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    • 2. 发明授权
    • Five crystal forms, methods of preparation, pharmaceutical compositions and applications of XLF-III-43
    • 五种晶体形式,制备方法,药物组合物和XLF-III-43的应用
    • US08729280B2
    • 2014-05-20
    • US13131492
    • 2009-11-28
    • Yang LvXiaoguang ChenPing XieLi ZhangCheng Wang
    • Yang LvXiaoguang ChenPing XieLi ZhangCheng Wang
    • C07D311/00
    • C07D311/16A61K31/37
    • This invention discloses that the five crystal forms of XLF-III-43 can be used as crude drugs. The invention also relates to the preparation methods of the five crystal forms of XLF-III-43 as crude drugs, to the applications of the sterling of the five crystal forms of XLF-III-43 and mixed crystals in different proportions as medicinally active components to develop various kinds of medicines and compound medicines. In addition, this invention also relates to applying the crystal samples of XLF-III-43 as crude drugs to treat kidney dysfunction, cardiocerebral vessel diseases, hypertension, type II diabetic mellitus, complications of hypertension and diabetic mellitus, tumor, precancerosis, edema, and achieves therapeutic effects by enhancing blood drug levels resulted from effects of crystal forms in the processes of treating all kinds of diseases.
    • 本发明公开了XLF-III-43的五种晶体形式可用作生药。 本发明还涉及作为生药的XLF-III-43的五种结晶形式的制备方法,将XLF-III-43的五种晶型和不同比例的混晶的英制应用作为药物活性成分 开发各种药品和复合药物。 此外,本发明还涉及将XLF-III-43的晶体样品作为生药用于治疗肾功能障碍,心脑血管疾病,高血压,II型糖尿病,高血压和糖尿病并发症,肿瘤,癌前病变,水肿, 并且通过在治疗各种疾病的过程中增强由结晶形式的作用引起的血药浓度来达到治疗效果。