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    • 2. 发明授权
    • Benzamide derivatives
    • 苯甲酰胺衍生物
    • US5395832A
    • 1995-03-07
    • US104095
    • 1993-08-11
    • Yasuo ItoHideo KatoShingo YasudaNobuhiko IwasakiHiroyuki NishinoMakoto Takeshita
    • Yasuo ItoHideo KatoShingo YasudaNobuhiko IwasakiHiroyuki NishinoMakoto Takeshita
    • C07D211/58C07D451/04C07D451/14A61K31/46A61K31/44
    • C07D451/04C07D211/58C07D451/14
    • A benzamide derivative represented by the following formula: ##STR1## wherein R.sup.1 represents a hydrogen atom or a lower alkanoyl group; R.sup.2 represents a hydrogen atom or a halogen atom; R.sup.3 represents a lower alkoxy group; R.sup.4 represents a hydrogen atom or a lower alkyl group; R.sup.5 represents a hydrogen atom, a lower alkyl group, or a lower alkoxy group; A represents C.sub.1 -C.sub.7 alkylene group which may optionally be substituted with a lower alkyl group; X represents a methylene group, an oxygen atom, or a sulfur atom; m represents an integer of from 0 to 3; n represents an integer of from 0 to 3; and p represents an integer of from 0 to 2 and a pharmacologically acceptable salt thereof is provided. These compounds are useful since they have gastrointestinal stimulating activity, and a pharmaceutical composition comprising said compound is useful for the treatment of gastrointestinal diseases.
    • PCT No.PCT / JP92 / 00134 Sec。 371日期:1993年8月11日 102(e)日期1993年8月11日PCT提交1992年2月12日PCT公布。 公开号WO92 / 14705 日本9月3日,1992。一种苯甲酰胺衍生物,由下式表示:其中R1表示氢原子或低级烷酰基; R2表示氢原子或卤素原子; R3表示低级烷氧基; R4代表氢原子或低级烷基; R5表示氢原子,低级烷基或低级烷氧基; A表示可以被低级烷基取代的C1-C7亚烷基; X表示亚甲基,氧原子或硫原子; m表示0〜3的整数, n表示0〜3的整数, p表示0〜2的整数,并且其药理学上可接受的盐。 这些化合物是有用的,因为它们具有胃肠道刺激活性,并且包含所述化合物的药物组合物可用于治疗胃肠道疾病。
    • 6. 发明授权
    • Benzenesulfonamide derivatives and use thereof
    • 苯磺酰胺衍生物及其用途
    • US5597848A
    • 1997-01-28
    • US397068
    • 1995-03-16
    • Yasuo ItoHideo KatoShingo YasudaNobuo OgawaShunichiro SakuraiTomio Suzuki
    • Yasuo ItoHideo KatoShingo YasudaNobuo OgawaShunichiro SakuraiTomio Suzuki
    • C07C311/19C07C311/29A61K31/24
    • C07C311/29C07C311/19
    • A benzenesulfonamide derivative represented by the following general formula: ##STR1## wherein R.sup.1 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group or a halogen atom; R.sup.2 represents a C.sub.1 -C.sub.10 straight- or branched-chain alkyl group, a C.sub.3 -C.sub.8 cycloalkyl group which may be substituted with one or more C.sub.1 -C.sub.6 alkyl groups on its ring, a C.sub.1 -C.sub.6 alkyl group substituted with one or more C.sub.3 -C.sub.8 cycloalkyl groups, 1-adamantylmethyl group, 2-norbornylmethyl group, or a C.sub.1 -C.sub.6 alkyl group substituted with one or more phenyl groups whose benzene ring may have one or more substituents; R.sup.3 represents a hydrogen atom or a lower alkyl group; and n is an integer of from 2 to 4, and a pharmacologically acceptable salt thereof. The present compounds have thromboxane A.sub.2 antagonistic activity, leucotriene antagonistic activity and the like and useful as a platelet aggregation inhibitor, antithrombotic agent, antiasthmatic agent and antiallergic agent.
    • PCT No.PCT / JP93 / 01382 Sec。 371日期1995年3月16日 102(e)1995年3月16日PCT PCT 1993年9月29日PCT公布。 公开号WO94 / 07848 日本1994年4月14日由以下通式表示的苯磺酰胺衍生物:其中R 1表示氢原子,低级烷基,低级烷氧基或卤素原子; R2表示C1-C10直链或支链烷基,可以在其环上被一个或多个C 1 -C 6烷基取代的C 3 -C 8环烷基,被一个或多个C 3取代的C 1 -C 6烷基 -C8环烷基,1-金刚烷基甲基,2-降冰片基甲基或被苯环可以具有一个或多个取代基的一个或多个苯基取代的C 1 -C 6烷基; R3表示氢原子或低级烷基; n为2〜4的整数,及其药理学上可接受的盐。 本发明化合物具有血栓素A2拮抗活性,白三烯拮抗活性等,可用作血小板聚集抑制剂,抗血栓形成剂,止喘剂和抗过敏剂。
    • 10. 发明授权
    • Drawing machine and game apparatus using the same
    • 绘图机和游戏机使用相同
    • US08221235B2
    • 2012-07-17
    • US12084328
    • 2006-10-27
    • Nobuhiro GotoKazuhiro KusudaDaisuke SatoShingo YasudaYuichi Nakahara
    • Nobuhiro GotoKazuhiro KusudaDaisuke SatoShingo YasudaYuichi Nakahara
    • A63F9/24
    • G07F17/3276G07F17/32G07F17/3286
    • The present invention provides a drawing machine and a game apparatus using the same by which it is easier to give the participants of the drawing an impression like drawing is carried out fairly when the computer drawing in which a winning-probability of each of drawing-objects is changed is carried out.A drawing machine for determining a winning-object from a plurality of drawing-objects includes: a winning-probability data storage unit for storing winning-probability data showing respective winning-probabilities of the plurality of drawing-objects; a drawing unit for carrying out a drawing in accordance with the winning-probability of each of the drawing-objects determined by the winning-probability data stored in the winning-probability data storage unit and determining a winning-object from the plurality of drawing-objects; a winning-probability data changing unit for changing the winning-probability data stored in the winning-probability data storage unit; a winning-probability image displaying unit for displaying a winning-probability image showing the winning-probability of each of the drawing-objects determined by the winning-probability data stored in the winning-probability data storage unit; and a winning-probability displaying control unit for changing the winning-probability image displayed on the winning-probability image displaying unit, when the winning-probability data changing unit changes the winning-probability data, so as to correspond to the changed winning-probability data.
    • 本发明提供了一种绘图机和使用该绘图机的游戏装置,其中当每个绘图对象的获胜概率的计算机绘图时,更容易给予绘图的参与者像绘图的印象 被改变了。 用于从多个绘图对象确定获胜对象的绘图机包括:获胜概率数据存储单元,用于存储显示多个绘图对象的各个获胜概率的获胜概率数据; 绘制单元,用于根据存储在获胜概率数据存储单元中的获胜概率数据确定的每个绘制对象的获胜概率执行绘图,并从多个绘制单元确定获胜对象, 物体 获胜概率数据改变单元,用于改变存储在获胜概率数据存储单元中的获胜概率数据; 获胜概率图像显示单元,用于显示表示由获胜概率数据存储单元中存储的获胜概率数据确定的每个绘图对象的获胜概率的获胜概率图像; 以及获胜概率显示控制单元,用于当获胜概率数据改变单元改变获胜概率数据时,改变在获胜概率图像显示单元上显示的获胜概率图像,以便对应于改变的获胜概率 数据。