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1. 发明授权

US08426376B2 Angiogenesis inhibitor 有权
标题翻译：血管生成抑制剂
公开(公告)号：US08426376B2
公开(公告)日：2013-04-23
申请号：US12702272
申请日：2010-02-08
申请人： Yasufumi Sato , Hikaru Sonoda , Hideki Ohta
发明人： Yasufumi Sato , Hikaru Sonoda , Hideki Ohta
IPC分类号： A61K31/7088 , C12Q1/68 , A61P9/10
CPC分类号： A61K45/06 , A61K31/7088 , A61K38/00 , C07K14/4703 , C07K16/22 , G01N33/574 , G01N2333/515 , G01N2500/04 , Y10T436/143333 , A61K2300/00
摘要： Because AK022567 has angiogenesis inhibitory activity, it is useful as an angiogenesis inhibitor. Furthermore, 4 splicing variants obtained from the same gene are also useful as an angiogenesis inhibitor. These 5 polypeptides, polynucleotides encoding the polypeptides and antibodies against the polypeptides are useful for screening of a candidate compound as an angiogenesis inhibitor or promoter. A compound obtained from the screening is useful as a medicine and can be used for a preventive or therapeutic agent for an angiogenesis related disease.
摘要翻译：由于AK022567具有血管发生抑制活性，因此可用作血管生成抑制剂。此外，从相同基因获得的4个剪接变体也可用作血管发生抑制剂。这5种多肽，编码多肽的多核苷酸和针对多肽的抗体可用于筛选作为血管生成抑制剂或启动子的候选化合物。从筛选获得的化合物可用作药物，并且可用于血管生成相关疾病的预防或治疗剂。

2. 发明授权

US07956036B2 Polypeptide and DNA thereof useful as a neovascular marker 有权
标题翻译：多肽及其DNA可用作新生血管标志物
公开(公告)号：US07956036B2
公开(公告)日：2011-06-07
申请号：US12027873
申请日：2008-02-07
申请人： Yasufumi Sato , Hikaru Sonoda , Hideki Ohta
发明人： Yasufumi Sato , Hikaru Sonoda , Hideki Ohta
IPC分类号： C12N5/00 , A61K38/17 , A61K31/711 , C12Q1/68 , A61P35/00
CPC分类号： C12Q1/6883 , A61K38/00 , C07K14/47 , C12N2799/026 , C12Q2600/158
摘要： A marker for neovascularization, vascular disease, inflammatory disease, entoptic neovascular disease, reproductive system disease, central nervous system disease and cancer, the method of detection of the marker and a diagnosis kit of the diseases are provided. Additionally, therapeutic agents of the diseases are provided.The expression of KIAA1036 is enhanced in ovarian cancer and large bowel cancer and KIAA1036 expresses in umbilical vein endothelial cell and inhibits DNA synthesis in the cells, cell migrating and lumen formation. Therefore KIAA1036 is useful as a marker for neovascularization, vascular disease, inflammatory disease, entoptic neovascular disease, reproductive system disease, central nervous system disease or cancer. Additionally, KIAA1036 is useful for screening of agonists, antagonists, DNA synthesis inhibitors, cell migrating inhibitors and neovascular inhibitors. The substances obtained by the screening, KIAA1036 and the antibodies are useful as therapeutic agents the above disease.
摘要翻译：提供新生血管形成，血管疾病，炎性疾病，新生血管新生血管疾病，生殖系统疾病，中枢神经系统疾病和癌症的标志物，检测标志物的方法和疾病的诊断试剂盒。此外，提供了疾病的治疗剂。 KIAA1036在卵巢癌和大肠癌中的表达增强，KIAA1036在脐静脉内皮细胞中表达，抑制细胞中的DNA合成，细胞迁移和管腔形成。因此，KIAA1036可用作新生血管形成，血管疾病，炎性疾病，新生血管新生，生殖系统疾病，中枢神经系统疾病或癌症的标志物。另外，KIAA1036可用于筛选激动剂，拮抗剂，DNA合成抑制剂，细胞迁移抑制剂和新生血管抑制剂。通过筛选获得的物质，KIAA1036和抗体可用作上述疾病的治疗剂。

