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1. 发明授权

US09492842B2 Cell culture membrane, cell culture substrate, and method for manufacturing cell culture substrate 有权
标题翻译：细胞培养膜，细胞培养基质和细胞培养基质的制造方法
公开(公告)号：US09492842B2
公开(公告)日：2016-11-15
申请号：US14128089
申请日：2012-06-22
申请人： Yasuo Yoshimoto , Kentaro Kamimae , Yuki Tanabe , Taku Oguni , Takashi Inoue , Tsutomu Mochizuki , Makoto Hirama , Teruo Fujii , Hiroshi Kimura , Hideto Tozawa
发明人： Yasuo Yoshimoto , Kentaro Kamimae , Yuki Tanabe , Taku Oguni , Takashi Inoue , Tsutomu Mochizuki , Makoto Hirama , Teruo Fujii , Hiroshi Kimura , Hideto Tozawa
IPC分类号： B05D1/00 , C12M1/12 , C12N5/00 , C12M1/00
CPC分类号： B05D1/60 , C12M23/20 , C12M25/02 , C12N5/0068 , C12N2533/30
摘要： Provided is: a cell culture membrane, which is free from materials derived from living organisms, can easily be industrially mass-produced, exhibits superior long-term storage properties and chemical resistance, has excellent cell adhesion properties and long-term culture properties and is capable of replicating a cell adhesion morphology that is similar to that of collagen derived from living organisms and being used for conventional cell cultivation. Also provided are a cell culture substrate, and a method for manufacturing the cell culture substrate. In the present invention, as a cell adhesion layer, a polymer membrane represented by formula (I) is formed on the base of a cell culture substrate so as to have a membrane thickness equal to or greater than 0.2 μm (in the formula, R1 and R2 represent a —(CH2)n—NH2 moiety (n is an integer of 1-10 inclusive.) or H, with at least one of R1 and R2 being a —(CH2)n—NH2 moiety. Moreover, l and m are positive integers expressing polymerization degree).

2. 发明申请

US20140212974A1 CELL CULTURE MEMBRANE, CELL CULTURE SUBSTRATE, AND METHOD FOR MANUFACTURING CELL CULTURE SUBSTRATE 有权
标题翻译：细胞培养膜，细胞培养基质和制备细胞培养基质的方法
公开(公告)号：US20140212974A1
公开(公告)日：2014-07-31
申请号：US14128089
申请日：2012-06-22
申请人： Yasuo Yoshimoto , Kentaro Kamimae , Yuki Tanabe , Taku Oguni , Takashi Inoue , Tsutomu Mochizuki , Makoto Hirama , Teruo Fujii , Hiroshi Kimura , Hideto Tozawa
发明人： Yasuo Yoshimoto , Kentaro Kamimae , Yuki Tanabe , Taku Oguni , Takashi Inoue , Tsutomu Mochizuki , Makoto Hirama , Teruo Fujii , Hiroshi Kimura , Hideto Tozawa
IPC分类号： C12N5/00 , B05D1/00
CPC分类号： B05D1/60 , C12M23/20 , C12M25/02 , C12N5/0068 , C12N2533/30
摘要： Provided is: a cell culture membrane, which is free from materials derived from living organisms, can easily be industrially mass-produced, exhibits superior long-term storage properties and chemical resistance, has excellent cell adhesion properties and long-term culture properties and is capable of replicating a cell adhesion morphology that is similar to that of collagen derived from living organisms and being used for conventional cell cultivation. Also provided are a cell culture substrate, and a method for manufacturing the cell culture substrate. In the present invention, as a cell adhesion layer, a polymer membrane represented by formula (I) is formed on the base of a cell culture substrate so as to have a membrane thickness equal to or greater than 0.2 μm (in the formula, R1 and R2 represent a —(CH2)n—NH2 moiety (n is an integer of 1-10 inclusive.) or H, with at least one of R1 and R2 being a —(CH2)n—NH2 moiety. Moreover, l and m are positive integers expressing polymerization degree).
摘要翻译：提供：不含活体的物质的细胞培养膜可以容易地在工业上批量生产，具有优异的长期保存性和耐化学性，具有优异的细胞粘附性和长期培养性，并且是能够复制与来自活生物体的胶原相似的细胞粘附形态，并用于常规细胞培养。还提供了细胞培养基质和细胞培养基质的制造方法。在本发明中，作为细胞粘附层，在细胞培养基材的基材上形成由式（I）表示的聚合物膜，以使膜厚等于或大于0.2μm（式中，R1 并且R 2表示 - （CH 2）n -NH 2部分（n是包括1-10的整数）或H，其中R 1和R 2中的至少一个是 - （CH 2）n -NH 2部分，此外， m是表示聚合度的正整数）。

