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1. 发明授权

US4929378A Bath preparation 失效
标题翻译：浴准备
公开(公告)号：US4929378A
公开(公告)日：1990-05-29
申请号：US352680
申请日：1989-05-10
申请人： Yasuhiko Morita , Yoshitomi Kakiguchi , Seiji Izuhara
发明人： Yasuhiko Morita , Yoshitomi Kakiguchi , Seiji Izuhara
IPC分类号： A61K8/00 , A61K8/23 , A61K8/33 , A61K8/44 , A61K8/64 , A61K8/67 , A61K36/00 , A61Q19/10 , C11D3/20 , D06L4/30
CPC分类号： A61K8/676 , A61K8/23 , A61Q19/10 , A61K2800/222
摘要： The bath preparation of the present invention comprises an ascorbic acid compound and at least one reducing agent selected from the group consisting of water-soluble thiosulfate, water-soluble dithionite, L-cysteine hydrochloride, glutathione and gallic acid ester.
摘要翻译：本发明的浴制剂包含抗坏血酸化合物和至少一种选自水溶性硫代硫酸盐，水溶性连二亚硫酸盐，L-半胱氨酸盐酸盐，谷胱甘肽和没食子酸酯的还原剂。

2. 发明授权

US5064829A Composition of a B vitamin and mannitol and a method for production 失效
标题翻译： B维生素和芒硝的组合物和生产方法
公开(公告)号：US5064829A
公开(公告)日：1991-11-12
申请号：US500249
申请日：1990-03-27
申请人： Seiji Izuhara , Yoshitomi Kakiguchi , Kunihiko Yokota
发明人： Seiji Izuhara , Yoshitomi Kakiguchi , Kunihiko Yokota
IPC分类号： A61K9/14 , A23K1/16 , A61K9/16 , A61K9/50 , A61K31/44 , A61K31/505 , A61K31/51 , A61K31/525 , A61K47/26 , A61K47/44 , A61P3/02
CPC分类号： A61K31/525 , A23K20/174 , A61K31/505 , A61K9/145 , A61K9/1623 , A61K9/5015 , Y10S514/904
摘要： A composition which consists of a compound belonging to the Vitamin B group and having a solubility in water at 20.degree. C. of not more than 5%, and mannitol, is stable in itself and undergoes less influence under ambient humidity conditions.Its good flowability is retained during storage, only with very small changes, if any.

3. 发明授权

US5290568A Production of .beta.-form thiamine hydrochloride crystals 失效
标题翻译：生产β型盐酸硫胺素晶体
公开(公告)号：US5290568A
公开(公告)日：1994-03-01
申请号：US945728
申请日：1992-09-15
申请人： Tatsuo Asogawa , Yoshitomi Kakiguchi , Seiji Izuhara
发明人： Tatsuo Asogawa , Yoshitomi Kakiguchi , Seiji Izuhara
IPC分类号： A61K9/20 , A61K31/51 , C07B63/00 , C07D415/00 , A61K9/14
CPC分类号： C07D415/00 , Y10S514/951 , Y10S514/952
摘要： A method of producing .beta.-form thiamine hydrochloride crystals which comprises moistening .alpha.-form thiamine hydrochloride crystals in the presence of .beta.-form thiamine hydrochloride crystals as seed crystals and stirring the mixture and a method of producing pharmaceutical preparations containing .beta.-form thiamine hydrochloride crystals which comprises moistening .alpha.-form thiamine hydrochloride crystals, together with a binder, with water in the presence of .beta.-form thiamine hydrochloride crystals as seed crystals and stirring the mixture..beta.-Form thiamine hydrochloride crystals which are stable and resistant to caking and pharmaceutical preparations containing the same can be produced in a simple and easy manner.
摘要翻译：一种生产（β）形式的盐酸硫胺素晶体的方法，其包括在（β）形式的硫胺素盐酸盐晶体存在下，加入（α）形式的硫胺素盐酸盐晶体作为晶种并搅拌所述混合物，以及制备含有（β）形式的硫胺素盐酸盐晶体，其包含在（β）形式的盐酸硫胺素晶体存在下，将水溶性（α）型硫胺素盐酸盐晶体与粘合剂一起加入水中并搅拌该混合物。（β） - 稳定且耐结块的盐酸硫胺素晶体和含有它的药物制剂可以以简单和容易的方式制备。

