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1. 发明授权

US07172796B2 Balloon catheter 有权
标题翻译：气球导管
公开(公告)号：US07172796B2
公开(公告)日：2007-02-06
申请号：US10632952
申请日：2003-08-04
申请人： Yasushi Kinoshita , Hiraku Murayama
发明人： Yasushi Kinoshita , Hiraku Murayama
IPC分类号： B29D22/00 , B29D23/00 , B32B1/08
CPC分类号： A61L29/126 , Y10T428/1334 , Y10T428/1352 , Y10T428/1362 , Y10T428/1369
摘要： A balloon catheter includes a long-sized body extending between a proximal end and a distal end, the body internally having at least one lumen, and a balloon made from a composite material composed of short-fibers for reienforcement and a matrix resin, the balloon being disposed on the distal side of the long-sized body. The short-fibers are oriented in the balloon in such a manner that in a longitudinal cross-section of the balloon, 25% or more of the short-fibers are oriented in the major-axis direction of the balloon, 25% or more of the short-fibers are oriented in the direction oblique to the major-axis direction, and the remaining short-fibers are oriented in the direction nearly perpendicular to the major-axis direction; and in a diametrical cross-section of the balloon, 8% or more of the short-fibers are oriented in the circumferential direction of the balloon, 25% or more of the short-fibers are oriented in the direction perpendicular to the circumferential direction, that is, in the major-axis direction, and the remaining short-fibers are oriented in the direction oblique to the circumferential direction. The balloon catheter exhibits a high strength to withstand pressure and a good trackability.
摘要翻译：气囊导管包括在近端和远端之间延伸的长尺寸的身体，身体内部具有至少一个内腔，以及由复合材料制成的气囊，用于再纤维的短纤维和基质树脂，气囊设置在长型身体的远侧。短纤维以这样的方式定向在气囊中：在气囊的纵向截面中，25％以上的短纤维在球囊的长轴方向上取向，25％以上的短纤维短纤维在与长轴方向倾斜的方向上取向，剩余的短纤维在大致垂直于长轴方向的方向上取向; 并且在气囊的直径截面中，短纤维的8％以上在球囊的圆周方向上取向，短纤维的25％以上在与圆周方向垂直的方向上取向，即在长轴方向上，剩余的短纤维在与圆周方向倾斜的方向上取向。气囊导管具有高强度以承受压力和良好的追踪性。

2. 发明授权

US08052620B2 Guide wire and stent 有权
标题翻译：导丝和支架
公开(公告)号：US08052620B2
公开(公告)日：2011-11-08
申请号：US12108882
申请日：2008-04-24
申请人： Kiyohito Ishida , Kiyoshi Yamauchi , Ryosuke Kainuma , Yuji Sutou , Toshihiro Omori , Yuuki Tanaka , Hiraku Murayama , Ryouichi Souba
发明人： Kiyohito Ishida , Kiyoshi Yamauchi , Ryosuke Kainuma , Yuji Sutou , Toshihiro Omori , Yuuki Tanaka , Hiraku Murayama , Ryouichi Souba
IPC分类号： A61B5/00 , A61M25/00
CPC分类号： A61L31/10 , A61F2/91 , A61F2/915 , A61F2002/9155 , A61F2230/005 , A61F2230/0054 , A61F2230/008 , A61L31/022 , A61L2400/16 , A61M25/09 , A61M2025/09091 , A61M2025/0915
摘要： A guide wire includes a distal core member made of a ferrous alloy which has shape memory properties and superelasticity. The ferrous alloy preferably includes substantially two phases, and has a difference of 100° C. or less between an Af point and an Ms point in a thermal hysteresis of martensitic transformation and reverse transformation. The guide wire may include a proximal core member made of an iron-containing alloy and having a higher modulus of elasticity than the distal core member. The two core members may be joined together by welding to form a core of the guide wire.
摘要翻译：引导线包括具有形状记忆特性和超弹性的由铁合金制成的远端芯部件。铁合金优选包括基本上两相，并且在马氏体相变和逆转变的热滞后的Af点和Ms点之间具有100℃以下的差。引导线可以包括由含铁合金制成并且具有比远侧芯部构件更高的弹性模量的近侧芯部构件。两个芯构件可以通过焊接连接在一起以形成导丝的芯。

