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1. 发明授权

US5480963A Absorbable copolymers derived from tricarboxylic acids and surgical articles made therefrom 失效
标题翻译：由三羧酸衍生的可吸收共聚物和由其制成的外科用品
公开(公告)号：US5480963A
公开(公告)日：1996-01-02
申请号：US279126
申请日：1994-07-22
申请人： Ying Jiang , John S. Bobo , Elliott A. Gruskin
发明人： Ying Jiang , John S. Bobo , Elliott A. Gruskin
IPC分类号： A61L17/08 , A61L17/14 , A61L24/00 , A61L26/00 , A61L27/52 , C08G63/12 , C08G63/685
CPC分类号： A61L27/52 , A61L17/08 , A61L17/145 , A61L24/0031 , A61L26/008 , C08G63/12 , C08G63/6854
摘要： Bioabsorbable copolymers are derived from tricarboxylic acids and triols. The copolymers are useful in forming surgical articles including, sutures, suture coatings, and gels for promoting tissue repair.
摘要翻译：生物可吸收共聚物衍生自三羧酸和三醇。共聚物可用于形成外科用品，包括缝线，缝线涂层和用于促进组织修复的凝胶。

2. 发明授权

US5578662A Bioabsorbable branched polymers containing units derived from dioxanone and medical/surgical devices manufactured therefrom 失效
公开(公告)号：US5578662A
公开(公告)日：1996-11-26
申请号：US477098
申请日：1995-06-07
申请人： Steven L. Bennett , Ying Jiang , Elliott A. Gruskin , Kevin M. Connolly
发明人： Steven L. Bennett , Ying Jiang , Elliott A. Gruskin , Kevin M. Connolly
IPC分类号： A61L17/12 , A61L31/06 , C08G63/06 , C08G63/91 , C08G63/08 , C08G65/26 , C08G65/32
CPC分类号： C08G63/912 , A61L17/12 , A61L31/06 , C08G63/06
摘要： Star polymers of soft segment forming monomers are useful in forming surgical devices. The star polymers can be endcapped with isocyanate, mixed with a filler and/or cross-linked. The polymer compositions are useful, for example, as fiber coatings, surgical adhesives or bone putty, or tissue growth substrate.

3. 发明授权

US5502042A Methods and compositions for treating wounds 失效
标题翻译：治疗伤口的方法和组合物
公开(公告)号：US5502042A
公开(公告)日：1996-03-26
申请号：US278778
申请日：1994-07-22
申请人： Elliott A. Gruskin , Ying Jiang
发明人： Elliott A. Gruskin , Ying Jiang
IPC分类号： A61L26/00 , A01N43/04 , C07H5/04
CPC分类号： A61L26/0023
摘要： Wound treatment compositions include an oxidized cross-linked polysaccharide which has a chemically induced charge. Preferred polysaccharides are cross-linked dextrans. A charge is preferably provided by diethylaminoethyl groups (DEAE groups) or carboxymethyl groups. The oxidized cross-linked polysaccharide can be applied as a powder directly to a wound site. Alternatively, the oxidized cross-linked polysaccharide can be combined with a delivery vehicle to form a liquid or past to be applied to a wound site.
摘要翻译：伤口治疗组合物包括具有化学诱导电荷的氧化交联多糖。优选的多糖是交联的葡聚糖。优选由二乙基氨基乙基（DEAE基团）或羧甲基提供电荷。氧化交联多糖可以直接作为粉末施用于伤口部位。或者，氧化的交联多糖可以与递送载体组合以形成液体或过去以施用于伤口部位。

4. 发明授权

US06207767B1 Bioabsorbable branched polymer containing units derived from dioxanone and medical/surgical devices manufactured therefrom 失效
标题翻译：含有衍生自二恶烷酮的单体的生物可吸收支化聚合物和由其制造的医疗/手术装置
公开(公告)号：US06207767B1
公开(公告)日：2001-03-27
申请号：US08979009
申请日：1997-11-26
申请人： Steven L. Bennett , Ying Jiang , Elliott A. Gruskin , Kevin M. Connolly
发明人： Steven L. Bennett , Ying Jiang , Elliott A. Gruskin , Kevin M. Connolly
IPC分类号： C08G6402
CPC分类号： C08G63/912 , A61L17/12 , A61L31/06 , C08G63/06 , A61L31/148 , A61B17/11 , A61B17/08 , A61B17/58 , C08L67/04
摘要： Star polymers of soft segment forming monomers are useful in forming surgical devices. The star polymers can be encapped with isocyanate, mixed with a filler and/or cross-linked. The polymer compositions are useful, for example, as fiber coatings, surgical adhesives or bone putty, or tissue growth substrate.
摘要翻译：软链段形成单体的星形聚合物可用于形成外科装置。星形聚合物可以与异氰酸酯包裹，与填料混合和/或交联。聚合物组合物可用作例如纤维涂层，手术粘合剂或骨腻子或组织生长底物。

