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1. 发明授权

US5670381A Devices for performing ion-capture binding assays 失效
标题翻译：用于进行离子捕获结合测定的装置
公开(公告)号：US5670381A
公开(公告)日：1997-09-23
申请号：US436950
申请日：1995-05-08
申请人： Yi-Her Jou , Stephen D. Stroupe , James J. Markese
发明人： Yi-Her Jou , Stephen D. Stroupe , James J. Markese
IPC分类号： G01N33/538 , G01N33/543 , G01N33/558 , G01N33/574 , G01N33/53
CPC分类号： G01N33/57473 , G01N33/538 , G01N33/54366 , G01N33/558 , Y10S435/97 , Y10S435/971 , Y10S436/808 , Y10S436/81
摘要： This invention presents novel assay devices employing capture reagents, involving a specific binding member attached to a charged substance, and porous material containing a capture or reaction zone that is oppositely charged with respect to the charged substance included in the capture reagent. In one embodiment, a test sample suspected of containing the analyte of interest is contacted with the capture reagent to form a charged capture reagent/analyte complex. The complex is then contacted to the oppositely charged capture or reaction zone to attract, attach, and immobilize the capture reagent/analyte complex. With an appropriate indicator reagent, both sandwich and competitive assays can be performed.
摘要翻译：本发明提出了使用捕获试剂的新型测定装置，其涉及附着于带电物质的特异性结合部件，以及含有与包含在捕获试剂中的带电物质相反的捕获或反应区域的多孔材料。在一个实施方案中，怀疑含有感兴趣分析物的测试样品与捕获试剂接触以形成带电的捕获试剂/分析物复合物。然后将复合物与相反电荷的捕获或反应区接触以吸引，附着和固定捕获试剂/分析物复合物。使用适当的指示剂，可以进行三明治和竞争性测定。

2. 发明授权

US5459078A Methods and reagents for performing ion-capture digoxin assays 失效
标题翻译：用于进行离子捕获地高辛测定的方法和试剂
公开(公告)号：US5459078A
公开(公告)日：1995-10-17
申请号：US074719
申请日：1993-06-09
申请人： Steven Kline , Yi-Her Jou , Stephen D. Stroupe , Janina Adamczyk , Daniel S. Berry , Rosario M. Fico , James J. Markese
发明人： Steven Kline , Yi-Her Jou , Stephen D. Stroupe , Janina Adamczyk , Daniel S. Berry , Rosario M. Fico , James J. Markese
IPC分类号： G01N33/532 , G01N33/538 , G01N33/543 , G01N33/545 , G01N33/569 , G01N33/574 , G01N33/58 , G01N33/74 , G01N33/76 , G01N33/94
CPC分类号： G01N33/54366 , G01N33/532 , G01N33/538 , G01N33/543 , G01N33/545 , G01N33/56988 , G01N33/57473 , G01N33/58 , G01N33/743 , G01N33/76 , G01N33/9453 , Y10S435/97 , Y10S435/971 , Y10S435/975 , Y10S436/808 , Y10S436/81 , Y10S436/824 , Y10S436/825
摘要： The present invention includes novel digoxin assays employing a capture reagent, involving a first binding member conjugated to a polymeric anion substance, and a solid phase material containing a reaction site comprising a polymeric cation substance having a nitrogen content of at least about two percent. A test sample suspected of containing the analyte of interest may be contacted with the capture reagent to form a charged capture reagent/analyte complex. The complex is then contacted to the oppositely charged solid phase to attract, attach, and immobilize the capture reagent/analyte complex.
摘要翻译：本发明包括采用捕获试剂的新型地高辛测定法，其涉及与聚合阴离子物质缀合的第一结合成员，以及含有含有至少约2％氮含量的聚合阳离子物质的反应位点的固相材料。怀疑含有感兴趣的分析物的测试样品可以与捕获试剂接触以形成带电的捕获试剂/分析物复合物。然后将络合物与相反电荷的固相接触以吸引，附着和固定捕获试剂/分析物复合物。

