naohisa Kawamura , Hidenori Sawada
发明人： Fumio Kamiyama , Ying Shu Quan , Naohisa Kawamura , Hidenori Sawada
IPC分类号： A61L24/04
CPC分类号： A61L24/043 , A61K8/8158 , A61K9/7061 , A61L15/585 , A61Q19/00 , C08L33/14 , C08L33/24 , C08L2666/04
摘要： A composition for production of a crosslinkable pressure-sensitive adhesive for skin, obtained by dissolving in a solvent 100 parts by weight of an acrylic copolymer (copolymer A) comprising a (meth)acrylic acid alkyl ester as the main constituent component and 3-45 wt % diacetoneacrylamide as an essential constituent component, and containing no free carboxyl groups, and 0.1-30 parts by weight of an acrylic copolymer (copolymer B) comprising a (meth)acrylic acid alkyl ester as the main constituent component and a primary amino group and/or carboxyhydrazide group on a side chain, and containing no free carboxyl groups.
摘要翻译：通过在溶剂中溶解100重量份的以（甲基）丙烯酸烷基酯为主要成分的丙烯酸系共聚物（共聚物A）和3-45的丙烯酸系共聚物（共聚物A）而制造的皮肤用交联性粘合剂用组合物重量％的双丙酮丙烯酰胺作为必需组分，不含游离羧基，0.1-30重量份以（甲基）丙烯酸烷基酯为主要成分的丙烯酸共聚物（共聚物B）和伯氨基和/或羧基酰肼基，并且不含游离羧基。

6. 发明申请

US20070196455A1 Crosslinkable pressure-sensitive adhesive for skin 审中-公开
标题翻译：可交联的皮肤粘合剂
公开(公告)号：US20070196455A1
公开(公告)日：2007-08-23
申请号：US10593242
申请日：2005-04-12
申请人： Fumio Kamiyama , Ying Shu Quan , Naohisa Kawamura , Hidenori Sawada
发明人： Fumio Kamiyama , Ying Shu Quan , Naohisa Kawamura , Hidenori Sawada
IPC分类号： C08G63/08 , A61K9/70
CPC分类号： A61L24/043 , A61K8/8158 , A61K9/7061 , A61L15/585 , A61Q19/00 , C08L33/14 , C08L33/24 , C08L2666/04
摘要： It is an object of the invention to provide a crosslinkable pressure-sensitive adhesive for skin that exhibits satisfactory adhesion and releasability for human skin and low irritation to skin, and a crosslinkable pressure-sensitive adhesive sheet for skin that is suitable for medical and cosmetic use, as well as to provide a composition for production of a crosslinkable pressure-sensitive adhesive for skin that has superior storage properties and is suitable for preparation of the crosslinkable pressure-sensitive adhesive for skin. The crosslinkable pressure-sensitive adhesive for skin of the invention is formed by 100 parts by weight of an acrylic copolymer (copolymer A) comprising a (meth) acrylic acid alkyl ester as the main constituent component and 3-45 wt % diacetoneacrylamide as an essential constituent component, and containing no free carboxyl groups, and 0.1-30 parts by weight of an acrylic copolymer (copolymer B) comprising a (meth)acrylic acid alkyl ester as the main constituent component and a primary amino group and/or carboxyhydrazide group on a side chain, and containing no free carboxyl groups. A composition of copolymer A and copolymer B dissolved in a solvent containing at least 5.0 wt % acetone and/or butanone with respect to the total amount of solvent can be stored for prolonged periods.
摘要翻译：本发明的目的是提供一种适用于医疗和美容用途的皮肤用交联性粘合剂，其表现出令人满意的对人体皮肤的粘附和释放性以及对皮肤的低刺激性。，以及提供具有优异的储存性能并且适于制备用于皮肤的交联性压敏粘合剂的用于皮肤的可交联粘合剂的组合物。本发明的交联性皮肤用粘合剂由100重量份以（甲基）丙烯酸烷基酯为主要成分的丙烯酸共聚物（共聚物A）和3-45重量％的双丙酮丙烯酰胺作为必要成分构成成分，不含有游离羧基的化合物，以及0.1-30重量份包含（甲基）丙烯酸烷基酯作为主要成分的丙烯酸共聚物（共聚物B）和伯氨基和/或羧酰肼基团侧链，不含游离羧基。相对于溶剂的总量，溶解在含有至少5.0重量％丙酮和/或丁酮的溶剂中的共聚物A和共聚物B的组合物可以长时间储存。

7. 发明授权

US08393199B2 Apparatus for measuring diffusion of transdermal absorption preparation 有权
标题翻译：用于测量经皮吸收制剂扩散的装置
公开(公告)号：US08393199B2
公开(公告)日：2013-03-12
申请号：US12525305
申请日：2007-01-31
申请人： Fumio Kamiyama , Ying-shu Quan
发明人： Fumio Kamiyama , Ying-shu Quan
IPC分类号： G01N13/04
CPC分类号： G01N13/00 , G01N2013/003
摘要： This invention is to provide a diffusion testing device to facilitate determination of diffusivity of prolonged release of drugs from transdermal therapeutic preparation.The diffusion testing device is characterized by a receptor liquid reservoir; a diffusion testing cell having a receptor chamber functioning to be full of receptor liquid and within which a stirrer be placed, a receptor liquid supply unit, a thermostat bath to hold the diffusion testing cell, a stirring apparatus located beneath the thermostat bath to cause the rotation action of the stirrer set in the receptor chamber, a sampling unit permitting sampling and storage of receptor liquid dissolving permeated drugs. Said receptor liquid reservoir, said receptor chamber, said receptor liquid supply unit and said sampling unit are connected with each other via infusion tube. Said thermostat bath comprises aperturees or through-holes functioning to hold the diffusion testing cells, and metal block which has temperature regulation unit to be installed.
摘要翻译：本发明提供一种扩散测试装置，以便于确定药物从经皮治疗制剂中延长释放的扩散性。扩散测试装置的特征在于受体液体储存器; 扩散测试电池，其具有充满受体液体并且其中放置搅拌器的受体室，受体液体供应单元，用于保持扩散测试电池的恒温槽，位于恒温槽下方的搅拌设备，受体室中设置的搅拌器的旋转作用，允许取样和储存受溶液溶解渗透药物的取样单元。所述受体液体储存器，所述受体室，所述受体液体供应单元和所述取样单元通过输注管相互连接。所述恒温槽包括用于保持扩散测试电池的孔或通孔，以及具有要安装的温度调节单元的金属块。