3. 发明申请

US20070265552A1 Guide wire 有权
公开(公告)号：US20070265552A1
公开(公告)日：2007-11-15
申请号：US11878140
申请日：2007-07-20
申请人： Hiraku Murayama , Akihiko Umeno , Jun Iwami , Yutaka Itou , Youki Aimi
发明人： Hiraku Murayama , Akihiko Umeno , Jun Iwami , Yutaka Itou , Youki Aimi
IPC分类号： A61M25/09
CPC分类号： A61M25/09 , A61M2025/09083 , A61M2025/09108
摘要： A method of making a guide wire involves butting a connection end face at a proximal end of a first wire against a connection end face at a distal end of a second wire while applying voltage and a pressing force to weld together the first and second wires at a welded portion. The welded portion forms a projection that projects outwardly in an outer peripheral direction relative to portions of the first and second wire adjacent the projection. The outer dimension of the projection at the welded portion is adjusted so that upon completing adjusting the outer dimension of the projection the projection still projects outwardly in the outer peripheral direction relative to the portions of the first and second wire adjacent the projection.

4. 发明申请

US20070232957A1 Guide wire 审中-公开
标题翻译：导丝
公开(公告)号：US20070232957A1
公开(公告)日：2007-10-04
申请号：US11797328
申请日：2007-05-02
申请人： Hiraku Murayama , Akihiko Umeno , Jun Iwami , Yutaka Itou , Youki Aimi
发明人： Hiraku Murayama , Akihiko Umeno , Jun Iwami , Yutaka Itou , Youki Aimi
IPC分类号： A61M25/01
CPC分类号： A61M25/09033 , A61M25/09 , A61M2025/09083 , A61M2025/0915 , B21F15/08
摘要： A guide wire includes a first wire disposed on the distal side, and a second wire disposed on the proximal side and made from a material having an elastic modulus larger than that of the first wire. The first wire and the second wire are joined to each other by welding. The second wire has, in the vicinity of the welded portion, a small cross-sectional area portion having a cross-sectional area smaller than that of a proximal end portion of the first wire. The outer diameter of the small cross-sectional area portion is gradually reduced in the direction toward the distal end. The first wire may be made from a superelastic alloy, whereas the second wire may be made from a stainless steel. The first wire and the second wire may be welded to each other by a butt resistance welding process. Since the change in rigidity of the guide wire becomes smooth in the longitudinal direction, the operationality and kink resistance of the guide wire are improved.
摘要翻译：引导线包括设置在远侧的第一线，以及设置在近侧的由具有大于第一线的弹性模量的材料制成的第二线。第一线和第二线通过焊接彼此接合。第二线在焊接部附近具有截面积小于第一线的基端部的截面积的小截面积部。小横截面积部分的外径在朝向远端的方向上逐渐减小。第一线可以由超弹性合金制成，而第二线可以由不锈钢制成。第一线和第二线可以通过对接电阻焊接方法彼此焊接。由于导丝的刚性的变化在长度方向上变得平滑，所以导丝的操作性和抗扭结性提高。

5. 发明申请

US20050197663A1 Device for introduction of long item 有权
标题翻译：设备介绍长项目
公开(公告)号：US20050197663A1
公开(公告)日：2005-09-08
申请号：US11067771
申请日：2005-03-01
申请人： Katsuaki Soma , Toshiaki Takagi , Hiroshi Yagi , Takayuki Mori , Katsuhiro Shirakawa , Hiraku Murayama
发明人： Katsuaki Soma , Toshiaki Takagi , Hiroshi Yagi , Takayuki Mori , Katsuhiro Shirakawa , Hiraku Murayama
IPC分类号： A61M25/01 , A61M25/09 , A61F11/00
CPC分类号： A61M25/0113 , A61M25/09 , A61M25/09041
摘要： Disclosed herein is a device (such as guidewire inserter) for easily and certainly inserting a medical long item having a curved tip into a tube such as catheter and sheath. The guidewire inserter is a tubular member having therein a bore for passage of a guidewire. The tubular member has a slit cutting across the wall thereof over the total length thereof. The tubular member has at the proximal end thereof an aperture, which results from the slit expanding toward the proximal end. The tubular member has at the proximal end of the aperture an open part and a connecting part adjacent thereto for the holder tube. There are a pair of wing-like protruded pieces projecting in the mutually opposite directions at both sides of the open part. The distal end of the tubular member has on its outer surface a pair of protruded rims, which project in the mutually opposite directions with respect to the central axis of the tubular member. When the distal end of the tubular member is connected by insertion into the bore at the proximal end of the tube, such as sheath, the protruded rims come into contact with the inside of the hub.
摘要翻译：这里公开了一种用于容易且肯定地将具有弯曲尖端的医疗长项目插入诸如导管和鞘的管中的装置（例如导丝插入器）。导丝插入器是其中具有用于导丝通过的孔的管状构件。管状构件在其总长度上具有穿过其壁的狭缝切割。管状构件在其近端处具有孔，其由狭缝朝向近端扩展而产生。管状构件在孔的近端处具有敞开部分和与其相邻的用于保持管的连接部分。在开口部的两侧，在相反的方向上突出有一对翼状突起片。管状构件的远端在其外表面上具有一对突出的边缘，该突出的边缘相对于管状构件的中心轴线在相互相反的方向上突出。当管状构件的远端通过插入到管的近端（例如护套）中的孔中而连接时，突出的轮缘与轮毂的内部接触。

