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1. 发明申请

US20100179492A1 METHODS FOR INCREASING TRICHOGENICITY OF DERMAL CELLS 审中-公开
标题翻译：增加细胞的致癌性的方法
公开(公告)号：US20100179492A1
公开(公告)日：2010-07-15
申请号：US12353699
申请日：2009-01-14
申请人： Ying Zheng , Arben Nace , Luke Sergott , Michael Ensslin , Ying Homan , Kurt Stenn
发明人： Ying Zheng , Arben Nace , Luke Sergott , Michael Ensslin , Ying Homan , Kurt Stenn
IPC分类号： A61M35/00 , C12N5/08 , A61B17/50 , A61B18/20 , A61B18/04 , A61K35/12
CPC分类号： A61B18/203 , A61B2018/00452 , A61K35/36
摘要： Methods for increasing trichogenic activity of populations of dermal cells by inducing local trauma to skin tissue that serves as a source of the dermal cells are provided. Methods for obtaining dermal cells with increased trichogenic activity and for using the disclosed dermal cells to implant into a mammalian host at a site of desired follicle generation are also provided.
摘要翻译：提供了通过诱导作为真皮细胞来源的皮肤组织的局部创伤来增加真皮细胞群体的致毛菌活性的方法。还提供了获得具有增加的致毛细胞活性的真皮细胞和使用公开的真皮细胞在期望的卵泡发生部位植入哺乳动物宿主的方法。

2. 发明申请

US20120022433A1 METHODS FOR INCREASING TRICHOGENICITY OF DERMAL CELLS 审中-公开
标题翻译：增加细胞的致癌性的方法
公开(公告)号：US20120022433A1
公开(公告)日：2012-01-26
申请号：US13250536
申请日：2011-09-30
申请人： Ying Zheng , Arben Nace , Luke Sergott , Michael Ensslin , Ying Homan , Kurt Stenn
发明人： Ying Zheng , Arben Nace , Luke Sergott , Michael Ensslin , Ying Homan , Kurt Stenn
IPC分类号： A61M37/00 , C12N5/071
CPC分类号： A61B18/203 , A61B2018/00452 , A61K35/36
摘要： Methods for increasing trichogenic activity of populations of dermal cells by inducing local trauma to skin tissue that serves as a source of the dermal cells are provided. Methods for obtaining dermal cells with increased trichogenic activity and for using the disclosed dermal cells to implant into a mammalian host at a site of desired follicle generation are also provided.
摘要翻译：提供了通过诱导作为真皮细胞来源的皮肤组织的局部创伤来增加真皮细胞群体的致毛菌活性的方法。还提供了获得具有增加的致毛细胞活性的真皮细胞和使用公开的真皮细胞在期望的卵泡发生部位植入哺乳动物宿主的方法。

