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1. 发明申请

US20210338694A1 SOS1 ALLOSTERIC SITE TARGETING 有权
公开(公告)号：US20210338694A1
公开(公告)日：2021-11-04
申请号：US17306646
申请日：2021-05-03
申请人： Yi Zheng , Chris Evelyn , William Seibel , Jaroslaw Meller , Jing Zhang
发明人： Yi Zheng , Chris Evelyn , William Seibel , Jaroslaw Meller , Jing Zhang
IPC分类号： A61K31/609 , A61K31/04 , A61K31/341 , A61K31/12 , A61K31/166 , A61K31/167 , A61K31/423 , A61K31/428 , A61K31/085 , A61K31/195 , A61K31/196 , A61P35/00
摘要： Disclosed herein are small molecule SOS1 allosteric site inhibitors, pharmaceutical compositions, and methods of use thereof.

2. 发明申请

US20190066197A1 System and Method for Clothing Promotion 审中-公开
公开(公告)号：US20190066197A1
公开(公告)日：2019-02-28
申请号：US15687527
申请日：2017-08-27
申请人： Jing Zhang
发明人： Jing Zhang
IPC分类号： G06Q30/06 , G06Q30/02 , H04N5/232 , H04N13/02
摘要： A clothing promotion system having virtue clothes fitting function, and evolving consumers in promotion. The clothing promotion system comprises a 360 degree image collecting apparatus collecting image data of clothing articles worn by models; an image processor processing the image data to generate 3D components; a database storing the image data and 3D components; and a plurality of interaction units interacting with the image processor and the database to select 3D components to create a 3D effect image, and displaying the created 3D effect image to illustrate the effect of the selected model wearing the selected clothing articles.

3. 发明申请

US20180070782A1 Toilet Tissue Dispenser 审中-公开
公开(公告)号：US20180070782A1
公开(公告)日：2018-03-15
申请号：US15253768
申请日：2016-08-31
申请人： Jing Zhang
发明人： Jing Zhang
IPC分类号： A47K10/38
CPC分类号： A47K10/3827 , A47K2010/3206 , A47K2010/3233
摘要： A new and improved rolled paper dispenser is mainly comprising with two semi-cylinders that are hinged together. It has the simplicity configurations and is manufactured at a low cost. It can be adapted both in cored rolled or coreless and solid rolled products. It can also be easily used and installed. It can prevent pets to unroll the tissue paper and keep the paper sanitary.

4. 发明授权

US09786202B2 Robot assisted surgical training 有权
公开(公告)号：US09786202B2
公开(公告)日：2017-10-10
申请号：US13582907
申请日：2011-03-04
申请人： Weimin Huang , Jiang Liu , Jiayin Zhou , Jing Zhang , Beng Hai Lee , Wing Kee Wong , Ngan Meng Tan , Zhuo Zhang , Fengshou Yin , Stephen Chang , Chee Kong Chui , Yi Su
发明人： Weimin Huang , Jiang Liu , Jiayin Zhou , Jing Zhang , Beng Hai Lee , Wing Kee Wong , Ngan Meng Tan , Zhuo Zhang , Fengshou Yin , Stephen Chang , Chee Kong Chui , Yi Su
IPC分类号： G09B23/28 , G09B23/30
CPC分类号： G09B23/28 , G06F19/00 , G09B23/30
摘要： A surgical training system and method. The system comprises means for recording reference data representing a reference manipulation of a computer generated model of an object by a master user; means for physically guiding a trainee user based on the recorded reference data during a training manipulation of the model of the object by the trainee user; and means for recording assessment data representing an assessment manipulation of the model of the object by the trainee user without guidance.