3. 发明申请

US20090270314A1 POLYPEPTIDE HAVING ANTI-ANGIOGENIC ACTIVITY 审中-公开
标题翻译：具有抗血小板活性的多肽
公开(公告)号：US20090270314A1
公开(公告)日：2009-10-29
申请号：US12088234
申请日：2006-09-27
申请人： Yasufumi Sato , Hikaru Sonoda , Hideki Ohta
发明人： Yasufumi Sato , Hikaru Sonoda , Hideki Ohta
IPC分类号： A61K38/16 , C07K14/00 , G01N33/53 , A61P9/00 , A61P25/00 , A61P35/00
CPC分类号： C07K14/47 , A61K38/00 , G01N33/5011 , G01N33/57496 , G01N2333/475
摘要： The present inventors found out four kinds of fragments (42 kD, 36 kD, 32 kD, 27 kD) by forcibly expressing vasohibin in a vascular endothelial cell. The present inventors analyzed those fragments and, as a result, found out low molecular weight vasohibin which has an anti-angiogenic activity. The low molecular weight vasohibin is useful as a therapeutic agent for various diseases such as a vascular disease associated with angiogenesis, an inflammatory disease, an entoptic neovascular disease, a reproductive disease, a central nervous system disease and cancer and the like. In addition, the low molecular weight vasohibin is also useful as a marker for angiogenesis.
摘要翻译：本发明人通过在血管内皮细胞中强制表达血管舒缓，发现了四种片段（42kD，36kD，32kD，27kD）。本发明人分析了这些片段，结果发现具有抗血管生成活性的低分子量血管舒缓素。低分子量血管舒缓剂可用作各种疾病的治疗剂，例如与血管发生，炎性疾病，内在的新血管病，生殖疾病，中枢神经系统疾病和癌症等有关的血管疾病。此外，低分子量血管舒张也可用作血管生成的标志物。

4. 发明申请

US20050158719A1 Polypeptide serving as angiogenic marker and dna thereof 审中-公开
标题翻译：多肽作为血管生成标记物和dna
公开(公告)号：US20050158719A1
公开(公告)日：2005-07-21
申请号：US10476985
申请日：2002-04-26
申请人： Yasufumi Sato , Hikaru Sonoda , Hideki Ohta
发明人： Yasufumi Sato , Hikaru Sonoda , Hideki Ohta
IPC分类号： A61K38/00 , A61P9/00 , A61P15/00 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07K14/47 , C12N15/12 , C12Q1/68 , C07H21/04 , C07K14/705 , G01N33/574
CPC分类号： C12Q1/6883 , A61K38/00 , C07K14/47 , C12N2799/026 , C12Q2600/158
摘要： A marker for neovascularization, vascular disease, inflammatory disease, entoptic neovascular disease, reproductive system disease, central nervous system disease and cancer, the method of detection of the marker and a diagnosis kit of the diseases are provided. Additionally, therapeutic agents of the diseases are provided. The expression of KIAA1036 is enhanced in ovarian cancer and large bowel cancer and KIAA1036 expresses in umbilical vein endothelial cell and inhibits DNA synthesis in the cells, cell migrating and lumen formation. Therefore KIAA1036 is useful as a marker for neovascularization, vascular disease, inflammatory disease, entoptic neovascular disease, reproductive system disease, central nervous system disease or cancer. Additionally, KIAA1036 is useful for screening of agonists, antagonists, DNA synthesis inhibitors, cell migrating inhibitors and neovascular inhibitors. The substances obtained by the screening, KIAA1036 and the antibodies are useful as therapeutic agents the above disease.
摘要翻译：提供新生血管形成，血管疾病，炎性疾病，新生血管新生血管疾病，生殖系统疾病，中枢神经系统疾病和癌症的标志物，检测标志物的方法和疾病的诊断试剂盒。此外，提供了疾病的治疗剂。 KIAA1036在卵巢癌和大肠癌中的表达增强，KIAA1036在脐静脉内皮细胞中表达，抑制细胞中的DNA合成，细胞迁移和管腔形成。因此，KIAA1036可用作新生血管形成，血管疾病，炎性疾病，新生血管新生，生殖系统疾病，中枢神经系统疾病或癌症的标志物。另外，KIAA1036可用于筛选激动剂，拮抗剂，DNA合成抑制剂，细胞迁移抑制剂和新生血管抑制剂。通过筛选获得的物质，KIAA1036和抗体可用作上述疾病的治疗剂。

