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1. 发明授权

US07354567B2 Method of encapsulating metal complex within liposomes 失效
标题翻译：将金属络合物包封在脂质体内的方法
公开(公告)号：US07354567B2
公开(公告)日：2008-04-08
申请号：US10503139
申请日：2003-02-25
申请人： Yasushi Arano , Emi Kaneko , Masahiro Murakami
发明人： Yasushi Arano , Emi Kaneko , Masahiro Murakami
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： A61K51/1234
摘要： An object of the present invention is to provide a method of producing liposome wherein a complex of a short half-life metallic radioactive nuclide such as 99mTc and CD is encapsulated, with radiochemical yield and purity enabling practical application. The present invention provides a method of producing a liposome wherein a complex of a short half-life metallic radioactive nuclide and ethylenedicysteine (CD) is encapsulated, which comprises mixing a complex of a short half-life metallic radioactive nuclide and N-[2-(1H-pyrrolylmethyl)]-N′-(4-penten-3-on-2)-ethane-1,2-diamine with an ethylenedicysteine (CD)-encapsulated liposome, and incubating the mixture.
摘要翻译：本发明的一个目的是提供一种生产脂质体的方法，其中封装了半衰期短的金属放射性核素如99m Tc和CD的复合物，其放射化学产率和纯度使得实际应用。本发明提供了一种制备脂质体的方法，其中包含短半衰期金属放射性核素和乙基半胱氨酸（CD）的复合物，其包括将短半衰期金属放射性核素和N- [2- （1H-吡咯基甲基）] -N' - （4-戊烯-3-酮-2） - 乙烷-1,2-二胺与乙二
氨酸（CD）封装的脂质体混合，并温育该混合物。

2. 发明申请

US20050129613A1 Method of encapsulating metal complex within liposomes 失效
标题翻译：将金属络合物包封在脂质体内的方法
公开(公告)号：US20050129613A1
公开(公告)日：2005-06-16
申请号：US10503139
申请日：2003-02-25
申请人： Yasushi Arano , Emi Kaneko , Masahiro Murakami
发明人： Yasushi Arano , Emi Kaneko , Masahiro Murakami
IPC分类号： A61K51/12 , A61P35/00 , A61K51/00 , C07F13/00
CPC分类号： A61K51/1234
摘要： An object of the present invention is to provide a method of producing liposome wherein a complex of a short half-life metallic radioactive nuclide such as 99mTc and CD is encapsulated, with radiochemical yield and purity enabling practical application. The present invention provides a method of producing a liposome wherein a complex of a short half-life metallic radioactive nuclide and ethylenedicysteine (CD) is encapsulated, which comprises mixing a complex of a short half-life metallic radioactive nuclide and N-[2-(1H-pyrrolylmethyl)]-N′-(4-penten-3-on-2)-ethane-1,2-diamine with an ethylenedicysteine (CD)-encapsulated liposome, and incubating the mixture.
摘要翻译：本发明的一个目的是提供一种生产脂质体的方法，其中封装了半衰期短的金属放射性核素如99m Tc和CD的复合物，其放射化学产率和纯度使得实际应用。本发明提供了一种制备脂质体的方法，其中包含短半衰期金属放射性核素和乙基半胱氨酸（CD）的复合物，其包括将短半衰期金属放射性核素和N- [2- （1H-吡咯基甲基）] -N' - （4-戊烯-3-酮-2） - 乙烷-1,2-二胺与乙二
氨酸（CD）封装的脂质体混合，并温育该混合物。

3. 发明授权

US4444743A Radioactive diagnostic agent and its preparation 失效
标题翻译：放射性诊断剂及其制备方法
公开(公告)号：US4444743A
公开(公告)日：1984-04-24
申请号：US302563
申请日：1981-09-15
申请人： Akira Yokoyama , Hisashi Tanaka , Akira Yamada , Yasushi Arano
发明人： Akira Yokoyama , Hisashi Tanaka , Akira Yamada , Yasushi Arano
IPC分类号： A61K51/04 , A61K43/00 , A61K49/00
CPC分类号： A61K51/0491 , A61K2123/00
摘要： A radioactive diagnostic agent for imaging of various organs, particularly of brain, which comprises a radioactive element such as .sup.99m TC and a non-radioactive carrier comprising as the essential component glucosone-bis(thiosemecarbazone) of the formula: ##STR1##
摘要翻译：用于成像各种器官，特别是脑的放射性诊断剂，其包含诸如99mTC的放射性元件和非放射性载体，所述非放射性载体包含下式的基于葡萄糖 - 双（硫代吗啡巴豆）的基本组分：