5. 发明授权

US09045381B2 Ruthenium complexes and their uses in processes for formation and/or hydrogenation of esters, amides and derivatives thereof 有权
标题翻译：钌络合物及其在酯，酰胺和衍生物的形成和/或氢化方法中的用途
公开(公告)号：US09045381B2
公开(公告)日：2015-06-02
申请号：US13880328
申请日：2011-10-11
申请人： David Milstein , Ekambaram Balaraman , Chidambaram Gunanathan , Boopathy Gnanaprakasam , Jing Zhang
发明人： David Milstein , Ekambaram Balaraman , Chidambaram Gunanathan , Boopathy Gnanaprakasam , Jing Zhang
IPC分类号： B01J31/18 , C07B41/08 , C07C29/136 , C07C29/149 , C07C29/17 , C07C41/16 , C07C45/00 , C07C51/23 , C07C67/00 , C07C67/03 , C07C209/62 , C07C213/00 , C07C231/02 , C07C231/10 , C07D207/08 , C07D213/38 , C07D241/08 , C07D241/12 , C07D295/023 , C07D307/14 , C07D307/33 , C07D307/83 , C07D309/30 , C07D487/14 , C07F9/58 , C07F15/00 , C08G69/00 , C07C51/02 , C07C51/295 , C07B41/02 , C07B41/12 , C07B43/06 , C07C209/00 , C07C213/02 , C07F9/6558 , C07K1/00
CPC分类号： C07K5/12 , B01J31/18 , B01J31/189 , B01J31/2404 , B01J31/2409 , B01J31/248 , B01J31/2485 , B01J2231/40 , B01J2231/49 , B01J2231/643 , B01J2231/763 , B01J2531/0244 , B01J2531/821 , C07B41/02 , C07B41/08 , C07B41/12 , C07B43/04 , C07B43/06 , C07C29/136 , C07C29/149 , C07C29/177 , C07C41/16 , C07C41/26 , C07C45/002 , C07C45/006 , C07C51/00 , C07C51/02 , C07C51/23 , C07C51/295 , C07C67/00 , C07C67/03 , C07C67/297 , C07C209/00 , C07C209/62 , C07C213/00 , C07C213/02 , C07C231/02 , C07C231/10 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07D207/06 , C07D207/08 , C07D211/12 , C07D213/38 , C07D241/08 , C07D241/12 , C07D295/023 , C07D295/027 , C07D295/185 , C07D305/06 , C07D307/14 , C07D307/33 , C07D307/44 , C07D307/52 , C07D307/83 , C07D309/30 , C07D487/14 , C07F9/58 , C07F9/65583 , C07F15/0046 , C07F15/0053 , C07K1/00 , C08G69/00 , Y02P20/52 , C07C233/05 , C07C235/06 , C07C233/07 , C07C235/16 , C07C235/14 , C07C235/10 , C07C211/27 , C07C211/07 , C07C211/35 , C07C211/46 , C07C211/10 , C07C215/28 , C07C217/58 , C07C69/14 , C07C69/24 , C07C31/125 , C07C31/12 , C07C49/78 , C07C49/04 , C07C49/10 , C07C49/08 , C07C49/403 , C07C31/205 , C07C31/202 , C07C31/04 , C07C31/08 , C07C33/20 , C07C33/22 , C07C31/1355 , C07C31/10 , C07C43/13 , C07C69/78 , C07C69/75 , C07C53/124 , C07C53/126 , C07C59/125 , C07C57/32 , C07C61/08 , C07C57/30 , C07C65/21 , C07C63/08 , C07C63/06
摘要： The present invention relates to novel Ruthenium catalysts and related borohydride complexes, and the use of such catalysts, inter alia, for (1) hydrogenation of amides (including polyamides) to alcohols and amines; (2) preparing amides from alcohols with amines (including the preparation of polyamides (e.g., polypeptides) by reacting dialcohols and diamines and/or by polymerization of amino alcohols); (3) hydrogenation of esters to alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di-lactones) or polyesters); (4) hydrogenation of organic carbonates (including polycarbonates) to alcohols and hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (5) dehydrogenative coupling of alcohols to esters; (6) hydrogenation of secondary alcohols to ketones; (7) amidation of esters (i.e., synthesis of amides from esters and amines); (8) acylation of alcohols using esters; (9) coupling of alcohols with water to form carboxylic acids; and (10) dehydrogenation of beta-amino alcohols to form pyrazines. The present invention further relates to the novel uses of certain pyridine Ruthenium catalysts.
摘要翻译：本发明涉及新的钌催化剂和相关的硼氢化物络合物，以及这种催化剂的用途，特别是（1）将酰胺（包括聚酰胺）氢化成醇和胺; （2）由醇与胺制备酰胺（包括通过使二醇和二胺反应和/或通过氨基醇的聚合反应制备聚酰胺（例如多肽）; （3）将酯氢化成醇（包括环酯（内酯）或环状二酯（二内酯）或聚酯）的氢化）; （4）将有机碳酸酯（包括聚碳酸酯）氢化成醇，并将氨基甲酸酯（包括聚氨基甲酸酯）或脲衍生物氢化成醇和胺; （5）醇与酯的脱氢偶联; （6）将仲醇醇化成酮类; （7）酯的酰胺化（即从酯和胺合成酰胺）; （8）使用酯酰化醇; （9）将醇与水偶联以形成羧酸; 和（10）β-氨基醇脱氢形成吡嗪。本发明还涉及某些吡啶钌催化剂的新用途。