5. 发明申请

US20080213759A1 Novel Angiogenesis Inhibitor 审中-公开
标题翻译：新型血管生成抑制剂
公开(公告)号：US20080213759A1
公开(公告)日：2008-09-04
申请号：US11722799
申请日：2005-12-20
申请人： Yasufumi Sato , Hikaru Sonoda , Hideki Ohta
发明人： Yasufumi Sato , Hikaru Sonoda , Hideki Ohta
IPC分类号： C12Q1/68 , C07K14/00 , C12N15/00 , C07K16/00 , G01N33/53 , C12Q1/02 , G01N33/68
CPC分类号： A61K45/06 , A61K31/7088 , A61K38/00 , C07K14/4703 , C07K16/22 , G01N33/574 , G01N2333/515 , G01N2500/04 , Y10T436/143333 , A61K2300/00
摘要： Because AK022567 has angiogenesis inhibitory activity, it is useful as an angiogenesis inhibitor. Furthermore, 4 splicing variants obtained from the same gene are also useful as an angiogenesis inhibitor. These 5 polypeptides, polynucleotides encoding the polypeptides and antibodies against the polypeptides are useful for screening of a candidate compound as an angiogenesis inhibitor or promoter. A compound obtained from the screening is useful as a medicine and can be used for a preventive or therapeutic agent for an angiogenesis related disease.
摘要翻译：由于AK022567具有血管发生抑制活性，因此可用作血管生成抑制剂。此外，从相同基因获得的4个剪接变体也可用作血管发生抑制剂。这5种多肽，编码多肽的多核苷酸和针对多肽的抗体可用于筛选作为血管生成抑制剂或启动子的候选化合物。从筛选获得的化合物可用作药物，并且可用于血管生成相关疾病的预防或治疗剂。

6. 发明申请

US20100113354A1 THERAPEUTIC AGENT COMPRISING VASOHIBIN 审中-公开
标题翻译：包括VASOHIBIN的治疗药物
公开(公告)号：US20100113354A1
公开(公告)日：2010-05-06
申请号：US12593597
申请日：2008-03-26
申请人： Yasufumi Sato , Yohei Maeshima , Tatsuyo Nasu , Katsuyuki Tanabe , Hirofumi Makino
发明人： Yasufumi Sato , Yohei Maeshima , Tatsuyo Nasu , Katsuyuki Tanabe , Hirofumi Makino
IPC分类号： A61K38/16 , C07K14/00 , A61P1/00 , A61P13/12 , C12N15/63 , C07H21/00
CPC分类号： C07K14/47 , A61K38/1709 , C12N2710/10343
摘要： A therapeutic agent containing Vasohibin for diabetic nephropathy, and a therapeutic agent containing Vasohibin for peritoneal sclerosis. Since the therapeutic agent containing Vasohibin of the present invention is a substance in which Vasohibin inhibits angiogenesis in an autocrine manner, the therapeutic agent is effective for inhibiting the progression of diabetic nephropathy and peritoneal sclerosis in which the inhibition in the angiogenesis or the production of cytokine is important, so that the therapeutic agent is suitably used in, for example, the treatment of a disease requiring an action for inhibiting the progression of diabetic nephropathy, and a disease requiring an inhibitory action for peritoneal sclerosis, or the like.
摘要翻译：含有血管舒缓因子用于糖尿病肾病的治疗剂和含有血管舒张素用于腹膜硬化的治疗剂。由于含有本发明的血管舒缓因子的治疗剂是以自分泌方式抑制血管发生的物质，所以治疗剂对于抑制血管新生或抑制细胞因子的糖尿病性肾病和腹膜硬化的发展是有效的是重要的，因此治疗剂适合用于例如治疗需要抑制糖尿病性肾病进展的疾病，以及需要腹膜硬化症的抑制作用的疾病等。