3. 发明授权

US5459080A Ion-capture assays using a specific binding member conjugated to carboxymethylamylose 失效
标题翻译：使用与羧甲基纤维素缀合的特异性结合成分的离子捕获测定
公开(公告)号：US5459080A
公开(公告)日：1995-10-17
申请号：US187814
申请日：1994-01-27
申请人： Janina Adamczyk , Daniel S. Berry , Yi-Her Jou , Stephen D. Stroupe
发明人： Janina Adamczyk , Daniel S. Berry , Yi-Her Jou , Stephen D. Stroupe
IPC分类号： G01N33/538 , G01N33/543 , G01N33/548 , G01N33/574 , G01N33/544 , G01N33/532
CPC分类号： G01N33/548 , G01N33/538 , G01N33/54353 , G01N33/54366 , G01N33/57473 , Y10S435/961
摘要： The present invention includes novel assays employing a capture reagent, involving a first specific binding member conjugated to a polymeric anion such as carboxymethylamylose, and a solid phase material containing a reaction site comprising a polymeric cation substance. A test sample suspected of containing the analyte of interest may be contacted with the capture reagent to form a charged capture reagent/analyte complex. The complex is then contacted to/ the oppositely charged solid phase to attract, attach, and immobilize the capture reagent/analyte complex. The use of carboxymethylamylose to prepare a suitably charged capture reagent provides a superior capture reagent that is capable of binding and retaining the analyte on the solid phase even in the presence of polyanionic non-specific binding blockers.
摘要翻译：本发明包括使用捕获试剂的新试验，涉及与聚合阴离子缀合的第一特异性结合部件，例如羧甲基纤维素，以及含有包含聚合物阳离子物质的反应位点的固相材料。怀疑含有感兴趣的分析物的测试样品可以与捕获试剂接触以形成带电的捕获试剂/分析物复合物。然后将络合物与相对电荷的固相接触以吸引，附着和固定捕获试剂/分析物复合物。使用羧甲基纤维素来制备适当带电的捕获剂提供了一种优异的捕获试剂，即使在聚阴离子非特异性结合阻断剂存在下也能将分析物结合并保留在固相上。

4. 发明授权

US5866322A Method for performing Rubella assay 失效
标题翻译：风疹试验方法
公开(公告)号：US5866322A
公开(公告)日：1999-02-02
申请号：US776495
申请日：1991-10-11
申请人： Yi-Her Jou , Stephen D. Stroupe , Janina Adamczyk , John Safford
发明人： Yi-Her Jou , Stephen D. Stroupe , Janina Adamczyk , John Safford
IPC分类号： G01N33/538 , G01N33/543 , G01N33/569 , G01N33/574
CPC分类号： G01N33/538 , G01N33/54366 , G01N33/56983 , G01N33/57473 , Y10S435/969 , Y10S435/971 , Y10S436/811 , Y10S436/823
摘要： The present invention includes novel rubella assays employing a Rubella virus capture reagent and a solid phase material containing a reaction site comprising a polymeric cation substance. A test sample suspected of containing Rubella antibody may be contacted with the capture reagent to form a capture reagent/analyte complex. The complex is then contacted to the positively charged solid phase to attract, attach, and immobilize the capture reagent/analyte complex.
摘要翻译：本发明包括使用风疹病毒捕获试剂的新型风疹试验和含有包含聚合物阳离子物质的反应位点的固相材料。怀疑含有风疹抗体的测试样品可以与捕获试剂接触以形成捕获试剂/分析物复合物。然后将络合物与带正电的固相接触以吸引，附着和固定捕获试剂/分析物复合物。

5. 发明授权

US06538119B2 Reagents and methods useful for detecting diseases of the breast 失效
标题翻译：用于检测乳腺疾病的试剂和方法
公开(公告)号：US06538119B2
公开(公告)日：2003-03-25
申请号：US09193881
申请日：1998-11-18
申请人： Patricia A. Billing-Medel , Maurice Cohen , Tracey L. Colpitts , Paula N. Friedman , Edward N. Granados , Michael R. Klass , John C. Russell , Stephen D. Stroupe
发明人： Patricia A. Billing-Medel , Maurice Cohen , Tracey L. Colpitts , Paula N. Friedman , Edward N. Granados , Michael R. Klass , John C. Russell , Stephen D. Stroupe
IPC分类号： C07H2102
CPC分类号： C07K14/47
摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BS249 and transcribed from breast tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast, such as breast cancer. Also provided are antibodies which specifically bind to BS249-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS249 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases
摘要翻译：描述了一组由此编码的连续和部分重叠的cDNA序列和多肽，命名为BS249并从乳腺组织转录。这些序列可用于检测，诊断，分期，监测，预后，体内成像，预防或治疗或确定个体对乳腺疾病和病症如乳腺癌的倾向。还提供了特异性结合BS249编码的多肽或蛋白质的抗体，以及预防组织特异性BS249多肽的作用的激动剂或抑制剂，该分子可用于治疗乳腺疾病，肿瘤或转移瘤