3. 发明申请

US20070105997A1 Method for improving heat stability of polyparaxylylene and derivative film thereof and polyparaxylylene derivative 有权
标题翻译：聚对二甲苯及其衍生物膜和聚对二甲苯衍生物的热稳定性的改进方法
公开(公告)号：US20070105997A1
公开(公告)日：2007-05-10
申请号：US10596589
申请日：2003-12-19
申请人： Hiroshi Maruyama , Tsutomu Mochizuki , Takashi Inoue
发明人： Hiroshi Maruyama , Tsutomu Mochizuki , Takashi Inoue
IPC分类号： C23C16/00 , C08K5/00
CPC分类号： C08G61/025 , C08G61/02 , C08G2261/3424 , C08L65/04
摘要： A method for improving the heat stability of polyparaxylylene and a derivative film thereof to improve the heat resistance of the polyparaxylylene and the derivative film thereof without deteriorating deposition characteristics or profitability, and a polyparaxylylene derivative whose heat resistance is improved are provided. When the polyparaxylylene or the derivative film thereof represented by a below-described general formula 1 is formed by a chemical vapor deposition method, an amino-(2.2)-paracyclophane compound represented by a below-described general formula 3 is mixed in a (2.2)-paracyclophane compound represented by a below-described general formula 2 to form a film. (In the formula 1, X1 and X2 designate hydrogen, lower alkyl or halogen. X1 and X2 may be the same or different. n represents a degree of polymerization.) (In the formula 2, X1 and X2 have the same meanings as those of the formula 1.) (In the formula 3, X3 designates hydrogen or a lower alkyl group. Y1 and Y2 designate hydrogen or an amino group and both Y1 and Y2 are not hydrogens at the same time.)
摘要翻译：提供聚对二甲苯的热稳定性的方法及其衍生膜，以提高聚对二甲苯及其衍生物膜的耐热性，而不会降低沉积特性或获利能力，并提供耐热性改善的聚对二甲苯衍生物。当通过化学气相沉积法形成由下述通式1表示的聚对二甲苯或其衍生物膜时，将下述通式3所示的氨基 - （2.2） - 环烷基化合物混合在（2.2 ） - 由下述通式2表示的 - 环烷基化合物以形成膜。（在式1中，X 1和X 2表示氢，低级烷基或卤素。X 1和X 2， SUB可以相同或不同，n表示聚合度。）（在式2中，X 1和X 2具有与上述相同的含义式1）（在式3中，X 3表示氢或低级烷基，Y 1和Y 2表示氢或氨基并且Y 1和Y 2都不同时为氢。）

4. 发明授权

US07763318B2 Method for improving heat stability of polyparaxylylene and derivative film thereof and polyparaxylylene derivative 有权
标题翻译：聚对二甲苯及其衍生物膜和聚对二甲苯衍生物的热稳定性的改进方法
公开(公告)号：US07763318B2
公开(公告)日：2010-07-27
申请号：US10596589
申请日：2003-12-19
申请人： Hiroshi Maruyama , Tsutomu Mochizuki , Takashi Inoue
发明人： Hiroshi Maruyama , Tsutomu Mochizuki , Takashi Inoue
IPC分类号： C23C16/00
CPC分类号： C08G61/025 , C08G61/02 , C08G2261/3424 , C08L65/04
摘要： A method for improving the heat stability of polyparaxylylene and a derivative film thereof to improve the heat resistance of the polyparaxylylene and the derivative film thereof without deteriorating deposition characteristics or profitability, and a polyparaxylylene derivative whose heat resistance is improved are provided. When the polyparaxylylene or the derivative film thereof represented by a below-described general formula 1 is formed by a chemical vapor deposition method, an amino-(2.2)-paracyclophane compound represented by a below-described general formula 3 is mixed in a (2.2)-paracyclophane compound represented by a below-described general formula 2 to form a film. (In the formula 1, X1 and X2 designate hydrogen, lower alkyl or halogen. X1 and X2 may be the same or different. n represents a degree of polymerization.) (In the formula 2, X1 and X2 have the same meanings as those of the formula 1.) (In the formula 3, X3 designates hydrogen or a lower alkyl group. Y1 and Y2 designate hydrogen or an amino group and both Y1 and Y2 are not hydrogens at the same time.)
摘要翻译：提供聚对二甲苯的热稳定性的方法及其衍生膜，以提高聚对二甲苯及其衍生物膜的耐热性，而不会降低沉积特性或获利能力，并提供耐热性改善的聚对二甲苯衍生物。当通过化学气相沉积法形成由下述通式1表示的聚对二甲苯或其衍生物膜时，将下述通式3所示的氨基 - （2.2） - 环烷基化合物混合在（2.2 ） - 由下述通式2表示的 - 环烷基化合物以形成膜。（式1中，X 1和X 2表示氢，低级烷基或卤素，X 1和X 2可以相同或不同，n表示聚合度。）（式2中，X1，X2表示与上述相同的含义）式（3）中，X3表示氢或低级烷基，Y 1和Y 2表示氢或氨基，Y1和Y2两者不同时为氢。）

