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1. 发明授权

US06687712B2 Scientific information viewing system, and a host computer and a viewing computer therefor 失效
标题翻译：科学信息查看系统，主机和观看计算机
公开(公告)号：US06687712B2
公开(公告)日：2004-02-03
申请号：US09745418
申请日：2000-12-26
申请人： Yasuhiro Mito , Katsuhiro Nakagawa
发明人： Yasuhiro Mito , Katsuhiro Nakagawa
IPC分类号： G06F1730
CPC分类号： G06F17/3089 , Y10S707/99933 , Y10S707/99935 , Y10S707/99945 , Y10S707/99948
摘要： An uploading computer, a host computer and a viewing computer are interconnected through communication lines. The host computer hierarchizes software information received from the uploading computer by field, category and software product to be stored in software information memory. In response to search information inputted from the viewing computer, the software information is displayed as search results on the viewing computer. The software information hierarchized in the order of field, category and software product is retrieved quickly and displayed immediately to browsed efficiently.
摘要翻译：上传计算机，主机和观看计算机通过通信线互连。主机将通过现场，类别和软件产品从上传的计算机接收的软件信息进行分级，以存储在软件信息存储器中。响应于从观看计算机输入的搜索信息，软件信息作为搜索结果显示在观看计算机上。以字段，类别和软件产品顺序分级的软件信息被快速检索并立即显示，以便有效地浏览。

2. 发明授权

US10386346B2 System and method for processing chromatogram data 有权
公开(公告)号：US10386346B2
公开(公告)日：2019-08-20
申请号：US14342701
申请日：2012-08-31
申请人： Yasuhiro Mito , Etsuho Kamata , Hiroshi Miura , Kenichi Mishima , Toshinobu Yanagisawa
发明人： Yasuhiro Mito , Etsuho Kamata , Hiroshi Miura , Kenichi Mishima , Toshinobu Yanagisawa
IPC分类号： G01N30/86 , G01N30/74
摘要： A data processing system for a chromatograph has an impurity detector including a differential chromatogram creator and a determining section. The differential chromatogram creator calculates a wavelength differential coefficient by differentiating an absorbance spectrum with respect to the wavelength at each point in time of the measurement and creates a differential chromatogram which shows a temporal change in the wavelength differential coefficient. Based on a shape of the thus created differential chromatogram, the determining section determines whether or not a peak of a target component contains an impurity. By this method, whether or not the peak of the target component contains an impurity can be determined with high accuracy, without requiring complex calculations.

3. 发明授权

US09453825B2 Chromatogram peak purity determination apparatus 有权
标题翻译：色谱峰纯度测定装置
公开(公告)号：US09453825B2
公开(公告)日：2016-09-27
申请号：US13603174
申请日：2012-09-04
申请人： Yasuhiro Mito
发明人： Yasuhiro Mito
IPC分类号： G01N30/86
CPC分类号： G01N30/8634 , G01N30/8693
摘要： An apparatus and a method for chromatogram peak purity determination are provided, where the chromatogram's dimensions consist of retention time, wavelength and absorbance. The apparatus or method accumulates, at each retention time, absorbance in the wavelength direction for all or a part of a wavelength range in a predetermined retention time range; extracts a plurality of groups where, for each group, the absorbance accumulation value is the same for one point on a rising slope and one point on a falling slope regarding a peak that exists on a chromatogram that is prepared based on a 2-dimensional data whose dimensions are absorbance accumulation value and retention time; calculates similarities between absorption spectrum pattern at one point on the rising slope and at one point on the falling slope for each group; and determines from the plurality of groups, whether the peak consists of a single component based on similarity.
摘要翻译：提供了一种用于色谱峰纯度测定的仪器和方法，其中色谱图的尺寸由保留时间，波长和吸光度组成。该装置或方法在每个保留时间内在预定的保持时间范围内累积波长范围的全部或部分波长方向的吸光度; 提取多个组，其中对于每个组，对于在基于二维数据准备的色谱上存在的峰，吸光度积累值对于上升斜坡上的一个点和下降斜率上的一个点是相同的其尺寸为吸光度积累值和保留时间; 计算上升斜坡上一个点的吸收光谱图与每组下降斜率上的一个点的相似度; 并且从多个组确定该峰是否由基于相似性的单个分量组成。