3. 发明申请

US20120095445A1 METHODS AND COMPOSITIONS FOR INCREASING TRICHOGENIC POTENCY OF DERMAL CELLS 审中-公开
标题翻译：增加细胞的多发性磷酸化的方法和组合物
公开(公告)号：US20120095445A1
公开(公告)日：2012-04-19
申请号：US13378732
申请日：2010-06-16
申请人： Ying Zheng , Marylene Boucher , Ying Homan , Charles Hollow , Polina Mamontov , Kurt Stenn
发明人： Ying Zheng , Marylene Boucher , Ying Homan , Charles Hollow , Polina Mamontov , Kurt Stenn
IPC分类号： A61K35/12 , A61P17/14 , A61M37/00 , C12N5/071
CPC分类号： C07D409/12 , A61K31/381 , A61K31/4436
摘要： Methods and compositions for increasing trichogenicity of cells in culture are provided. One embodiment provides culturing dissociated mammalian dermal cells in vitro in the presence of an effective amount of one or more sonic hedgehog (Shh) pathway agonists to increase the trichogenicity of the dissociated mammalian dermal cells compared to untreated dissociated mammalian dermal cells. The cell culture optionally includes epidermal cells. Preferred Shh agonists include, but are not limited to CUR-0236715 and CUR-0201365 available from Curis, Inc. Trichogenicity is measured using the Aderans Hair Patch Assay™. The cultured dermal cells can be maintained in culture in the presence of the one or more Shh agonists for at least 1 to 7 or more days prior to harvest. The treated, cultured dermal cells can be used to treat hair loss in a mammalian subject, preferably a human, by implanting them in an effective amount to induce hair follicle formation.
摘要翻译：提供了用于增加培养物中细胞的致毛性的方法和组合物。一个实施方案在有效量的一种或多种声刺猬（Shh）途径激动剂的存在下提供培养解离的哺乳动物真皮细胞，以增加与未处理的解离的哺乳动物真皮细胞相比，解离的哺乳动物真皮细胞的致毛性。细胞培养物任选地包括表皮细胞。优选的Shh激动剂包括但不限于可从Curis，Inc。获得的CUR-0236715和CUR-0201365。使用Aderans Hair Patch Assay TM测量Trichoigenicity。培养的真皮细胞可以在收获前至少1至7天或更多天在一种或多种Shh激动剂存在下保持培养。经处理的培养的真皮细胞可用于通过将它们植入有效量以诱导毛囊形成来治疗哺乳动物受试者，优选人类的脱发。

4. 发明申请

US20100291580A1 BIOMARKERS FOR TRICHOGENICITY 审中-公开
标题翻译：生物标志物的生物多样性
公开(公告)号：US20100291580A1
公开(公告)日：2010-11-18
申请号：US12808623
申请日：2008-12-18
申请人： Satish Parimoo , Honghua Yang , Ying Homan , Wei Chen , Ying Zheng , Kurt Stenn
发明人： Satish Parimoo , Honghua Yang , Ying Homan , Wei Chen , Ying Zheng , Kurt Stenn
IPC分类号： C12Q1/68 , G01N33/566 , C12N15/79
CPC分类号： C12Q1/6881 , C12Q2600/178 , G01N33/6881 , G01N33/6893 , G01N2500/10
摘要： Biomarkers for identifying trichogenic cells have been identified. The biomarkers include microRNA as wells as mRNA and proteins. Certain biomarkers are upregulated in trichogenic cells compared to non-trichogenic cells; whereas, other biomarkers are down-regulated in trichogenic cells compared to non-trichogenic cells. The cells can be dermal cells, epidermal cells, or a combination thereof. Preferably the cells are mammalian, more preferably the cells are human. One embodiment provides a method for selecting trichogenic cells by assaying the cells for expression of one or more biomarkers for trichogenicity, and selecting the cells having increased expression of the one or more biomarkers relative to a control, wherein increased expression of the a biomarker in the cells is indicative of trichogenicity. Preferably, the one or more biomarkers are selected from the group consisting of hsa-miR-200c, hsa-miR-205, hsa-miR-200a*, hsa-miR-200a, hsa-miR-141, hsa-miR-182, DEPDC1, hFLEG1, ESM1, TOME-1, THBD and combinations thereof.
摘要翻译：已鉴定出用于鉴定发生细胞的生物标志物。生物标志物包括微RNA作为mRNA和蛋白质的孔。与非致毛细胞相比，某些生物标志物在致毛细胞中上调; 而与非致毛细胞相比，其他生物标志物在发育细胞中下调。细胞可以是真皮细胞，表皮细胞或其组合。优选地，细胞是哺乳动物，更优选细胞是人。一个实施方案提供了一种用于通过测定细胞用于表达一种或多种针刺性生物标志物的细胞并选择相对于对照而增加一种或多种生物标志物表达的细胞的方法，其中所述生物标志物在细胞表示毛发性。优选地，一种或多种生物标志物选自hsa-miR-200c，hsa-miR-205，hsa-miR-200a *，hsa-miR-200a，hsa-miR-141，hsa-miR-182 ，DEPDC1，hFLEG1，ESM1，TOME-1，THBD及其组合。

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