6. 发明授权

US06368792B1 Reagents and methods useful for detecting diseases of the gastrointestinal tract 失效
公开(公告)号：US06368792B1
公开(公告)日：2002-04-09
申请号：US09049698
申请日：1998-03-27
申请人： Patricia A. Billing-Medel , Maurice Cohen , Tracey L. Colpitts , Paula N. Friedman , Mark Hayden , Michael R. Klass , Lisa Roberts-Rapp , John C. Russell , Stephen D. Stroupe
发明人： Patricia A. Billing-Medel , Maurice Cohen , Tracey L. Colpitts , Paula N. Friedman , Mark Hayden , Michael R. Klass , Lisa Roberts-Rapp , John C. Russell , Stephen D. Stroupe
IPC分类号： C12Q168
CPC分类号： C07K16/3046 , C07K2317/34 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136
摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as CS193 and transcribed from GI tract tissue, are described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the GI tract, such as GI tract cancer. Also provided are antibodies which specifically bind to CS193-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific CS193 polypeptide, which molecules are useful for the therapeutic treatment of GI tract diseases, tumors or metastases.

7. 发明授权

US06183952B2 Reagents and methods useful for detecting diseases of the breast 失效
标题翻译：用于检测乳腺疾病的试剂和方法
公开(公告)号：US06183952B2
公开(公告)日：2001-02-06
申请号：US08912276
申请日：1997-08-15
申请人： Patricia A. Billing-Medel , Maurice Cohen , Tracey L. Colpitts , Paula N. Friedman , Julian Gordon , Edward N. Granados , Steven C. Hodges , Michael R. Klass , Jon D. Kratochvil , Lisa Roberts-Rapp , John C. Russell , Stephen D. Stroupe
发明人： Patricia A. Billing-Medel , Maurice Cohen , Tracey L. Colpitts , Paula N. Friedman , Julian Gordon , Edward N. Granados , Steven C. Hodges , Michael R. Klass , Jon D. Kratochvil , Lisa Roberts-Rapp , John C. Russell , Stephen D. Stroupe
IPC分类号： C12Q168
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/136 , Y10S435/81
摘要： A novel member of the uteroglobin family of proteins, designated as BU101, is described. BU101 is defined by a set of contiguous and partially overlapping RNA sequences transcribed from breast tissue, and polypeptides encoded thereby. A fully sequenced clone representing the longest continuous sequence of BU101 is also disclosed. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast such as breast cancer. Also provided are antibodies which specifically bind to BU101-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BU101 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.
摘要翻译：描述了称为BU101的蛋白质的子宫肌血清蛋白家族的新成员。 BU101由一组从乳腺组织转录的连续和部分重叠的RNA序列以及由此编码的多肽来定义。还公开了表示BU101的最长连续序列的完全测序的克隆。这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对乳腺疾病和状况（例如乳腺癌）的倾向。还提供了特异性结合BU101编码的多肽或蛋白质的抗体，以及预防组织特异性BU101多肽的作用的激动剂或抑制剂，该分子可用于治疗乳腺疾病，肿瘤或转移瘤。

