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1. 发明授权

US09238657B2 Cephalosporin having catechol group 有权
标题翻译：具有儿茶酚基团的头孢菌素
公开(公告)号：US09238657B2
公开(公告)日：2016-01-19
申请号：US13063878
申请日：2009-10-27
申请人： Yasuhiro Nishitani , Kenji Yamawaki , Yusuke Takeoka , Hideki Sugimoto , Shinya Hisakawa , Toshiaki Aoki
发明人： Yasuhiro Nishitani , Kenji Yamawaki , Yusuke Takeoka , Hideki Sugimoto , Shinya Hisakawa , Toshiaki Aoki
IPC分类号： C07D501/46 , C07D505/24 , C07D519/06 , A61K31/546
CPC分类号： C07D501/46 , C07D505/24 , C07D519/06
摘要： The present disclosure describes Cephem compounds of the formula: wherein, X is N, CH or C—Cl; T is S or the like; A and G are lower alkylene or the like; B is a single bond or the like; D is optionally present, and when present is, —NR7—, —CO—, —CO—NR7—, —NR7—CO—, —NR7—CO—NR7—, or the like; F is optionally present, and when present is or phenylene; R3 and R4 are —OR8; R5 and R6 each is independently hydrogen, halogen, nitrile, or —OR8; or an ester at the carboxyl at the 7-position side chain or at the 4-position, a compound protected at the amino on the ring in the 7-side chain, a pharmaceutically acceptable salt, or a solvate thereof, which have a wide antimicrobial spectrum and have potent antimicrobial activity against beta-lactamase producing Gram negative bacteria.
摘要翻译：本公开内容描述了具有下式的Cephem化合物：其中X是N，CH或C-Cl; T是S等; A和G是低级亚烷基等; B是单键等; D是任选存在的，并且当存在时为-NR 7 - ， - CO - ， - CO-NR 7 - ， - NR 7 -CO-，-NR 7 -CO-NR 7 - 等; F任选存在，当存在时为或亚苯基; R3和R4是-OR8; R5和R6各自独立地为氢，卤素，腈或-OR8; 或在7-位侧链或4-位的羧基处的酯，在7-侧链的环上的氨基保护的化合物，其药学上可接受的盐或溶剂合物，其具有宽的抗菌谱，对抗β-内酰胺酶产生革兰氏阴性细菌具有有效的抗菌活性。

2. 发明申请

US20110190254A1 CEPHALOSPORIN HAVING CATECHOL GROUP 有权
标题翻译： CEPHALOSPORIN拥有CATECHOL集团
公开(公告)号：US20110190254A1
公开(公告)日：2011-08-04
申请号：US13063878
申请日：2009-10-27
申请人： Yasuhiro Nishitani , Kenji Yamawaki , Yusuke Takeoka , Hideki Sugimoto , Shinya Hisakawa , Toshiaki Aoki
发明人： Yasuhiro Nishitani , Kenji Yamawaki , Yusuke Takeoka , Hideki Sugimoto , Shinya Hisakawa , Toshiaki Aoki
IPC分类号： A61K31/546 , C07D501/60 , A61P31/00
CPC分类号： C07D501/46 , C07D505/24 , C07D519/06
摘要： The present invention provides Cephem compounds which have a wide antimicrobial spectrum and have potent antimicrobial activity against beta-lactamase producing Gram negative bacteria as follows:A compound of the formula: wherein, X is N, CH or C—Cl; T is S or the like; A and G are lower alkylene or the like; B is a single bond or the like; D is a single bond, —NR7—, —CO—, —CO—NR7—, —NR7—CO—, —NR7—CO—NR7—, or the like; E is optionally substituted lower alkylene; F is a single bond or optionally substituted phenylene; R3, R4, R5 and R6 each is independently hydrogen, halogene, nitrile, or the like; or an ester, a compound protected at the amino on the ring in the 7-side chain, a pharmaceutically acceptable salt, or a solvate thereof.
摘要翻译：本发明提供了具有广泛抗微生物谱并且对产生β-内酰胺酶的革兰氏阴性细菌具有强效抗微生物活性的Cephem化合物，如下式所示：其中X是N，CH或C-Cl; T是S等; A和G是低级亚烷基等; B是单键等; D是单键，-NR 7 - ， - CO - ， - CO-NR 7 - ， - NR 7 -CO-， - NR 7 -CO-NR 7 - 等; E是任选取代的低级亚烷基; F是单键或任选取代的亚苯基; R 3，R 4，R 5和R 6各自独立地为氢，卤素，腈等; 或酯，在7-侧链的环上的氨基保护的化合物，其药学上可接受的盐或其溶剂合物。

