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1. 发明申请

US20120038888A1 METHODS FOR IMAGING OCULAR DEVICES USING OPTICAL COHERENCE TOMOGRAPHY 有权
标题翻译：使用光学相干图像成像眼科装置的方法
公开(公告)号：US20120038888A1
公开(公告)日：2012-02-16
申请号：US13207171
申请日：2011-08-10
申请人： Yeming Gu , Rebeca Kyker Bowden , William Jordan Hall , Deborah J. Mulcahy , Yongxing Qiu , Benjamin David Sullivan , Robert Carey Tucker
发明人： Yeming Gu , Rebeca Kyker Bowden , William Jordan Hall , Deborah J. Mulcahy , Yongxing Qiu , Benjamin David Sullivan , Robert Carey Tucker
IPC分类号： A61B3/14
CPC分类号： A61B3/102 , G01M11/025
摘要： Described herein are methods for imaging ocular devices. The methods generally involve (a) applying a scattering agent to the ocular device; and (b) imaging the ocular device using optical coherence tomography (OCT). The methods described herein provide useful structural information about the surface of the device with high sensitivity.
摘要翻译：这里描述了用于对眼睛装置进行成像的方法。所述方法通常涉及（a）将散射剂施加到眼睛装置; 和（b）使用光学相干断层扫描（OCT）对眼睛装置进行成像。本文描述的方法提供了关于具有高灵敏度的装置的表面的有用的结构信息。

2. 发明授权

US08708496B2 Methods for imaging ocular devices using optical coherence tomography 有权
标题翻译：使用光学相干断层扫描成像眼睛装置的方法
公开(公告)号：US08708496B2
公开(公告)日：2014-04-29
申请号：US13207171
申请日：2011-08-10
申请人： Yeming Gu , Rebeca Kyker Bowden , William Jordan Hall , Deborah J. Mulcahy , Yongxing Qiu , Benjamin David Sullivan , Robert Carey Tucker
发明人： Yeming Gu , Rebeca Kyker Bowden , William Jordan Hall , Deborah J. Mulcahy , Yongxing Qiu , Benjamin David Sullivan , Robert Carey Tucker
IPC分类号： A61B3/00 , A61B3/10
CPC分类号： A61B3/102 , G01M11/025
摘要： Described herein are methods for imaging ocular devices. The methods generally involve (a) applying a scattering agent to the ocular device; and (b) imaging the ocular device using optical coherence tomography (OCT). The methods described herein provide useful structural information about the surface of the device with high sensitivity.
摘要翻译：这里描述了用于对眼睛装置进行成像的方法。所述方法通常涉及（a）将散射剂施加到眼睛装置; 和（b）使用光学相干断层扫描（OCT）对眼睛装置进行成像。本文描述的方法提供了关于具有高灵敏度的装置的表面的有用的结构信息。

3. 发明授权

US08480227B2 Silicone hydrogel lenses with water-rich surfaces 有权
公开(公告)号：US08480227B2
公开(公告)日：2013-07-09
申请号：US13193653
申请日：2011-07-29
申请人： Yongxing Qiu , John Dallas Pruitt , Sibichen J. Thekveli , Robert Carey Tucker , Jared Nelson
发明人： Yongxing Qiu , John Dallas Pruitt , Sibichen J. Thekveli , Robert Carey Tucker , Jared Nelson
IPC分类号： G02C7/00
CPC分类号： C09D177/06 , B29D11/00067 , C08G77/388 , C08J5/00 , C08J7/042 , C08J2383/04 , C08J2383/08 , C08J2433/02 , C08J2433/26 , C08J2487/00 , C08L83/04 , C09D5/1637 , C09D5/1681 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , G02B1/043 , G02B1/10 , G02B1/18 , G02C7/049 , G02C2202/06 , G02C2202/16 , C08L101/14
摘要： The invention is related to a hydrated silicone hydrogel contact lens having a layered structural configuration: a lower water content silicone hydrogel core (or bulk material) completely covered with a layer of a higher water content hydrogel totally or substantially free of silicone. A hydrated silicone hydrogel contact lens of the invention possesses high oxygen permeability for maintaining the corneal health and a soft, water-rich, lubricious surface for wearing comfort.