6. 发明授权

US08568470B2 Guide wire and stent 有权
标题翻译：导丝和支架
公开(公告)号：US08568470B2
公开(公告)日：2013-10-29
申请号：US13243651
申请日：2011-09-23
申请人： Kiyohito Ishida , Kiyoshi Yamauchi , Ryosuke Kainuma , Yuji Sutou , Toshihiro Omori , Yuuki Tanaka , Hiraku Murayama , Ryouichi Souba
发明人： Kiyohito Ishida , Kiyoshi Yamauchi , Ryosuke Kainuma , Yuji Sutou , Toshihiro Omori , Yuuki Tanaka , Hiraku Murayama , Ryouichi Souba
IPC分类号： A61F2/82
CPC分类号： A61L31/10 , A61F2/91 , A61F2/915 , A61F2002/9155 , A61F2230/005 , A61F2230/0054 , A61F2230/008 , A61L31/022 , A61L2400/16 , A61M25/09 , A61M2025/09091 , A61M2025/0915
摘要： A guide wire includes a distal core member made of a ferrous alloy which has shape memory properties and superelasticity. The ferrous alloy preferably includes substantially two phases, and has a difference of 100° C. or less between an Af point and an Ms point in a thermal hysteresis of martensitic transformation and reverse transformation. The guide wire may include a proximal core member made of an iron-containing alloy and having a higher modulus of elasticity than the distal core member. The two core members may be joined together by welding to form a core of the guide wire.
摘要翻译：引导线包括具有形状记忆特性和超弹性的由铁合金制成的远端芯部件。铁合金优选包括基本上两相，并且在马氏体相变和逆转变的热滞后的Af点和Ms点之间具有100℃以下的差。引导线可以包括由含铁合金制成并且具有比远侧芯部构件更高的弹性模量的近侧芯部构件。两个芯构件可以通过焊接连接在一起以形成导丝的芯。

7. 发明申请

US20130004362A1 PROCESS FOR PRODUCTION OF MEDICAL INSTRUMENT, AND MEDICAL INSTRUMENT 审中-公开
标题翻译：医疗器械生产工艺及医用仪器
公开(公告)号：US20130004362A1
公开(公告)日：2013-01-03
申请号：US13636521
申请日：2011-03-10
申请人： Ryoichi Soba , Hiraku Murayama , Kensuke Uemura
发明人： Ryoichi Soba , Hiraku Murayama , Kensuke Uemura
IPC分类号： B01J19/12 , C22C14/00 , C22C19/03 , C25F3/16
CPC分类号： C22C14/00 , A61L31/022 , A61L31/14 , A61L2400/16 , C22C19/03 , C22F1/10 , C22F1/183 , C25F3/16
摘要： A process for producing a medical instrument, such as a stent and a guide wire, which has an excellent fatigue life; and a medical instrument, such as a stent and a guide wire, which has an excellent fatigue life. The process for producing a medical instrument includes: a preparation step of preparing a medical instrument including a NiTi-based alloy as a base material; and an ion irradiation step of irradiating the medical instrument prepared in the preparation step with Xe ions. The medical instrument is produced by irradiating a medical instrument including a NiTi-based alloy as a base material with Xe ions.
摘要翻译：一种具有优异疲劳寿命的医用器具如支架和导丝的制造方法; 以及具有优异的疲劳寿命的诸如支架和导丝的医疗器械。医疗器具的制造方法包括：准备包含NiTi系合金作为基材的医疗器具的制备工序; 以及离子照射步骤，用Xe离子照射在制备步骤中制备的医疗仪器。医疗器械通过以Xe离子照射包括NiTi基合金作为基材的医疗仪器来制造。