4. 发明授权

US6002986A Fraction purity measuring apparatus for chromatogram peak 失效
标题翻译：用于色谱峰的馏分纯度测定装置
公开(公告)号：US6002986A
公开(公告)日：1999-12-14
申请号：US792404
申请日：1991-11-15
申请人： Yasuhiro Mito
发明人： Yasuhiro Mito
IPC分类号： G01J3/28 , G01N30/74 , G01N30/82 , G01N30/86 , G01N35/08 , B01D15/08 , G01N21/00
CPC分类号： G01N30/82 , G01N30/8624 , G01J2003/2873 , G01N2201/12753 , G01N30/74 , G01N30/8689 , G01N35/085
摘要： A detection signal from a multi-wavelength detector provided in a liquid chromatograph is stored in a data storage part, and a chromatogram is formed from the stored data with respect to a specific wavelength, to detect a peak from the chromatogram. The spectrum at a top of the peak to be identified or a known spectrum of a component to be identified is used as a reference spectrum, to calculate the degree of coincidence between the spectrum at each position of the chromatogram peak and the reference spectrum as fraction purity at each position of the chromatogram peak. The calculated fraction purity values are classified in colors, for example, and displayed on a display part. Thus, it is possible to readily decide whether the measured peak consists of a single component or at least two components, and which time range consists of a single component.
摘要翻译：将从液相色谱仪中提供的多波长检测器的检测信号存储在数据存储部分中，并根据存储的数据相对于特定波长形成色谱图，以检测色谱图中的峰。将要鉴定的峰的顶部的光谱或待鉴定的组分的已知光谱用作参考光谱，以计算色谱峰的每个位置的光谱与参考光谱之间的一致度作为分数纯度在色谱峰的每个位置。计算的馏分纯度值例如分类为颜色，并显示在显示部分上。因此，可以容易地确定测量的峰值是由单个分量还是至少两个分量组成，哪个时间范围由单个分量组成。

5. 发明授权

US5596135A Apparatus for and method of determining purity of a peak of a peak of a chromatogram 失效
标题翻译：用于确定色谱峰的峰的纯度的装置和方法
公开(公告)号：US5596135A
公开(公告)日：1997-01-21
申请号：US373573
申请日：1995-01-13
申请人： Yasuhiro Mito , Hideki Minegishi
发明人： Yasuhiro Mito , Hideki Minegishi
IPC分类号： G01N30/74 , G01N30/82 , G01N30/86 , G06F17/00 , G01N30/02
CPC分类号： G01N30/8624 , G01N30/8689 , G01N30/82 , G01N30/8634
摘要： It is judged whether a part of a peak section of a chromatogram corresponding to a component of a sample is pure by comparing a similarity value of the absorbance spectrum of the part to a threshold value. The similarity value r and the threshold value t are calculated as follows. a) A series of absorbance spectra of a sample effluent from a column of the chromatograph are obtained repeatedly at a plurality of time points of short intervals. An absorbance spectrum is composed of a set of absorbance data with respect to wavelengths of light passing through the sample. b) A chromatogram of the sample is constructed using the series of absorbance spectra. c) A peak section including an object component of the sample is detected in the chromatogram. d) A similarity value is then calculated as a cosine of the angle between an absorbance spectrum vector and a standard spectrum vector. e) The threshold value is calculated by a cosine of the angle between two outermost tangential lines of an n-dimensional sphere centering an end of the absorbance spectrum vector and another n-dimensional sphere centering an end of the standard spectrum vector.
摘要翻译：通过将该部分的吸收光谱的相似值与阈值进行比较来判断与样品成分相对应的色谱图的峰部分的一部分是否为纯。相似度值r和阈值t如下计算。 a）在短时间间隔的多个时间点重复获得来自色谱柱的样品流出物的一系列吸收光谱。吸收光谱由相对于通过样品的光的波长的一组吸光度数据组成。 b）使用一系列吸光度光谱构建样品的色谱图。 c）在色谱图中检测包括样品的对象成分的峰部分。 d）然后将相似值计算为吸收光谱矢量与标准光谱矢量之间的角度的余弦值。 e）通过以吸收光谱向量的一端为中心的另一个n维球体与以标准光谱矢量的端点为中心的n维球体的两个最外切向线之间的角度的余弦来计算阈值。