6. 发明授权

US08934117B2 Equipment management system 有权
标题翻译：设备管理系统
公开(公告)号：US08934117B2
公开(公告)日：2015-01-13
申请号：US11484135
申请日：2006-07-10
申请人： Jing Zhang , Robert B. Evans
发明人： Jing Zhang , Robert B. Evans
IPC分类号： G06F3/12 , H04L12/26 , H04L12/24 , G06Q40/00
CPC分类号： H04L43/12 , H04L41/046 , H04L43/0876
摘要： Systems and methods of management of electronic office equipment through automated monitoring and reporting of usage and status are disclosed. A monitoring agent monitors electronic office equipment on a network and collects usage and status information to send to a control system. The control system can use the usage and status information to compile various reports responsive to the received information. The system allows for the automatic assessment, monitoring, re-supply, maintenance, and billing of networks of printing devices from a variety of different manufacturers. In some embodiments, the system enables a pay per use lease arrangement.
摘要翻译：披露了电子办公设备管理的系统和方法，通过自动监测和报告使用情况和状况。监控代理监控网络上的电子办公设备，并收集使用和状态信息，以发送给控制系统。控制系统可以使用使用和状态信息来响应所接收的信息来编制各种报告。该系统允许从各种不同的制造商自动评估，监控，重新供应，维护和计费打印设备的网络。在一些实施例中，该系统实现了每次使用租金安排。

7. 发明授权

US08809364B2 Polycyclic aryl substituted triazoles and polycyclic heteroaryl substituted triazoles useful as axl inhibitors 有权
标题翻译：可用作axl抑制剂的多环芳基取代的三唑和多环杂芳基取代的三唑
公开(公告)号：US08809364B2
公开(公告)日：2014-08-19
申请号：US13078759
申请日：2011-04-01
申请人： Rajinder Singh , Dane Goff , Jiaxin Yu , Sacha Holland , Thilo J. Heckrodt , Pingyu Ding , Joane Litvak , Jing Zhang
发明人： Rajinder Singh , Dane Goff , Jiaxin Yu , Sacha Holland , Thilo J. Heckrodt , Pingyu Ding , Joane Litvak , Jing Zhang
IPC分类号： A61K31/4439 , A61K31/4375 , A61K31/4196 , C07D401/14 , C07D403/14 , C07D471/08 , C07D405/14
CPC分类号： A61K31/4439 , A61K31/4196 , A61K31/4375 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D471/08 , C07D471/18 , C07D491/14
摘要： Polycyclic aryl and polycyclic heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditions associated with Axl catalytic activity are also disclosed.
摘要翻译：公开了多环芳基和多环杂芳基取代的三唑和含有这些化合物的药物组合物可用于抑制受体蛋白酪氨酸激酶Ax1的活性。还公开了使用该化合物治疗与Axl催化活性相关的疾病或病症的方法。