5. 发明申请

US20100034970A1 APPARATUS AND METHOD FOR CHEMICAL VAPOR DEPOSITION 审中-公开
标题翻译：化学气相沉积的装置和方法
公开(公告)号：US20100034970A1
公开(公告)日：2010-02-11
申请号：US12375332
申请日：2006-07-28
申请人： Tsutomu Mochizuki , Takashi Inoue , Kazuyoshi Uetake
发明人： Tsutomu Mochizuki , Takashi Inoue , Kazuyoshi Uetake
IPC分类号： C23C16/44 , C23C16/00 , C23C16/52
CPC分类号： C08G61/025 , B05D1/60 , C08G2261/3424
摘要： A chemical vapor deposition apparatus includes a charging section 10 for charging a feedstock material for vapor deposition, a decomposition oven 2 for decomposing a feedstock material for vapor deposition, an opening/closing valve 4 for interconnecting the charging section 10 and the decomposition oven 2, and a polymerization section 3 for polymerizing the feedstock material decomposed by the decomposition oven for depositing a coating film on the surface of a substrate. The feedstock material for vapor deposition charged into the charging section 10 is vaporized, and the so vaporized feedstock material is delivered to the decomposition oven 2 by opening the opening/closing valve 4 to deposit the coating film.
摘要翻译：一种化学气相沉积设备包括用于对用于气相沉积的原料进行充电的充电部分10，用于分解气相沉积原料的分解炉2，用于将充电部分10和分解炉2互连的开/关阀4，以及用于聚合由分解炉分解的原料的聚合部分3，用于在基材的表面上沉积涂膜。将装入充电部10的气相沉积原料蒸发，通过打开开闭阀4将蒸发的原料输送到分解炉2，沉积涂膜。

6. 外观设计

USD433015S Pickup for an optical disc player 失效
公开(公告)号：USD433015S
公开(公告)日：2000-10-31
申请号：US93950
申请日：1998-09-22
申请人： Tsutomu Mochizuki
设计人： Tsutomu Mochizuki

7. 发明授权

US06097690A Optical pickup and disc player 失效
标题翻译：光学拾音器和光盘播放器
公开(公告)号：US06097690A
公开(公告)日：2000-08-01
申请号：US983617
申请日：1998-01-09
申请人： Tsutomu Mochizuki , Katsuhiko Yamada
发明人： Tsutomu Mochizuki , Katsuhiko Yamada
IPC分类号： G11B7/00 , G11B7/08 , G11B7/085 , G11B7/09 , G11B7/095 , G11B7/12 , G11B7/125 , G11B7/135
CPC分类号： G11B7/1372 , G11B7/08 , G11B7/08582 , G11B7/0925 , G11B7/12 , G11B7/127 , G11B7/1374 , G11B2007/0006 , G11B7/0956
摘要： A disc player provided with an optical pick-up including plural object lens so that write and read operations of information signals can be carried out with respect to plural kinds of discs in which thicknesses of transparent bases are different from each other. In order that tracking error signal can be satisfactorily detected even in the case where either one of object lenses is used, a biaxial actuator 3 for supporting an object lens 5 moved on a line which is off the central axis C of a spindle motor 17 is disposed in a manner inclined by a predetermined angle .theta. with respect to the axis of a guide shaft 18, and movement operation direction of the object lens 5 is caused to be close to the direction perpendicular to recording tracks of the optical disc caused to undergo rotational operation by the spindle motor 17.
摘要翻译： PCT No.PCT / JP97 / 01573 Sec。 371日期1998年1月9日 102（e）1998年1月9日PCT PCT 1997年5月9日PCT公布。公开号WO97 / 42632 PCT 日期：1997年11月13日具有包括多个物镜的光学拾取器的光盘播放器，可以相对于透明基底的厚度彼此不同的多种盘来执行信息信号的写入和读取操作。为了即使在使用任一个物镜的情况下也能令人满意地检测到跟踪误差信号，用于支撑在主轴电动机17的中心轴线C的线上移动的物镜5的双轴致动器3是以相对于引导轴18的轴线倾斜了预定角度θ的方式设置，并且使物镜5的移动操作方向接近垂直于光盘的记录轨道的方向，以使其经受旋转由主轴电动机17进行操作。

