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1. 发明授权

US5556621A Tissue plasminogen activator and method of use 失效
标题翻译：组织纤溶酶原激活剂及其使用方法
公开(公告)号：US5556621A
公开(公告)日：1996-09-17
申请号：US237249
申请日：1994-05-04
申请人： Yasushi Kawauchi , Toshiyuki Takemoto , Makoto Takayama , Masami Yokota , Masao Kato , Kimio Katsuta , Hiroshi Gushima
发明人： Yasushi Kawauchi , Toshiyuki Takemoto , Makoto Takayama , Masami Yokota , Masao Kato , Kimio Katsuta , Hiroshi Gushima
IPC分类号： C12N9/64 , A61K38/00 , A61K38/46 , A61P7/02 , C07K14/745 , C12N9/72 , C12N15/09 , C12R1/91 , A61K38/49 , C12N9/50
CPC分类号： C12N9/6459 , C12Y304/21069 , A61K38/00
摘要： The present invention relates to improved plasminogen activators (improved t-PA) which have a prolonged biological half life, an increased stability to heat and acids and can be expected to be effective as inhibiting inflammation around the site in which thrombus is formed.
摘要翻译：本发明涉及具有延长的生物半衰期，增加的对于热和酸的稳定性的增强的纤溶酶原激活剂（改进的t-PA），并且可以预期作为抑制形成血栓的部位周围的炎症是有效的。

2. 发明授权

US5739012A Tissue plasminogen activator and process of preparation 失效
标题翻译：组织纤溶酶原激活剂及其制备方法
公开(公告)号：US5739012A
公开(公告)日：1998-04-14
申请号：US712999
申请日：1996-09-10
申请人： Yasushi Kawauchi , Toshiyuki Takemoto , Makoto Takayama , Masami Yokota , Masao Kato , Kimio Katsuta
发明人： Yasushi Kawauchi , Toshiyuki Takemoto , Makoto Takayama , Masami Yokota , Masao Kato , Kimio Katsuta
IPC分类号： C12N9/64 , A61K38/00 , A61K38/46 , A61P7/02 , C07K14/745 , C12N9/72 , C12N15/09 , C12R1/91 , C12P21/02 , C07H21/04 , C12N1/21 , C12N5/10
CPC分类号： C12N9/6459 , C12Y304/21069 , A61K38/00
摘要： The present invention relates to improved plasminogen activators (improved t-PA) which have a prolonged biological half life, an increased stability to heat and acids and can be expected to be effective as inhibiting inflammation around the site in which thrombus is formed.
摘要翻译：本发明涉及具有延长的生物半衰期，增加的对于热和酸的稳定性的增强的纤溶酶原激活剂（改进的t-PA），并且可以预期作为抑制形成血栓的部位周围的炎症是有效的。

3. 发明授权

US08101674B2 Rubber compound and molded article 有权
标题翻译：橡胶复合物和成型品
公开(公告)号：US08101674B2
公开(公告)日：2012-01-24
申请号：US12668377
申请日：2008-06-09
申请人： Yasushi Kawauchi , Katsuhiko Kimura
发明人： Yasushi Kawauchi , Katsuhiko Kimura
IPC分类号： C08F2/46 , C08L9/00 , C08L7/00
CPC分类号： A61L31/049 , C08G77/12 , C08L23/04 , C08L23/22 , C08L2666/06
摘要： A pharmaceutical/medical rubber compound contains the following components: (A) a composition obtainable by crosslinking (a) 100 parts by weight of an isobutylene polymer having terminal alkenyl groups with (d) a hydrosilyl-containing compound in the presence of (b) from 5 to 100 parts by weight of a polyolefin and (c) from 5 to 100 parts by weight of polybutene during melt kneading, and (B) an ultra-high molecular weight polyethylene powder. Compared with conventional thermoplastic elastomers, the pharmaceutical/medical rubber compound and its molded article are free from deformations and have sufficient permanent set resistance even under high temperature conditions, have excellent mechanical properties, low water absorption property, low reactivity and superb gas barrier properties, and can withstand high-temperature sterilization.
摘要翻译：药物/医用橡胶化合物包含以下成分：（A）通过在（b）存在下将（d）含有氢化甲硅烷基的化合物与100重量份具有末端烯基的异丁烯聚合物交联（A） 5〜100重量份的聚烯烃和（c）5〜100重量份的聚丁烯在熔融捏合过程中，和（B）超高分子量聚乙烯粉末。与传统的热塑性弹性体相比，药物/医用橡胶组合物及其模塑制品没有变形，即使在高温条件下也具有足够的永久固化电阻，具有优异的机械性能，低吸水性，低反应性和极好的阻气性，并能耐高温灭菌。

4. 发明申请

US20100197862A1 RUBBER COMPOUND AND MOLDED ARTICLE 有权
标题翻译：橡胶化合物和成型品
公开(公告)号：US20100197862A1
公开(公告)日：2010-08-05
申请号：US12668377
申请日：2008-06-09
申请人： Yasushi Kawauchi , Katsuhiko Kimura
发明人： Yasushi Kawauchi , Katsuhiko Kimura
IPC分类号： C08L9/00
CPC分类号： A61L31/049 , C08G77/12 , C08L23/04 , C08L23/22 , C08L2666/06
摘要： A pharmaceutical/medical rubber compound contains the following components: (A) a composition obtainable by crosslinking (a) 100 parts by weight of an isobutylene polymer having terminal alkenyl groups with (d) a hydrosilyl-containing compound in the presence of (b) from 5 to 100 parts by weight of a polyolefin and (c) from 5 to 100 parts by weight of polybutene during melt kneading, and (B) an ultra-high molecular weight polyethylene powder. Compared with conventional thermoplastic elastomers, the pharmaceutical/medical rubber compound and its molded article are free from deformations and have sufficient permanent set resistance even under high temperature conditions, have excellent mechanical properties, low water absorption property, low reactivity and superb gas barrier properties, and can withstand high-temperature sterilization.
摘要翻译：药物/医用橡胶化合物包含以下成分：（A）通过在（b）存在下将（d）含有氢化甲硅烷基的化合物与100重量份具有末端烯基的异丁烯聚合物交联（A） 5〜100重量份的聚烯烃和（c）5〜100重量份的聚丁烯在熔融捏合过程中，和（B）超高分子量聚乙烯粉末。与传统的热塑性弹性体相比，药物/医用橡胶组合物及其模塑制品没有变形，即使在高温条件下也具有足够的永久固化电阻，具有优异的机械性能，低吸水性，低反应性和极好的阻气性，并能耐高温灭菌。

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