8. 发明授权

US5612223A Cyanide-free reagent and method for the determination of hemoglobin 失效
标题翻译：无氰试剂和测定血红蛋白的方法
公开(公告)号：US5612223A
公开(公告)日：1997-03-18
申请号：US524128
申请日：1995-08-31
申请人： Young R. Kim , Stephen D. Stroupe
发明人： Young R. Kim , Stephen D. Stroupe
IPC分类号： G01N33/50 , G01N33/72 , G01N33/52
CPC分类号： G01N33/5094 , G01N33/721 , Y10T436/10 , Y10T436/107497 , Y10T436/25375
摘要： A cyanide-free method and reagent for determining the concentration of total hemoglobin in a whole blood sample accurately in less than 10 seconds comprising a ligand selected from the group consisting of imidiazole, imidazole derivatives, N-hydroxyacetamide, N-hydroxyl amine, pyridine, oxazole, thiazole, pyrazole, pyrimidine, purine, quinoline, and isoquinoline, and a surfactant with strong erythrolytic capability selected from the group consisting of lauryl dimethylamine oxide and octylphenoxy polyethoxyethanol. The reagent pH is adjusted to about 11 to about 14. Rapid mixing of the reagent with a blood sample leads to the formation of a stable chromogen whose absorbance can be measured between 540 and 550 nm. The cyanide-free reagent is ideal for use on an automated high through-put clinical hematology analyzer.
摘要翻译：一种不含氰化物的方法和用于在小于10秒钟内精确测定全血样品中总血红蛋白浓度的试剂，其包含选自亚氨基二唑，咪唑衍生物，N-羟基乙酰胺，N-羟基胺，吡啶，恶唑，噻唑，吡唑，嘧啶，嘌呤，喹啉和异喹啉，以及选自月桂基二甲基氧化胺和辛基苯氧基聚乙氧基乙醇的具有强的红细胞能力的表面活性剂。将试剂pH调节至约11至约14.试剂与血液样品的快速混合导致形成稳定的色原，其吸光度可以在540和550nm之间测量。无氰试剂非常适用于自动化高通量临床血液分析仪。

9. 发明授权

US4420568A Fluorescent polarization immunoassay utilizing substituted triazinylaminofluoresceins 失效
标题翻译：荧光偏振免疫测定利用取代的三嗪基氨基荧光素
公开(公告)号：US4420568A
公开(公告)日：1983-12-13
申请号：US325872
申请日：1981-11-30
申请人： Chao-Huei J. Wang , Stephen D. Stroupe , Michael E. Jolley
发明人： Chao-Huei J. Wang , Stephen D. Stroupe , Michael E. Jolley
IPC分类号： C07D473/08 , C07H15/236 , G01N33/533 , G01N33/54 , G01N33/52 , G01N33/58 , G01N33/74
CPC分类号： C07H15/234 , C07D473/08 , G01N33/533 , Y10S436/80 , Y10S436/817
摘要： An immunochemical method and reagent compounds for determining ligands in a sample. The reagent compounds are derivatives of a triazinylaminofluorescein and are represented by the structural formula ##STR1## wherein Y is halo or lower alkyl; andR is a ligand-analog wherein said ligand-analog has at least one common epitope with said ligand so as to be specifically recognizable by a common antibody.The reagent compound and an antibody specific to the ligand are added to the sample in a fluorescence polarization immunoassay.
摘要翻译：用于测定样品中配体的免疫化学方法和试剂化合物。试剂化合物是三嗪基氨基荧光素的衍生物，其结构式为：其中Y为卤素或低级烷基; 并且R是配体 - 类似物，其中所述配体 - 类似物与所述配体具有至少一个共同表位，以便被共同抗体特异性地识别。将试剂化合物和对配体特异的抗体以荧光偏振免疫测定法加入到样品中。

10. 发明授权

US4200435A Determination of glycosylated hemoglobin in blood 失效
标题翻译：血液中糖基化血红蛋白的测定
公开(公告)号：US4200435A
公开(公告)日：1980-04-29
申请号：US973368
申请日：1978-12-26
申请人： Stephen D. Stroupe , Edwin G. Moore
发明人： Stephen D. Stroupe , Edwin G. Moore
IPC分类号： G01L1/22 , G01N33/66 , G01N33/72 , H04M19/04 , G01N33/16 , G01N21/00
CPC分类号： G01N33/723 , H04M19/04
摘要： A method for determining glycosylated hemoglobin in blood samples which involves liberating hemoglobins from red blood cells by chemical or physical means and reacting non-glycosylated hemoglobin with an allosteric site binding substance which reacts with the allosteric binding site of non-glycosylated hemoglobin and thereby alters the distribution between allosteric forms of the hemoglobins and measuring the change. This method is useful in monitoring glucose metabolism for detecting and controlling diabetes.
摘要翻译：一种用于测定血液样品中糖基化血红蛋白的方法，其包括通过化学或物理方法从红细胞释放血红蛋白，并使非糖基化血红蛋白与与非糖基化血红蛋白的变构结合位点反应的变构位点结合物质反应，从而改变分布在变性形式的血红蛋白和测量变化。该方法可用于监测葡萄糖代谢以检测和控制糖尿病。

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