8. 发明授权

US4311715A Method of preparing albumin rich foodstuff raw materials 失效
标题翻译：制备白蛋白丰富食品原料的方法
公开(公告)号：US4311715A
公开(公告)日：1982-01-19
申请号：US126943
申请日：1980-03-03
申请人： Hideki Oka , Keiji Itoga , Tsutomu Mochizuki
发明人： Hideki Oka , Keiji Itoga , Tsutomu Mochizuki
IPC分类号： A23L7/20 , A23L11/00 , A23L27/60 , A23J1/14 , A23L1/20
CPC分类号： A23L27/60 , A23L11/09 , A23L7/20
摘要： In preparing miso like albumin rich foodstuff raw material, malt of rice or the like is sterilized with ethyl alcohol or an aqueous solution thereof, the sterilized malt is admixed with steamed or boiled soya beans and the resulting mixture is aged at a temperature of 20.degree. C.-50.degree. C. for about one week or more.
摘要翻译：在制备如白蛋白丰富的食品原料的味噌时，用乙醇或其水溶液灭菌麦芽等，将灭菌的麦芽与蒸或煮沸的大豆混合，并将所得混合物在20℃的温度下老化 C.-50℃约1周或更长时间。

9. 发明申请

US20130089609A1 CONTROLLED RELEASE NUCLEATED TABLET 有权
标题翻译：控制释放核片
公开(公告)号：US20130089609A1
公开(公告)日：2013-04-11
申请号：US13704345
申请日：2011-06-15
申请人： Kentaro Fujinaga , Susumu Maruo , Hideaki Nakamura , Kenji Sunagawa , Tsutomu Mochizuki , Michiharu Kageyama
发明人： Kentaro Fujinaga , Susumu Maruo , Hideaki Nakamura , Kenji Sunagawa , Tsutomu Mochizuki , Michiharu Kageyama
IPC分类号： A61K9/28
CPC分类号： A61K9/2866 , A61K9/2018 , A61K9/2054 , A61K9/209 , A61K31/426
摘要： Disclosed is a controlled release nucleated tablet which is composed of an inner nucleus and an outer layer that covers the inner nucleus and is capable of maintaining the level of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid in the blood to a certain value or higher for a long period of time. The controlled release nucleated tablet is characterized in that the inner nucleus contains 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid and the outer layer contains 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid and a gel-forming water-soluble polymer that is in an amount of 16 (w/w) % or more relative to the weight of the outer layer.
摘要翻译：公开了一种控制释放有核的片剂，其由内核和覆盖内核的外层组成，并且能够维持2-（3-氰基-4-异丁氧基苯基）-4-甲基-5-噻唑甲酸血液中的酸长时间达到一定值或更高。控释片的特征在于内核含有2-（3-氰基-4-异丁氧基苯基）-4-甲基-5-噻唑甲酸，外层含有2-（3-氰基-4-异丁氧基苯基） - 4-甲基-5-噻唑甲酸和相对于外层重量为16（w / w）％以上的凝胶形成性水溶性聚合物。

10. 发明授权

US06172958B2 Optical pick-up and disk player 失效
标题翻译：光学拾音器和磁盘播放器
公开(公告)号：US06172958B2
公开(公告)日：2001-01-09
申请号：US09043002
申请日：1998-01-09
申请人： Tsutomu Mochizuki , Yutaka Sugawara
发明人： Tsutomu Mochizuki , Yutaka Sugawara
IPC分类号： G11B712
CPC分类号： G11B7/1353 , G11B7/08582 , G11B7/0903 , G11B7/093 , G11B7/0933 , G11B7/0935 , G11B7/0956 , G11B7/12 , G11B7/123 , G11B7/127 , G11B7/135 , G11B7/1374 , G11B19/12 , G11B2007/0006
摘要： In order to provide an optical pick-up capable of carrying out write and read operations of information signals with respect to plural kinds of optical discs in which thicknesses of transparent bases are different from each other and simple in configuration, a first object lens 7a for converging light beams from a first light source onto an optical disc 101 of the first kind and a second object lens 7b for converging light beams from a second light source 6 onto an optical disc 102 of the second kind are provided on the same lens bobbin 8. The lens bobbin 8 is movably supported by the columnar support shaft and is caused to undergo movement operation by magnetic circuit.
摘要翻译：为了提供能够对透明基板的厚度彼此不同并且结构简单的多种光盘执行信息信号的写入和读取操作的光学拾取器，第一物镜7a 将来自第一光源的光束会聚到第一种光盘101上，以及用于将来自第二光源6的光束会聚到第二类光盘102上的第二物镜7b设置在同一透镜架8上透镜架8由柱状支撑轴可动地支撑，通过磁路进行移动动作。

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