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1. 发明授权

US4818540A Transdermal fertility control system and process 失效
标题翻译：透皮生育控制系统和过程
公开(公告)号：US4818540A
公开(公告)日：1989-04-04
申请号：US902440
申请日：1986-08-29
申请人： Yie W. Chien , Te-Yen Chien , Yih-Chain Huang
发明人： Yie W. Chien , Te-Yen Chien , Yih-Chain Huang
IPC分类号： A61K9/70 , A61K31/565 , A61K31/57 , A61F13/00
CPC分类号： A61K9/7069 , A61K9/7084
摘要： Transdermal fertility-controlling absorption polymer matrix dosage units have been developed which comprise a backing layer, an adjoining layer of a solid polymer matrix in which minimum effective daily doses of an estrogen and a progestin are microdispersed and released for transdermal absorption. Presently preferred is use of the natural estrogen, 17-beta-estradiol, and of the progestin, levonorgestrel. The units have a biologically acceptable adhesive polymer layer. The polymer matrix as well as the adhesive layer can have dispersed one or more skin permeation enhancers. Dosage units are provided which transdermally deliver at least minimum daily doses of the estrogen and progestin for multiple days, such as for one week. The invention also provides a process of fertility control using the novel polymer matrix dosage units for the first three weeks of consecutive menstrual cycles of the subject desiring fertility control.
摘要翻译：已经开发了经皮生育控制吸收聚合物基质剂量单位，其包含背衬层，固体聚合物基质的相邻层，其中雌激素和孕激素的最小有效日剂量被微分散并释放用于经皮吸收。目前优选使用天然雌激素17-β-雌二醇和孕激素左炔诺孕酮。这些单元具有生物可接受的粘合剂聚合物层。聚合物基质以及粘合剂层可以分散一种或多种皮肤渗透促进剂。提供剂量单位，其经皮递送至少最小日剂量的雌激素和孕激素多天，例如一周。本发明还提供了一种使用新型聚合物基质剂量单位进行育性控制的方法，该方法用于需要生育控制的受试者的连续月经周期的前三周。

2. 发明授权

US5296230A Transdermal fertility control system and process 失效
标题翻译：透皮生育控制系统和过程
公开(公告)号：US5296230A
公开(公告)日：1994-03-22
申请号：US332471
申请日：1989-04-03
申请人： Yie W. Chien , Te-Yen Chien , Yih-Chain Huang
发明人： Yie W. Chien , Te-Yen Chien , Yih-Chain Huang
IPC分类号： A61K9/70 , A61F13/00
CPC分类号： A61K9/7069 , A61K9/7084 , A61K9/7092
摘要： Transdermal fertility-controlling absorption polymer matrix dosage units have been developed which comprise a backing layer, an adjoining layer of a solid polymer matrix in which minimum effective daily doses of an estrogen and a progestin are microdispersed and released for transdermal absorption. Presently preferred is use of the natural estrogen, 17-beta-estradiol, and of the progestin, levonorgestrel. The units have a biologically acceptable adhesive polymer layer. The polymer matrix as well as the adhesive layer can have dispersed one or more skin permeation enhancers. Dosage units are provided which transdermally deliver at least minimum daily doses of the estrogen and progestin for multiple days, such as for one week. The invention also provides a process of fertility control using the novel polymer matrix dosage units for the first three weeks of consecutive menstrual cycles of the subject desiring fertility control.
摘要翻译：已经开发了经皮生育控制吸收聚合物基质剂量单位，其包含背衬层，固体聚合物基质的邻接层，其中雌激素和孕激素的最小有效日剂量被微分散并释放用于经皮吸收。目前优选使用天然雌激素17-β-雌二醇和孕激素左炔诺孕酮。这些单元具有生物可接受的粘合剂聚合物层。聚合物基质以及粘合剂层可以分散一种或多种皮肤渗透促进剂。提供剂量单位，其经皮递送至少最小日剂量的雌激素和孕激素多天，例如一周。本发明还提供了一种使用新型聚合物基质剂量单位进行育性控制的方法，该方法用于需要生育控制的受试者的连续月经周期的前三周。

3. 发明授权

US4906169A Transdermal estrogen/progestin dosage unit, system and process 失效
标题翻译：经皮雌激素/孕激素剂量单位，系统和过程
公开(公告)号：US4906169A
公开(公告)日：1990-03-06
申请号：US131462
申请日：1988-12-16
申请人： Yie W. Chien , Te-Yen Chien , Yih-Chain Huang
发明人： Yie W. Chien , Te-Yen Chien , Yih-Chain Huang
IPC分类号： A61K9/70 , A61K31/565
CPC分类号： A61K9/7092 , A61K31/565 , A61K31/567 , A61K9/7061
摘要： Transdermal estrogen/progestin absorption dosage unit have been developed which comprise a backing layer, an adjoining polymer layer is an adhesive layer in which at least minimum effective dose of an estrogen is dissolved or microdispersed. Adhered to the polymer layer in an adhesive layer in which is dissolved and/or microdispersed at least minimum doses of progestin. Presently preferred is use of the natural estrogen, 17-beta-estradiol, or ethinyl estradiol or combinations thereof and of the progestin, norethindrone or norgestimate or combinations thereof. The units have biologically acceptable adhesive and polymer layers. The adhesive layer can have dispersed one or more skin permeation enhancing agents. A separating layer can optionally be used in making the dosage units, which separate space the adhesive and polymer layers, which permits estrogen tansmission from the polymer layer during treatment. Dosage units are provided which transdermally deliver at least minimum daily doses of the estrogen and progestin for multiple days, such as for one week. The invention also provides a process of fertility control and estrogen replacement therapy using the novel dosage units. Also, the invention provides a fertility control system for fertility control using the novel dosage units.
摘要翻译：已经开发了经皮雌激素/孕激素吸收剂量单位，其包含背衬层，相邻的聚合物层是其中至少最小有效剂量的雌激素溶解或微分散的粘合剂层。粘附到其中溶解和/或微分散至少最小剂量的孕激素的粘合剂层中的聚合物层。目前优选使用天然雌激素，17-β-雌二醇或乙炔雌二醇或其组合以及孕激素，炔诺酮或诺孕酯或其组合。这些单元具有生物可接受的粘合剂和聚合物层。粘合剂层可以具有分散的一种或多种皮肤渗透增强剂。分离层可以任选地用于制备剂量单位，其分离空间粘合剂和聚合物层，其允许在治疗期间从聚合物层中雌激素脱落。提供剂量单位，其经皮递送至少最小日剂量的雌激素和孕激素多天，例如一周。本发明还提供了使用新型剂量单位的生育调节和雌激素替代疗法的方法。此外，本发明提供了使用新型剂量单位的育性控制的育性控制系统。

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