8. 发明授权

US07892187B2 Guide wire 有权
标题翻译：导丝
公开(公告)号：US07892187B2
公开(公告)日：2011-02-22
申请号：US11878140
申请日：2007-07-20
申请人： Hiraku Murayama , Akihiko Umeno , Jun Iwami , Yutaka Itou , Youki Aimi
发明人： Hiraku Murayama , Akihiko Umeno , Jun Iwami , Yutaka Itou , Youki Aimi
IPC分类号： A61M25/00
CPC分类号： A61M25/09 , A61M2025/09083 , A61M2025/09108
摘要： A method of making a guide wire involves butting a connection end face at a proximal end of a first wire against a connection end face at a distal end of a second wire while applying voltage and a pressing force to weld together the first and second wires at a welded portion. The welded portion forms a projection that projects outwardly in an outer peripheral direction relative to portions of the first and second wire adjacent the projection. The outer dimension of the projection at the welded portion is adjusted so that upon completing adjusting the outer dimension of the projection the projection still projects outwardly in the outer peripheral direction relative to the portions of the first and second wire adjacent the projection.
摘要翻译：制造导丝的方法包括将第一线的近端处的连接端面与第二线的远端处的连接端面对接，同时施加电压和压力以将第一和第二线焊接在一起焊接部分。焊接部形成相对于邻近突起的第一和第二线的部分在外周方向向外突出的突起。调整焊接部分处的突起的外部尺寸，使得在完成调整突起的外部尺寸后，突出部相对于邻近突起的第一和第二线的部分在外周方向上仍向外突出。

9. 发明授权

US07785274B2 Guide wire 有权
标题翻译：导丝
公开(公告)号：US07785274B2
公开(公告)日：2010-08-31
申请号：US11013384
申请日：2004-12-17
申请人： Katsuro Mishima , Yutaka Itou , Hiraku Murayama , Hideo Satou
发明人： Katsuro Mishima , Yutaka Itou , Hiraku Murayama , Hideo Satou
IPC分类号： A61M25/00
CPC分类号： A61M25/09 , A61M2025/09091 , A61M2025/09133 , A61M2025/0915
摘要： A guide wire includes a wire body having a first wire disposed at a distal end thereof and a second wire joined to a proximal end of the first wire. The first wire and the second wire are preferably joined to each other by welding, providing a layer joint therebetween. The joint is of a curved shape, particularly a convex curved shape that is convex toward the proximal end of the wire body. In the joint, at least one component (e.g., Ti) of the material of the first wire decreases toward the proximal end and at least one component (e.g., Fe) of the material of the second wire decreases toward the distal end. When a tensile test is conducted on a region of the wire body including the joint, the region of the wire body has, in a tensile load and elongation diagram, an elastic section extending substantially straight upwardly to the right, a yield section extending substantially horizontally or upwardly to the right from the elastic section, and a substantially straight section extending upwardly to the right from the yield section. This region of the wire body possesses characteristics such that the region is fracturable near a terminal end of the straight section at a fracture position on other than the joint.
摘要翻译：引导线包括具有设置在其远端处的第一线的线主体和连接到第一线的近端的第二线。第一线和第二线优选通过焊接彼此连接，在它们之间提供层接合。接头是弯曲形状，特别是凸起的弯曲形状，其朝向线体的近端凸出。在接头中，第一线材料的至少一个部件（例如Ti）朝向近端减小，并且第二线材料的至少一个部件（例如，Fe）朝向远端减小。当在包括接头的线体的区域上进行拉伸试验时，线体的区域在拉伸载荷和延伸率图中具有基本向上向右延伸的弹性部分，基本上水平地延伸的屈服部分或从弹性部分向上或向右的右侧，以及从屈服部分向右向上延伸的基本上直的部分。线体的该区域具有这样的特性，使得该区域在除了接头之外的断裂位置处在直线部分的终端附近是可断裂的。

10. 发明授权

US07632237B2 Guide wire and method of manufacturing the guide wire 有权
标题翻译：导丝及制造导丝的方法
公开(公告)号：US07632237B2
公开(公告)日：2009-12-15
申请号：US10802869
申请日：2004-03-18
申请人： Hiraku Murayama , Katsuro Mishima
发明人： Hiraku Murayama , Katsuro Mishima
IPC分类号： A61M25/00 , A61M5/178
CPC分类号： A61M25/09 , A61M2025/09075 , A61M2025/09108 , Y10T29/5187
摘要： A guide wire includes a distal end side portion formed of a first metallic material, a proximal end side portion formed of a second metallic material higher in rigidity than the first metallic material, and an intermediate portion provided between the distal end side portion and the proximal end side portion and formed of a mixture of the first metallic material and the second metallic material. The intermediate portion includes a gradient physical property portion in which the content of the second metallic material increases from the distal end side toward the proximal end side.
摘要翻译：导丝包括由第一金属材料形成的前端侧部分，刚性高于第一金属材料的第二金属材料形成的近端侧部分和设置在前端侧部分和近端部分之间的中间部分并且由第一金属材料和第二金属材料的混合物形成。中间部分包括梯度物理性质部分，其中第二金属材料的含量从远端侧朝向近端侧增加。

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