4. 发明申请

US20120065367A1 Radioactively Labeled Substance 审中-公开
标题翻译：放射性标签物质
公开(公告)号：US20120065367A1
公开(公告)日：2012-03-15
申请号：US13266249
申请日：2009-04-28
申请人： Yasushi Arano , Tomoya Uehara
发明人： Yasushi Arano , Tomoya Uehara
IPC分类号： C07K7/64 , C07C233/01 , C07D499/21
CPC分类号： A61K51/088 , A61K51/0406 , A61K51/082
摘要： Provided are: a radiolabeled drug, which is efficiently accumulated in a target and has high in vivo stability; and diagnosis and treatment each using the radiolabeled drug. Specifically provided are: a radiolabeled drug showing increased accumulation in a target site, which comprises a complex composed of a ligand that is bound to a compound capable of binding to a target molecule and forms a polycoordinated complex with a metal (e.g., technetium or rhenium) and a radionuclide of the metal; the radiolabeled drug for diagnosis or treatment; a ligand for preparing the radiolabeled drug; a kit that comprises a drug comprising the ligand and a drug comprising a radionuclide of a metal, as separate package units; and a method of increasing accumulation of a radiolabeled drug in a target site, comprising using the above-mentioned radiolabeled drug.
摘要翻译：提供：放射性标记的药物，其有效地积聚在靶中并具有高的体内稳定性; 并使用放射性标记药物进行诊断和治疗。具体提供的是：放射性标记的药物在靶位点显示增加的积累，其包含由与能与靶分子结合的化合物结合的配体组成的复合物，并与金属形成多配位络合物（例如锝或铼）和金属的放射性核素; 用于诊断或治疗的放射性标记药物; 用于制备放射性标记药物的配体; 包含包含配体的药物和包含金属的放射性核素的药物作为分开的包装单元的试剂盒; 以及增加放射性标记的药物在靶位点中的积累的方法，包括使用上述放射性标记的药物。

5. 发明授权

US4559221A P-Glyoxyloylphenylalkanoic acid bis(thiosemicarbazone) derivatives, and their production and use 失效
标题翻译： P-缩水甘油基苯基链烷酸双（缩氨基硫脲）衍生物及其生产和使用
公开(公告)号：US4559221A
公开(公告)日：1985-12-17
申请号：US539884
申请日：1983-10-07
申请人： Yasushi Arano , Yasuhiro Magata , Akira Yokoyama
发明人： Yasushi Arano , Yasuhiro Magata , Akira Yokoyama
IPC分类号： A61K51/04 , A61K49/00 , A61K43/00
CPC分类号： A61K51/04 , A61K2123/00
摘要： A radioactive diagnostic agent which comprises a physiologically active substance and a radioactive metallic element combined with a compound of the formula: ##STR1## wherein R is a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group and n is an integer of 0 to 4. The agent is characteristic in having a high stability even after being administered into a human body and showing the substantially the same behavior as the physiologically active substance itself in a human body.
摘要翻译：一种放射性诊断剂，其包含与以下化合物组合的生理活性物质和放射性金属元素：其中R为氢原子或C1-C3烷基，n为0〜即使施用于人体后，药剂也具有高稳定性，并具有与人体内的生理活性物质本身基本相同的作用。

6. 发明授权

US4338248A 2-Oxopropionaldehyde bis(thiosemicarbazone) protein derivatives, and their production and use 失效
标题翻译： 2-氧代丙醛双（缩氨基硫脲）蛋白衍生物及其生产和使用
公开(公告)号：US4338248A
公开(公告)日：1982-07-06
申请号：US177947
申请日：1980-08-14
申请人： Akira Yokoyama , Yasushi Arano
发明人： Akira Yokoyama , Yasushi Arano
IPC分类号： A61K51/04 , A61K51/08 , C07G7/00 , C07G7/04
CPC分类号： A61K51/081 , A61K51/04 , A61K51/088 , A61K2123/00
摘要： A radioactive diagnostic agent which comprises a protein and a radioactive metallic element combined with intervention of a bifunctional chelating agent of the formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group and is characteristic in having high stability even after administered into a human body.