7. 发明授权

US4839669A Liquid jet recording head 失效
标题翻译：液体喷射记录头
公开(公告)号：US4839669A
公开(公告)日：1989-06-13
申请号：US30377
申请日：1987-03-26
申请人： Yasufumi Sato , Megumi Munakata , Hiromichi Noguchi
发明人： Yasufumi Sato , Megumi Munakata , Hiromichi Noguchi
IPC分类号： B41J2/045 , B41J2/05 , B41J2/055 , B41J2/16 , C08F2/48 , G03F7/033
CPC分类号： B41J2/1604 , B41J2/1623 , B41J2/1631 , B41J2/1632 , B41J2/1639 , B41J2/1645 , G03F7/033
摘要： A liquid jet recording head, having a liquid pathway communicated to the discharging outlet of the liquid provided on a substrate surface, said pathway being formed by subjecting a layer of a resin composition curable with an active energy ray to a predetermined pattern exposure with the use of said active energy ray to thereby form a cured region of said resin composition and removing the uncured region from said layer, said resin composition being an active energy ray curable resin composition comprising;(A) a graft copolymerized polymer comprises; trunk chains composed mainly of structural units as monomer represented by the general formula (I) shown below: ##STR1## (wherein R.sub.1 to R.sub.8 each represent hydrogen or methyl group) and at least one monomer selected from the group consisting of alkyl (meth)acrylate, acrylonitride and styrene, having graft chains composed mainly of structural units derived from at least one monomer selected from the group consisting of (a) hydroxyl containing(meth) arcylic monomers, (b) amino or alkylamino containing (meth)acrylic monomer, (c) carboxyl containing(meth) acrylic or vinyl monomers, (d) N-vinylpyrrolidone, (e) vinylpyridine or its derivatives and (f) (meth) acrylamide derivatives represented by the following general formula(II): ##STR2## (wherein R.sup.1 is hydrogen or methyl group, and R.sup.2 is hydrogen or alkyl or acyl group having 1 to 4 carbon atoms which may have hydroxy group.), added to said trunk chains; and(B) a monomer having an ethylenically unsaturated bond.
摘要翻译：一种液体喷射记录头，具有连接到设置在基板表面上的液体的排出口的液体通道，所述通路是通过使用可用活性能量射线固化的树脂组合物层进行预定图案曝光而形成的，的所述活性能量射线，从而形成所述树脂组合物的固化区域并从所述层去除未固化区域，所述树脂组合物是活性能量射线固化树脂组合物，其包含：（A）接枝共聚聚合物包括：主要由作为由下述通式（I）表示的单体的结构单元组成的主链：（I）（其中R 1至R 8各自表示氢或甲基）和至少一种选自以下的单体：烷基（甲基）丙烯酸酯，丙烯腈和苯乙烯，具有主要由衍生自至少一种选自（a）含羟基（甲基）环氧基单体，（b）氨基或含有（甲基）丙烯酸单体，（c）含羧基的（甲基）丙烯酸或乙烯基单体，（d）N-乙烯基吡咯烷酮，（e）乙烯基吡啶或其衍生物和（f）由以下通式（II）表示的（甲基）丙烯酰胺衍生物：（II）（其中R 1为氢或甲基，R 2为氢或可具有羟基的具有1至4个碳原子的烷基或酰基）。和（B）具有烯属不饱和键的单体。

8. 发明申请

US20060041286A1 Method for inducing angiogenesis by electrical stimulation of muscles 审中-公开
公开(公告)号：US20060041286A1
公开(公告)日：2006-02-23
申请号：US11257840
申请日：2005-10-25
申请人： Shinichi Kanno , Yasufumi Sato
发明人： Shinichi Kanno , Yasufumi Sato
IPC分类号： A61N1/32
CPC分类号： A61N1/326
摘要： The present invention discloses a method for angiogenesis. The method comprises the steps of electrically stimulating a muscle below the threshold for muscle contraction.

9. 发明授权

US4839400A Active energy ray-curable resin composition 失效
标题翻译：活性能量射线固化型树脂组合物
公开(公告)号：US4839400A
公开(公告)日：1989-06-13
申请号：US022930
申请日：1987-03-06
申请人： Yasufumi Sato , Megumi Munakata , Hiromichi Noguchi
发明人： Yasufumi Sato , Megumi Munakata , Hiromichi Noguchi
IPC分类号： C08F2/48 , C08F2/46 , C08F2/54 , C08F285/00 , C08F290/04 , G03F7/032 , G03F7/038
CPC分类号： G03F7/032 , C08F285/00 , C08F290/04
摘要： An active energy ray-curable resin composition comprises (A) a graft copolymerized polymer comprising graft chains composed mainly of structural units derived from at least one monomer selected from the group consisting of (a) hydroxyl containing (meth)acrylic monomers, (b) amino or alkylamino containing (meth)acrylic monomers, (c) carboxyl containing (meth)acrylic or vinyl monomers, (d) N-vinylpyrrolidone, (e) vinylpyridine or its derivatives and (f) (meth)acrylic amide derivatives represented by the general formula (II) shown below: ##STR1## (wherein R.sub.1 is hydrogen or methyl group and R.sub.2 is hydrogen or an alkyl or acyl group having 1 to 4 carbon atoms which may have hydroxyl group added to trunk chains composed mainly of structural units compsiting at least one monomer selected from the group consisting of the monomer represented by the general formula (I) shown below: ##STR2## (wherein R.sub.1 to R.sub.8 each represent hydrogen or methyl group), alkyl (meth)acrylates, acrylonitrile and styrene, and (B) a monomer having an ethylenically unsaturated bond.
摘要翻译：活性能量射线固化树脂组合物包含（A）接枝共聚聚合物，其包含主要由衍生自至少一种选自以下的单体的结构单元构成的接枝链：（a）含羟基的（甲基）丙烯酸单体，（b）含（甲基）丙烯酸单体，（c）含羧基的（甲基）丙烯酸或乙烯基单体，（d）N-乙烯基吡咯烷酮，（e）乙烯基吡啶或其衍生物和（f）（甲基）（II）（其中R1是氢或甲基，R2是氢或可以具有羟基的烷基或酰基，其可以主要由主要由构成选自下述通式（I）表示的单体的至少一种单体的结构单元：（I）（其中，R 1〜R 8各自表示氢或甲基），（甲基）丙烯酸烷基酯，丙烯腈和苯乙烯和（B）具有烯属不饱和键的单体。