3. 发明授权

US09334289B2 Cephem compound having catechol or pseudo-catechol structure 有权
标题翻译：具有儿茶酚或假儿茶酚结构的头孢烯化合物
公开(公告)号：US09334289B2
公开(公告)日：2016-05-10
申请号：US14113459
申请日：2012-04-25
申请人： Yasuhiro Nishitani , Toshiaki Aoki , Jun Sato , Kenji Yamawaki , Katsuki Yokoo , Masayuki Sano
发明人： Yasuhiro Nishitani , Toshiaki Aoki , Jun Sato , Kenji Yamawaki , Katsuki Yokoo , Masayuki Sano
IPC分类号： C07D501/16 , C07D501/60 , C07D501/18 , C07D501/46 , C07D519/06 , C07D519/00
CPC分类号： C07D501/60 , C07D501/18 , C07D501/46 , C07D519/00 , C07D519/06
摘要： The present invention provides a novel compound which has a wide antimicrobial spectrum, and in particular exhibits potent antimicrobial activity against beta-lactamase producing Gram negative bacteria. Specifically, the present invention provides a compound of the formula (I): wherein each symbol is as defined in the specification, or an amino-protected compound when the amino group is present on the ring in the 7-side chain, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same.
摘要翻译：本发明提供了具有广谱抗菌谱的新型化合物，并且特别表现出对产生β-内酰胺酶的革兰氏阴性菌具有强效的抗微生物活性。具体而言，本发明提供了式（I）化合物：其中各符号如说明书中所定义，或氨基保护的化合物，当氨基存在于7-侧链的环上时，或药学上可接受的盐，以及包含其的药物组合物。

4. 发明申请

US20140088302A1 NOVEL CEPHEM COMPOUND HAVING CATECHOL OR PSEUDO-CATECHOL STRUCTURE 有权
标题翻译：具有CATECHOL或PSEUDO-CATECHOL结构的新型CEPHEM化合物
公开(公告)号：US20140088302A1
公开(公告)日：2014-03-27
申请号：US14113459
申请日：2012-04-25
申请人： Yasuhiro Nishitani , Toshiaki Aoki , Jun Sato , Kenji Yamawaki , Katsuki Yokoo , Masayuki SANO
发明人： Yasuhiro Nishitani , Toshiaki Aoki , Jun Sato , Kenji Yamawaki , Katsuki Yokoo , Masayuki SANO
IPC分类号： C07D501/60 , C07D519/00
CPC分类号： C07D501/60 , C07D501/18 , C07D501/46 , C07D519/00 , C07D519/06
摘要： The present invention provides a novel compound which has a wide antimicrobial spectrum, and in particular exhibits potent antimicrobial activity against beta-lactamase producing Gram negative bacteria. Specifically, the present invention provides a compound of the formula (I): wherein each symbol is as defined in the specification, or an amino-protected compound when the amino group is present on the ring in the 7-side chain, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same.
摘要翻译：本发明提供了具有广谱抗菌谱的新型化合物，并且特别表现出对产生β-内酰胺酶的革兰氏阴性菌具有强效的抗微生物活性。具体而言，本发明提供了式（I）化合物：其中各符号如说明书中所定义，或氨基保护的化合物，当氨基存在于7-侧链的环上时，或药学上可接受的盐，以及包含其的药物组合物。