7. 发明授权

US09236153B2 Method of recovering enriched radioactive technetium and system therefor 有权
标题翻译：回收富集放射性锝的方法及其制法
公开(公告)号：US09236153B2
公开(公告)日：2016-01-12
申请号：US13378819
申请日：2009-07-03
申请人： Katsuyoshi Tatenuma , Tomomi Ueda , Kiyoko Kurosawa , Koji Ishikawa , Atsushi Tanaka , Tsuneyuki Noguchi , Yasushi Arano
发明人： Katsuyoshi Tatenuma , Tomomi Ueda , Kiyoko Kurosawa , Koji Ishikawa , Atsushi Tanaka , Tsuneyuki Noguchi , Yasushi Arano
IPC分类号： C01G49/00 , G21G1/00 , A61K51/12 , G21C19/42 , G21C19/46
CPC分类号： G21G1/001 , A61K51/1282 , G21C19/42 , G21C19/46 , G21G2001/0042 , Y02W30/883
摘要： To use 99mTc as a raw material for a radioactive medicine, a very small amount of 99mTc in the high concentration Mo(99Mo) solution is purified and recovered with high yield without contamination of 99Mo. 99mTc with high purity is recovered by forming a high concentration Mo(99Mo) solution which contains radionuclides 99Mo which is the parent nuclide of 99mTc used for the radioactive medicine and the raw material for its labeled compound, forming a high concentration Mo(99Mo) solution which contains radionuclides 99Mo and 99mTc by generating 99mTc to a radioactive-equilibrium state, getting 99mTc in the high concentration Mo(99Mo) solution adsorbed to activated carbon selectively by feeding the solution to an adsorption column which has activated carbon, and undergoing desorption and purification treatment of 99mTc with a desorbent from the activated carbon to which 99mTc is adsorbed.
摘要翻译：为了使用99mTc作为放射性药物的原料，高浓度Mo（99Mo）溶液中非常少量的99mTc以高产率纯化和回收而不污染99Mo。通过形成高浓度Mo（99Mo）溶液回收99mTc，该溶液含有作为放射性药物使用的99mTc的母核素和其标记化合物的原料的放射性核素99Mo，形成高浓度Mo（99Mo）溶液其通过产生99mTc至放射性平衡状态而含有放射性核素99Mo和99mTc，通过将溶液输送到具有活性炭的吸附塔并经历解吸和纯化，在吸附到活性炭上的高浓度Mo（99Mo）溶液中获得99mTc 用吸附有99mTc的活性炭的解吸剂处理99mTc。