4. 发明申请

US20100104635A1 PROCESS FOR PREPARING GRANULES OF HYDROPHILIC VITAMINS 审中-公开
标题翻译：制备水解维生素颗粒的方法
公开(公告)号：US20100104635A1
公开(公告)日：2010-04-29
申请号：US12441212
申请日：2007-09-14
申请人： Duane Hoagland , Anisul Quadir , Charles Onyiuke , Frank Tranor , Yoshitomi Kakiguchi , Tomoyoshi Kajiura , Kai Zhuang
发明人： Duane Hoagland , Anisul Quadir , Charles Onyiuke , Frank Tranor , Yoshitomi Kakiguchi , Tomoyoshi Kajiura , Kai Zhuang
IPC分类号： A61K9/32 , A61K31/341
CPC分类号： A61K9/1635 , A61K9/2013 , A61K9/2031 , A61K9/2054
摘要： The present invention relates to a process for preparing granules of a hydrophilic vitamin with polyvinylpyrrolidone as binder in a fluidized bed granulator, to the granules of a hydrophilic vitamin obtained by said process, to tablets made with said granules of a hydrophilic vitamin, to mixture of L-ascorbic acid for direct tabletting and tablets made with said mixtures.
摘要翻译：本发明涉及一种在流化床造粒机中制备具有聚乙烯吡咯烷酮作为粘合剂的亲水性维生素颗粒的方法，将由所述方法获得的亲水性维生素的颗粒制成由所述亲水性维生素颗粒制成的片剂，用于直接压片的L-抗坏血酸和用所述混合物制成的片剂。

5. 发明申请

US20080069875A1 Disintegrating Buccal Tablets 审中-公开
标题翻译：崩解颊面片
公开(公告)号：US20080069875A1
公开(公告)日：2008-03-20
申请号：US11662483
申请日：2005-09-10
申请人： Yoshitomi Kakiguchi , Kunihiko Yokota , Mitsunori Tanabe , Tomoyoshi Kajiura , Tadaaki Tanaka
发明人： Yoshitomi Kakiguchi , Kunihiko Yokota , Mitsunori Tanabe , Tomoyoshi Kajiura , Tadaaki Tanaka
IPC分类号： A61K9/20 , A61K47/30
CPC分类号： A61K9/0056 , A61K9/2031
摘要： Disintegrating buccal tablets comprising a physiologically active material and a polyvinyl alcohol/polyethylene glycol graft copolymer are disclosed along with methods of making the same.
摘要翻译：公开了包含生理活性物质和聚乙烯醇/聚乙二醇接枝共聚物的崩解颊含片及其制备方法。

6. 发明申请

US20070218140A1 Slow-Release Preparations And Their Method Of Production 审中-公开
标题翻译：缓释制剂及其生产方法
公开(公告)号：US20070218140A1
公开(公告)日：2007-09-20
申请号：US11578698
申请日：2005-04-15
申请人： Mitsunori Tanabe , Tadaaki Tanaka , Kunihiko Yokota , Yoshitomi Kakiguchi , Tomoyoshi Kajiura
发明人： Mitsunori Tanabe , Tadaaki Tanaka , Kunihiko Yokota , Yoshitomi Kakiguchi , Tomoyoshi Kajiura
IPC分类号： A61K9/16 , A61K31/135 , A61K9/50 , B65D83/04 , A61K9/00
CPC分类号： A61K31/135 , A61K9/5078
摘要： [Problem] To provide pharmaceutical preparations where the dissolution of an amine drug can be effectively controlled. [Resolution Means] Slow-release granules formed by providing a coating layer containing polyvinyl acetate and surfactant on drug-containing particles comprising an amine drug and a water-soluble binder coated onto the surface of a core material; together with a method for the production of slow-release granules which includes (i) a stage in which a liquid comprising an amine drug and a water-soluble binder dissolved or dispersed in an aqueous solvent is sprayed onto the surface of a core material and dried to form a drug layer, and (ii) a stage in which an aqueous coating liquid containing polyvinyl acetate and surfactant is sprayed onto the drug-containing particles obtained in stage (i) and dried to form a coating layer.
摘要翻译： [问题]提供可以有效控制胺药物溶解的药物制剂。 [解决方法]通过在包含胺药物和涂覆在芯材表面上的水溶性粘合剂的含药颗粒上提供含有聚乙酸乙烯酯和表面活性剂的涂层形成的缓释颗粒; 以及用于制备缓释颗粒的方法，其包括（i）将包含胺药物和溶于或分散在水性溶剂中的水溶性粘合剂的液体喷雾到芯材的表面上的阶段，以及干燥以形成药物层，并且（ii）将含有聚乙酸乙烯酯和表面活性剂的水性涂布液喷雾到在阶段（i）中获得的含药颗粒上并干燥以形成涂层的阶段。