5. 发明授权

US5505952A Modified synthetic cross-linked amino acid polymers and medical devices formed therefrom 失效
标题翻译：改性的合成交联氨基酸聚合物和由其形成的医疗装置
公开(公告)号：US5505952A
公开(公告)日：1996-04-09
申请号：US229970
申请日：1994-04-19
申请人： Ying Jiang , Elliott A. Gruskin
发明人： Ying Jiang , Elliott A. Gruskin
IPC分类号： A61L15/26 , A61L31/06 , A61L15/00 , A61L31/00
CPC分类号： A61L15/26 , A61L31/06
摘要： Synthetic, cross-linked amino-acid containing polymers are useful in forming medical devices. The hydrogels of the invention are particularly useful in wound healing and anti-adhesion applications.
摘要翻译：合成的含交联氨基酸的聚合物可用于形成医疗装置。本发明的水凝胶特别可用于伤口愈合和抗粘连应用。

6. 发明授权

US08226941B2 Methods of purifying chondroitinase and stable formulations thereof 有权
标题翻译：软骨素酶的纯化方法及其稳定配方
公开(公告)号：US08226941B2
公开(公告)日：2012-07-24
申请号：US11568831
申请日：2005-05-18
申请人： Anthony O. Caggiano , Elliott A. Gruskin , Yelena G. Sheptovitsky , Sarah Kasperbauer
发明人： Anthony O. Caggiano , Elliott A. Gruskin , Yelena G. Sheptovitsky , Sarah Kasperbauer
IPC分类号： A61K38/46 , A61K38/47 , C12N9/24 , C07H21/04
CPC分类号： C12N9/88 , A61K38/00 , C12Y402/02004
摘要： An aspect of the present invention relates to stable formulations of chondroitinase and to methods of purifying chondroitinase. The methods of purifying chondroitinase includes the steps of extracting the enzyme from a cell, separating the chondroitinase from the crude cell extract using cation-exchange chromatography, removing impurities through gel filtration chromatography, and removing endotoxin through an anion-exchange membrane to produce a purified chondroitinase.
摘要翻译：本发明的一个方面涉及软骨素酶的稳定制剂和软骨素酶的纯化方法。纯化软骨素酶的方法包括从细胞中提取酶的步骤，使用阳离子交换层析从粗细胞提取物中分离软骨素酶，通过凝胶过滤色谱法除去杂质，以及通过阴离子交换膜除去内毒素以产生纯化的软骨素酶。

7. 发明授权

US11240977B2 Compact photobioreactor with built-in lights 有权
公开(公告)号：US11240977B2
公开(公告)日：2022-02-08
申请号：US15658297
申请日：2017-07-24
申请人： Elliott A. Gruskin
发明人： Elliott A. Gruskin
IPC分类号： A01G31/02 , A01K61/20 , A01K63/04 , A01K63/06 , A01K63/00 , C12M1/00 , A01G33/00
摘要： A photobioreactor device for growing photosynthetic organisms, organisms that feed on photosynthetic organisms and hydroponics is disclosed. The device may include a lighting system integrated around the circumference of the device. In embodiments, a cap configured to seal the container has ports configured to permit passage of fluid out of or into a container without removing the cap. In some embodiments, organisms are grown in a disposable bag secured between the cap and the container.

