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2. 发明授权

US4772681A Porphyrin derivatives 失效
标题翻译：卟啉衍生物
公开(公告)号：US4772681A
公开(公告)日：1988-09-20
申请号：US4333
申请日：1987-01-15
申请人： Yozo Fukuda , Takuzo Otani , Haruo Yamada , Michikazu Sawada , Katsuo Aizawa , Mari Uchimoto , Michito Karasawa
发明人： Yozo Fukuda , Takuzo Otani , Haruo Yamada , Michikazu Sawada , Katsuo Aizawa , Mari Uchimoto , Michito Karasawa
IPC分类号： C07D487/22
CPC分类号： C07D487/22
摘要： Novel porphyrin derivatives of the general formula: ##STR1## wherein R.sub.1 each independently denotes a hydrogen, a C.sub.1 -C.sub.4 alkyl group or an ethenyl group, and R.sub.2 each independently denotes COZ(C.sub.m H.sub.2m)Q, COZCH(C.sub.m H.sub.2m Q).sub.2, --CH.sub.2 --Q [wherein Z is O, S or NH, m is an integer of 1 to 23, and Q is a di-(C.sub.1 -C.sub.4 alkyl)amino group or tri-(C.sub.1 -C.sub.4 alkyl)ammonium halide group] or ##STR2## (wherein X is a halogen); or R.sub.1 each independently denotes --C.sub.2 H.sub.4 --Q (wherein Q is the same as defined above), ##STR3## (wherein X is the same as defined above), and R.sub.2 each independently denotes a carboxyl group or a C.sub.1 -C.sub.4 alkoxycarbonyl group, and the production thereof are described. The quarternary ammonium salt type of the above compounds exhibit affinity and photosensitizing activity for cancer cells and can be employed for diagnosing and treating cancer under irradiation of laser light.
摘要翻译：其中R1各自独立地表示氢，C1-C4烷基或乙烯基，R2各自独立地表示COZ（CmH2m）Q，COZCH（CmH2mQ）2，-CH2- Q [其中Z为O，S或NH，m为1〜23的整数，Q为二（C1-C4烷基）氨基或三（C1-C4烷基）卤化铵基]或（其中X是卤素）; 或R 1各自独立地表示-C 2 H 4 -Q（其中Q与上述定义相同），＆lt; IMAGE＆gt;（其中X与上述定义相同），R 2各自独立地表示羧基或C 1 -C 4烷氧基羰基，并描述其生产。上述化合物的季铵盐类型对癌细胞表现出亲和力和光敏作用，可用于在激光照射下诊断和治疗癌症。

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