6. 发明申请

US20140257712A1 SYSTEM AND METHOD FOR PROCESSING CHROMATOGRAM DATA 审中-公开
标题翻译：用于处理色谱数据的系统和方法
公开(公告)号：US20140257712A1
公开(公告)日：2014-09-11
申请号：US14342701
申请日：2012-08-31
申请人： Yasuhiro Mito , Etsuho Kamata , Hiroshi Miura , Kenichi Mishima , Toshinobu Yanagisawa
发明人： Yasuhiro Mito , Etsuho Kamata , Hiroshi Miura , Kenichi Mishima , Toshinobu Yanagisawa
IPC分类号： G01N30/86
CPC分类号： G01N30/8675 , G01N30/74 , G01N30/86
摘要： A data processing system for a chromatograph has an impurity detector including a differential chromatogram creator and a determining section. The differential chromatogram creator calculates a wavelength differential coefficient by differentiating an absorbance spectrum with respect to the wavelength at each point in time of the measurement and creates a differential chromatogram which shows a temporal change in the wavelength differential coefficient. Based on a shape of the thus created differential chromatogram, the determining section determines whether or not a peak of a target component contains an impurity. By this method, whether or not the peak of the target component contains an impurity can be determined with high accuracy, without requiring complex calculations.
摘要翻译：用于色谱仪的数据处理系统具有包括差示色谱图创建器和确定部分的杂质检测器。差示色谱图创建者通过在每个测量时间点相对于波长区分吸收光谱来计算波长微分系数，并产生显示波长微分系数的时间变化的差示色谱图。基于由此产生的差分色谱图的形状，确定部分确定目标成分的峰值是否含有杂质。通过该方法，可以高精度地确定目标成分的峰值是否含有杂质，而不需要复杂的计算。

7. 发明授权

US06990500B2 Scientific information inquiry-answer system, and a host computer and an inquiring computer therefor 失效
公开(公告)号：US06990500B2
公开(公告)日：2006-01-24
申请号：US09789770
申请日：2001-02-22
申请人： Yasuhiro Mito
发明人： Yasuhiro Mito
IPC分类号： G06F17/00 , G06F7/00 , G06F17/30
CPC分类号： G06Q30/02 , Y10S707/956 , Y10S707/99933 , Y10S707/99935 , Y10S707/99945
摘要： In a system of this invention, an inquiring computer supplies a host computer with inquiry information indicated open or closed to third parties. The host computer applies inquiry information indicated open to a wide range of inquiring and answering computers, but does not apply inquiry information indicated closed to third party inquiring computers. Inquiry information indicated closed is applied to a small range including only the inquiring computer having inputted the inquiry information and answering computers. When answer search information is transmitted from the inquiring computer to the host computer, answer information supplied from an answering computer may be received through communication lines. Thus, the answer information for the inquiry information may be obtained efficiently while taking the security protection for the inquiry information presenting party into account.

8. 发明授权

US4482966A Detector for chromatographs 失效
标题翻译：色谱仪检测仪
公开(公告)号：US4482966A
公开(公告)日：1984-11-13
申请号：US347756
申请日：1982-02-10
申请人： Yasuhiro Mito , Hideo Iwasaki
发明人： Yasuhiro Mito , Hideo Iwasaki
IPC分类号： G01N21/27 , G01J3/42 , G01N30/74 , G06G7/75
CPC分类号： G01N30/74 , G01J3/42
摘要： Spectrum images of chromatograph column effluent are formed on a photodiode array (7). The photodiode array (7) is scanned to produce plural detection data for predetermined plural wavelengths. The data are analytically processed and recorded to provide data ratios wherein the numerators are processed data from individual wavelengths, and the denominator in each of the ratios is the square root of the sum of the square of the processed data for the individual wavelengths. A plot of ratios versus time provides a curve which indicates completeness of chromatographic separation.
摘要翻译：色谱柱流出物的光谱图像形成在光电二极管阵列（7）上。扫描光电二极管阵列（7）以产生预定多个波长的多个检测数据。分析处理和记录数据以提供数据比率，其中分子是来自各个波长的处理数据，并且每个比率中的分母是针对各个波长的经处理数据的平方和之和的平方根。比率与时间的关系曲线表明色谱分离的完整性。

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