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    • 1. 发明授权
    • Dissolution liquid for drug in iontophoresis
    • 药物溶出液在离子电渗疗法中的应用
    • US5993848A
    • 1999-11-30
    • US659372
    • 1996-06-06
    • Yasuyuki SuzukiKatsumi IgaYukihiro Matsumoto
    • Yasuyuki SuzukiKatsumi IgaYukihiro Matsumoto
    • A61N1/30A61K31/785A61F13/00
    • A61N1/30
    • A drug held or supported by an interface comprising a porous matrix is dissolved with a drug dissolution liquid containing a humectant, and the drug is transdermally delivered by iontophoresis. The humectant includes e.g. glycerin and other polyhydric alcohols, sugar alcohols, proline and other amino acids and acidic mucopolysaccharides. The concentration of the humectant may be about 1 to 50% by weight, and the concentration of proline or other amino acid or its salt may be about 1 to 30% by weight. The drug includes (1) a physiologically active peptide or protein with a molecular weight of 100 to 30,000 or (2) a nonpeptide physiologically active compound with a molecular weight of 100 to 1,000.
    • 由包含多孔基质的界面保持或负载的药物与含有保湿剂的药物溶解液溶解,并且通过离子电渗法透皮递送药物。 保湿剂包括例如 甘油等多元醇,糖醇,脯氨酸等氨基酸和酸性粘多糖。 保湿剂的浓度可以为约1至50重量%,脯氨酸或其它氨基酸或其盐的浓度可以为约1至30重量%。 药物包括(1)分子量为100〜30,000的生理活性肽或蛋白质,或(2)分子量为100〜1,000的非肽生理活性化合物。
    • 3. 发明授权
    • Dissolution liquid for drug in iontophoresis
    • 药物溶出液在离子电渗疗法中的应用
    • US06248349B1
    • 2001-06-19
    • US09137744
    • 1998-08-21
    • Yasuyuki SuzukiKatsumi IgaYukihiro Matsumoto
    • Yasuyuki SuzukiKatsumi IgaYukihiro Matsumoto
    • A61K900
    • A61N1/30
    • A drug held or supported by an interface comprising a porous matrix is dissolved with a drug dissolution liquid containing a humectant, and the drug is transdermally delivered by iontophoresis. The humectant includes e.g. glycerin and other polyhydric alcohols, sugar alcohols, proline and other amino acids and acidic mucopolysaccharides. The concentration of the humectant may be about 1 to 50% by weight, and the concentration of proline or other amino acid or its salt may be about 1 to 30% by weight. The drug includes (1) a physiologically active peptide or protein with a molecular weight of 100 to 30,000 or (2) a nonpeptide physiologically active compound with a molecular weight of 100 to 1,000.
    • 由包含多孔基质的界面保持或负载的药物与含有保湿剂的药物溶解液溶解,并且通过离子电渗法透皮递送药物。 保湿剂包括例如 甘油等多元醇,糖醇,脯氨酸等氨基酸和酸性粘多糖。 保湿剂的浓度可以为约1至50重量%,脯氨酸或其它氨基酸或其盐的浓度可以为约1至30重量%。 药物包括(1)分子量为100〜30,000的生理活性肽或蛋白质,或(2)分子量为100〜1,000的非肽生理活性化合物。
    • 6. 发明授权
    • Iontophoresis method
    • 离子电渗法
    • US06526316B2
    • 2003-02-25
    • US09207605
    • 1998-12-09
    • Katsumi IgaYasuyuki SuzukiMasahiro Kawase
    • Katsumi IgaYasuyuki SuzukiMasahiro Kawase
    • A61N130
    • A61N1/0432A61N1/30A61N1/325
    • A method for transdermal administration of parathyroid hormone by iontophoresis, which comprises applying electric current at least 2 times a day, which method is repeated one to four times each week, or an apparatus for the iontophoresis can be widely applied for not only the prevention or treatment of osteoporosis but also for general bone diseases which require promotion of bone morphogenesis, for example, treatment of ordinary fractures. The method of the present invention produces excellent pharmacological effects such as few side effects and a high bioavailability in long term administration for the prevention and treatment of bone diseases.
    • 通过离子电渗法透皮给药甲状旁腺激素的方法,其包括每天施加电流至少2次,该方法每周重复1-4次,或者用于离子电渗疗法的装置不仅可广泛应用于预防或 治疗骨质疏松症,而且对于需要促进骨形态发生的一般骨病,例如治疗普通骨折。本发明的方法产生优异的药理作用,例如在长期给药中的副作用少,生物利用度高,用于预防 并治疗骨病。