4. 发明申请

US20120026458A1 SILICONE HYDROGEL LENSES WITH WATER-RICH SURFACES 有权
标题翻译：硅胶水镜与水面
公开(公告)号：US20120026458A1
公开(公告)日：2012-02-02
申请号：US13193653
申请日：2011-07-29
申请人： Yongxing Qiu , John Dallas Pruitt , Sibichen J. Thekveli , Robert Carey Tucker , Jared Nelson
发明人： Yongxing Qiu , John Dallas Pruitt , Sibichen J. Thekveli , Robert Carey Tucker , Jared Nelson
IPC分类号： G02C7/04 , B05D5/06
CPC分类号： C09D177/06 , B29D11/00067 , C08G77/388 , C08J5/00 , C08J7/042 , C08J2383/04 , C08J2383/08 , C08J2433/02 , C08J2433/26 , C08J2487/00 , C08L83/04 , C09D5/1637 , C09D5/1681 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , G02B1/043 , G02B1/10 , G02B1/18 , G02C7/049 , G02C2202/06 , G02C2202/16 , C08L101/14
摘要： The invention is related to a hydrated silicone hydrogel contact lens having a layered structural configuration: a lower water content silicone hydrogel core (or bulk material) completely covered with a layer of a higher water content hydrogel totally or substantially free of silicone. A hydrated silicone hydrogel contact lens of the invention possesses high oxygen permeability for maintaining the corneal health and a soft, water-rich, lubricious surface for wearing comfort.
摘要翻译：本发明涉及具有层状结构构型的水合硅氧水凝胶隐形眼镜：完全被完全或基本上不含有硅酮的较高水含量水凝胶层覆盖的较低水含量的硅氧烷水凝胶核（或本体材料）。本发明的水合硅氧水凝胶隐形眼镜具有高的透氧性，用于维持角膜健康和柔软，富水，润滑的表面，用于穿戴舒适。

5. 发明授权

US09156213B2 Atmospheric plasma coating for ophthalmic devices 有权
标题翻译：用于眼科装置的大气等离子涂层
公开(公告)号：US09156213B2
公开(公告)日：2015-10-13
申请号：US13303186
申请日：2011-11-23
申请人： Yongxing Qiu , John Dallas Pruitt , Chandana Kolluru , Maria A. Dunkle , Yasuo Matsuzawa
发明人： Yongxing Qiu , John Dallas Pruitt , Chandana Kolluru , Maria A. Dunkle , Yasuo Matsuzawa
IPC分类号： B29D11/00
CPC分类号： B29D11/00038 , B29D11/00865
摘要： The invention provides a method of coating and thereby affecting the surface properties of a substrate such as a contact lens or other ophthalmic device. The method comprises the steps of generating an atmospheric plasma flow from a working gas and controlling the continuity of the atmospheric plasma flow with a power generator, and, introducing the atmospheric plasma flow to a substrate surface.
摘要翻译：本发明提供一种涂覆方法，从而影响诸如隐形眼镜或其它眼科装置的基底的表面性质。该方法包括以下步骤：从工作气体产生大气等离子体流，并用发电机控制大气等离子体流的连续性，以及将大气等离子体流引入衬底表面。

6. 发明授权

US08425926B2 Antimicrobial medical devices 有权
标题翻译：抗微生物医疗器械
公开(公告)号：US08425926B2
公开(公告)日：2013-04-23
申请号：US10891407
申请日：2004-07-14
申请人： Yongxing Qiu , John Martin Lally
发明人： Yongxing Qiu , John Martin Lally
IPC分类号： A61F2/00
CPC分类号： G02B1/043 , A01N59/16 , A61L12/088 , A61L27/54 , A61L2300/104 , A61L2300/404 , A61L2300/442 , A61L2300/624 , B29D11/00038 , B82Y30/00
摘要： The present invention provides methods for making an antimicrobial medical device, preferably an antimicrobial ophthalmic device, more preferably an antimicrobial extended-wear contact lens, which contains silver nano-particles distributed uniformly therein. The antimicrobial medical device can exhibit antimicrobial activity over an extended period of time.
摘要翻译：本发明提供了制备抗微生物医疗器械，优选抗微生物眼科装置，更优选抗微生物延长耐磨隐形眼镜的方法，该隐形眼镜含有均匀分布的银纳米颗粒。抗微生物医疗装置可以在长时间内显示出抗菌活性。

7. 发明申请

US20120139137A1 LENS MOLDS HAVING ATMOSPHERIC PLASMA COATINGS THEREON 有权
标题翻译：具有大气等离子体涂层的镜片
公开(公告)号：US20120139137A1
公开(公告)日：2012-06-07
申请号：US13303190
申请日：2011-11-23
申请人： Yongxing Qiu
发明人： Yongxing Qiu
IPC分类号： B29D11/00
CPC分类号： B29D11/00038 , B29D11/00865
摘要： The invention provides a method of making ophthalmic lenses with an enhanced quality and enhanced yield achieved by reducing mold separation force and lens-mold adhesion. The method comprises the steps of generating an atmospheric plasma flow from a working gas and controlling the continuity of the atmospheric plasma flow with a power generator, and, introducing the atmospheric plasma flow to a molding surface of a mold for making an ophthalmic lens (preferably contact lens, more preferably a silicone hydrogel contact lens) and increasing the surface hydrophobicity of the molding surface of the mold and thereby to reduce a mold separation force after molding a lens formulation in the mold.
摘要翻译：本发明提供一种通过降低模具分离力和晶状体模具附着力而制造具有增强的质量和提高的成品率的眼镜片的方法。该方法包括以下步骤：产生来自工作气体的大气等离子体流，并利用发电机控制大气等离子体流的连续性;以及将大气等离子体流引入用于制造眼用透镜的模具的成型表面隐形眼镜，更优选硅酮水凝胶隐形眼镜），并且增加模具的模制表面的表面疏水性，从而降低在模具中模制透镜配方之后的模具分离力。