8. 发明申请

US20120090431A1 METHOD OF RECOVERING ENRICHED RADIOACTIVE TECHNETIUM AND SYSTEM THEREFOR 有权
标题翻译：回收放射性放射性技术及其系统的方法
公开(公告)号：US20120090431A1
公开(公告)日：2012-04-19
申请号：US13378819
申请日：2009-07-03
申请人： Katsuyoshi Tatenuma , Tomomi Ueda , Kiyoko Kurosawa , Koji Ishikawa , Atsushi Tanaka , Tsuneyuki Noguchi , Yasushi Arano
发明人： Katsuyoshi Tatenuma , Tomomi Ueda , Kiyoko Kurosawa , Koji Ishikawa , Atsushi Tanaka , Tsuneyuki Noguchi , Yasushi Arano
IPC分类号： C22B60/00 , C22B5/00
CPC分类号： G21G1/001 , A61K51/1282 , G21C19/42 , G21C19/46 , G21G2001/0042 , Y02W30/883
摘要： To use 99mTc as a raw material for a radioactive medicine, a very small amount of 99mTc in the high concentration Mo(99Mo) solution is purified and recovered with high yield without contamination of 99Mo. 99mTc with high purity is recovered by forming a high concentration Mo(99Mo) solution which contains radionuclides 99Mo which is the parent nuclide of 99mTc used for the radioactive medicine and the raw material for its labeled compound, forming a high concentration Mo(99Mo) solution which contains radionuclides 99Mo and 99mTc by generating 99mTc to a radioactive-equilibrium state, getting 99mTc in the high concentration Mo(99Mo) solution adsorbed to activated carbon selectively by feeding the solution to an adsorption column which has activated carbon, and undergoing desorption and purification treatment of 99mTc with a desorbent from the activated carbon to which 99mTc is adsorbed.
摘要翻译：为了使用99mTc作为放射性药物的原料，高浓度Mo（99Mo）溶液中非常少量的99mTc以高产率纯化和回收而不污染99Mo。通过形成高浓度Mo（99Mo）溶液回收99mTc，该溶液含有作为放射性药物使用的99mTc的母核素和其标记化合物的原料的放射性核素99Mo，形成高浓度Mo（99Mo）溶液其通过产生99mTc至放射性平衡状态而含有放射性核素99Mo和99mTc，通过将溶液供入具有活性炭的吸附塔并经历解吸和纯化，在吸附到活性炭上的高浓度Mo（99Mo）溶液中获得99mTc 用吸附有99mTc的活性炭的解吸剂处理99mTc。

9. 发明授权

US4915931A Tc-99m mononuclide complex compound 失效
标题翻译： Tc-99m单核素复合物
公开(公告)号：US4915931A
公开(公告)日：1990-04-10
申请号：US297385
申请日：1989-01-17
申请人： Akira Yokoyama , Yasushi Arano
发明人： Akira Yokoyama , Yasushi Arano
IPC分类号： A61K51/00 , A61K51/04 , C07F13/00
CPC分类号： A61K51/0478 , A61K2123/00 , Y10S424/06
摘要： A Tc-99m mononuclide complex compound of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group and X is an anion, which is useful as a radioactive diagnostic agent for imaging of brain, cardiac muscle, pancreas or the like.
摘要翻译：具有下式的Tc-99m单核素络合物：其中R 1和R 2各自为氢原子或C 1 -C 3烷基，X为阴离子，其可用作脑成像，心脏放射性诊断剂肌肉，胰腺等。

10. 发明授权

US4511550A 1-(p-Substituted or unsubstituted aminoalkyl)phenylpropane-1,2-dione bis(thiosemicarbazone) derivatives, and their production and use 失效
标题翻译： 1-（对取代或未取代的氨基烷基）苯基丙烷-1,2-二酮双（缩氨基硫脲）衍生物及其生产和使用
公开(公告)号：US4511550A
公开(公告)日：1985-04-16
申请号：US438776
申请日：1982-11-03
申请人： Akira Yokoyama , Yasushi Arano , Takeo Hosotani
发明人： Akira Yokoyama , Yasushi Arano , Takeo Hosotani
IPC分类号： A61K51/04 , A61K51/08 , A61K43/00 , A61K49/00
CPC分类号： A61K51/081 , A61K51/0406 , A61K51/088 , A61K2123/00
摘要： A radioactive diagnostic agent which comprises a physiologically active substance and a radioactive metallic element combined with a compound of the formula: ##STR1## wherein R, R', R.sup.1 and R.sup.2 are each a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group and n is an integer of 0 to 3. The agent is characteristic in having a high stability even after being administered into a human body and showing the substantially the same behavior as the physiologically active substance itself in a human body.
摘要翻译：一种放射性诊断剂，其包含与下式化合物组合的生理活性物质和放射性金属元素：其中R，R'，R 1和R 2各自为氢原子或C 1 -C 3烷基，n为整数为0〜3。该试剂即使在施用于人体后也具有高稳定性，并且在人体内显示与生理活性物质本身基本相同的作用。

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