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1. 发明授权

US6013826A Method formation of a carbon-carbon bond 失效
标题翻译：方法形成碳 - 碳键
公开(公告)号：US6013826A
公开(公告)日：2000-01-11
申请号：US63825
申请日：1998-04-22
申请人： Yasuyuki Kita , Atsunori Sano , Takahiro Yamaguchi , Masahisa Oka , Masato Matsugi , Kentoku Gotanda
发明人： Yasuyuki Kita , Atsunori Sano , Takahiro Yamaguchi , Masahisa Oka , Masato Matsugi , Kentoku Gotanda
IPC分类号： B01J31/02 , C07B37/02 , C07B39/00 , C07C253/30 , C07C255/00
CPC分类号： C07B39/00 , B01J31/0235 , C07B37/02 , C07C253/30 , B01J2231/323
摘要： A method for an addition reaction with the formation of an additional carbon--carbon bond comprising reacting an .alpha.-halogeno carboxylic acid derivative with an alkene in the presence of a catalyst shown by the general formula (1): ##STR1## wherein R.sub.1 is a lower alkyl group.
摘要翻译：一种形成另外的碳 - 碳键的加成反应的方法，包括在由通式（1）表示的催化剂存在下使α-卤代羧酸衍生物与烯烃反应：其中R1是低级烷基。

2. 发明授权

US5665394A Matrix for sustained-release preparation 失效
标题翻译：用于缓释制剂的基质
公开(公告)号：US5665394A
公开(公告)日：1997-09-09
申请号：US723152
申请日：1996-09-30
申请人： Yasutaka Igari , Akira Saikawa , Kayoko Okamoto , Shigeru Kamei , Masahisa Oka , Atsunori Sano
发明人： Yasutaka Igari , Akira Saikawa , Kayoko Okamoto , Shigeru Kamei , Masahisa Oka , Atsunori Sano
IPC分类号： A61K9/16 , C08G63/06 , A61K9/50 , A61F2/02 , A61F9/02 , A61K9/48
CPC分类号： C08G63/06 , A61K9/1647
摘要： The present invention relates to a matrix for sustained-release preparation comprising an ester formed at a terminal carboxyl group of a straight-chain polyester which essentially consists of an .alpha.-hydroxymonocarboxylic acid. The matrix is stable to light, heat, moisture, coloring etc., and is of low toxicity. The sustained-release preparation produced by using the ester of the present invention offers stable drug release over an extended period of time, ensuring sustained stable effect. Furthermore, the sustained-release preparation does not show excess drug release just after administration.
摘要翻译：本发明涉及用于缓释制剂的基质，其包含在直链聚酯的末端羧基上形成的酯，其基本上由α-羟基单羧酸组成。基质对光，热，水分，着色等均稳定，毒性低。通过使用本发明的酯制备的缓释制剂在延长的时间内提供稳定的药物释放，确保持续的稳定的效果。此外，缓释制剂在施用后不显示过量的药物释放。

3. 发明授权

US5594091A Matrix for sustained-release preparation 失效
公开(公告)号：US5594091A
公开(公告)日：1997-01-14
申请号：US391699
申请日：1995-02-21
申请人： Yasutaka Igari , Akira Saikawa , Kayoko Okamoto , Shigeru Kamei , Masahisa Oka , Atsunori Sano
发明人： Yasutaka Igari , Akira Saikawa , Kayoko Okamoto , Shigeru Kamei , Masahisa Oka , Atsunori Sano
IPC分类号： A61K9/16 , C08G63/06 , A61K47/32 , C08G63/08 , C08G63/66
CPC分类号： C08G63/06 , A61K9/1647
摘要： The present invention relates to a matrix for sustained-release preparation comprising an ester formed at a terminal carboxyl group of a straight-chain polyester which essentially consists of an .alpha.-hydroxymonocarboxylic acid. The matrix is stable to light, heat, moisture, coloring etc., and is of low toxicity. The sustained-release preparation produced by using the ester of the present invention offers stable drug release over an extended period of time, ensuring sustained stable effect. Furthermore, the sustained-release preparation does not show excess drug release just after administration.