7. 发明授权

US06770296B2 Process for producing coated preparation and its use 失效
标题翻译：生产涂层制剂及其用途的方法
公开(公告)号：US06770296B2
公开(公告)日：2004-08-03
申请号：US10245123
申请日：2002-09-17
申请人： Yoshitomi Kakiguchi , Kunihiko Yokota , Masaru Miyawaki
发明人： Yoshitomi Kakiguchi , Kunihiko Yokota , Masaru Miyawaki
IPC分类号： A61K920
CPC分类号： A61K9/5015 , A61K9/0056 , A61K9/2018
摘要： There is provide a novel process for producing a coated preparation composed of a hydrophilic core material coated with a coat material selected from hydrophobic hot-melt lipid to control dissolution of the core material in water and to prevent blocking during the production thereof. In this process, the melted coat material is added dropwise to the core material with fluidizing the core material to form at least one coating layer about the core material in the presence of, or by addition of &bgr;-form seed crystals of the coat material. Further, there is provided a water-soluble vitamin preparation having an improved flavor which contains a coated water-soluble vitamin having an unpleasant flavor produced by the novel process.
摘要翻译：提供了一种制备涂覆制剂的新方法，该涂覆制剂由涂覆有选自疏水性热熔融脂质的涂层材料的亲水芯材组成，以控制芯材在水中的溶解并防止在其生产过程中的堵塞。在该过程中，将熔融的涂层材料滴加到芯材料中，使核心材料流化，以在涂层材料的β型晶种的存在下或通过添加β型晶种来形成围绕芯材料的至少一个涂层。此外，提供了具有改善的风味的水溶性维生素制剂，其含有通过新方法产生的令人不愉快的风味的包衣的水溶性维生素。

8. 发明授权

US06485742B1 Process for producing coated preparation and its use 失效
标题翻译：生产涂层制剂及其用途的方法
公开(公告)号：US06485742B1
公开(公告)日：2002-11-26
申请号：US09542929
申请日：2000-04-04
申请人： Yoshitomi Kakiguchi , Kunihiko Yokota , Masaru Miyawaki
发明人： Yoshitomi Kakiguchi , Kunihiko Yokota , Masaru Miyawaki
IPC分类号： A61K920
CPC分类号： A61K9/5015 , A61K9/0056 , A61K9/2018
摘要： There is provide a process for producing a coated preparation composed of a hydrophilic core material coated with a coat material selected from hydrophobic hot-melt lipid to control dissolution of the core material in water and to prevent blocking during the production thereof. In this process, the melted coat material is added dropwise to the core material with fluidizing the core material to form at least one coating layer about the core material in the presence of, or by addition of &bgr;-form seed crystals of the coat material. Further, there is provided a water-soluble vitamin preparation having an improved flavor which contains a coated water-soluble vitamin having an unpleasant flavor produced by the novel process.
摘要翻译：提供一种制备涂覆制剂的方法，所述涂覆制剂由涂覆有选自疏水性热熔融脂质的涂层材料的亲水芯材组成，以控制芯材在水中的溶解并防止在其生产过程中堵塞。在该过程中，将熔融的涂层材料滴加到芯材料中，使核心材料流化，以在涂层材料的β型晶种的存在下或通过添加β型晶种来形成围绕芯材料的至少一个涂层。此外，提供了具有改善的风味的水溶性维生素制剂，其含有通过新方法产生的令人不愉快的风味的包衣的水溶性维生素。

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