10. 发明授权

US4839668A Liquid jet recording head 失效
标题翻译：液体喷射记录头
公开(公告)号：US4839668A
公开(公告)日：1989-06-13
申请号：US30111
申请日：1987-03-26
申请人： Yasufumi Sato , Megumi Munakata , Hiromichi Noguchi
发明人： Yasufumi Sato , Megumi Munakata , Hiromichi Noguchi
IPC分类号： B41J2/045 , B41J2/05 , B41J2/055 , B41J2/16 , C08F289/00 , G03F7/033
CPC分类号： B41J2/1604 , B41J2/1623 , B41J2/1631 , B41J2/1632 , B41J2/1639 , B41J2/1645 , G03F7/033
摘要： A liquid jet recording head, having a liquid pathway communicated to the discharging outlet of the liquid provided on a substrate surface, said pathway being formed by subjecting a layer of a resin composition curable with an active energy ray to a predetermined pattern exposure with the use of said active energy ray to thereby form a cured region of said resin composition and removing the uncured region from said layer, said resin composition being an active energy ray curable resin composition comprises,(A) a graft copolymerized polymer comprising trunk chains composed mainly of structural units comprising a monomer comprising in the molecule one (meth)acryloyl group and a dicyclopentenyl derivative group represented by the general formula (I) shown below: ##STR1## (wherein Z represents a 5-membered ring represented by ##STR2## R.sub.1 and R.sub.2 each represents hydrogen atom or analkyl group having 1 to 3 carbon atoms) and at least one monomer selected from the group consisting of alkyl (meth)acrylates, acrylonitrile and styrene, having graft chains composed mainly of structural units derived from at least one monomer selected from the group consisting of (a) hydroxyl containing(meth) acrylic monomers, (b) amino or alkylamino containing (meth)acrylic monomer, (c) carboxyl containing(meth) acrylic or vinyl monomers, (d) N-vinylpyrrrolidone, (e) vinylpyridine or its derivatives and (f) (meth) acrylamide derivatives represented by the following general formula(II): ##STR3## (wherein R.sup.1 is hydrogen or methyl group, and R.sup.2 is hydrogen or alkyl or acyl group having 1 to 4 carbon atoms which may have hydroxy group.), added to said trunk chains; and(B) a monomer having an ethylenically unsaturated bond.
摘要翻译：一种液体喷射记录头，具有连接到设置在基板表面上的液体的排出口的液体通道，所述通路是通过使用可用活性能量射线固化的树脂组合物层进行预定图案曝光而形成的，的所述活性能量射线，从而形成所述树脂组合物的固化区域并从所述层除去未固化区域，所述树脂组合物为活性能量射线固化树脂组合物，其包含：（A）包含主链的主链的主链的接枝共聚聚合物，包含分子中含有一个（甲基）丙烯酰基的单体和由以下通式（I）表示的二环戊烯基衍生物的单体的结构单元：其中Z表示由下式（I）表示的5元环： > R 1和R 2各自表示氢原子或碳原子数1〜3的烷基）和选自烷基（（a）含羟基的（甲基）丙烯酸单体，（b）氨基或含烷基氨基的（甲基）丙烯酸酯的至少一种单体的结构单元构成的接枝链，单体，（c）含羧基的（甲基）丙烯酸或乙烯基单体，（d）N-乙烯基吡咯烷酮，（e）乙烯基吡啶或其衍生物和（f）由以下通式（II）表示的（甲基）丙烯酰胺衍生物：

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