4. 发明授权

US5300634A Process for producing maltooligosaccharide derivative 失效
标题翻译：生产麦芽低聚糖衍生物的方法
公开(公告)号：US5300634A
公开(公告)日：1994-04-05
申请号：US878266
申请日：1992-05-04
申请人： Atsunori Sano , Naoki Teno
发明人： Atsunori Sano , Naoki Teno
IPC分类号： C07H3/06 , C12Q1/40 , C07H15/00
CPC分类号： C12Q1/40 , C07H3/06 , C12Q2334/10
摘要： A maltooligosaccharide derivative very useful, for example, as a precursor of a modified oligosaccharide derivative having one or more modifying groups at the 6-position or the 4- and 6-positions of the non-reducing end glucose residue which can be effectively used as a substrate for determining .alpha.-amylase activity or an intermediate thereof, can be produced by reacting a compound of the formula: ##STR1## with a compound of the formula: ##STR2## to convert at least the hydroxyl groups at the 4- and 6-positions of non-reducing end glucose residue of the compound of the formula (1) into a cyclic boric acid ester, acylating the reaction product, and then treating the acylated product.
摘要翻译：非常有用的麦芽低聚糖衍生物，例如作为在非还原性末端葡萄糖残基的6位或4位和6位上具有一个或多个修饰基团的修饰的寡糖衍生物的前体，其可以有效地用作用于确定（α） - 淀粉酶活性的底物或其中间体可以通过使下式化合物：（* CHEMICAL STRUCTURE *）（1）与下式化合物反应来制备：（* CHEMICAL STRUCTURE *）（2 ）将至少将式（1）化合物的非还原性末端葡萄糖残基的4-位和6-位的羟基转化成环状硼酸酯，酰化反应产物，然后处理酰化产物。

5. 发明授权

US5081243A Process for producing 3-tetrazolyl pyrido[1,2-a]pyrimidine derivatives 失效
标题翻译：生产3-四唑啉基吡啶（1,2-A）吡嗪衍生物的方法
公开(公告)号：US5081243A
公开(公告)日：1992-01-14
申请号：US483191
申请日：1990-02-22
申请人： Atsunori Sano , Masami Ishihara , Jun Yoshihara , Hiroyoshi Nawa
发明人： Atsunori Sano , Masami Ishihara , Jun Yoshihara , Hiroyoshi Nawa
IPC分类号： C07D401/12 , C07D471/04
CPC分类号： C07D401/12 , C07D471/04
摘要： 3-Tetrazolylpyrido[1,2-a]pyrimidin-4-one derivatives useful as an antiallergy agent are produced by reacting a cyano derivative of pyrido[1,2-a]pyrimidin-4-one compound with (i) hydrazoic acid, followed by hydrolysis, or with (ii) a salt of hydrazoic acid, reacting the resulting product with an acid or a base, followed by hydrolysis.

6. 发明授权

US07741242B2 Palladium catalyst composition 失效
标题翻译：钯催化剂组合物
公开(公告)号：US07741242B2
公开(公告)日：2010-06-22
申请号：US10527699
申请日：2003-09-01
申请人： Shu Kobayashi , Atsunori Sano , Keiji Oono
发明人： Shu Kobayashi , Atsunori Sano , Keiji Oono
IPC分类号： B01J23/44 , B01J37/00
CPC分类号： B01J31/06 , B01J2231/44 , B01J2231/645 , B01J2231/70 , C07B2200/11 , C07C17/16 , C07C41/16 , C07C45/29 , C07C45/62 , C07C67/343 , C07D303/16 , C07F15/006 , C07F15/0066 , C07C22/04 , C07C47/232 , C07C49/213 , C07C69/618 , C07C43/215
摘要： The present invention discloses 1) a catalyst composition consisting of a crosslinked organic polymer compound and a palladium catalyst, wherein said catalyst is physically carried on said crosslinked organic polymer compound, 2) a manufacturing method of the above catalyst composition 1), characterized by homogenizing a straight chain organic polymer compound, having a crosslinkable functional group, and a palladium catalyst in a solvent dissolving said straight chain organic polymer compound, then depositing a composition thus formed and subjecting the crosslinkable functional group in said deposit to a crosslinking reaction, 3) a method for substitution reaction at an allyl position, characterized by reacting an allyl carbonate and a neucleophilic agent in the presence of the above catalyst composition 1), and 4) a method for oxidizing an alcohol, characterized by subjecting the above catalyst composition 1) to reaction with an alcohol.
摘要翻译：本发明公开了1）由交联的有机高分子化合物和钯催化剂组成的催化剂组合物，其中所述催化剂物理地携带在所述交联的有机高分子化合物上，2）上述催化剂组合物1）的制备方法，其特征在于均化具有可交联官能团的直链有机高分子化合物和溶解所述直链有机高分子化合物的溶剂中的钯催化剂，然后沉积由此形成的组合物，并对所述沉积物中的可交联官能团进行交联反应; 3）在烯丙基位置进行取代反应的方法，其特征在于在上述催化剂组合物1）的存在下使碳酸烯丙酯和亲核试剂反应，和4）一种氧化醇的方法，其特征在于将上述催化剂组合物1）与酒精反应。