8. 发明授权

US08389001B2 Precursor composition for crosslinkable pressure-sensitive adhesive for skin 有权
标题翻译：用于皮肤的交联性压敏粘合剂的前体组合物
公开(公告)号：US08389001B2
公开(公告)日：2013-03-05
申请号：US12592348
申请日：2009-11-24
申请人： Fumio Kamiyama , Ying Shu Quan , Naohisa Kawamura , Hidenori Sawada
发明人： Fumio Kamiyama , Ying Shu Quan , Naohisa Kawamura , Hidenori Sawada
IPC分类号： A61F13/02 , A61K9/70 , A61K47/30 , A61L24/06 , C08F18/02
CPC分类号： A61L24/043 , A61K8/8158 , A61K9/7061 , A61L15/585 , A61Q19/00 , C08L33/14 , C08L33/24 , C08L2666/04
摘要： A composition for production of a crosslinkable pressure-sensitive adhesive for skin, obtained by dissolving in a solvent 100 parts by weight of an acrylic copolymer (copolymer A) comprising a (meth)acrylic acid alkyl ester as the main constituent component and 3-45 wt % diacetoneacrylamide as an essential constituent component, and containing no free carboxyl groups, and 0.1-30 parts by weight of an acrylic copolymer (copolymer B) comprising a (meth)acrylic acid alkyl ester as the main constituent component and a primary amino group and/or carboxyhydrazide group on a side chain, and containing no free carboxyl groups.
摘要翻译：通过在溶剂中溶解100重量份的以（甲基）丙烯酸烷基酯为主要成分的丙烯酸系共聚物（共聚物A）和3-45的丙烯酸系共聚物（共聚物A）而制造的皮肤用交联性粘合剂用组合物重量％的双丙酮丙烯酰胺作为必需组分，不含游离羧基，0.1-30重量份以（甲基）丙烯酸烷基酯为主要成分的丙烯酸共聚物（共聚物B）和伯氨基和/或羧基酰肼基，并且不含游离羧基。

9. 发明授权

US08167852B2 Microneedle device and method for producing the same 有权
标题翻译：微针装置及其制造方法
公开(公告)号：US08167852B2
公开(公告)日：2012-05-01
申请号：US12599860
申请日：2008-04-01
申请人： Ying-shu Quan , Fumio Kamiyama , Yoshikazu Tobinaga , Tomoya Kitagawa , Kentaro Ohshima , Akira Yamamoto
发明人： Ying-shu Quan , Fumio Kamiyama , Yoshikazu Tobinaga , Tomoya Kitagawa , Kentaro Ohshima , Akira Yamamoto
IPC分类号： A61M5/32 , A61M35/00 , A61K9/02
CPC分类号： A61M37/0015 , A61M2037/0046 , A61M2037/0053 , Y10T83/0467
摘要： Microneedle device is provided, which include microneedles that can be easily inserted into skin and dissolve or swell in skin. The microneedle devices comprise a substrate and cone-shaped or pyramid-shaped microneedles for skin insertion set on the substrate. The microneedles for skin insertion contain over 50 weight percent of one or multiple biomaterials chosen from chitosan, collagen, gelatin, hyaluronic acid, and they are fabricated from the materials that can dissolve or swell in the body.
摘要翻译：提供微针装置，其包括可以容易地插入皮肤并溶解或溶胀在皮肤中的微针。微针装置包括用于皮肤插入的衬底和锥形或金字塔形的微针，其设置在衬底上。用于皮肤插入的微针含有超过50重量％的选自壳聚糖，胶原，明胶，透明质酸的一种或多种生物材料，并且它们由可在体内溶解或溶胀的材料制成。

10. 发明授权

US09993423B2 Microneedle deposition method 有权
公开(公告)号：US09993423B2
公开(公告)日：2018-06-12
申请号：US14352397
申请日：2011-10-20
申请人： Ying-shu Quan , Fumio Kamiyama
发明人： Ying-shu Quan , Fumio Kamiyama
IPC分类号： A61M37/00 , A61K9/00 , A61K9/08
CPC分类号： A61K9/0021 , A61K9/08 , A61M37/0015 , A61M2037/0046 , A61M2037/0053
摘要： The present invention provides a microneedle array which holds a drug only in the microneedle portions, and a method of manufacturing the same.The microneedle array 2A which holds the drug only on the tips of the microneedles can be manufactured by the microneedle deposition method, i.e. a) the microneedle array 2 is prepared using an water-soluble polymer as a base material; b) a drug solution 1 to be applied to the tips of the microneedle array 2 is prepared; and c) the tips of the microneedle array 2 are contacted with the drug solution 1 for a short time. When the drug solution 1 is a water solution, the biodegradable polymer is of water-soluble, and in addition to the drug, the biodegradable polymer is dissolved in the solution at high concentration, the applied drug is integrated with the microneedle so that only the drug does not fall away during insertion.

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