8. 发明授权

US08791186B2 Indication of improperly molded parts 有权
标题翻译：指示不正确模制的零件
公开(公告)号：US08791186B2
公开(公告)日：2014-07-29
申请号：US13312550
申请日：2011-12-06
申请人： Joseph Kuczynski , Melissa K. Miller , Heidi D. Williams , Jing Zhang
发明人： Joseph Kuczynski , Melissa K. Miller , Heidi D. Williams , Jing Zhang
IPC分类号： C08K3/16 , C08K3/30 , B29C33/10 , B29C39/44 , B29C43/52
CPC分类号： B29B13/065 , B29C39/003 , B29C39/026 , B29C39/42 , B29C43/52 , B29C44/005 , B29C67/202 , B29C2043/5816
摘要： A method of determining that a thermoplastic was insufficiently dried before forming into a molded plastic part. The method comprises preparing a mixture of a thermoplastic polymer and an off-gassing compound, wherein the off-gassing compound is selected to release all water of hydration in response to target drying conditions specified for the thermoplastic polymer. The mixture is dried at actual drying conditions, and then heated to reduce the viscosity of the thermoplastic polymer and allow the mixture to flow. The mixture is then made to flow into a mold to form a plastic part at a molding temperature, wherein the molding temperature will cause any remaining water of hydration in the off-gas sing compound to off-gas and form surface irregularities in the plastic part. Non-limiting examples of the off-gassing compound include hydrated metal halides and ionic hydrates.
摘要翻译：在形成模制塑料部件之前确定热塑性塑料未充分干燥的方法。该方法包括制备热塑性聚合物和脱气化合物的混合物，其中根据为热塑性聚合物规定的目标干燥条件，选择脱气化合物释放所有的水合水。将混合物在实际干燥条件下干燥，然后加热以降低热塑性聚合物的粘度并允许混合物流动。然后将混合物流入模具以在成型温度下形成塑料部件，其中成型温度将使废气中化合物中的任何剩余的水合水排出废气，并在塑料部件中形成表面不规则。脱气化合物的非限制性实例包括水合金属卤化物和离子水合物。

9. 发明授权

US08746157B2 Bottom ash discharging device for coal-fired boiler 有权
标题翻译：燃煤锅炉底灰排放装置
公开(公告)号：US08746157B2
公开(公告)日：2014-06-10
申请号：US13407785
申请日：2012-02-29
申请人： Yuwei Wang , Zhenqiang Liu , Jing Zhang , Qian Yu
发明人： Yuwei Wang , Zhenqiang Liu , Jing Zhang , Qian Yu
IPC分类号： F23J1/00 , F23J1/02 , C10J3/34
CPC分类号： F23J1/02
摘要： A bottom ash discharging device for a coal-fired boiler including: a clinker case, installed between a bottom ash hopper outlet of the coal-fired boiler and a bottom ash conveyer, an impact bar including a plurality of heat-resistant metal rods supporting inside the clinker case, a clinker crusher, installed above the impact bar for crushing the clinker, and a guiding device, installed between the bottom ash hopper outlet and the clinker crusher for limiting the clinker to drop into the clinker crushing area of the clinker crusher. The bottom ash discharging device ensures that the clinkers drop from the bottom ash hopper outlet to the rear area of the clinker crusher, and that the impact bar can be replaced and repaired without stopping the coal-fired boiler.
摘要翻译：一种用于燃煤锅炉的底灰排放装置，包括：安装在燃煤锅炉的底灰料斗出口和底灰输送机之间的熟料箱，包括多个支撑在内部的耐热金属棒的冲击杆熟料盒，熟料破碎机，安装在冲击棒上方，用于破碎熟料;以及引导装置，安装在底灰斗出料口和熟料破碎机之间，用于限制熟料落入熟料破碎机的熟料破碎区域。底灰排放装置可确保熟料从底灰料斗出口落到熟料破碎机的后部区域，并可在不停止燃煤锅炉的情况下更换和修理冲击棒。

10. 发明授权

US08741898B2 Polycyclic heteroaryl substituted triazoles useful as Axl inhibitors 有权
标题翻译：可用作Axl抑制剂的多环杂芳基取代的三唑
公开(公告)号：US08741898B2
公开(公告)日：2014-06-03
申请号：US13423924
申请日：2012-03-19
申请人： Dane Goff , Jing Zhang , Rajinder Singh , Sacha Holland , Jiaxin Yu , Thilo J. Heckrodt , Pingyu Ding , Joane Litvak
发明人： Dane Goff , Jing Zhang , Rajinder Singh , Sacha Holland , Jiaxin Yu , Thilo J. Heckrodt , Pingyu Ding , Joane Litvak
IPC分类号： A61K31/502
CPC分类号： C07D401/14 , A61K31/502 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/04 , C07D417/14 , C07D451/04 , C07D471/04 , C07D487/04 , C07D487/10 , C07D491/04 , C07D491/20 , C07D495/04 , C07D519/00
摘要： Polycyclic heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditions associated with Axl activity are also disclosed.
摘要翻译：公开了多环杂芳基取代的三唑和含有这些化合物的药物组合物可用于抑制受体蛋白酪氨酸激酶Ax1的活性。还公开了使用该化合物治疗与Axl活性相关的疾病或病症的方法。

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