8. 发明授权

US07968089B2 Proteoglycan degrading mutants for the treatment of CNS 有权
标题翻译：蛋白多糖降解突变体用于治疗CNS
公开(公告)号：US07968089B2
公开(公告)日：2011-06-28
申请号：US12167573
申请日：2008-07-03
申请人： Elliott A. Gruskin , Anthony O. Caggiano , Gargi Roy , Rohini D'Souza
发明人： Elliott A. Gruskin , Anthony O. Caggiano , Gargi Roy , Rohini D'Souza
IPC分类号： A61K38/51 , C12N15/60 , C12N9/88
CPC分类号： C12N9/88 , A61K35/30 , A61K38/00 , A61K38/51 , A61K45/06 , C07K14/005 , C07K19/00 , C07K2319/00 , C07K2319/03 , C07K2319/10 , C12N9/2408 , C12Y302/01035 , C12Y302/01036 , C12Y402/02001 , C12Y402/02004 , C12Y402/02005
摘要： The present disclosure relates to the preparation and deletion mutants of chondroitinase proteins and their use in methods for promoting the diffusion of therapeutic composition into tissues and their use for neurological functional recovery after central nervous system (“CNS”) injury or disease.
摘要翻译：本公开涉及软骨素酶蛋白的制备和缺失突变体及其在促进治疗组合物扩散到组织中的方法及其在中枢神经系统（“CNS”）损伤或疾病之后神经功能恢复的用途。

9. 发明申请

US20090041728A1 Proteoglycan Degrading Mutants for the Treatment of CNS 有权
标题翻译：蛋白多糖降解突变体用于治疗CNS
公开(公告)号：US20090041728A1
公开(公告)日：2009-02-12
申请号：US12167573
申请日：2008-07-03
申请人： Elliott A. Gruskin , Rohini D'Souza , Gargi Roy , Anthony O. Caggiano
发明人： Elliott A. Gruskin , Rohini D'Souza , Gargi Roy , Anthony O. Caggiano
IPC分类号： A61K35/74 , A61K38/16 , A61P25/00
CPC分类号： C12N9/88 , A61K35/30 , A61K38/00 , A61K38/51 , A61K45/06 , C07K14/005 , C07K19/00 , C07K2319/00 , C07K2319/03 , C07K2319/10 , C12N9/2408 , C12Y302/01035 , C12Y302/01036 , C12Y402/02001 , C12Y402/02004 , C12Y402/02005
摘要： The present disclosure relates to the preparation and deletion mutants of chondroitinase proteins and their use in methods for promoting the diffusion of therapeutic composition into tissues and their use for neurological functional recovery after central nervous system (“CNS”) injury or disease.
摘要翻译：本公开涉及软骨素酶蛋白的制备和缺失突变体及其在促进治疗组合物扩散到组织中的方法及其在中枢神经系统（“CNS”）损伤或疾病之后神经功能恢复的用途。

10. 发明授权

US06756518B2 Scar reduction 有权
标题翻译：疤痕减少
公开(公告)号：US06756518B2
公开(公告)日：2004-06-29
申请号：US10058182
申请日：2002-01-25
申请人： Elliott A. Gruskin , Christofer T. Chistoforou
发明人： Elliott A. Gruskin , Christofer T. Chistoforou
IPC分类号： A61F1300
CPC分类号： A61L17/145 , A61K31/715 , A61K31/738 , A61L27/34 , C08L5/02
摘要： A method of reducing scar formation at a wound site includes contacting the wound site with an effective scar reducing amount of a cross-linked polysaccharide having a positive charge and thereby reducing scar formation as the wound site heals. Such polysaccharide include bioabsorbable cross-linked dextrans or alginates. The positive charge may be provided by diethylaminoethyl (DEAE) moieties. The cross-linked polysaccharide can be applied to the wound site as a powder or bead. The cross-linked polysaccharide may also be contained in a composition including a pharmaceutically acceptable vehicle. Biocompatable surgical devices are provided with an effective scar reducing amount of a cross-linked polysaccharide having a positive charge which reduce scar formation at healing wound sites. A method of reducing TGF-&bgr; activity is also provided.
摘要翻译：在伤口部位减少瘢痕形成的方法包括使伤口部位与有效的瘢痕减少量的具有正电荷的交联多糖接触，从而减少伤口部位愈合时的瘢痕形成。这种多糖包括生物可吸收的交联葡聚糖或藻酸盐。正电荷可以由二乙基氨基乙基（DEAE）部分提供。交联多糖可作为粉末或珠粒施用于伤口部位。交联多糖也可以包含在包含药学上可接受的载体的组合物中。提供生物相容性手术装置，其具有有效的瘢痕减少量的具有正电荷的交联多糖，其减少愈合伤口部位处的瘢痕形成。还提供了降低TGF-β活性的方法。

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