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    • 3. 发明申请
    • Novel external agent
    • 小说外部代理
    • US20050158371A1
    • 2005-07-21
    • US10921960
    • 2004-08-20
    • Fumio NishikadoShuzo TagashiraKoichi SaitoToshiyuki Hosokawa
    • Fumio NishikadoShuzo TagashiraKoichi SaitoToshiyuki Hosokawa
    • A61K9/70A61K31/277A61K31/42A61K31/5377A61K47/06A61K47/08A61K47/10
    • A61K31/5377A61K9/0014A61K9/7023A61K31/277A61K31/42A61K47/06A61K47/08A61K47/10
    • The present invention relates to a transdermal administration preparation for external application such as ointment, cream and the like, which contains SMP-114 or leflunomide or a pharmaceutically acceptable acid addition salt thereof as an active ingredient. The present invention further relates to a pharmaceutical composition for transdermal administration which contains, a) as an active ingredient, N-(4-trifluoromethylphenyl)-5-methylisoxazole-4-carboxamide or an active motabolite thereof or a pharmaceutically acceptable salt thereof; and B)(1) a carrier for transdermal administration which contains a base for dissolution in a proportion of not less than 40 w/w %, or (2) a carrier for transdermal administration which contains a hydrophobic base for suspension having no polar group in a molecule in a proportion of not less than 70 w/w %. According to the present invention, a novel means of transdermal administration of SMP-114 or leflunomide or an active motabolite thereof or a pharmaceutically acceptable acid addition salt thereof can be provided.
    • 本发明涉及含有SMP-114或来氟米特或其药学上可接受的酸加成盐作为活性成分的外用施用皮肤给药制剂,如软膏,霜剂等。 本发明还涉及用于透皮给药的药物组合物,其包含a)作为活性成分的N-(4-三氟甲基苯基)-5-甲基异恶唑-4-甲酰胺或其活性成分代谢物或其药学上可接受的盐; 和B)(1)经皮给药的载体,其含有不少于40w / w%的比例溶解的碱,或(2)用于透皮给药的载体,其含有不具有极性基团的悬浮的疏水性碱 在分子中的比例不小于70w / w%。 根据本发明,可以提供透皮给药SMP-114或来氟米特或其活性成
      胶体或其药学上可接受的酸加成盐的新方法。
    • 7. 发明申请
    • Heat Sink
    • 散热器
    • US20120132400A1
    • 2012-05-31
    • US13389117
    • 2010-08-03
    • Toshiyuki HosokawaSeizo Ueno
    • Toshiyuki HosokawaSeizo Ueno
    • F28D15/00
    • H01L23/467H01L23/3672H01L23/473H01L2924/0002H01L2924/00
    • The present invention provides a heat sink having improved heat-exchange. A heat sink (10) which transfers heat dissipated from a heat generating device (12) to a cooling fluid (CF), said heat sink comprises: a planar base plate portion (11) that is thermally connected to the heat generating device (12); and a fin unit (10A) having a plurality of louvers (13) and a frame portion (14) that connects to the plurality of louvers and surrounds thereof. One edge of said plurality of louvers is thermally connected to the base plate portion; and said frame portion is situated apart from a principal surface of said base plate portion.
    • 本发明提供了具有改进的热交换的散热器。 1.一种散热片(10),其将从发热装置(12)散发的热量传递给冷却流体(CF),所述散热器包括:平面基板部分(11),其热连接到所述发热装置 ); 以及具有多个百叶窗(13)的翅片单元(10A)和连接到多个百叶窗并围绕的框架部分(14)。 所述多个百叶窗的一个边缘热连接到基板部分; 并且所述框架部分与所述基板部分的主表面分开。