5. 发明申请

US20070219191A1 3-Pyridinium Methyl Cephem Compound 审中-公开
标题翻译： 3-吡啶鎓甲基头孢烯化合物
公开(公告)号：US20070219191A1
公开(公告)日：2007-09-20
申请号：US10591398
申请日：2005-03-03
申请人： Yasuhiro Nishitani , Tatsuro Yasukata , Kenji Yamawaki
发明人： Yasuhiro Nishitani , Tatsuro Yasukata , Kenji Yamawaki
IPC分类号： C07D501/56
CPC分类号： C07D501/00
摘要： A compound of Formula 1: (wherein A is optionally substituted lower alkylene (substituent: mono- or di-lower alkyl, lower alkylidene, or lower alkylene having two or more carbons); Z+ is either of the groups shown below: (wherein R1 and R2 are each independently hydrogen, optionally substituted amino lower alkyl, optionally substituted aminocycloalkyl, optionally substituted cyclic amino, or optionally substituted cyclic amino lower alkyl; R9 is hydrogen or lower alkyl, or R1 and R9 taken together with an adjacent N atom may form optionally substituted cyclic amino; R3 is hydrogen or amino; X is N or CR4 (R4 is hydrogen or optionally substituted lower alkyl)), a pharmaceutically acceptable salt or a solvate thereof.
摘要翻译：式1的化合物：（其中A是任选取代的低级亚烷基（取代基：一或二低级烷基，低级亚烷基或具有两个或更多个碳的低级亚烷基）; Z + 下列基团：（其中R 1和R 2各自独立地为氢，任选取代的氨基低级烷基，任选取代的氨基环烷基，任选取代的环状氨基或任选取代的环状氨基氨基低级烷基; R 9是氢或低级烷基，或者R 1和R 9与相邻的N原子一起可以形成任选取代的环状氨基; R 3是氢或氨基; X是N或CR 4（R 4是氢或任选取代的低级烷基）），其药学上可接受的盐或其溶剂合物。

6. 发明授权

US09242999B2 Cephem compound having pyridinium group 有权
标题翻译：具有吡啶鎓基的头孢烯化合物
公开(公告)号：US09242999B2
公开(公告)日：2016-01-26
申请号：US14129631
申请日：2012-06-26
申请人： Yasuhiro Nishitani , Toshiaki Aoki
发明人： Yasuhiro Nishitani , Toshiaki Aoki
IPC分类号： C07D501/36 , C07D501/60 , C07D505/00
CPC分类号： C07D501/60 , C07D501/36 , C07D505/00
摘要： The present invention provides a novel compound which has a broad antibacterial spectrum and particularly exhibits a high antibacterial activity on β-lactamase-producing gram-negative bacteria. Specifically provided are: a compound represented by formula (I) wherein the meaning of each symbol is as defined in the description, an amino-group-protected form of a type of the compound which has the amino group on a ring in a position-7 side chain, or a pharmaceutically acceptable salt of the compound or the amino-group-protected form; and a pharmaceutical composition containing the compound, the amino-group-protected form or the pharmaceutically acceptable salt.
摘要翻译：本发明提供了具有广谱抗菌谱的新型化合物，特别是对产生β-内酰胺酶的革兰氏阴性细菌表现出高抗菌活性。具体提供的是：式（I）表示的化合物，其中每个符号的含义如说明书中所定义，具有位置上具有环上的氨基的化合物的类型的氨基保护形式， 7侧链，或化合物的药学上可接受的盐或氨基保护形式; 和含有该化合物，氨基保护形式或药学上可接受的盐的药物组合物。

7. 发明申请

US20140114060A1 CEPHEM COMPOUND HAVING PYRIDINIUM GROUP 有权
标题翻译：具有吡咯烷基的化合物
公开(公告)号：US20140114060A1
公开(公告)日：2014-04-24
申请号：US14129631
申请日：2012-06-26
申请人： Yasuhiro Nishitani , Toshiaki Aoki
发明人： Yasuhiro Nishitani , Toshiaki Aoki
IPC分类号： C07D501/60
CPC分类号： C07D501/60 , C07D501/36 , C07D505/00
摘要： The present invention provides a novel compound which has a broad antibacterial spectrum and particularly exhibits a high antibacterial activity on β-lactamase-producing gram-negative bacteria. Specifically provided are: a compound represented by formula (I) wherein the meaning of each symbol is as defined in the description, an amino-group-protected form of a type of the compound which has the amino group on a ring in a position-7 side chain, or a pharmaceutically acceptable salt of the compound or the amino-group-protected form; and a pharmaceutical composition containing the compound, the amino-group-protected form or the pharmaceutically acceptable salt.
摘要翻译：本发明提供了具有广谱抗菌谱的新型化合物，特别是对产生β-内酰胺酶的革兰氏阴性细菌表现出高抗菌活性。具体提供的是：式（I）表示的化合物，其中每个符号的含义如说明书中所定义，具有位置上具有环上的氨基的化合物的类型的氨基保护形式， 7侧链，或化合物的药学上可接受的盐或氨基保护形式; 和含有该化合物，氨基保护形式或药学上可接受的盐的药物组合物。