8. 发明授权

US08163302B2 Methods of making and using surfactant polymers 有权
标题翻译：制造和使用表面活性剂聚合物的方法
公开(公告)号：US08163302B2
公开(公告)日：2012-04-24
申请号：US12062768
申请日：2008-04-04
申请人： Roger E. Marchant , Tianhong Zhang , Yongxing Qiu , Mark A. Ruegsegger
发明人： Roger E. Marchant , Tianhong Zhang , Yongxing Qiu , Mark A. Ruegsegger
IPC分类号： A61F2/08
CPC分类号： A61L27/34 , A61L29/085 , A61L31/10 , A61L33/0017 , A61L33/08 , A61L33/128 , C08B37/0021 , C08B37/0078 , C08F8/00 , C08L101/00 , C08F26/02 , C08F16/06
摘要： Comblike, surfactant polymers for changing the surface properties of biomaterials are provided. Such surfactant polymers comprise a polymeric backbone of repeating monomeric units having functional groups for coupling with side chains, a plurality of hydrophobic side chains linked to the backbone via the functional groups, and a plurality of hydrophilic side chains linked to said backbone via the functional groups. Medical devices coated with the surfactant polymers are also provided. The surfactant polymers may be used to decrease the thrombogenic properties, encapsulation, and bacterial colonization of medical devices.
摘要翻译：提供了梳状，用于改变生物材料表面性质的表面活性剂聚合物。这种表面活性剂聚合物包含具有用于与侧链偶联的官能团的重复单体单元的聚合物主链，经由官能团与主链连接的多个疏水侧链，以及通过官能团连接至所述骨架的多个亲水侧链。还提供了涂有表面活性剂聚合物的医疗装置。表面活性剂聚合物可用于降低医疗装置的血栓形成性质，包封和细菌定植。

9. 发明授权

US06926965B2 LbL-coated medical device and method for making the same 有权
公开(公告)号：US06926965B2
公开(公告)日：2005-08-09
申请号：US10654566
申请日：2003-09-03
申请人： Yongxing Qiu , Lynn Cook Winterton , John Martin Lally
发明人： Yongxing Qiu , Lynn Cook Winterton , John Martin Lally
IPC分类号： G02C7/04 , A61F9/00 , A61L27/00 , A61L27/34 , A61L31/10 , G02B1/04 , B32B25/20 , B32B27/08 , B32B27/30
CPC分类号： A61L31/10 , A61L27/34 , G02B1/043 , Y10T428/31504 , Y10T428/31663 , Y10T428/31855 , C08L39/00
摘要： The present invention provides a medical device, preferably an ophthalmic device, more preferably a contact lens, which comprises a core material and a biocompatible LbL coating non-covalently attached to said core material. The biocompatible LbL coating comprises at least one charge/non-charge bilayer, wherein said charge/non-charge bilayer is composed of, in no particular order, one layer of a charged polymeric material and one layer of a non-charged polymeric material which is capable of being non-covalently bond to the charged polymeric material.

10. 发明授权

US06896926B2 Method for applying an LbL coating onto a medical device 有权
标题翻译：将LbL涂层施加到医疗装置上的方法
公开(公告)号：US06896926B2
公开(公告)日：2005-05-24
申请号：US10654340
申请日：2003-09-03
申请人： Yongxing Qiu , Lynn Cook Winterton , John Martin Lally , Yasuo Matsuzawa
发明人： Yongxing Qiu , Lynn Cook Winterton , John Martin Lally , Yasuo Matsuzawa
IPC分类号： G02C7/04 , A61L27/00 , A61L27/34 , A61L29/00 , A61L31/00 , B05D1/18 , G02B1/04 , G02C13/00 , B05D1/36 , B05D1/38
CPC分类号： A61L27/34 , B05D1/185 , G02B1/043
摘要： The present invention provides an improved LbL-coating process for modifying the surface of a medical device, preferably an ophthalmic device, more preferably a contact lens. An LbL coating on a contact lens, which is prepared according to the process of the invention, can have increased hydrophilicity characterized by an averaged contact angle of about 80 degree or less, preferably about 50 degrees or less, while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material.
摘要翻译：本发明提供改进的LbL涂覆方法，用于改变医疗装置的表面，优选眼科装置，更优选隐形眼镜。根据本发明的方法制备的隐形眼镜上的LbL涂层可以具有增强的亲水性，其特征在于约80度或更小，优选约50度或更小的平均接触角，同时保持所需的松散性作为透镜材料的透氧性和离子透过性。

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