7. 发明授权

US5516919A Process for producing ascorbic acid derivative 失效
标题翻译：生产抗坏血酸衍生物的方法
公开(公告)号：US5516919A
公开(公告)日：1996-05-14
申请号：US423988
申请日：1995-04-18
申请人： Atsunori Sano , Kuniaki Okamoto , Jun Ebashi
发明人： Atsunori Sano , Kuniaki Okamoto , Jun Ebashi
IPC分类号： C07F9/655 , C07D307/62
CPC分类号： C07F9/65515
摘要： Metal salts or substitutted or non-substituted ammonium salts of ascorbic acid derivatives can be produced in high yield by treating an acidic aqueous solution containing ascorbic acid-2-phosphate or ascorbic acid-2-sulfate with a porous adsorbent such as activated carbon, followed by treating the adsorbent with a basic aqueous solution containing e.g. a metal salt of an organic acid or substituted or non-substituted ammonium salt ion to elute the desired salt of ascorbic acid derivative.
摘要翻译：通过用多孔吸附剂如活性炭处理含有抗坏血酸-2-磷酸或抗坏血酸-2-硫酸的酸性水溶液，可以高收率地生产抗坏血酸衍生物的金属盐或取代或未取代的铵盐，随后通过用含有例如的碱性水溶液处理吸附剂有机酸的金属盐或取代或未取代的铵盐离子洗脱所需的抗坏血酸衍生物盐。

8. 发明授权

US06414159B2 Method for preparation of a quaternary ammonium salt 有权
标题翻译：季铵盐的制备方法
公开(公告)号：US06414159B2
公开(公告)日：2002-07-02
申请号：US09779743
申请日：2001-02-09
申请人： Kimihiko Sano , Yoji Urano , Takuhiro Kimura , Atsunori Sano
发明人： Kimihiko Sano , Yoji Urano , Takuhiro Kimura , Atsunori Sano
IPC分类号： C07D21320
CPC分类号： C07D213/20 , C07D231/12 , C07D233/56 , C07D249/08
摘要： The present invention provides a method for preparation of a quaternary ammonium salt comprising reacting an alkyl halide with 2 equimolar amount or more per the alkyl halide of a pyridine compound or an N-lower alkyl imidazole at 120° C. to 350° C., and a method for the continuous production of a quatemary ammonium salt comprises introducing continuously an alkyl halide and 2 equimolar amount or more per the alkyl halide of a pyridine compound or an N-lower alkyl imidazole into a pipe reactor from the one end thereof under heating at 120 to 350° C. to pass through the pipe reactor wherein a reaction is allowed to take place, and taking out continuously the resulting quaternary ammonium salt from the other end of the reactor.
摘要翻译：本发明提供了一种制备季铵盐的方法，包括使卤代烷与卤代吡啶化合物或N-低级烷基咪唑的烷基卤化物在120℃至350℃下反应2摩尔以上，和连续生产季铵盐的方法包括在加热下从其一端连续引入吡啶化合物或N-低级烷基咪唑的烷基卤化物的烷基卤和2当量等于或更多的烷基卤化物进入管式反应器在120至350℃下通过允许发生反应的管式反应器，并从反应器的另一端连续取出所得的季铵盐。

9. 发明授权

US5393876A Process for producing maltooligosaccharide derivatives 失效
标题翻译：麦芽低聚糖衍生物的制备方法
公开(公告)号：US5393876A
公开(公告)日：1995-02-28
申请号：US44627
申请日：1993-04-09
申请人： Atsunori Sano , Satoshi Hashizume , Hiroyuki Tsurumoto
发明人： Atsunori Sano , Satoshi Hashizume , Hiroyuki Tsurumoto
IPC分类号： C07H13/02 , C07H13/04 , C07H15/203 , C08B37/00 , C07H15/00 , C07H15/04
CPC分类号： C07H13/04 , C07H15/203
摘要： A polyacyl maltooligosaccharide derivative which is a precursor of a maltooligosaccharide derivative having modified groups at the 6-position or 4- and 6-positions of non-reducing end glucose unit and being effectively used as a substrate for measuring .alpha.-amylase activity, can be produced under mild conditions by crosslinking OH groups in the non-reducing end glucose unit of oligosaccharide with a benzylidene group having an alkoxy group, followed by acylation and treatment with a dilute acid.
摘要翻译：作为在非还原性末端葡萄糖单元的6位或4位和6位具有改性基团并且有效地用作测定α-淀粉酶活性的底物的具有修饰基团的麦芽低聚糖衍生物的前体的多酰基麦芽低聚糖衍生物可以是通过将低聚糖的非还原性末端葡萄糖单元中的OH基与具有烷氧基的亚苄基交联，然后进行酰化和用稀酸处理，在温和条件下生产。

10. 发明授权

US5254688A Process for producing pyrido[1,2-a]pyrimidine derivative 失效
标题翻译：制备吡啶并[1,2-a]嘧啶衍生物的方法
公开(公告)号：US5254688A
公开(公告)日：1993-10-19
申请号：US717591
申请日：1991-06-19
申请人： Atsunori Sano , Motoshige Sumino , Masami Ishihara , Kazuo Maruhashi
发明人： Atsunori Sano , Motoshige Sumino , Masami Ishihara , Kazuo Maruhashi
IPC分类号： C07D471/04 , C07D239/10
CPC分类号： C07D471/04
摘要： A pyrido[1,2-a]pyrimidine derivative which is useful as an antiallergic agent can be produced from a 2-aminopyridine derivative or a hydrazoic acid salt thereof by a one-pot and substantially one-step process.

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