8. 发明申请

US20090131655A1 Cephem Compounds Having Broad Antibacterial Spectrum 失效
标题翻译：具有广泛抗菌谱的头孢烯化合物
公开(公告)号：US20090131655A1
公开(公告)日：2009-05-21
申请号：US12100307
申请日：2008-04-09
申请人： Yasuhiro Nishitani , Yoshinori Yamano
发明人： Yasuhiro Nishitani , Yoshinori Yamano
IPC分类号： C07D501/60
CPC分类号： C07D501/56 , A61K31/546 , C07D501/00
摘要： A compound of the formula: (wherein, T is S, SO or O; X is halogen, CN, carbamoyl optionally substituted with lower alkyl, lower alkyl, lower alkoxy, or lower alkylthio; A is substituted lower alkylene (wherein the substituent is optionally substituted mono lower alkyl, optionally substituted lower alkylidene, or optionally substituted lower alkylene) Z+ is an optionally substituted, a cation and an N atom-containing heterocyclic group), ester, amino-protected compound wherein the amino bonds to a thiazole ring at the 7-position, or pharmaceutically acceptable salt or solvate thereof.
摘要翻译：下式的化合物：其中T是S，SO或O; X是卤素，CN，任选被低级烷基，低级烷基，低级烷氧基或低级烷硫基取代的氨基甲酰基; A是取代的低级亚烷基（其中取代基是任选取代的单低级烷基，任选取代的低级亚烷基或任选取代的低级亚烷基）Z +是任选取代的阳离子和含N原子的杂环基），酯，氨基保护的化合物，其中氨基与噻唑环上的氨基键连接 7-位或其药学上可接受的盐或溶剂化物。

9. 发明授权

US06421504B1 Hybrid camera 失效
标题翻译：混合相机
公开(公告)号：US06421504B1
公开(公告)日：2002-07-16
申请号：US09583923
申请日：2000-05-31
申请人： Tatsuo Saito , Yasuhiro Nishitani
发明人： Tatsuo Saito , Yasuhiro Nishitani
IPC分类号： G03B1748
CPC分类号： H04N1/2116 , H04N1/2112 , H04N5/225 , H04N5/2352 , H04N5/2354 , H04N2101/00
摘要： To record images by a film recording system and an electronic recording system with one light-emission of a flashing device, the flashing device is controlled according to set values of photo film recording conditions since the sensitivity of a silver halide film is different from that of an imaging device. Information about exposure control of the electronic recording system is transmitted from a CPU that is equivalent to a controlling device of the film recording system to a CPU of the electronic recording system, and the electronic recording system sets a CCD aperture, a CCD gain and so on according to the information.
摘要翻译：为了通过具有闪光装置的一次发光的胶卷记录系统和电子记录系统记录图像，根据摄影胶片记录条件的设定值来控制闪光装置，因为卤化银膜的灵敏度不同于成像装置。关于电子记录系统的曝光控制的信息从等同于胶片记录系统的控制装置的CPU传送到电子记录系统的CPU，并且电子记录系统设置CCD孔径，CCD增益等根据信息。

10. 发明授权

US5933662A Frame counting method and device in camera 失效
标题翻译：相框中的帧计数方法和设备
公开(公告)号：US5933662A
公开(公告)日：1999-08-03
申请号：US746780
申请日：1996-11-15
申请人： Yasuhiro Nishitani
发明人： Yasuhiro Nishitani
IPC分类号： G03B17/36 , G03B17/42 , G03B1/66
CPC分类号： G03B17/425 , G03B17/36 , G03B2217/244 , G03B2217/263
摘要： The time after film is rewound up to a first frame until a film cartridge holding the film is allowed to be taken out is divided with the time required for rewinding the film by the currently-exposed frames. A delayed frame number is displayed at the time which is delayed from a time when the actual frame corresponding to the delayed frame number has been rewound for a delay time which is found based upon a number of the currently-exposed frames. Thus, a time in which a displayed number "1" changes to such a mark as "E" can be decreased, thereby preventing the user from opening a film cartridge chamber before the film is completely rewound.
摘要翻译：将胶卷重新卷绕到第一框架之后的时间直到允许取出胶片的胶片暗盒被用当前曝光的框架重新卷绕胶片所需的时间来分割。在从与对应于延迟帧号的实际帧已经被倒回延迟时间延迟的时间显示延迟帧号，延迟时间是基于当前曝光帧的数量而找到的。因此，可以减少显示的数字“1”变为这样的标记为“E”的时间，从而防止用户在胶卷完全倒带之前打开暗盒。

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